HUP0201088A2 - Új alfa-aminosav-szulfonil-vegyületek, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Új alfa-aminosav-szulfonil-vegyületek, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0201088A2
HUP0201088A2 HU0201088A HUP0201088A HUP0201088A2 HU P0201088 A2 HUP0201088 A2 HU P0201088A2 HU 0201088 A HU0201088 A HU 0201088A HU P0201088 A HUP0201088 A HU P0201088A HU P0201088 A2 HUP0201088 A2 HU P0201088A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
hydrogen atom
alkyl
compounds
Prior art date
Application number
HU0201088A
Other languages
English (en)
Inventor
Alain Benoist
Bernadette Husson-Robert
Nigel Levens
Olivier Nosjean
Bernard Portevin
Guillaume De Nanteuil
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of HU0201088D0 publication Critical patent/HU0201088D0/hu
Publication of HUP0201088A2 publication Critical patent/HUP0201088A2/hu
Publication of HUP0201088A3 publication Critical patent/HUP0201088A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A találmány az (I) általános képletű vegyületekre, valamint optikaiizomerjeikre és e vegyületek gyógyászati szempontból elfogadhatósavval alkotott addíciós sóira vonatkozik. Az (I) képletben aszubsztituensek főbb jelentései a következők: (a) jelentése adottesetben szubsztituált öttagú, nitrogént tartalmazó heterociklus; R1jelentése hidrogénatom vagy alkil-, acil-, prolil-, alanil-,hisztidilprolil- vagy fenilalanilprolilcsoport; Ak jelentése alkilén-vagy heteroalkilénlánc; X jelentése egyszeres kötés, vagy adottesetben szubsztituált feniléncsoport; R2 jelentése adott esetbenszubsztituált alkilcsoport vagy 3-10 szénatomos cikloalkilcsoport; Yjelentése -NR3-, (b), (c) vagy (d) képletű csoport; ahol R3 jelentésehidrogénatom vagy alkil-, 3-7 szénatomos cikloalkil- vagy arilcsoport;R4, R5 és R6 azonosak vagy eltérők lehetnek, és jelentésükhidrogénatom vagy alkilcsoport. A találmány a fenti vegyületettartalmazó gyógyászati készítményekre is kiterjed. A találmányszerinti gyógyászati készítmények többek között a dipeptidil-peptidázIV gátlására; glükózintolerancia kezelésére; átültetett szervek ésszövetek kivetésének a megakadályozására; rák kezelésére és rákosáttételek megelőzésére; valamint AIDS kezelésére alkalmazhatók. Ó
HU0201088A 2001-03-28 2002-03-28 New alpha-amino acid sulphonyl compounds, a process for their preparation and pharmaceutical compositions containing them HUP0201088A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0104142A FR2822826B1 (fr) 2001-03-28 2001-03-28 Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
HU0201088D0 HU0201088D0 (hu) 2002-06-29
HUP0201088A2 true HUP0201088A2 (hu) 2002-12-28
HUP0201088A3 HUP0201088A3 (en) 2006-02-28

Family

ID=8861608

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201088A HUP0201088A3 (en) 2001-03-28 2002-03-28 New alpha-amino acid sulphonyl compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US6716843B2 (hu)
EP (1) EP1245568B1 (hu)
JP (1) JP3761827B2 (hu)
KR (1) KR100457725B1 (hu)
CN (1) CN1166633C (hu)
AR (1) AR033620A1 (hu)
AT (1) ATE316080T1 (hu)
AU (1) AU780373B2 (hu)
BR (1) BR0200982A (hu)
CA (1) CA2379197C (hu)
DE (1) DE60208763T2 (hu)
DK (1) DK1245568T3 (hu)
EA (1) EA004591B1 (hu)
ES (1) ES2256421T3 (hu)
FR (1) FR2822826B1 (hu)
HK (1) HK1050357B (hu)
HU (1) HUP0201088A3 (hu)
MX (1) MXPA02002720A (hu)
NO (1) NO322895B1 (hu)
NZ (1) NZ518035A (hu)
PL (1) PL353084A1 (hu)
PT (1) PT1245568E (hu)
SI (1) SI1245568T1 (hu)
ZA (1) ZA200202525B (hu)

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Also Published As

Publication number Publication date
NZ518035A (en) 2003-11-28
JP3761827B2 (ja) 2006-03-29
CA2379197A1 (fr) 2002-09-28
SI1245568T1 (sl) 2006-04-30
DK1245568T3 (da) 2006-05-15
CN1166633C (zh) 2004-09-15
HUP0201088A3 (en) 2006-02-28
JP2002363167A (ja) 2002-12-18
EP1245568A1 (fr) 2002-10-02
BR0200982A (pt) 2002-12-31
NO20021542L (no) 2002-09-30
ES2256421T3 (es) 2006-07-16
MXPA02002720A (es) 2004-11-12
ZA200202525B (en) 2002-10-24
ATE316080T1 (de) 2006-02-15
EA004591B1 (ru) 2004-06-24
NO20021542D0 (no) 2002-03-27
HK1050357B (zh) 2005-05-13
FR2822826A1 (fr) 2002-10-04
EP1245568B1 (fr) 2006-01-18
CN1377879A (zh) 2002-11-06
CA2379197C (fr) 2007-04-10
AU780373B2 (en) 2005-03-17
EA200200299A1 (ru) 2002-10-31
AR033620A1 (es) 2003-12-26
KR20020077180A (ko) 2002-10-11
US20030087950A1 (en) 2003-05-08
AU2935002A (en) 2002-10-03
DE60208763T2 (de) 2006-09-28
HK1050357A1 (en) 2003-06-20
PL353084A1 (en) 2002-10-07
FR2822826B1 (fr) 2003-05-09
HU0201088D0 (hu) 2002-06-29
DE60208763D1 (de) 2006-04-06
KR100457725B1 (ko) 2004-11-17
NO322895B1 (no) 2006-12-18
US6716843B2 (en) 2004-04-06
PT1245568E (pt) 2006-05-31

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