GT199800205A - Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos. - Google Patents

Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos.

Info

Publication number
GT199800205A
GT199800205A GT199800205A GT199800205A GT199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A GT 199800205 A GT199800205 A GT 199800205A
Authority
GT
Guatemala
Prior art keywords
indol
inflammatory
substituted compounds
analgesic agents
compounds
Prior art date
Application number
GT199800205A
Other languages
English (en)
Inventor
Kazunari Nakao
Rodney William Stevens
Kiyoshi Kawamura
Chikara Uchida
Hiroki Koike
Stephane Caron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT199800205A publication Critical patent/GT199800205A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

ESTA INVENCION SE REFIERE A NUEVOS INDOLES 2,3SUSTITUIDOS COMO AGENTES FARMACEUTICOS. ESTA INVENCION SE REFIERE ESPECIFICAMENTE A COMPUESTOS, COMPOSICIONES Y PROCEDIMIENTOS PARA EL TRATAMIENTO O ALIVIO DEL DOLOR Y LA INFLAMACION, Y DE OTROS TRASTORNOS ASOCIADOS CON LA INFLAMACION, TALES COMO LA ARTRITIS. ESTOS COMPUESTOS POSEEN LA ESTRUCTURA QUIMICA (I), EN LA QUE Q, R1, X & Z, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.
GT199800205A 1998-01-05 1998-12-29 Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos. GT199800205A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9800003 1998-01-05

Publications (1)

Publication Number Publication Date
GT199800205A true GT199800205A (es) 2000-06-21

Family

ID=11004645

Family Applications (1)

Application Number Title Priority Date Filing Date
GT199800205A GT199800205A (es) 1998-01-05 1998-12-29 Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos.

Country Status (39)

Country Link
US (1) US6608070B1 (es)
EP (1) EP1045833B1 (es)
JP (1) JP3347136B2 (es)
KR (1) KR100404054B1 (es)
CN (1) CN1284064A (es)
AP (1) AP869A (es)
AR (1) AR016977A1 (es)
AT (1) ATE308519T1 (es)
AU (1) AU748107B2 (es)
BG (1) BG104643A (es)
BR (1) BR9813124A (es)
CA (1) CA2316863A1 (es)
CO (1) CO4970807A1 (es)
DE (1) DE69832200T2 (es)
DZ (1) DZ2700A1 (es)
EA (1) EA200000614A1 (es)
ES (1) ES2255190T3 (es)
GT (1) GT199800205A (es)
HN (1) HN1997000098A (es)
HR (1) HRP20000454A2 (es)
HU (1) HUP0102922A3 (es)
ID (1) ID24876A (es)
IL (1) IL136885A0 (es)
IS (1) IS5532A (es)
MA (1) MA24736A1 (es)
NO (1) NO20003451L (es)
OA (1) OA11441A (es)
PA (1) PA8466201A1 (es)
PE (1) PE20000055A1 (es)
PL (1) PL341696A1 (es)
SA (1) SA99191299A (es)
SK (1) SK9912000A3 (es)
TN (1) TNSN99001A1 (es)
TR (1) TR200001906T2 (es)
TW (1) TW436482B (es)
UY (2) UY25332A1 (es)
WO (1) WO1999035130A1 (es)
YU (1) YU41600A (es)
ZA (1) ZA9911B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555540B1 (en) * 1999-06-30 2003-04-29 Pfizer Inc Combinations of aldose reductase inhibitors and selective cyclooxygenase-2 inhibitors
MXPA00006605A (es) 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
ES2182755T3 (es) * 1999-07-02 2003-03-16 Pfizer Compuestos de tetrazolilalquilindol como agentes antiinflamtorios y analgesicos.
US20070093485A1 (en) * 2002-12-19 2007-04-26 Elan Pharmaceuticals, Inc. Substituted n-phenyl sulfonamide bradykinin antagonists
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
PT1534305E (pt) 2003-05-07 2007-02-28 Osteologix As Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
KR100795462B1 (ko) 2006-09-27 2008-01-16 한국생명공학연구원 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물
EP2114895A4 (en) 2006-10-17 2011-06-22 Stiefel Laboratories TALARAZOLMETABOLITEN
US20120022121A1 (en) * 2007-11-29 2012-01-26 Dalton James T Indoles, derivatives and analogs thereof and uses therefor
MX2012012092A (es) 2010-04-19 2012-12-17 Metabolic Solutions Dev Co Llc Sintesis novedosa para compuestos de tiazolidinadiona.
WO2012006477A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012006474A2 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5823514B2 (ja) 2010-07-07 2015-11-25 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
JP5827326B2 (ja) 2010-07-07 2015-12-02 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
NZ606597A (en) 2010-08-10 2014-12-24 Metabolic Solutions Dev Co Llc Synthesis for thiazolidinedione compounds
EP2603498B1 (en) 2010-08-10 2016-11-09 Octeta Therapeutics, LLC Novel synthesis for thiazolidinedione compounds
WO2013138600A1 (en) * 2012-03-16 2013-09-19 Rosen Eliot M Radioprotector compounds
US9808443B1 (en) 2016-11-28 2017-11-07 King Saud University Cyclooxygenase inhibitors
CN111004121A (zh) * 2019-12-09 2020-04-14 南京杰运医药科技有限公司 一种4-烷氧基乙酰乙酸酯类化合物的制备方法
CN112409281B (zh) * 2020-08-20 2022-11-18 上海大学 (e)-3-(3-氯-2-氟-6-(1h-四氮唑-1-基)苯基)丙烯酸的合成方法
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

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US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5510368A (en) * 1995-05-22 1996-04-23 Merck Frosst Canada, Inc. N-benzyl-3-indoleacetic acids as antiinflammatory drugs
CO5190664A1 (es) * 1999-06-30 2002-08-29 Pfizer Prod Inc Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2

Also Published As

Publication number Publication date
SA99191299A (ar) 2005-12-03
IS5532A (is) 2000-06-13
HUP0102922A2 (hu) 2001-12-28
YU41600A (sh) 2003-08-29
JP3347136B2 (ja) 2002-11-20
ZA9911B (en) 2000-07-04
EA200000614A1 (ru) 2001-02-26
BG104643A (bg) 2001-02-28
CO4970807A1 (es) 2000-11-07
NO20003451L (no) 2000-09-01
TR200001906T2 (tr) 2001-01-22
WO1999035130A1 (en) 1999-07-15
US6608070B1 (en) 2003-08-19
MA24736A1 (fr) 1999-10-01
NO20003451D0 (no) 2000-07-04
SK9912000A3 (en) 2001-11-06
KR100404054B1 (ko) 2003-11-01
UY25332A1 (es) 2001-01-31
DE69832200D1 (de) 2005-12-08
PA8466201A1 (es) 2000-09-29
BR9813124A (pt) 2000-10-10
OA11441A (en) 2004-04-27
ES2255190T3 (es) 2006-06-16
DE69832200T2 (de) 2006-04-20
ATE308519T1 (de) 2005-11-15
EP1045833A1 (en) 2000-10-25
AR016977A1 (es) 2001-08-01
AU1500599A (en) 1999-07-26
UY25590A1 (es) 1999-09-27
CN1284064A (zh) 2001-02-14
PE20000055A1 (es) 2000-02-08
HUP0102922A3 (en) 2003-06-30
AP869A (en) 2000-09-04
HN1997000098A (es) 1998-12-28
ID24876A (id) 2000-08-31
AP9801423A0 (en) 1998-12-31
JP2002500217A (ja) 2002-01-08
TNSN99001A1 (fr) 2005-11-10
EP1045833B1 (en) 2005-11-02
CA2316863A1 (en) 1999-07-15
KR20010033859A (ko) 2001-04-25
PL341696A1 (en) 2001-04-23
AU748107B2 (en) 2002-05-30
DZ2700A1 (fr) 2003-09-01
HRP20000454A2 (en) 2001-04-30
TW436482B (en) 2001-05-28
IL136885A0 (en) 2001-06-14

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