TNSN90003A1 - Derives de 2-aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation - Google Patents

Derives de 2-aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation

Info

Publication number
TNSN90003A1
TNSN90003A1 TNTNSN90003A TNSN90003A TNSN90003A1 TN SN90003 A1 TNSN90003 A1 TN SN90003A1 TN TNSN90003 A TNTNSN90003 A TN TNSN90003A TN SN90003 A TNSN90003 A TN SN90003A TN SN90003 A1 TNSN90003 A1 TN SN90003A1
Authority
TN
Tunisia
Prior art keywords
6alkyl
hydrogen
aminopyrimidinon
preparation
derivatives useful
Prior art date
Application number
TNTNSN90003A
Other languages
English (en)
Inventor
Edmond Ludo
Vandenberk Jan
Martin Boey Jozef
Kennis Josephine
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN90003A1 publication Critical patent/TNSN90003A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'INVENTION CONCERNE DES DERIVES DE 2-AMINOPYRIMIDINONES POSSEDANT DES PROPRIETES D'ANTAGONISME DE LA SEROTONINE ET DES PROPRIETES ANTIHISTAMINIQUES, DES PROCEDES POUR PREPARER CES COMPOSES, DES COMPOSITIONS LES CONTENANT COMME INGREDIENT ACTIF ET UN PROCEDE POUR TRAITER DES SUJETS ATTEINTS DE MALADIES ET/OU DE TROUBLES ASSOCIES A LA LIBERATION DES NEUROTRANSMETTEURS, EN PARTICULIER DES SUJETS PRESENTANT DES TROUBLES DU SOMMEIL, AVEC DES DERIVES DE 2-AMINOPYRIMIDINONE SUBSTITUES PAR UN GROUPE 4-BIS(ARYL) METHYLENE-1-PIPERIDINYLE, ET UN PROCEDE POUR TRAITER DES SUJETS ATTEINTS DE MALADIE ET/OU DE TROUBLES PSYCHOTIQUES AVEC DES DERIVES DE 2-AMINOPYRIMIDINONE SUBSTITUES PAR UN GROUPE 4-ARYLCARBONYL-1-PIPERIDINYLE, 4-BENZAZOLYL-1-PIPERIDINYLE, 4- BENZAZOLYL-1-PIPERAZINYLE OU 4-INDOLYL-1-PIPERIDINYLE, 4-BENZO[B] FURANNYL-1-PIPERIDINYLE OU 4-BENZO[B]THIENYL-1-PIPERIDINYLE
TNTNSN90003A 1989-01-09 1990-01-09 Derives de 2-aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation TNSN90003A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898900382A GB8900382D0 (en) 1989-01-09 1989-01-09 2-aminopyrimidinone derivatives

Publications (1)

Publication Number Publication Date
TNSN90003A1 true TNSN90003A1 (fr) 1991-03-05

Family

ID=10649779

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN90003A TNSN90003A1 (fr) 1989-01-09 1990-01-09 Derives de 2-aminopyrimidinones utiles notamment comme antagonistes des neurotransmetteurs et procede pour leur preparation

Country Status (25)

Country Link
EP (1) EP0378255B1 (fr)
JP (1) JP2938492B2 (fr)
KR (1) KR0159099B1 (fr)
CN (1) CN1034865C (fr)
AT (1) ATE104971T1 (fr)
AU (1) AU617918B2 (fr)
CA (1) CA2007200C (fr)
DE (1) DE69008366T2 (fr)
DK (1) DK0378255T3 (fr)
ES (1) ES2055860T3 (fr)
FI (1) FI94525C (fr)
GB (1) GB8900382D0 (fr)
HU (1) HU203747B (fr)
IE (1) IE62874B1 (fr)
IL (1) IL92730A (fr)
JO (1) JO1605B1 (fr)
MA (1) MA21722A1 (fr)
MY (1) MY106259A (fr)
NO (1) NO173139C (fr)
NZ (1) NZ231788A (fr)
PT (1) PT92806B (fr)
RU (1) RU2028297C1 (fr)
TN (1) TNSN90003A1 (fr)
ZA (1) ZA90123B (fr)
ZW (1) ZW290A1 (fr)

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EP0347146B1 (fr) * 1988-06-16 1993-09-01 Smith Kline & French Laboratories Limited Dérivés de pyrimidine condensés, procédé et intermédiaires pour leur préparation et compositions pharmaceutiques les contenant
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US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
NZ254113A (en) * 1992-07-13 1995-08-28 Janssen Pharmaceutica Nv Fused piperidine derivatives and medicaments
CN1050604C (zh) * 1993-02-04 2000-03-22 明治制果株式会社 具有抗精神病作用的化合物
GB9305623D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
JPH11502816A (ja) * 1995-03-20 1999-03-09 イーライ・リリー・アンド・カンパニー ５−置換−３−（１，２，３，６−テトラヒドロピリジン−４−イル）−および３−（ピペリジン−４−イル）−１ｈ−インドール類：新規５−ｈｔ▲下１ｆ▼アゴニスト
ZA979781B (en) 1996-11-14 1998-06-08 Akzo Nobel Nv Piperidine derivatives.
ES2165274B1 (es) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
ES2201907B1 (es) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
EP1608317B1 (fr) 2003-03-25 2012-09-26 Takeda Pharmaceutical Company Limited Inhibiteurs de dipeptidyle peptidase
EP1911754B1 (fr) * 2003-08-13 2013-10-09 Takeda Pharmaceutical Company Limited Inhibiteurs de peptidase dipeptidyl
US7470700B2 (en) 2003-08-13 2008-12-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007505121A (ja) * 2003-09-08 2007-03-08 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
AU2004318013B8 (en) 2004-03-15 2011-10-06 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2006061373A2 (fr) * 2004-12-07 2006-06-15 Solvay Pharmaceuticals B.V. Indoles de tetrahydropyridine-4-yle comportant une combinaison de sites a affinite avec des recepteurs de dopamine d2 et inhibant la reabsorption de la serotonine
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20070072870A2 (en) 2004-12-08 2007-03-29 Solvay Pharmeceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
JP2008524331A (ja) 2004-12-21 2008-07-10 武田薬品工業株式会社 ジペプチジルペプチダーゼ阻害剤
CA2622472C (fr) 2005-09-14 2013-11-19 Takeda Pharmaceutical Company Limited Inhibiteurs de la dipeptidyl peptidase permettant de traiter le diabete
CN101360723A (zh) 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
TW200813015A (en) 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
BR102012024778A2 (pt) * 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
WO2015064714A1 (fr) * 2013-10-31 2015-05-07 国立大学法人東京大学 Dérivé substitué en position 1 d'imidazopyrimidinone ayant une activité inhibitrice sur l'autotaxine
AU2018240172C1 (en) 2017-03-20 2019-10-24 Novo Nordisk Health Care Ag Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators
JP7090639B2 (ja) * 2017-04-11 2022-06-24 サンシャイン・レイク・ファーマ・カンパニー・リミテッド フッ素置換されたインダゾール化合物及びその使用
CN113226356A (zh) 2018-09-19 2021-08-06 福马治疗股份有限公司 活化丙酮酸激酶r
US10675274B2 (en) 2018-09-19 2020-06-09 Forma Therapeutics, Inc. Activating pyruvate kinase R

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US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
FR2537764A1 (fr) * 1982-12-08 1984-06-15 Framatome Sa Dispositif de commande de deux grappes de crayons de reglage deplacables verticalement dans un meme assemblage combustible du coeur d'un reacteur nucleaire
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
EP0378255A3 (fr) 1991-01-09
KR900011755A (ko) 1990-08-02
NO173139B (no) 1993-07-26
DK0378255T3 (da) 1994-05-24
NO900071D0 (no) 1990-01-08
CN1034865C (zh) 1997-05-14
FI94525B (fi) 1995-06-15
IL92730A (en) 1993-06-10
JP2938492B2 (ja) 1999-08-23
GB8900382D0 (en) 1989-03-08
HU900064D0 (en) 1990-03-28
NO900071L (no) 1990-07-10
EP0378255B1 (fr) 1994-04-27
IE62874B1 (en) 1995-03-08
MY106259A (en) 1995-04-29
IL92730A0 (en) 1990-09-17
EP0378255A2 (fr) 1990-07-18
CA2007200A1 (fr) 1990-07-09
ES2055860T3 (es) 1994-09-01
HUT52770A (en) 1990-08-28
DE69008366T2 (de) 1994-08-25
CA2007200C (fr) 1999-07-20
IE900069L (en) 1990-07-09
FI94525C (fi) 1995-09-25
JPH02225482A (ja) 1990-09-07
PT92806B (pt) 1995-11-30
PT92806A (pt) 1990-07-31
AU4777990A (en) 1990-07-12
ATE104971T1 (de) 1994-05-15
FI900085A0 (fi) 1990-01-08
HU203747B (en) 1991-09-30
NZ231788A (en) 1990-12-21
CN1044094A (zh) 1990-07-25
JO1605B1 (en) 1990-07-01
RU2028297C1 (ru) 1995-02-09
MA21722A1 (fr) 1990-10-01
ZA90123B (en) 1991-09-25
ZW290A1 (en) 1991-09-11
DE69008366D1 (de) 1994-06-01
AU617918B2 (en) 1991-12-05
NO173139C (no) 1993-11-03
KR0159099B1 (ko) 1998-12-01
FI900085A (fi) 1990-07-10

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