CO5080778A1 - Inhibidores de enzimas - Google Patents

Inhibidores de enzimas

Info

Publication number
CO5080778A1
CO5080778A1 CO99015434A CO99015434A CO5080778A1 CO 5080778 A1 CO5080778 A1 CO 5080778A1 CO 99015434 A CO99015434 A CO 99015434A CO 99015434 A CO99015434 A CO 99015434A CO 5080778 A1 CO5080778 A1 CO 5080778A1
Authority
CO
Colombia
Prior art keywords
protected
group
hydrogen
arylamino
methylene group
Prior art date
Application number
CO99015434A
Other languages
English (en)
Inventor
Mciver John Mcmillan
Todd Laurence Uneriner
Timothy Bates
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO5080778A1 publication Critical patent/CO5080778A1/es

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
    • C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)

Abstract

La presente invención se relaciona con un compuesto que tiene la estructura:<EMI FILE="99015434_1" ID="1" IMF=JPEG >Y los tautómeros, sales aceptables y amidas biohidrolizables, ésteres e imidas de los mismos, en donde:a) B1 se selecciona del grupo que consta de hidrógeno, metilo, etilo, propilo, un grupo metileno conectado a B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B2 a través de un enlace simple de manera que B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B2 a través de otro grupo metileno tal que B1 y B2 formen un anillo de seis miembros;b) B2 se selecciona del grupo que consta de hidrógeno, metilo, etilo, propilo, un grupo metileno conectado a B1 a través de un enlace simple de manera que B1 y B2 formen un anillo de cinco miembros, y un grupo metileno conectado a B1 a través de otro grupo metileno tal que B1 y B2 formen un anillo de seis miembros;c) X se selecciona del grupo que consta de cero, -CH2 -, y-NH-;d) Z es un anillo carboxílico aromático, o no sustituido, monocíclico o policíclico, o anillo heterocíclico;e) L1, L2 , L3 se seleccionan, cada uno, independientemente del grupo que consta de cero, -NH-, -O-, -S-, -C(O)-, -CF2-, alquilo, alquenilo, cicloalquilo, arilo, arilalquilo, arilalquenilo, -C(O)NH-, -NH-SO2-R1-, -C(O)-R2-, -C(O)R3-O-, -C(O)R4-S-, -C(O)R5-NH-, NH-R6-, -O-R7-, -C(O)O-R8-, C(O)NH-R9-, NHC(O)-R10-, -OC(O)-R11-y-C(O)-CH(R12)-N(R13 )-Y-, en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 y R11 se seleccionan, independientemente del grupo que consta de alquilo, alquenilo, cicloalquilo, arilo, arilalquilo, arilalquenilo, alquilamino, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, en donde R12 se selecciona del grupo que consta de hidrógeno, alquilo, alquenilo, cicloalquilo, arilo arilalquilo, arilalquenilo, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, y -AA en donde -AA es una cadena lateral de aminoácido, y R13 es hidrógeno, o R12 y R13 juntos forman un anillo heterocíclico monocíclico o policíclico que incluye el nitrógeno al cual se enlaza R13 , y en donde Y es cero o -C(O)-CH(R14)-N(R15)-en donde R14 se selecciona del grupo que consta de hidrógeno, alquilo, alquenilo, cicloalquilo, arilo, arilalquenilo, alquilamino, alquilamino protegido, arilamino, arilamino protegido, arilalquilamino, arilalquilamino protegido, y -AA en donde -AA es una cadena lateral de aminoácido, y R15 es hidrógeno, ...
CO99015434A 1998-03-12 1999-03-12 Inhibidores de enzimas CO5080778A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/041,196 US6066673A (en) 1998-03-12 1998-03-12 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
CO5080778A1 true CO5080778A1 (es) 2001-09-25

Family

ID=21915262

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99015434A CO5080778A1 (es) 1998-03-12 1999-03-12 Inhibidores de enzimas

Country Status (18)

Country Link
US (2) US6066673A (es)
EP (1) EP1062264A2 (es)
JP (1) JP2002506099A (es)
KR (1) KR20010041860A (es)
CN (1) CN1300303A (es)
AU (1) AU2903799A (es)
BR (1) BR9909248A (es)
CA (1) CA2323496A1 (es)
CO (1) CO5080778A1 (es)
HU (1) HUP0102516A2 (es)
ID (1) ID27574A (es)
IL (1) IL138387A0 (es)
NO (1) NO20004550L (es)
PE (1) PE20000345A1 (es)
PL (1) PL364704A1 (es)
SK (1) SK13652000A3 (es)
WO (1) WO1999046316A2 (es)
ZA (1) ZA991975B (es)

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BR9909248A (pt) 2001-10-09
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US6211186B1 (en) 2001-04-03
ZA991975B (en) 1999-09-27
IL138387A0 (en) 2001-10-31
AU2903799A (en) 1999-09-27
NO20004550D0 (no) 2000-09-12
CN1300303A (zh) 2001-06-20
JP2002506099A (ja) 2002-02-26
PE20000345A1 (es) 2000-05-16
HUP0102516A2 (hu) 2001-11-28
NO20004550L (no) 2000-11-10
KR20010041860A (ko) 2001-05-25
US6066673A (en) 2000-05-23
ID27574A (id) 2001-04-12
PL364704A1 (en) 2004-12-13
WO1999046316A3 (en) 2000-03-23
CA2323496A1 (en) 1999-09-16
SK13652000A3 (sk) 2001-04-09

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