EA200500095A1 - Производные 4-(7-гало-2-хино(кса-)линилокси)феноксипропионовой кислоты в качестве противоопухолевых средств - Google Patents
Производные 4-(7-гало-2-хино(кса-)линилокси)феноксипропионовой кислоты в качестве противоопухолевых средствInfo
- Publication number
- EA200500095A1 EA200500095A1 EA200500095A EA200500095A EA200500095A1 EA 200500095 A1 EA200500095 A1 EA 200500095A1 EA 200500095 A EA200500095 A EA 200500095A EA 200500095 A EA200500095 A EA 200500095A EA 200500095 A1 EA200500095 A1 EA 200500095A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- linoiloxy
- galo
- ksa
- hino
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
Abstract
Изобретение касается соединений формулы (I), где A, X, Y и Z имеют значения, изложенные в описании. Эти соединения являются эффективными противоопухолевыми средствами. Изобретение также касается фармацевтических композиций, включающих соединение вышеуказанной формулы или его соль, промежуточных химических соединений, пригодных для получения соединения вышеуказанной формулы, и терапевтических способов, включающих введение соединения вышеуказанной формулы или его соли млекопитающему, нуждающемуся в такой терапии.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39385802P | 2002-07-03 | 2002-07-03 | |
PCT/US2003/021062 WO2004005260A1 (en) | 2002-07-03 | 2003-07-03 | A-`7-halo-2-quino (xa-) linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500095A1 true EA200500095A1 (ru) | 2005-06-30 |
EA009679B1 EA009679B1 (ru) | 2008-02-28 |
Family
ID=30115656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500095A EA009679B1 (ru) | 2002-07-03 | 2003-07-03 | Производные 4-(7-гало-2-хино(кса-)линилокси)феноксипропионовой кислоты в качестве противоопухолевых средств |
Country Status (18)
Country | Link |
---|---|
US (3) | US7109341B2 (ru) |
EP (1) | EP1539699A1 (ru) |
JP (1) | JP2005532397A (ru) |
CN (1) | CN1688547A (ru) |
AU (2) | AU2003249704B2 (ru) |
BR (1) | BR0311491A (ru) |
CA (1) | CA2491612C (ru) |
EA (1) | EA009679B1 (ru) |
GE (1) | GEP20074058B (ru) |
IL (1) | IL164555A0 (ru) |
MX (1) | MXPA05000233A (ru) |
NO (1) | NO20050573L (ru) |
NZ (1) | NZ535887A (ru) |
PL (1) | PL373624A1 (ru) |
SG (1) | SG145570A1 (ru) |
UA (1) | UA79293C2 (ru) |
WO (2) | WO2004005260A1 (ru) |
ZA (1) | ZA200408191B (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1412332E (pt) * | 2001-07-31 | 2005-06-30 | Jerome P Horwitz | Derivados de quinolina e sua utilizacao como agentes antitumorais |
UA79293C2 (en) * | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
KR20050038632A (ko) * | 2002-08-24 | 2005-04-27 | 젠타리스 게엠베하 | 양성 및 악성 종양 질환의 치료를 위한 디스오라졸 및 이의유도체를 함유하는 의약 |
CN100427482C (zh) * | 2005-08-01 | 2008-10-22 | 复旦大学 | N,n-二甲胺酰基-2,3-二呋喃基-6-氨基喹噁啉,其制备方法与应用 |
US7470788B2 (en) * | 2005-09-07 | 2008-12-30 | Wayne State University | Antitumor agents |
US20070054938A1 (en) * | 2005-09-07 | 2007-03-08 | Horwitz Jerome P | Antitumor agents |
US8183379B2 (en) * | 2005-09-07 | 2012-05-22 | Wayne State University | Antitumor agents |
EP1897542A1 (en) * | 2006-09-07 | 2008-03-12 | Sanofi-Aventis | Aqueous formulation comprising an antitumor agent |
AU2008251557B2 (en) * | 2007-05-10 | 2012-12-06 | Albany Molecular Research, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
WO2011079305A1 (en) * | 2009-12-23 | 2011-06-30 | Wayne State University | Therapeutic compounds |
CN103127112A (zh) * | 2013-02-27 | 2013-06-05 | 江苏先声药物研究有限公司 | 一类喹啉酮衍生物在肿瘤治疗中的应用 |
CN105085506B (zh) * | 2014-05-16 | 2018-01-19 | 湖南大学 | 2‑[4‑(苯并噁唑‑2‑氧基)苯氧基]脂肪酰吡啶胺的医药用途 |
CN105085480B (zh) * | 2014-05-16 | 2017-12-29 | 湖南大学 | 2‑[4‑(喹喔啉‑2‑氧基)苯氧基]脂肪酰吡啶胺的医药用途 |
CN107827828B (zh) * | 2017-11-21 | 2021-03-30 | 南京华漫新材料科技有限公司 | 含苯酰肼骨架的喹喔啉衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
CN110698418B (zh) * | 2019-09-11 | 2022-07-01 | 广西师范大学 | 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用 |
TWI826034B (zh) * | 2022-10-07 | 2023-12-11 | 宏碁股份有限公司 | 影像過曝改善方法及電子裝置 |
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JPS54112628A (en) | 1978-02-23 | 1979-09-03 | Canon Inc | Electromagnetic driving device |
JPS6033389B2 (ja) * | 1979-02-22 | 1985-08-02 | 日産化学工業株式会社 | 複素環エ−テル系フェノシキ脂肪酸誘導体、その製造法および該誘導体を含有する除草剤 |
US6197728B1 (en) * | 1980-08-06 | 2001-03-06 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
US5364831A (en) * | 1980-08-06 | 1994-11-15 | Nissan Chemical Industries Ltd. | Quinoxaline derivatives and herbicidal composition |
US4760066A (en) * | 1982-09-21 | 1988-07-26 | Wayne State University | Method for treating human tumor cell metastasis |
US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
PT79699B (en) | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
US5250690A (en) * | 1985-05-02 | 1993-10-05 | Dowelanco | Haloalkoxy anilide derivatives of 2-4(-heterocyclic oxyphenoxy)alkanoic or alkenoic acids and their use as herbicides |
JPS62190172A (ja) * | 1986-02-14 | 1987-08-20 | Teijin Ltd | フエノキシ脂肪族カルボン酸誘導体および除草剤 |
US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
AU5686794A (en) * | 1992-12-15 | 1994-07-04 | Du Pont Merck Pharmaceutical Company, The | (2-quinoxalinyloxy)phenoxypropanoic acids and related derivatives as anticancer agents |
EP0932601A4 (en) * | 1996-08-30 | 2000-02-02 | Lilly Co Eli | METHOD FOR PRODUCING PHARMACEUTICALS |
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BR9712805A (pt) * | 1996-09-06 | 1999-11-23 | Lilly Co Eli | Processo para a preparação de compostos farmecêuticos |
US6160006A (en) * | 1996-10-18 | 2000-12-12 | Wayne State University | 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit |
US6352991B1 (en) * | 1997-01-08 | 2002-03-05 | Wayne State University | 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents |
US6238644B1 (en) * | 1997-09-03 | 2001-05-29 | Wayne State University | Method for treating and/or imaging breast cancer using radioactive iodide |
US6586461B1 (en) * | 1998-06-16 | 2003-07-01 | Wayne State University | Prenyl transferase inhibitors |
US6103913A (en) * | 1998-10-16 | 2000-08-15 | Eli Lilly And Company | Process for preparing enollactone derivatives |
DE60114022T2 (de) * | 2000-05-30 | 2006-07-13 | Board Of Governors Of Wayne State University, Detroit | Matrix metalloproteinase-inhibitoren |
US6747021B2 (en) * | 2000-10-02 | 2004-06-08 | Eli Lilly And Company | Cryptophycin compound |
PT1412332E (pt) * | 2001-07-31 | 2005-06-30 | Jerome P Horwitz | Derivados de quinolina e sua utilizacao como agentes antitumorais |
UA79293C2 (en) | 2002-07-03 | 2007-06-11 | Univ Wayne State | 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents |
-
2003
- 2003-03-07 UA UAA200500921A patent/UA79293C2/uk unknown
- 2003-07-03 AU AU2003249704A patent/AU2003249704B2/en not_active Ceased
- 2003-07-03 SG SG200700010-2A patent/SG145570A1/en unknown
- 2003-07-03 CA CA2491612A patent/CA2491612C/en not_active Expired - Fee Related
- 2003-07-03 MX MXPA05000233A patent/MXPA05000233A/es active IP Right Grant
- 2003-07-03 BR BR0311491-0A patent/BR0311491A/pt not_active IP Right Cessation
- 2003-07-03 CN CNA038158809A patent/CN1688547A/zh active Pending
- 2003-07-03 US US10/613,914 patent/US7109341B2/en not_active Expired - Fee Related
- 2003-07-03 EA EA200500095A patent/EA009679B1/ru not_active IP Right Cessation
- 2003-07-03 EP EP03763213A patent/EP1539699A1/en not_active Withdrawn
- 2003-07-03 PL PL03373624A patent/PL373624A1/xx unknown
- 2003-07-03 WO PCT/US2003/021062 patent/WO2004005260A1/en active Application Filing
- 2003-07-03 WO PCT/US2003/021126 patent/WO2004004651A2/en not_active Application Discontinuation
- 2003-07-03 NZ NZ535887A patent/NZ535887A/en unknown
- 2003-07-03 AU AU2003249722A patent/AU2003249722A1/en not_active Abandoned
- 2003-07-03 GE GEAP8611A patent/GEP20074058B/en unknown
- 2003-07-03 JP JP2004519888A patent/JP2005532397A/ja active Pending
-
2004
- 2004-10-11 ZA ZA200408191A patent/ZA200408191B/en unknown
- 2004-10-13 IL IL16455504A patent/IL164555A0/xx unknown
-
2005
- 2005-02-02 NO NO20050573A patent/NO20050573L/no not_active Application Discontinuation
-
2006
- 2006-08-31 US US11/469,205 patent/US7585863B2/en not_active Expired - Fee Related
-
2008
- 2008-10-29 US US12/260,296 patent/US7728007B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BR0311491A (pt) | 2005-04-26 |
AU2003249704B2 (en) | 2010-05-20 |
UA79293C2 (en) | 2007-06-11 |
CN1688547A (zh) | 2005-10-26 |
IL164555A0 (en) | 2005-12-18 |
US7728007B2 (en) | 2010-06-01 |
SG145570A1 (en) | 2008-09-29 |
US7109341B2 (en) | 2006-09-19 |
AU2003249704A1 (en) | 2004-01-23 |
US7585863B2 (en) | 2009-09-08 |
EP1539699A1 (en) | 2005-06-15 |
WO2004004651A2 (en) | 2004-01-15 |
NZ535887A (en) | 2006-11-30 |
US20090076073A1 (en) | 2009-03-19 |
AU2003249722A1 (en) | 2004-01-23 |
JP2005532397A (ja) | 2005-10-27 |
CA2491612C (en) | 2012-01-03 |
MXPA05000233A (es) | 2005-04-11 |
ZA200408191B (en) | 2006-07-26 |
NO20050573L (no) | 2005-02-02 |
CA2491612A1 (en) | 2004-01-15 |
US20040132618A1 (en) | 2004-07-08 |
PL373624A1 (en) | 2005-09-05 |
GEP20074058B (en) | 2007-03-12 |
WO2004005260A1 (en) | 2004-01-15 |
US20060293333A1 (en) | 2006-12-28 |
EA009679B1 (ru) | 2008-02-28 |
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Legal Events
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |