YU41600A - 2,3-substituisana indol jedinjenja kao cox-2 inhibitori - Google Patents
2,3-substituisana indol jedinjenja kao cox-2 inhibitoriInfo
- Publication number
- YU41600A YU41600A YU41600A YU41600A YU41600A YU 41600 A YU41600 A YU 41600A YU 41600 A YU41600 A YU 41600A YU 41600 A YU41600 A YU 41600A YU 41600 A YU41600 A YU 41600A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- alkyl
- halo
- alkoxy
- optionally substituted
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pronalazak obezbedjuje jedinjenje formule (I) ili njegove farmaceutski prihvatljive soli gde Z je OH, C1-6 alkoksi, -NR2R3 ili heterocikl; Q je odabran od sledeceg: (a) opcionalno supstituisanog fenila, (b) opcionalno supstituisane 6-clane monociklicne aromaticne grupe koja sadrzi jedan, dva, tri ili cetiri atoma azota, (c) opcionalno supstituisane 5-clane monociklicne aromaticne grupe koja sadrzi jedan heteroatom odabran od O, S i N i opcionalno sadrzi 1, 2 ili 3 atoma azota dodatno pomenutom heteroatomu, (d) C3-7 cikloalkila opcionalno supstituisanog i (e) opcionalno supstituisanog benzostopljenog heterocikla; R1 je vodonik, C1-4 alkil ili halo; R2 i R3 su nezavisno H, OH, C1-4 alkoksi, C1-4 alkil ili C1-4 alkil supstituisan sa halo, OH, C1-4 alkoksi, NH2 ili CN; X je nezavisno odabran od halo, C1-4 alkila, halo-supstituisanog C1-4 alkila, OH, C1-4 akoksi, halo-supstituisanog C1-4 alkoksi, C1-4 alkiltio, NO2, NH2, di-( C1-4 alkil)amino, C1-4 alkilamina, CN, HO-( C1-4 ) alkila, C1-4 alkoksi- C1-4 alkila, C1-4 alkilsulfonila, aminosulfonila, -NH2S(O)2NR2NR3, acetila, -COOH, C1-4 alkilsulfonilamino i C3-7 cikloalkila; R5 je C1-6 alkil; i n je 0, 1, 2, 3 ili 4. Ovaj pronalazak takodje obezbedjuje famaceutski preparat koristan za tretman medicinskog stanja u kome su prostaglandini sadrzani kao patogeni.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9800003 | 1998-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU41600A true YU41600A (sh) | 2003-08-29 |
Family
ID=11004645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU41600A YU41600A (sh) | 1998-01-05 | 1998-12-18 | 2,3-substituisana indol jedinjenja kao cox-2 inhibitori |
Country Status (39)
Country | Link |
---|---|
US (1) | US6608070B1 (sh) |
EP (1) | EP1045833B1 (sh) |
JP (1) | JP3347136B2 (sh) |
KR (1) | KR100404054B1 (sh) |
CN (1) | CN1284064A (sh) |
AP (1) | AP869A (sh) |
AR (1) | AR016977A1 (sh) |
AT (1) | ATE308519T1 (sh) |
AU (1) | AU748107B2 (sh) |
BG (1) | BG104643A (sh) |
BR (1) | BR9813124A (sh) |
CA (1) | CA2316863A1 (sh) |
CO (1) | CO4970807A1 (sh) |
DE (1) | DE69832200T2 (sh) |
DZ (1) | DZ2700A1 (sh) |
EA (1) | EA200000614A1 (sh) |
ES (1) | ES2255190T3 (sh) |
GT (1) | GT199800205A (sh) |
HN (1) | HN1997000098A (sh) |
HR (1) | HRP20000454A2 (sh) |
HU (1) | HUP0102922A3 (sh) |
ID (1) | ID24876A (sh) |
IL (1) | IL136885A0 (sh) |
IS (1) | IS5532A (sh) |
MA (1) | MA24736A1 (sh) |
NO (1) | NO20003451L (sh) |
OA (1) | OA11441A (sh) |
PA (1) | PA8466201A1 (sh) |
PE (1) | PE20000055A1 (sh) |
PL (1) | PL341696A1 (sh) |
SA (1) | SA99191299A (sh) |
SK (1) | SK9912000A3 (sh) |
TN (1) | TNSN99001A1 (sh) |
TR (1) | TR200001906T2 (sh) |
TW (1) | TW436482B (sh) |
UY (2) | UY25332A1 (sh) |
WO (1) | WO1999035130A1 (sh) |
YU (1) | YU41600A (sh) |
ZA (1) | ZA9911B (sh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555540B1 (en) * | 1999-06-30 | 2003-04-29 | Pfizer Inc | Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors |
MXPA00006605A (es) | 1999-07-02 | 2004-12-09 | Pfizer | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. |
PT1065206E (pt) * | 1999-07-02 | 2003-01-31 | Pfizer | Compostos de tetrazolilalquilindole e como agentes anti-inflamatorios e analgesicos |
EP1572678A4 (en) * | 2002-12-19 | 2008-05-07 | Elan Pharm Inc | SUBSTITUTED N-PHENYL SULPHONAMIDES ALSBRADYKININ ANTAGONISTS |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
PT1534305E (pt) | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
KR100795462B1 (ko) | 2006-09-27 | 2008-01-16 | 한국생명공학연구원 | 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
KR101419965B1 (ko) | 2006-10-17 | 2014-07-16 | 스티펠 래버러토리즈, 인코포레이티드 | 탈라로졸 대사물 |
US20120022121A1 (en) * | 2007-11-29 | 2012-01-26 | Dalton James T | Indoles, derivatives and analogs thereof and uses therefor |
DK2560956T3 (en) | 2010-04-19 | 2017-01-23 | Octeta Therapeutics Llc | Hitherto UNKNOWN SYNTHESIS OF THIAZOLIDE INDION COMPOUNDS |
EP2590510B1 (en) | 2010-07-07 | 2016-09-28 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
JP5827326B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
JP5827327B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス,インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
WO2012054110A2 (en) | 2010-07-07 | 2012-04-26 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
WO2012021476A1 (en) | 2010-08-10 | 2012-02-16 | Metabolic Solutions Development Company, Llc | Novel synthesis for thiazolidinedione compounds |
EP2603507B1 (en) | 2010-08-10 | 2016-06-29 | Metabolic Solutions Development Company LLC | Synthesis for thiazolidinedione compounds |
US10266490B2 (en) * | 2012-03-16 | 2019-04-23 | Georgetown University | Radioprotector compounds |
US9808443B1 (en) | 2016-11-28 | 2017-11-07 | King Saud University | Cyclooxygenase inhibitors |
CN111004121A (zh) * | 2019-12-09 | 2020-04-14 | 南京杰运医药科技有限公司 | 一种4-烷氧基乙酰乙酸酯类化合物的制备方法 |
CN112409281B (zh) * | 2020-08-20 | 2022-11-18 | 上海大学 | (e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法 |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
US5510368A (en) * | 1995-05-22 | 1996-04-23 | Merck Frosst Canada, Inc. | N-benzyl-3-indoleacetic acids as antiinflammatory drugs |
CO5190664A1 (es) * | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
-
1998
- 1998-12-17 AP APAP/P/1998/001423A patent/AP869A/en active
- 1998-12-18 EP EP98959082A patent/EP1045833B1/en not_active Expired - Lifetime
- 1998-12-18 KR KR10-2000-7007419A patent/KR100404054B1/ko not_active IP Right Cessation
- 1998-12-18 BR BR9813124-9A patent/BR9813124A/pt not_active IP Right Cessation
- 1998-12-18 DE DE69832200T patent/DE69832200T2/de not_active Expired - Fee Related
- 1998-12-18 ES ES98959082T patent/ES2255190T3/es not_active Expired - Lifetime
- 1998-12-18 WO PCT/IB1998/002065 patent/WO1999035130A1/en active IP Right Grant
- 1998-12-18 ID IDW20001286A patent/ID24876A/id unknown
- 1998-12-18 EA EA200000614A patent/EA200000614A1/ru unknown
- 1998-12-18 AT AT98959082T patent/ATE308519T1/de not_active IP Right Cessation
- 1998-12-18 TR TR2000/01906T patent/TR200001906T2/xx unknown
- 1998-12-18 PL PL98341696A patent/PL341696A1/xx unknown
- 1998-12-18 CN CN98813530A patent/CN1284064A/zh active Pending
- 1998-12-18 HU HU0102922A patent/HUP0102922A3/hu unknown
- 1998-12-18 JP JP2000527531A patent/JP3347136B2/ja not_active Expired - Fee Related
- 1998-12-18 AU AU15005/99A patent/AU748107B2/en not_active Ceased
- 1998-12-18 CA CA002316863A patent/CA2316863A1/en not_active Abandoned
- 1998-12-18 YU YU41600A patent/YU41600A/sh unknown
- 1998-12-18 US US09/355,494 patent/US6608070B1/en not_active Expired - Fee Related
- 1998-12-18 IL IL13688598A patent/IL136885A0/xx unknown
- 1998-12-18 SK SK991-2000A patent/SK9912000A3/sk unknown
- 1998-12-22 TW TW087120865A patent/TW436482B/zh active
- 1998-12-28 PE PE1998001288A patent/PE20000055A1/es not_active Application Discontinuation
- 1998-12-28 HN HN1997000098A patent/HN1997000098A/es unknown
- 1998-12-29 GT GT199800205A patent/GT199800205A/es unknown
- 1998-12-30 CO CO98077588A patent/CO4970807A1/es unknown
- 1998-12-31 UY UY25332A patent/UY25332A1/es not_active IP Right Cessation
-
1999
- 1999-01-04 DZ DZ990001A patent/DZ2700A1/xx active
- 1999-01-04 MA MA25414A patent/MA24736A1/fr unknown
- 1999-01-04 AR ARP990100010A patent/AR016977A1/es not_active Application Discontinuation
- 1999-01-04 ZA ZA9900011A patent/ZA9911B/xx unknown
- 1999-01-04 TN TNTNSN99001A patent/TNSN99001A1/fr unknown
- 1999-01-05 PA PA19998466201A patent/PA8466201A1/es unknown
- 1999-04-13 SA SA99191299A patent/SA99191299A/ar unknown
- 1999-06-28 UY UY25590A patent/UY25590A1/es not_active Application Discontinuation
-
2000
- 2000-06-13 IS IS5532A patent/IS5532A/is unknown
- 2000-06-30 OA OA1200000195A patent/OA11441A/en unknown
- 2000-07-04 NO NO20003451A patent/NO20003451L/no unknown
- 2000-07-05 HR HR20000454A patent/HRP20000454A2/hr not_active Application Discontinuation
- 2000-07-28 BG BG104643A patent/BG104643A/bg unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU41600A (sh) | 2,3-substituisana indol jedinjenja kao cox-2 inhibitori | |
EA200300792A1 (ru) | Хиназолины в качестве ингибиторов ммр-13 | |
MXPA02002720A (es) | Nuevos compuestos de alfa-aminoacido-sulfonilo, un proceso para su preparacion y composiciones farmaceuticas que los comprenden. | |
DK0985666T3 (da) | Substituerede indolforbindelser som COX-2-inhibitorer | |
EE200300403A (et) | N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina | |
MXPA03011522A (es) | Derivados de naftil indol sustiduidos como inhibidores del tipo 1 del inhibidor del activador del plasmingeno. | |
DE60008206D1 (de) | Chinolinderivate verwendbar zur Hemmung der Farnesyl-Protein Transferase | |
ATE394383T1 (de) | Biphenylkarbonsäureamidderivate als p38 kinase- inhibitoren | |
HUP0004845A2 (hu) | PPAR-gamma agonista aktivitással rendelkező szubsztituált 4-hidroxi-fenil-alkánsav-származékok és ezeket tartalmazó gyógyszerkészítmények | |
MXPA00006605A (es) | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. | |
DK0976748T3 (da) | Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet | |
HUP0100388A2 (hu) | Készítmények és eljárások csontritkulás kezelésére és a koleszterinszint csökkentésére | |
DE3766839D1 (de) | 5,6-dihydro-2-(substituiertes phenyl)-1,2,4-triazin-3,5(2h,4h)-dione. | |
HUP0100732A2 (hu) | Amidvegyületet és azolszármazékot tartalmazó szinergetikus hatású fungicid kompozíció és alkalmazása | |
NO883487D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser. | |
SE9701304D0 (sv) | Compounds | |
AP9901578A0 (en) | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents. | |
NO944917D0 (no) | Anvendelse av 2-fenyl-3-aroyltiofener for inhibering av eggstokkdysgenese, forsinket pubertet eller seksuell infantilisme | |
ATE266401T1 (de) | Nefiracetam zur prophylaxe und behandlung von propofol verursachtem gedächtnisschwund | |
HK1000494A1 (en) | Thiazolidinone or oxazolidinone derivatives to treat angina pectoris or compositions containing the same as active ingredient | |
TR199903249T2 (xx) | �l-5 inhibit�rleri olarak 6-Azaurasil t�revleri. | |
SE9701396D0 (sv) | Compounds | |
BR9908948A (pt) | Composição farmacêutica contendo um inibidor de protease cisteìna para profilaxia e terapia de dano ao tecido cerebral | |
SE9802650D0 (sv) | Compounds | |
TH64548A (th) | 2-อะมิโน-2-อัลคิล-3 เฮปทีโนอิคและอนุพันธ์กรดเฮปไทโนอิคที่มีประโยชน์เป็นสารยับยั้งไนตริคออกไซด์ซินเธส |