AR004480A1 - Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen - Google Patents
Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyenInfo
- Publication number
- AR004480A1 AR004480A1 ARP960102027A AR10202796A AR004480A1 AR 004480 A1 AR004480 A1 AR 004480A1 AR P960102027 A ARP960102027 A AR P960102027A AR 10202796 A AR10202796 A AR 10202796A AR 004480 A1 AR004480 A1 AR 004480A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- prepare
- ascomicine
- procedure
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención proporciona nuevos compuestos de ascomicina que llevan uno o más grupos oxicarbonilo o porciones carboxi fisiológicamente hidrolizables yaceptables de fórmula (I). Estos compuestos son útiles como agentes farmacéuticos, especialmente en el tratamiento del asma y la dermatitis.También se porporcionan métodos para la producción de dichos compuestos y composiciones farmacéuticas que los comprenden, y el uso de los mismos parala fabricación de medicamentos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9507128.8A GB9507128D0 (en) | 1995-04-06 | 1995-04-06 | Organic compounds |
GBGB9526050.1A GB9526050D0 (en) | 1995-12-20 | 1995-12-20 | Organic compounds |
GBGB9526049.3A GB9526049D0 (en) | 1995-12-20 | 1995-12-20 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004480A1 true AR004480A1 (es) | 1998-12-16 |
Family
ID=27267660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960102027A AR004480A1 (es) | 1995-04-06 | 1996-04-02 | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
Country Status (21)
Country | Link |
---|---|
US (1) | US5925649A (es) |
EP (1) | EP0819130A1 (es) |
JP (1) | JP2000505044A (es) |
KR (1) | KR19980703583A (es) |
CN (1) | CN1088068C (es) |
AR (1) | AR004480A1 (es) |
AU (1) | AU703523B2 (es) |
BR (1) | BR9604808A (es) |
CA (1) | CA2216562A1 (es) |
CO (1) | CO4750668A1 (es) |
CZ (1) | CZ312397A3 (es) |
FI (1) | FI973529A (es) |
HU (1) | HUP9801993A3 (es) |
IL (1) | IL117815A (es) |
MX (1) | MX9707636A (es) |
NO (1) | NO309273B1 (es) |
NZ (1) | NZ307170A (es) |
PL (1) | PL322553A1 (es) |
SK (1) | SK133997A3 (es) |
TR (1) | TR199700999T1 (es) |
WO (1) | WO1996031514A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE464900T1 (de) | 1998-03-26 | 2010-05-15 | Astellas Pharma Inc | Retardpräparat mit makroliden wie tacrolimus |
GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
US6121257A (en) * | 1999-03-31 | 2000-09-19 | Abbott Laboratories | Sulfamate containing macrocyclic immunomodulators |
EP1173177B2 (en) * | 1999-04-30 | 2014-03-05 | Sucampo AG | Use of macrolide compounds for the treatment of dry eye |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
EP1210121A2 (en) | 1999-08-24 | 2002-06-05 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
AR033151A1 (es) * | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
CA2442969A1 (en) * | 2001-05-09 | 2002-11-14 | Novartis Ag | Methods for selective immunomodulation using pimecrolimus |
PL376169A1 (en) * | 2002-11-15 | 2005-12-27 | Novartis Ag | Drug delivery system |
EP1594484A2 (en) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmaceutical patch |
TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
JP2007516951A (ja) * | 2003-12-30 | 2007-06-28 | アステラス製薬株式会社 | 気道閉塞症の治療または予防のためのマクロライドの使用 |
US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
US20080233053A1 (en) * | 2005-02-07 | 2008-09-25 | Pharmalight Inc. | Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients |
US10143682B2 (en) | 2014-10-28 | 2018-12-04 | Koushi Yamaguchi | Medicine for improving state of pregnancy, and use thereof |
WO2020032252A1 (ja) | 2018-08-10 | 2020-02-13 | 晃史 山口 | 母体と胎児との関係における液性免疫関連疾患の治療薬 |
JPWO2020129348A1 (ja) | 2018-12-18 | 2021-11-04 | 晃史 山口 | 不妊・不育症または妊娠状態を改善するための薬剤 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
JPS6317884A (ja) * | 1986-05-30 | 1988-01-25 | Fujisawa Pharmaceut Co Ltd | トリシクロ化合物 |
JPH01125394A (ja) * | 1987-11-10 | 1989-05-17 | Mect Corp | シアロシルグリセロリピッド類及びその製造方法 |
AU630866B2 (en) * | 1987-12-09 | 1992-11-12 | Fisons Plc | Macrocyclic compounds |
AU6286690A (en) * | 1989-08-18 | 1991-04-03 | Fisons Plc | Macrocyclic compounds |
KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
DK0427680T3 (da) * | 1989-11-09 | 1995-12-18 | Sandoz Ltd | Heteroatom-holdige cykliske forbindelser |
JPH05504956A (ja) * | 1990-03-12 | 1993-07-29 | 藤沢薬品工業株式会社 | トリシクロ化合物 |
WO1991019495A1 (en) * | 1990-06-11 | 1991-12-26 | Fujisawa Pharmaceutical Co., Ltd. | Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease |
MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
ES2099112T3 (es) * | 1990-09-04 | 1997-05-16 | Fujisawa Pharmaceutical Co | Pomadas que contienen un compuesto triciclico. |
CA2054983A1 (en) * | 1990-11-08 | 1992-05-09 | Sotoo Asakura | Suspendible composition and process for preparing the same |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5457194A (en) * | 1993-03-17 | 1995-10-10 | Abbott Laboratories | Substituted aliphatic amine-containing macrocyclic immunomodulators |
DK1147766T3 (da) * | 1994-10-26 | 2005-08-29 | Novartis Ag | Farmaceutiske sammensætninger |
-
1996
- 1996-04-02 AR ARP960102027A patent/AR004480A1/es unknown
- 1996-04-03 CO CO96016454A patent/CO4750668A1/es unknown
- 1996-04-03 IL IL11781596A patent/IL117815A/xx not_active IP Right Cessation
- 1996-04-04 WO PCT/EP1996/001492 patent/WO1996031514A1/en not_active Application Discontinuation
- 1996-04-04 AU AU56453/96A patent/AU703523B2/en not_active Ceased
- 1996-04-04 HU HU9801993A patent/HUP9801993A3/hu unknown
- 1996-04-04 NZ NZ307170A patent/NZ307170A/xx unknown
- 1996-04-04 BR BR9604808A patent/BR9604808A/pt active Search and Examination
- 1996-04-04 US US08/930,730 patent/US5925649A/en not_active Expired - Fee Related
- 1996-04-04 CZ CZ973123A patent/CZ312397A3/cs unknown
- 1996-04-04 CN CN96193091A patent/CN1088068C/zh not_active Expired - Fee Related
- 1996-04-04 EP EP96913486A patent/EP0819130A1/en not_active Withdrawn
- 1996-04-04 SK SK1339-97A patent/SK133997A3/sk unknown
- 1996-04-04 CA CA002216562A patent/CA2216562A1/en not_active Abandoned
- 1996-04-04 JP JP8529996A patent/JP2000505044A/ja active Pending
- 1996-04-04 PL PL96322553A patent/PL322553A1/xx unknown
- 1996-04-04 TR TR97/00999T patent/TR199700999T1/xx unknown
- 1996-04-04 KR KR1019970706988A patent/KR19980703583A/ko not_active Application Discontinuation
-
1997
- 1997-08-27 FI FI973529A patent/FI973529A/fi unknown
- 1997-10-01 NO NO974536A patent/NO309273B1/no not_active IP Right Cessation
- 1997-10-03 MX MX9707636A patent/MX9707636A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUP9801993A3 (en) | 2000-04-28 |
AU5645396A (en) | 1996-10-23 |
CZ312397A3 (cs) | 1998-01-14 |
NZ307170A (en) | 1999-03-29 |
MX9707636A (es) | 1998-06-30 |
HUP9801993A2 (hu) | 1998-12-28 |
PL322553A1 (en) | 1998-02-02 |
CA2216562A1 (en) | 1996-10-10 |
IL117815A (en) | 2000-07-16 |
JP2000505044A (ja) | 2000-04-25 |
AU703523B2 (en) | 1999-03-25 |
IL117815A0 (en) | 1996-08-04 |
NO974536D0 (no) | 1997-10-01 |
NO309273B1 (no) | 2001-01-08 |
WO1996031514A1 (en) | 1996-10-10 |
CO4750668A1 (es) | 1999-03-31 |
TR199700999T1 (xx) | 1998-01-21 |
FI973529A0 (fi) | 1997-08-27 |
EP0819130A1 (en) | 1998-01-21 |
SK133997A3 (en) | 1998-05-06 |
CN1088068C (zh) | 2002-07-24 |
NO974536L (no) | 1997-10-01 |
CN1180359A (zh) | 1998-04-29 |
BR9604808A (pt) | 1998-06-09 |
FI973529A (fi) | 1997-11-25 |
US5925649A (en) | 1999-07-20 |
KR19980703583A (ko) | 1998-11-05 |
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