DK0625355T3 - Tablet med forbedret biologisk tilgængelighed indeholdende dichlormethylenphosphonsyre som virksomt stof - Google Patents

Tablet med forbedret biologisk tilgængelighed indeholdende dichlormethylenphosphonsyre som virksomt stof

Info

Publication number
DK0625355T3
DK0625355T3 DK93111827.7T DK93111827T DK0625355T3 DK 0625355 T3 DK0625355 T3 DK 0625355T3 DK 93111827 T DK93111827 T DK 93111827T DK 0625355 T3 DK0625355 T3 DK 0625355T3
Authority
DK
Denmark
Prior art keywords
tablet
active substance
phosphonic acid
improved bioavailability
dichloromethylene
Prior art date
Application number
DK93111827.7T
Other languages
English (en)
Other versions
DK0625355T4 (da
DK0625355T5 (da
Inventor
Walter Preis
Bernd Muesel
Guenter Dr Neugebauer
Rolf-Dieter Dr Gabel
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25927331&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0625355(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE9307393U external-priority patent/DE9307393U1/de
Priority claimed from DE19934322057 external-priority patent/DE4322057A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK0625355T3 publication Critical patent/DK0625355T3/da
Publication of DK0625355T4 publication Critical patent/DK0625355T4/da
Application granted granted Critical
Publication of DK0625355T5 publication Critical patent/DK0625355T5/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK93111827T 1993-05-15 1993-07-24 Tablet med forbedret biotilgængelighed indeholdende dichlormethylendiphosphonsyre som virksomt stof DK0625355T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE9307393U DE9307393U1 (de) 1993-05-15 1993-05-15 Tablette mit verbesserter Bioverfügbarkeit, enthaltend Dichlormethylendiphosphonsäure als Wirkstoff
DE19934322057 DE4322057A1 (de) 1993-07-02 1993-07-02 Tablette mit verbesserter Bioverfügbarkeit enthaltend Dichlormethylendiphosphonsäure als Wirkstoff

Publications (3)

Publication Number Publication Date
DK0625355T3 true DK0625355T3 (da) 1995-12-27
DK0625355T4 DK0625355T4 (da) 2003-10-06
DK0625355T5 DK0625355T5 (da) 2003-12-01

Family

ID=25927331

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93111827T DK0625355T5 (da) 1993-05-15 1993-07-24 Tablet med forbedret biotilgængelighed indeholdende dichlormethylendiphosphonsyre som virksomt stof

Country Status (25)

Country Link
US (1) US5650168A (da)
EP (2) EP0625355B2 (da)
JP (1) JP3699110B2 (da)
KR (1) KR100263284B1 (da)
CN (1) CN1041797C (da)
AT (2) ATE128363T1 (da)
AU (1) AU687744B2 (da)
BR (1) BR9307859A (da)
CA (1) CA2162470C (da)
CZ (1) CZ287984B6 (da)
DE (1) DE59300688D1 (da)
DK (1) DK0625355T5 (da)
ES (1) ES2065313T5 (da)
FI (1) FI111519B (da)
GR (2) GR940300095T1 (da)
HU (1) HU220872B1 (da)
IL (1) IL106743A (da)
NO (1) NO307548B1 (da)
NZ (1) NZ254765A (da)
PL (1) PL173026B1 (da)
RU (1) RU2134103C1 (da)
SK (1) SK281193B6 (da)
TW (1) TW350772B (da)
UA (1) UA39884C2 (da)
WO (1) WO1994026310A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94926C (fi) * 1993-11-12 1995-11-27 Leiras Oy Menetelmä klodronaattivalmisteen valmistamiseksi
DE19615812A1 (de) * 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation
CZ289261B6 (cs) * 2000-07-11 2001-12-12 Léčiva, A.S. Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby
RU2192848C1 (ru) * 2001-10-30 2002-11-20 Закрытое акционерное общество "ВЕРОФАРМ" Противорвотное средство
US10226428B2 (en) 2003-09-19 2019-03-12 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
US10213387B2 (en) 2003-09-19 2019-02-26 Sun Pharma Advanced Research Company Ltd. Oral drug delivery system
AU2004283565C1 (en) * 2003-09-19 2011-10-27 Sun Pharma Advanced Research Company Limited Oral drug delivery system
US7151400B2 (en) * 2004-07-13 2006-12-19 Taiwan Semiconductor Manufacturing Company, Ltd. Boost-biased level shifter
CN100370972C (zh) * 2006-01-10 2008-02-27 北京申科联华科技有限公司 一种具有益气养阴、活血复脉功效的片剂及制备方法
CN101808640A (zh) * 2007-08-02 2010-08-18 帝人制药株式会社 骨代谢异常所引起的疾病的预防药或治疗药
EP2242485A4 (en) * 2008-02-15 2013-05-08 Sun Pharma Advanced Res Co Ltd ORAL TABLET WITH CONTROLLED RELEASE
CN118370733B (zh) * 2024-06-21 2024-10-01 山东新时代药业有限公司 一种钙代谢调节药物氯膦酸二钠片及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH9776A (en) * 1967-12-11 1976-03-17 M Francis Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use
DE2813121A1 (de) * 1977-03-29 1978-10-12 Procter & Gamble Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) * 1980-10-07 1987-01-06 The Procter & Gamble Company Method for inhibiting tumor metastasis
US4517179A (en) * 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
SU1437023A1 (ru) * 1986-01-02 1988-11-15 Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств Антацидное средство "Кальмагин
SE457326B (sv) * 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
ES2040733T3 (es) * 1986-12-20 1993-11-01 Boehringer Mannheim Gmbh Medicamentos que contienen clodronato y procedimiento para su preparacion.
DE3804686A1 (de) * 1988-02-15 1989-08-24 Henkel Kgaa Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
FR2629716B1 (fr) * 1988-04-07 1991-07-19 Sanofi Sa Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
FI83421C (fi) † 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
DK0573604T3 (da) * 1991-02-26 1995-05-29 Procter & Gamble Pharma Fremgangsmåde til behandling af osteoporosis
SE501389C2 (sv) * 1992-04-24 1995-01-30 Leiras Oy Farmaceutiskt preparat och förfarande för dess framställning
AU5953894A (en) * 1992-12-23 1994-07-19 Merck & Co., Inc. Bisphosphonate/estrogen therapy for treating and preventing bone loss

Also Published As

Publication number Publication date
KR100263284B1 (ko) 2000-08-01
EP0625355B2 (de) 2003-06-25
SK4895A3 (en) 1997-01-08
AU4702093A (en) 1994-12-12
CZ287984B6 (cs) 2001-03-14
EP0697890A1 (de) 1996-02-28
TW350772B (en) 1999-01-21
UA39884C2 (uk) 2001-07-16
DK0625355T4 (da) 2003-10-06
PL307133A1 (en) 1995-05-02
CA2162470C (en) 1998-06-16
HU9403160D0 (en) 1995-02-28
KR960702322A (ko) 1996-04-27
NO307548B1 (no) 2000-04-25
IL106743A0 (en) 1993-12-08
CN1095267A (zh) 1994-11-23
ES2065313T3 (es) 1995-12-01
DK0625355T5 (da) 2003-12-01
PL173026B1 (pl) 1998-01-30
WO1994026310A1 (de) 1994-11-24
RU2134103C1 (ru) 1999-08-10
FI945313A0 (fi) 1994-11-11
NZ254765A (en) 1997-02-24
SK281193B6 (sk) 2001-01-18
ES2065313T5 (es) 2004-01-01
AU687744B2 (en) 1998-03-05
BR9307859A (pt) 1996-01-09
ES2065313T1 (es) 1995-02-16
EP0625355B1 (de) 1995-09-27
GR940300095T1 (en) 1995-01-31
HUT70214A (en) 1995-09-28
DE59300688D1 (de) 1995-11-02
JP3699110B2 (ja) 2005-09-28
NO944405L (no) 1994-11-24
ATE128363T1 (de) 1995-10-15
FI945313L (fi) 1994-12-13
US5650168A (en) 1997-07-22
CZ10095A3 (en) 1995-10-18
HU220872B1 (en) 2002-06-29
FI111519B (fi) 2003-08-15
EP0625355A1 (de) 1994-11-23
CA2162470A1 (en) 1994-11-24
GR3017547T3 (en) 1995-12-31
CN1041797C (zh) 1999-01-27
JPH08509697A (ja) 1996-10-15
NO944405D0 (no) 1994-11-17
AT128U1 (de) 1995-03-27
IL106743A (en) 1999-11-30

Similar Documents

Publication Publication Date Title
DK0625355T3 (da) Tablet med forbedret biologisk tilgængelighed indeholdende dichlormethylenphosphonsyre som virksomt stof
FI954990L (fi) Aktiiviainetta sisältävä transdermaalinen valmiste
NO179911C (no) Optisk aktivt 5H-pyrrolo[3,4-bÅpyrazinderivat samt farmasöytiske preparater inneholdende derivatet
FI961282A7 (fi) Transdermaalinen terapeuttinen systeemi, jossa on asetyylisalisyylihap po vaikuttavana aineena
DE69133371D1 (de) Pharmazeutische wirksame Benzochinazolin Verbindungen
AR240225A1 (es) Composicion insecticida que comprende mas de un compuesto activo.
NO934196D0 (no) N,N-disubstituerte arylcykloalkylaminer, deres salter, legemidler inneholdende disse forbindelser, deres anvendelseog fremgangsm}te for deres fremstilling
ITBO910351A0 (it) Elettrodo ad ancoraggio attivo per elettrocateteri
DK0868184T3 (da) Mikrogranula med forlænget frigivelse indeholdende diltiazem som aktivt stof
FI890123A0 (fi) Menetelmä valmistaa terapeuttisesti vaikuttavia indolyylipiperidiiniyhdisteitä
TR24383A (tr) Konsantre yuezey aktif madde granuelleri yapmaya mahsus yoentem
FI933477A7 (fi) 4-kloorifenyylitiometyleeni-bisfosfonihapon dinatriumsuolan monohydraatti, sen valmistus, sitä sisältävät farmaseuttiset koostumukset
DK640688D0 (da) Heterocyklisk substituerede imidater til anvendelse som insekticider
NO961783D0 (no) 5-arylisoxazol-4-yl-substituerte 2-aminokarboksylsyreforbindelser
NO893326L (no) Fremgangsmaate for noeytralisering av svovelsyre inneholdende sinkioner.
FI861557A7 (fi) Menetelmä farmakologisesti aktiivisten fosfiiniyhdisteiden valmistamiseksi.
NO980994D0 (no) Substituerte fosfinsyreforbindelser og deres anvendelse som farmasöytika
DK256689A (da) 1,2-dithiol-3-thion-s-oxid-forbindelser til anven delse som laegemidler
NO873628D0 (no) 2,3-dihydro-1h-fenalen-2-amino-forbindelser som antipsykotiske legemidler.
NO904496D0 (no) Fremgangsmaate for fremstilling av optisk aktive tiazetokinolin-3-karboksylsyreforbindelser.
DE69311355D1 (de) Persäure-verbindungen
DE59408911D1 (de) Phosphorsäure-Derivate als Schädlingsbekämpfungsmittel
DE69130099D1 (de) Antineoplastischer wirkstoff
FI900814A7 (fi) Farmaseuttiset aktiiviset yhdisteet
SE9301141D0 (sv) New active compounds iv