CO4750668A1 - Ascomicinas - Google Patents
AscomicinasInfo
- Publication number
- CO4750668A1 CO4750668A1 CO96016454A CO96016454A CO4750668A1 CO 4750668 A1 CO4750668 A1 CO 4750668A1 CO 96016454 A CO96016454 A CO 96016454A CO 96016454 A CO96016454 A CO 96016454A CO 4750668 A1 CO4750668 A1 CO 4750668A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkoxy
- oxycarbonyl
- phenylene
- oxo
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de la Fórmula I:caracterizado porque Y es fenileno o metileno;Z se selecciona de carboxi y oxicarbonilo fisiológicamente hidrolizable, o cuando Y es fenileno, también se selecciona de un grupo alquilo, alcoxi, alquilamino o dialquilamino que porta de uno a cuatro porciones carboxi o porciones oxicarbonilo fisiológicamente hidrolizables; Q es O ó S; R1 es H, alquilo o arilo; R2 es hidrógeno o hidroxi; R3 es metilo, etilo, propilo o alilo; R4 es hidroxi o alcoxi; R5 es oxo o (H, OH); R6 e oxo, (H, OH) o (H, alcoxi); n es 1 ó 2; y el enlace representado por líneas sólidas paralelas y líneas punteadas es ya sea un enlace sencillo o un enlace doble; en forma libre o en forma de sal fisiológicamente aceptable.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9507128.8A GB9507128D0 (en) | 1995-04-06 | 1995-04-06 | Organic compounds |
GBGB9526049.3A GB9526049D0 (en) | 1995-12-20 | 1995-12-20 | Organic compounds |
GBGB9526050.1A GB9526050D0 (en) | 1995-12-20 | 1995-12-20 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4750668A1 true CO4750668A1 (es) | 1999-03-31 |
Family
ID=27267660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO96016454A CO4750668A1 (es) | 1995-04-06 | 1996-04-03 | Ascomicinas |
Country Status (21)
Country | Link |
---|---|
US (1) | US5925649A (es) |
EP (1) | EP0819130A1 (es) |
JP (1) | JP2000505044A (es) |
KR (1) | KR19980703583A (es) |
CN (1) | CN1088068C (es) |
AR (1) | AR004480A1 (es) |
AU (1) | AU703523B2 (es) |
BR (1) | BR9604808A (es) |
CA (1) | CA2216562A1 (es) |
CO (1) | CO4750668A1 (es) |
CZ (1) | CZ312397A3 (es) |
FI (1) | FI973529A (es) |
HU (1) | HUP9801993A3 (es) |
IL (1) | IL117815A (es) |
MX (1) | MX9707636A (es) |
NO (1) | NO309273B1 (es) |
NZ (1) | NZ307170A (es) |
PL (1) | PL322553A1 (es) |
SK (1) | SK133997A3 (es) |
TR (1) | TR199700999T1 (es) |
WO (1) | WO1996031514A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2367294T3 (es) | 1998-03-26 | 2011-11-02 | Astellas Pharma Inc. | Preparación de liberación sostenida de un compuesto macrólido como tacrolimus. |
GB9826656D0 (en) * | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
US6121257A (en) * | 1999-03-31 | 2000-09-19 | Abbott Laboratories | Sulfamate containing macrocyclic immunomodulators |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
CZ20013769A3 (cs) * | 1999-04-30 | 2002-03-13 | Sucampo Ag | Činidlo pro léčbu suchého oka |
EP1210121A2 (en) | 1999-08-24 | 2002-06-05 | Cellgate Inc. | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
AR033151A1 (es) * | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
WO2002089796A2 (en) * | 2001-05-09 | 2002-11-14 | Novartis Ag | Methods for selective immunomodulation using pimecrolimus |
KR20050086648A (ko) * | 2002-11-15 | 2005-08-30 | 노파르티스 아게 | 약물 전달 시스템 |
EP1594484A2 (en) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmaceutical patch |
TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
US20050142161A1 (en) * | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
EP1699456A1 (en) * | 2003-12-30 | 2006-09-13 | Astellas Pharma Inc. | Use of macrolides for treating or preventing airflow obstruction |
EP1848541A4 (en) * | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR OPHTHALMIC DELIVERY OF PHARMACEUTICALLY ACTIVE INGREDIENTS |
ES2898849T3 (es) | 2014-10-28 | 2022-03-09 | Koushi Yamaguchi | Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo |
CA3108863A1 (en) | 2018-08-10 | 2020-02-13 | Koushi Yamaguchi | Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship |
CN113226331A (zh) | 2018-12-18 | 2021-08-06 | 山口晃史 | 用于改善不孕不育症或妊娠状态的药物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3244592A (en) * | 1962-06-09 | 1966-04-05 | Arai Tadashi | Ascomycin and process for its production |
US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
JPS6317884A (ja) * | 1986-05-30 | 1988-01-25 | Fujisawa Pharmaceut Co Ltd | トリシクロ化合物 |
JPH01125394A (ja) * | 1987-11-10 | 1989-05-17 | Mect Corp | シアロシルグリセロリピッド類及びその製造方法 |
DE3853477T2 (de) * | 1987-12-09 | 1995-11-09 | Fisons Plc | Makrozyklische verbindungen. |
JPH05504944A (ja) * | 1989-08-18 | 1993-07-29 | 藤沢薬品工業株式会社 | 巨大環式化合物 |
KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
NZ235991A (en) * | 1989-11-09 | 1993-05-26 | Sandoz Ltd | Macrolide compounds and pharmaceutical compositions thereof |
WO1991013899A1 (en) * | 1990-03-12 | 1991-09-19 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds |
JPH05507915A (ja) * | 1990-06-11 | 1993-11-11 | 藤沢薬品工業株式会社 | 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのfk506等のマクロライド化合物の用途 |
MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
DE69125230T2 (de) * | 1990-09-04 | 1997-07-10 | Fujisawa Pharmaceutical Co | Tricyclische Verbindungen enthaltende Salben |
IE65341B1 (en) * | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5252732A (en) * | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) * | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
US5457194A (en) * | 1993-03-17 | 1995-10-10 | Abbott Laboratories | Substituted aliphatic amine-containing macrocyclic immunomodulators |
AU714254B2 (en) * | 1994-10-26 | 1999-12-23 | Novartis Ag | Pharmaceutical compositions |
-
1996
- 1996-04-02 AR ARP960102027A patent/AR004480A1/es unknown
- 1996-04-03 CO CO96016454A patent/CO4750668A1/es unknown
- 1996-04-03 IL IL11781596A patent/IL117815A/xx not_active IP Right Cessation
- 1996-04-04 NZ NZ307170A patent/NZ307170A/xx unknown
- 1996-04-04 PL PL96322553A patent/PL322553A1/xx unknown
- 1996-04-04 US US08/930,730 patent/US5925649A/en not_active Expired - Fee Related
- 1996-04-04 AU AU56453/96A patent/AU703523B2/en not_active Ceased
- 1996-04-04 SK SK1339-97A patent/SK133997A3/sk unknown
- 1996-04-04 KR KR1019970706988A patent/KR19980703583A/ko not_active Application Discontinuation
- 1996-04-04 TR TR97/00999T patent/TR199700999T1/xx unknown
- 1996-04-04 BR BR9604808A patent/BR9604808A/pt active Search and Examination
- 1996-04-04 EP EP96913486A patent/EP0819130A1/en not_active Withdrawn
- 1996-04-04 CN CN96193091A patent/CN1088068C/zh not_active Expired - Fee Related
- 1996-04-04 CA CA002216562A patent/CA2216562A1/en not_active Abandoned
- 1996-04-04 CZ CZ973123A patent/CZ312397A3/cs unknown
- 1996-04-04 HU HU9801993A patent/HUP9801993A3/hu unknown
- 1996-04-04 JP JP8529996A patent/JP2000505044A/ja active Pending
- 1996-04-04 WO PCT/EP1996/001492 patent/WO1996031514A1/en not_active Application Discontinuation
-
1997
- 1997-08-27 FI FI973529A patent/FI973529A/fi unknown
- 1997-10-01 NO NO974536A patent/NO309273B1/no not_active IP Right Cessation
- 1997-10-03 MX MX9707636A patent/MX9707636A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR19980703583A (ko) | 1998-11-05 |
BR9604808A (pt) | 1998-06-09 |
AU5645396A (en) | 1996-10-23 |
CZ312397A3 (cs) | 1998-01-14 |
AR004480A1 (es) | 1998-12-16 |
NZ307170A (en) | 1999-03-29 |
HUP9801993A2 (hu) | 1998-12-28 |
HUP9801993A3 (en) | 2000-04-28 |
CN1180359A (zh) | 1998-04-29 |
SK133997A3 (en) | 1998-05-06 |
FI973529A (fi) | 1997-11-25 |
WO1996031514A1 (en) | 1996-10-10 |
MX9707636A (es) | 1998-06-30 |
CN1088068C (zh) | 2002-07-24 |
PL322553A1 (en) | 1998-02-02 |
JP2000505044A (ja) | 2000-04-25 |
IL117815A0 (en) | 1996-08-04 |
NO309273B1 (no) | 2001-01-08 |
IL117815A (en) | 2000-07-16 |
AU703523B2 (en) | 1999-03-25 |
CA2216562A1 (en) | 1996-10-10 |
TR199700999T1 (xx) | 1998-01-21 |
NO974536D0 (no) | 1997-10-01 |
EP0819130A1 (en) | 1998-01-21 |
NO974536L (no) | 1997-10-01 |
FI973529A0 (fi) | 1997-08-27 |
US5925649A (en) | 1999-07-20 |
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