IL117815A - Ascomycin-phenylaminocarbonyloxy derivatives substituted by carboxy or physiologically hydrolysable and acceptable oxycarbonyl moieties their preparation and pharmaceutical compositions containing them - Google Patents

Ascomycin-phenylaminocarbonyloxy derivatives substituted by carboxy or physiologically hydrolysable and acceptable oxycarbonyl moieties their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117815A
IL117815A IL11781596A IL11781596A IL117815A IL 117815 A IL117815 A IL 117815A IL 11781596 A IL11781596 A IL 11781596A IL 11781596 A IL11781596 A IL 11781596A IL 117815 A IL117815 A IL 117815A
Authority
IL
Israel
Prior art keywords
phenylaminocarbonyloxy
ascomycin
carboxy
preparation
pharmaceutical compositions
Prior art date
Application number
IL11781596A
Other languages
English (en)
Other versions
IL117815A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9507128.8A external-priority patent/GB9507128D0/en
Priority claimed from GBGB9526049.3A external-priority patent/GB9526049D0/en
Priority claimed from GBGB9526050.1A external-priority patent/GB9526050D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL117815A0 publication Critical patent/IL117815A0/xx
Publication of IL117815A publication Critical patent/IL117815A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL11781596A 1995-04-06 1996-04-03 Ascomycin-phenylaminocarbonyloxy derivatives substituted by carboxy or physiologically hydrolysable and acceptable oxycarbonyl moieties their preparation and pharmaceutical compositions containing them IL117815A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9507128.8A GB9507128D0 (en) 1995-04-06 1995-04-06 Organic compounds
GBGB9526049.3A GB9526049D0 (en) 1995-12-20 1995-12-20 Organic compounds
GBGB9526050.1A GB9526050D0 (en) 1995-12-20 1995-12-20 Organic compounds

Publications (2)

Publication Number Publication Date
IL117815A0 IL117815A0 (en) 1996-08-04
IL117815A true IL117815A (en) 2000-07-16

Family

ID=27267660

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11781596A IL117815A (en) 1995-04-06 1996-04-03 Ascomycin-phenylaminocarbonyloxy derivatives substituted by carboxy or physiologically hydrolysable and acceptable oxycarbonyl moieties their preparation and pharmaceutical compositions containing them

Country Status (21)

Country Link
US (1) US5925649A (es)
EP (1) EP0819130A1 (es)
JP (1) JP2000505044A (es)
KR (1) KR19980703583A (es)
CN (1) CN1088068C (es)
AR (1) AR004480A1 (es)
AU (1) AU703523B2 (es)
BR (1) BR9604808A (es)
CA (1) CA2216562A1 (es)
CO (1) CO4750668A1 (es)
CZ (1) CZ312397A3 (es)
FI (1) FI973529A (es)
HU (1) HUP9801993A3 (es)
IL (1) IL117815A (es)
MX (1) MX9707636A (es)
NO (1) NO309273B1 (es)
NZ (1) NZ307170A (es)
PL (1) PL322553A1 (es)
SK (1) SK133997A3 (es)
TR (1) TR199700999T1 (es)
WO (1) WO1996031514A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2198858T3 (da) 1998-03-26 2011-10-03 Astellas Pharma Inc Præparat med opretholdt frigivelse af en makrolidforbindelse såsom tacrolimus
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
WO2000066122A1 (en) * 1999-04-30 2000-11-09 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
EP1210121A2 (en) 1999-08-24 2002-06-05 Cellgate Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
US20030119797A1 (en) * 2001-05-09 2003-06-26 Salah-Dine Chibout Methods for selective immunomodulation
RU2005118750A (ru) * 2002-11-15 2006-03-20 Новартис АГ (CH) Органические соединения
EP1594484A2 (en) * 2003-02-17 2005-11-16 Cipla Ltd. Pharmaceutical patch
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
US7780973B2 (en) * 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
WO2005063242A1 (en) * 2003-12-30 2005-07-14 Astellas Pharma Inc. Use of macrolides for treating or preventing airflow obstruction
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
CN107106588B (zh) 2014-10-28 2020-08-11 山口晃史 用于改善妊娠状态的药剂及其使用
JP7465806B2 (ja) 2018-08-10 2024-04-11 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
CN113226331A (zh) 2018-12-18 2021-08-06 山口晃史 用于改善不孕不育症或妊娠状态的药物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JPS6317884A (ja) * 1986-05-30 1988-01-25 Fujisawa Pharmaceut Co Ltd トリシクロ化合物
JPH01125394A (ja) * 1987-11-10 1989-05-17 Mect Corp シアロシルグリセロリピッド類及びその製造方法
DE3853477T2 (de) * 1987-12-09 1995-11-09 Fisons Plc Makrozyklische verbindungen.
EP0487593A1 (en) * 1989-08-18 1992-06-03 FISONS plc Macrocyclic compounds
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
DK0427680T3 (da) * 1989-11-09 1995-12-18 Sandoz Ltd Heteroatom-holdige cykliske forbindelser
JPH05504956A (ja) * 1990-03-12 1993-07-29 藤沢薬品工業株式会社 トリシクロ化合物
WO1991019495A1 (en) * 1990-06-11 1991-12-26 Fujisawa Pharmaceutical Co., Ltd. Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
DK0474126T3 (es) * 1990-09-04 1997-04-07 Fujisawa Pharmaceutical Co
CA2054983A1 (en) * 1990-11-08 1992-05-09 Sotoo Asakura Suspendible composition and process for preparing the same
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
GB2308546B (en) * 1994-10-26 1999-06-02 Novartis Ag Topical macrolide compositions

Also Published As

Publication number Publication date
AU703523B2 (en) 1999-03-25
CA2216562A1 (en) 1996-10-10
NO974536D0 (no) 1997-10-01
AR004480A1 (es) 1998-12-16
SK133997A3 (en) 1998-05-06
JP2000505044A (ja) 2000-04-25
CN1180359A (zh) 1998-04-29
NO309273B1 (no) 2001-01-08
NO974536L (no) 1997-10-01
IL117815A0 (en) 1996-08-04
CN1088068C (zh) 2002-07-24
FI973529A0 (fi) 1997-08-27
MX9707636A (es) 1998-06-30
NZ307170A (en) 1999-03-29
EP0819130A1 (en) 1998-01-21
BR9604808A (pt) 1998-06-09
US5925649A (en) 1999-07-20
HUP9801993A2 (hu) 1998-12-28
HUP9801993A3 (en) 2000-04-28
TR199700999T1 (xx) 1998-01-21
CO4750668A1 (es) 1999-03-31
AU5645396A (en) 1996-10-23
CZ312397A3 (cs) 1998-01-14
KR19980703583A (ko) 1998-11-05
WO1996031514A1 (en) 1996-10-10
FI973529A (fi) 1997-11-25
PL322553A1 (en) 1998-02-02

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees