CY1108002T1 - Παραγωγα 4-ετεροκυκλυλοσουλφοναμιδυλο-6-μεθοξυ-5- (2-μεθοξυ-φαινοξυ)-2-πυριδυλο-πυριμιδινης, παρασκευη αυτων, και χρηση τους ως ανταγωνιστες υποδοχεα ενδοθηλινης - Google Patents
Παραγωγα 4-ετεροκυκλυλοσουλφοναμιδυλο-6-μεθοξυ-5- (2-μεθοξυ-φαινοξυ)-2-πυριδυλο-πυριμιδινης, παρασκευη αυτων, και χρηση τους ως ανταγωνιστες υποδοχεα ενδοθηλινηςInfo
- Publication number
- CY1108002T1 CY1108002T1 CY20071100324T CY071100324T CY1108002T1 CY 1108002 T1 CY1108002 T1 CY 1108002T1 CY 20071100324 T CY20071100324 T CY 20071100324T CY 071100324 T CY071100324 T CY 071100324T CY 1108002 T1 CY1108002 T1 CY 1108002T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methoxy
- pyridyl
- heterocyliculysulphonamylyl
- phenoxy
- producing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Οι ενώσεις του τύπου (I), όπου R1 είναι ετεροκυκλικό υπόλειμμα εκλεγόμενο από πυριδύλιο και θειαζολύλιο, και όπου το εν λόγω ετεροκυκλικό υπόλειμμα μπορεί να είναι προαιρετικώς υποκατεστημένο με κατώτερο αλκύλιο ή κατώτερο αλκενύλιο· και φαρμακευτικώς παραδεκτά άλατα αυτών, είναι αναστολείς υποδοχέων ενδοθηλίνης και μπορούν, έτσι, να χρησιμοποιηθούν για τη θεραπεία διαταραχών οι οποίες συνδέονται με μη-φυσιολογικό αγγειακό τόνο και ενδοθηλιακή δυσλειτουργία· και τα αντίστοιχα ενδιάμεσα των τύπων (III) και (V).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99104306 | 1999-03-03 | ||
EP00909263A EP1185525B1 (en) | 1999-03-03 | 2000-02-28 | 4-heterocyclylsulfonamidyl-6-methoxy-5-(2-methoxy-phenoxy)-2-pyridyl-pyrimidine derivatives, their preparation and use as endothelin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108002T1 true CY1108002T1 (el) | 2013-09-04 |
Family
ID=8237697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100324T CY1108002T1 (el) | 1999-03-03 | 2007-03-08 | Παραγωγα 4-ετεροκυκλυλοσουλφοναμιδυλο-6-μεθοξυ-5- (2-μεθοξυ-φαινοξυ)-2-πυριδυλο-πυριμιδινης, παρασκευη αυτων, και χρηση τους ως ανταγωνιστες υποδοχεα ενδοθηλινης |
Country Status (30)
Country | Link |
---|---|
US (2) | US6417360B1 (el) |
EP (1) | EP1185525B1 (el) |
JP (1) | JP3488203B2 (el) |
KR (1) | KR100478798B1 (el) |
CN (1) | CN1342158B (el) |
AR (1) | AR044720A1 (el) |
AT (1) | ATE353325T1 (el) |
AU (1) | AU756738B2 (el) |
BR (1) | BR0008717A (el) |
CA (1) | CA2364906C (el) |
CY (1) | CY1108002T1 (el) |
CZ (1) | CZ300324B6 (el) |
DE (1) | DE60033280T2 (el) |
DK (1) | DK1185525T3 (el) |
ES (1) | ES2280198T3 (el) |
HK (1) | HK1044943B (el) |
HR (1) | HRP20010630B1 (el) |
HU (1) | HUP0200080A3 (el) |
ID (1) | ID30484A (el) |
IL (1) | IL145051A0 (el) |
MA (1) | MA26776A1 (el) |
NO (1) | NO320809B1 (el) |
NZ (1) | NZ513671A (el) |
PL (1) | PL198815B1 (el) |
PT (1) | PT1185525E (el) |
RS (1) | RS50109B (el) |
RU (1) | RU2201928C1 (el) |
TR (1) | TR200102562T2 (el) |
WO (1) | WO2000052007A1 (el) |
ZA (1) | ZA200107157B (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY140724A (en) | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
US20020184047A1 (en) * | 2001-04-03 | 2002-12-05 | Plotnick Michael A. | Universal ad queue |
EP1454625A1 (en) * | 2003-03-06 | 2004-09-08 | Speedel Development AG | Pyridylsulfonamidyl-pyrimidines for the treatment of diabetic nephropathies |
EP1595880A1 (en) * | 2004-05-13 | 2005-11-16 | Speedel Pharma AG | Crystalline forms of a pyridinyl-sulfonamide and their use as endothelin receptor antagonists |
WO2007031501A2 (en) * | 2005-09-12 | 2007-03-22 | Speedel Pharma Ag | Pyridylsulfonamidyl-pyrimidines for the prevention of blood vessel graft failure |
US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
EP1938812A1 (en) * | 2006-12-22 | 2008-07-02 | Speedel Pharma AG | Pharmaceutical composition using aliskiren and avosentan |
WO2010011868A2 (en) * | 2008-07-23 | 2010-01-28 | Auspex Pharmaceuticals | Pyridine sulfonamide modulators of endothelin-a-receptor |
US20180022710A1 (en) | 2015-01-29 | 2018-01-25 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
KR101936054B1 (ko) | 2017-06-23 | 2019-01-11 | 한국과학기술연구원 | 항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학 조성물 |
WO2023111299A1 (en) | 2021-12-17 | 2023-06-22 | Idorsia Pharmaceuticals Ltd | Clazosentan disodium salt, its preparation and pharmaceutical compositions comprising the same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1064965C (zh) * | 1994-11-25 | 2001-04-25 | 弗·哈夫曼-拉罗切有限公司 | 新的磺酰胺类化合物及其作为药物的用途 |
CA2162630C (en) | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
US5837708A (en) | 1994-11-25 | 1998-11-17 | Hoffmann-La Roche Inc. | Sulphonamides |
TW313568B (el) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
DE69824090T2 (de) | 1997-08-19 | 2005-07-07 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von 2,5-disubstituierter Pyridine |
TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
-
2000
- 2000-02-17 US US09/505,548 patent/US6417360B1/en not_active Expired - Lifetime
- 2000-02-28 EP EP00909263A patent/EP1185525B1/en not_active Expired - Lifetime
- 2000-02-28 KR KR10-2001-7011184A patent/KR100478798B1/ko not_active IP Right Cessation
- 2000-02-28 CZ CZ20013108A patent/CZ300324B6/cs not_active IP Right Cessation
- 2000-02-28 DE DE60033280T patent/DE60033280T2/de not_active Expired - Lifetime
- 2000-02-28 NZ NZ513671A patent/NZ513671A/xx not_active IP Right Cessation
- 2000-02-28 RS YUP-628/01A patent/RS50109B/sr unknown
- 2000-02-28 CA CA002364906A patent/CA2364906C/en not_active Expired - Lifetime
- 2000-02-28 IL IL14505100A patent/IL145051A0/xx not_active IP Right Cessation
- 2000-02-28 RU RU2001126348/04A patent/RU2201928C1/ru not_active IP Right Cessation
- 2000-02-28 WO PCT/EP2000/001660 patent/WO2000052007A1/en active IP Right Grant
- 2000-02-28 ID IDW00200101897A patent/ID30484A/id unknown
- 2000-02-28 PL PL351794A patent/PL198815B1/pl unknown
- 2000-02-28 BR BR0008717-3A patent/BR0008717A/pt not_active IP Right Cessation
- 2000-02-28 AU AU31611/00A patent/AU756738B2/en not_active Ceased
- 2000-02-28 HU HU0200080A patent/HUP0200080A3/hu unknown
- 2000-02-28 CN CN008043582A patent/CN1342158B/zh not_active Expired - Lifetime
- 2000-02-28 ES ES00909263T patent/ES2280198T3/es not_active Expired - Lifetime
- 2000-02-28 PT PT00909263T patent/PT1185525E/pt unknown
- 2000-02-28 AT AT00909263T patent/ATE353325T1/de active
- 2000-02-28 DK DK00909263T patent/DK1185525T3/da active
- 2000-02-28 TR TR2001/02562T patent/TR200102562T2/xx unknown
- 2000-02-28 JP JP2000602233A patent/JP3488203B2/ja not_active Expired - Lifetime
- 2000-03-02 AR ARP000100921A patent/AR044720A1/es active IP Right Grant
-
2001
- 2001-08-28 HR HR20010630A patent/HRP20010630B1/xx not_active IP Right Cessation
- 2001-08-29 ZA ZA200107157A patent/ZA200107157B/en unknown
- 2001-08-31 NO NO20014224A patent/NO320809B1/no not_active IP Right Cessation
- 2001-09-03 MA MA26313A patent/MA26776A1/fr unknown
-
2002
- 2002-03-08 US US10/094,126 patent/US6521631B2/en not_active Expired - Lifetime
- 2002-08-27 HK HK02106318.0A patent/HK1044943B/zh not_active IP Right Cessation
-
2007
- 2007-03-08 CY CY20071100324T patent/CY1108002T1/el unknown
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