CO4910165A1 - Procedimiento para elaboracion de derivados de 2-amino-2- imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidi- na - Google Patents
Procedimiento para elaboracion de derivados de 2-amino-2- imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidi- naInfo
- Publication number
- CO4910165A1 CO4910165A1 CO97068899A CO97068899A CO4910165A1 CO 4910165 A1 CO4910165 A1 CO 4910165A1 CO 97068899 A CO97068899 A CO 97068899A CO 97068899 A CO97068899 A CO 97068899A CO 4910165 A1 CO4910165 A1 CO 4910165A1
- Authority
- CO
- Colombia
- Prior art keywords
- methylene group
- amino
- membered ring
- group connected
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se relaciona con un método paraelaborar derivados 2-amino-2-imidazolina, guanidina o 2-amino-3,4,5,6-tetrahidropirimidina que tiene la estructura general: o los tautómeros de ellos, donde: (a) R1 es metilo, etilo, un grupo metileno conectado a R2 a través de un enlace sencillo de forma que R1 y R2 formen un anillo de cinco miembros o un grupo metileno conectado a R" a través de otro grupo metileno forma que R1 y R2 formen un anillo de seis miembros; (b) R2 es metilo, etilo, un grupo metileno conectado a R1 a través de un enlace sencillo de forma que R1 y R2 formen un anillo de cinco miembros o un grupo metileno conectado a R1 a través de otro grupo metileno de forma que R1 y R2 formen un anillo de seis miembros; (c) Z es un carbociclo o heterociclo saturado, no saturado o aromático, monocíclico o policíclico que contiene uno o más heteroátomos seleccionados de O, N ó S; y (d) R4 es uno o más sustituyentes en el anillo Z que contiene independientemente hidrógeno, alcoxi, alquiltio alquilo, alquenilo, amino, ciano, halógeno, hidroxi, nitro y tiol; (e) o una forma protegida, sal, sal farmacéuticamente aceptable, éster biohidrolizable o solvato de ellos;el cual comprende los pasos de: (I) preparar un intermedio que tenga la estructura general: donde (a) R es seleccionado del grupo consistente de metilo, etilo y benzilo; (b) R1 es metilo, etilo, un grupo metileno conectado a R2 a través de un enlace sencillo de forma que R1 y R2 formen un anillo de cinco miembros o un grupo metileno conectado a R" a través de otro grupo metileno de forma que R1 y R2 formen un anillo de seis miembros;...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3431896P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4910165A1 true CO4910165A1 (es) | 2000-04-24 |
Family
ID=21875679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97068899A CO4910165A1 (es) | 1996-11-25 | 1997-11-25 | Procedimiento para elaboracion de derivados de 2-amino-2- imidazolina, guanidina y 2-amino-3,4,5,6-tetrahidropirimidi- na |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0944603B1 (es) |
| JP (1) | JP2001506605A (es) |
| KR (1) | KR20000069132A (es) |
| AR (1) | AR008920A1 (es) |
| AT (1) | ATE232851T1 (es) |
| AU (1) | AU732056B2 (es) |
| BR (1) | BR9713296A (es) |
| CA (1) | CA2272690C (es) |
| CO (1) | CO4910165A1 (es) |
| CZ (1) | CZ183599A3 (es) |
| DE (1) | DE69719210T2 (es) |
| DK (1) | DK0944603T3 (es) |
| ID (1) | ID22896A (es) |
| IL (1) | IL130095A0 (es) |
| NO (1) | NO312721B1 (es) |
| PE (1) | PE28099A1 (es) |
| SK (1) | SK69899A3 (es) |
| TR (1) | TR199901484T2 (es) |
| TW (1) | TW472043B (es) |
| WO (1) | WO1998023595A1 (es) |
| ZA (1) | ZA9710581B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0775134A4 (en) | 1994-08-04 | 1997-08-13 | Synaptic Pharma Corp | NEW BENZIMIDAZOLE DERIVATIVES |
| US6495583B1 (en) | 1997-03-25 | 2002-12-17 | Synaptic Pharmaceutical Corporation | Benzimidazole derivatives |
| US20040167194A1 (en) | 2003-02-20 | 2004-08-26 | Randall Jared Lynn | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
| US11077053B2 (en) | 2018-08-21 | 2021-08-03 | Allergan, Inc. | Alpha-2-adrenergic receptor agonists for treatment of presbyopia, visual glare, visual starbursts, visual halos and night myopia |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670807A1 (de) * | 1967-02-17 | 1971-03-11 | Bayer Ag | Verfahren zur Herstellung von cyclischen Guanidinen |
| DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
-
1997
- 1997-11-25 ZA ZA9710581A patent/ZA9710581B/xx unknown
- 1997-11-25 AR ARP970105531A patent/AR008920A1/es not_active Application Discontinuation
- 1997-11-25 JP JP52482898A patent/JP2001506605A/ja active Pending
- 1997-11-25 CO CO97068899A patent/CO4910165A1/es unknown
- 1997-11-25 TR TR1999/01484T patent/TR199901484T2/xx unknown
- 1997-11-25 KR KR1019997004620A patent/KR20000069132A/ko not_active Application Discontinuation
- 1997-11-25 CZ CZ991835A patent/CZ183599A3/cs unknown
- 1997-11-25 DK DK97949622T patent/DK0944603T3/da active
- 1997-11-25 EP EP97949622A patent/EP0944603B1/en not_active Expired - Lifetime
- 1997-11-25 AT AT97949622T patent/ATE232851T1/de not_active IP Right Cessation
- 1997-11-25 IL IL13009597A patent/IL130095A0/xx unknown
- 1997-11-25 WO PCT/US1997/021646 patent/WO1998023595A1/en active IP Right Grant
- 1997-11-25 DE DE69719210T patent/DE69719210T2/de not_active Expired - Lifetime
- 1997-11-25 SK SK698-99A patent/SK69899A3/sk unknown
- 1997-11-25 CA CA002272690A patent/CA2272690C/en not_active Expired - Fee Related
- 1997-11-25 ID IDW990413A patent/ID22896A/id unknown
- 1997-11-25 BR BR9713296-9A patent/BR9713296A/pt unknown
- 1997-11-25 AU AU74021/98A patent/AU732056B2/en not_active Ceased
- 1997-11-25 PE PE1997001068A patent/PE28099A1/es not_active Application Discontinuation
-
1998
- 1998-03-07 TW TW087103342A patent/TW472043B/zh active
-
1999
- 1999-05-25 NO NO19992501A patent/NO312721B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69719210D1 (de) | 2003-03-27 |
| SK69899A3 (en) | 2000-01-18 |
| NO992501L (no) | 1999-07-22 |
| ATE232851T1 (de) | 2003-03-15 |
| NO992501D0 (no) | 1999-05-25 |
| TR199901484T2 (xx) | 1999-09-21 |
| EP0944603B1 (en) | 2003-02-19 |
| BR9713296A (pt) | 1999-10-26 |
| NO312721B1 (no) | 2002-06-24 |
| CA2272690C (en) | 2004-07-13 |
| WO1998023595A1 (en) | 1998-06-04 |
| AU732056B2 (en) | 2001-04-12 |
| DE69719210T2 (de) | 2004-02-12 |
| AR008920A1 (es) | 2000-02-23 |
| ZA9710581B (en) | 1998-06-12 |
| IL130095A0 (en) | 2000-02-29 |
| TW472043B (en) | 2002-01-11 |
| PE28099A1 (es) | 1999-03-31 |
| JP2001506605A (ja) | 2001-05-22 |
| CZ183599A3 (cs) | 1999-10-13 |
| EP0944603A1 (en) | 1999-09-29 |
| KR20000069132A (ko) | 2000-11-25 |
| ID22896A (id) | 1999-12-16 |
| CA2272690A1 (en) | 1998-06-04 |
| DK0944603T3 (da) | 2003-06-16 |
| AU7402198A (en) | 1998-06-22 |
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