CO4750668A1 - Ascomicinas - Google Patents

Ascomicinas

Info

Publication number
CO4750668A1
CO4750668A1 CO96016454A CO96016454A CO4750668A1 CO 4750668 A1 CO4750668 A1 CO 4750668A1 CO 96016454 A CO96016454 A CO 96016454A CO 96016454 A CO96016454 A CO 96016454A CO 4750668 A1 CO4750668 A1 CO 4750668A1
Authority
CO
Colombia
Prior art keywords
alkoxy
oxycarbonyl
phenylene
oxo
hydroxy
Prior art date
Application number
CO96016454A
Other languages
English (en)
Inventor
Rene Hersperger
Reto Naef
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9507128.8A external-priority patent/GB9507128D0/en
Priority claimed from GBGB9526050.1A external-priority patent/GB9526050D0/en
Priority claimed from GBGB9526049.3A external-priority patent/GB9526049D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CO4750668A1 publication Critical patent/CO4750668A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un compuesto de la Fórmula I:caracterizado porque Y es fenileno o metileno;Z se selecciona de carboxi y oxicarbonilo fisiológicamente hidrolizable, o cuando Y es fenileno, también se selecciona de un grupo alquilo, alcoxi, alquilamino o dialquilamino que porta de uno a cuatro porciones carboxi o porciones oxicarbonilo fisiológicamente hidrolizables; Q es O ó S; R1 es H, alquilo o arilo; R2 es hidrógeno o hidroxi; R3 es metilo, etilo, propilo o alilo; R4 es hidroxi o alcoxi; R5 es oxo o (H, OH); R6 e oxo, (H, OH) o (H, alcoxi); n es 1 ó 2; y el enlace representado por líneas sólidas paralelas y líneas punteadas es ya sea un enlace sencillo o un enlace doble; en forma libre o en forma de sal fisiológicamente aceptable.
CO96016454A 1995-04-06 1996-04-03 Ascomicinas CO4750668A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9507128.8A GB9507128D0 (en) 1995-04-06 1995-04-06 Organic compounds
GBGB9526050.1A GB9526050D0 (en) 1995-12-20 1995-12-20 Organic compounds
GBGB9526049.3A GB9526049D0 (en) 1995-12-20 1995-12-20 Organic compounds

Publications (1)

Publication Number Publication Date
CO4750668A1 true CO4750668A1 (es) 1999-03-31

Family

ID=27267660

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96016454A CO4750668A1 (es) 1995-04-06 1996-04-03 Ascomicinas

Country Status (21)

Country Link
US (1) US5925649A (es)
EP (1) EP0819130A1 (es)
JP (1) JP2000505044A (es)
KR (1) KR19980703583A (es)
CN (1) CN1088068C (es)
AR (1) AR004480A1 (es)
AU (1) AU703523B2 (es)
BR (1) BR9604808A (es)
CA (1) CA2216562A1 (es)
CO (1) CO4750668A1 (es)
CZ (1) CZ312397A3 (es)
FI (1) FI973529A (es)
HU (1) HUP9801993A3 (es)
IL (1) IL117815A (es)
MX (1) MX9707636A (es)
NO (1) NO309273B1 (es)
NZ (1) NZ307170A (es)
PL (1) PL322553A1 (es)
SK (1) SK133997A3 (es)
TR (1) TR199700999T1 (es)
WO (1) WO1996031514A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1064942T1 (en) 1998-03-26 2004-12-31 Fujisawa Pharmaceutical Co., Ltd. Sustained release preparation of a macrolide
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
CN1190194C (zh) * 1999-04-30 2005-02-23 苏坎波公司 用于治疗干眼的大环内酯化合物的应用
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
EP1210121A2 (en) 1999-08-24 2002-06-05 Cellgate Inc. Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
CA2442969A1 (en) * 2001-05-09 2002-11-14 Novartis Ag Methods for selective immunomodulation using pimecrolimus
WO2004045578A2 (en) * 2002-11-15 2004-06-03 Novartis Ag Drug delivery system
US20060115522A1 (en) * 2003-02-17 2006-06-01 Cipla Ltd Pharmaceutical composition
TWI324604B (en) * 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
US7780973B2 (en) * 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
JP2007516951A (ja) * 2003-12-30 2007-06-28 アステラス製薬株式会社 気道閉塞症の治療または予防のためのマクロライドの使用
EP1848541A4 (en) * 2005-02-07 2013-01-16 Pharmalight Inc METHOD AND DEVICE FOR OPHTHALMIC DELIVERY OF PHARMACEUTICALLY ACTIVE INGREDIENTS
EP3977995A1 (en) 2014-10-28 2022-04-06 Koushi Yamaguchi Tacrolimus for ameliorating pregnancy conditions
EP3834826A4 (en) 2018-08-10 2022-07-27 Koushi Yamaguchi THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN THE MATERNO-FETAL RELATIONSHIP
US20220062245A1 (en) 2018-12-18 2022-03-03 Koushi Yamaguchi Agent for improving infertility, recurrent miscarriage, and state of pregnancy

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JPS6317884A (ja) * 1986-05-30 1988-01-25 Fujisawa Pharmaceut Co Ltd トリシクロ化合物
JPH01125394A (ja) * 1987-11-10 1989-05-17 Mect Corp シアロシルグリセロリピッド類及びその製造方法
JP2799208B2 (ja) * 1987-12-09 1998-09-17 フアイソンズ・ピーエルシー マクロ環状化合物
WO1991002736A1 (en) * 1989-08-18 1991-03-07 Fisons Plc Macrocyclic compounds
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
NZ235991A (en) * 1989-11-09 1993-05-26 Sandoz Ltd Macrolide compounds and pharmaceutical compositions thereof
JPH05504956A (ja) * 1990-03-12 1993-07-29 藤沢薬品工業株式会社 トリシクロ化合物
EP0533930A1 (en) * 1990-06-11 1993-03-31 Fujisawa Pharmaceutical Co., Ltd. Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
ATE150304T1 (de) * 1990-09-04 1997-04-15 Fujisawa Pharmaceutical Co Tricyclische verbindungen enthaltende salben
CA2054983A1 (en) * 1990-11-08 1992-05-09 Sotoo Asakura Suspendible composition and process for preparing the same
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
PL184750B1 (pl) * 1994-10-26 2002-12-31 Novartis Ag Kompozycja w postaci emulsji do stosowania miejscowego

Also Published As

Publication number Publication date
FI973529A0 (fi) 1997-08-27
NZ307170A (en) 1999-03-29
NO309273B1 (no) 2001-01-08
NO974536L (no) 1997-10-01
AU703523B2 (en) 1999-03-25
MX9707636A (es) 1998-06-30
SK133997A3 (en) 1998-05-06
CA2216562A1 (en) 1996-10-10
PL322553A1 (en) 1998-02-02
HUP9801993A3 (en) 2000-04-28
IL117815A (en) 2000-07-16
TR199700999T1 (xx) 1998-01-21
JP2000505044A (ja) 2000-04-25
CN1180359A (zh) 1998-04-29
EP0819130A1 (en) 1998-01-21
KR19980703583A (ko) 1998-11-05
US5925649A (en) 1999-07-20
CN1088068C (zh) 2002-07-24
CZ312397A3 (cs) 1998-01-14
AR004480A1 (es) 1998-12-16
BR9604808A (pt) 1998-06-09
NO974536D0 (no) 1997-10-01
AU5645396A (en) 1996-10-23
IL117815A0 (en) 1996-08-04
WO1996031514A1 (en) 1996-10-10
HUP9801993A2 (hu) 1998-12-28
FI973529A (fi) 1997-11-25

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