MXPA02002720A - Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden. - Google Patents

Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden.

Info

Publication number
MXPA02002720A
MXPA02002720A MXPA02002720A MXPA02002720A MXPA02002720A MX PA02002720 A MXPA02002720 A MX PA02002720A MX PA02002720 A MXPA02002720 A MX PA02002720A MX PA02002720 A MXPA02002720 A MX PA02002720A MX PA02002720 A MXPA02002720 A MX PA02002720A
Authority
MX
Mexico
Prior art keywords
alkyl
optionally substituted
same
preparation
amino acid
Prior art date
Application number
MXPA02002720A
Other languages
English (en)
Inventor
Husson-Robert Bernadette
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MXPA02002720A publication Critical patent/MXPA02002720A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compuesto de la formula (I): (Ver formula I) en donde: NA representa un heterociclo que contiene nitrogeno de 5 miembros, opcionalmente sustituido, - R1 representa un atomo de hidrogeno o un grupo alquilo, acilo, prolilo, alanilo, histidilprolilo o fenilalanil-prolilo, - Ak representa una cadena de alquileno o heteroalquileno, - X representa un enlace individual o un grupo fenileno opcionalmente sustituido, - R2 representa un grupo alquilo opcionalmente sustituido, un grupo cicloalquilo de 3 a 10 atomos de carbono, o -NR2aR2b en donde R2a y R2b, que pueden ser los mismo o diferentes, representan cada uno un atomo de hidrogeno o un grupo alquilo o un junto con el atomo de hidrogeno que los porta, forman un heterociclo que contienen nitrogeno, - Y representa un grupo -NR3- (Ver estructuras) R3 representa un atomo de hidrogeno o un grupo seleccionado de grupo alquilo, cicloalquilo de 3 a 7 atomos de carbono y arilo, o R1, R5 y R6 que pueden ser los mismos o diferentes, representan cada uno un atomo de hidrogeno o un grupo alquilo, o R4 y R6 o R5 y R6, junto con los atomos que los portan, forman un anillo de imidazolidina o dihidrobencimidazol, sus isomeros opticos y sales de adicion de los mismos con un acido farmaceuticamente aceptable.
MXPA02002720A 2001-03-28 2002-03-13 Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden. MXPA02002720A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0104142A FR2822826B1 (fr) 2001-03-28 2001-03-28 Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
MXPA02002720A true MXPA02002720A (es) 2004-11-12

Family

ID=8861608

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02002720A MXPA02002720A (es) 2001-03-28 2002-03-13 Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden.

Country Status (24)

Country Link
US (1) US6716843B2 (es)
EP (1) EP1245568B1 (es)
JP (1) JP3761827B2 (es)
KR (1) KR100457725B1 (es)
CN (1) CN1166633C (es)
AR (1) AR033620A1 (es)
AT (1) ATE316080T1 (es)
AU (1) AU780373B2 (es)
BR (1) BR0200982A (es)
CA (1) CA2379197C (es)
DE (1) DE60208763T2 (es)
DK (1) DK1245568T3 (es)
EA (1) EA004591B1 (es)
ES (1) ES2256421T3 (es)
FR (1) FR2822826B1 (es)
HK (1) HK1050357B (es)
HU (1) HUP0201088A3 (es)
MX (1) MXPA02002720A (es)
NO (1) NO322895B1 (es)
NZ (1) NZ518035A (es)
PL (1) PL353084A1 (es)
PT (1) PT1245568E (es)
SI (1) SI1245568T1 (es)
ZA (1) ZA200202525B (es)

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NZ518035A (en) 2003-11-28
JP3761827B2 (ja) 2006-03-29
CA2379197A1 (fr) 2002-09-28
SI1245568T1 (sl) 2006-04-30
DK1245568T3 (da) 2006-05-15
CN1166633C (zh) 2004-09-15
HUP0201088A3 (en) 2006-02-28
JP2002363167A (ja) 2002-12-18
EP1245568A1 (fr) 2002-10-02
BR0200982A (pt) 2002-12-31
NO20021542L (no) 2002-09-30
ES2256421T3 (es) 2006-07-16
ZA200202525B (en) 2002-10-24
ATE316080T1 (de) 2006-02-15
EA004591B1 (ru) 2004-06-24
NO20021542D0 (no) 2002-03-27
HK1050357B (zh) 2005-05-13
FR2822826A1 (fr) 2002-10-04
EP1245568B1 (fr) 2006-01-18
CN1377879A (zh) 2002-11-06
CA2379197C (fr) 2007-04-10
AU780373B2 (en) 2005-03-17
EA200200299A1 (ru) 2002-10-31
HUP0201088A2 (hu) 2002-12-28
AR033620A1 (es) 2003-12-26
KR20020077180A (ko) 2002-10-11
US20030087950A1 (en) 2003-05-08
AU2935002A (en) 2002-10-03
DE60208763T2 (de) 2006-09-28
HK1050357A1 (en) 2003-06-20
PL353084A1 (en) 2002-10-07
FR2822826B1 (fr) 2003-05-09
HU0201088D0 (es) 2002-06-29
DE60208763D1 (de) 2006-04-06
KR100457725B1 (ko) 2004-11-17
NO322895B1 (no) 2006-12-18
US6716843B2 (en) 2004-04-06
PT1245568E (pt) 2006-05-31

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