AR026711A1 - Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios /analgesicos - Google Patents
Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios /analgesicosInfo
- Publication number
- AR026711A1 AR026711A1 ARP000106402A ARP000106402A AR026711A1 AR 026711 A1 AR026711 A1 AR 026711A1 AR P000106402 A ARP000106402 A AR P000106402A AR P000106402 A ARP000106402 A AR P000106402A AR 026711 A1 AR026711 A1 AR 026711A1
- Authority
- AR
- Argentina
- Prior art keywords
- alquilsulfonil
- heterociclo
- inflammatory
- analgesic agents
- pirazol derivatives
- Prior art date
Links
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 241000282326 Felis catus Species 0.000 abstract 1
- 241000282412 Homo Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
Abstract
La presente se refiere a compuestos de la formula general (1), en la que R2, R3, R6 y A son como se han definido en la memoria descriptiva, a composicionesfarmacéuticas que los contienen y a su uso medicinal. Los compuestode la presente son utiles en el tratamiento o alivio de inflamacion y otros trastornosasociados con la inflamacion, tales como osteoartritis, artritis reumatoide, cáncer de colon y enfermedad de Alzheimer, en mamíferos (preferiblemente sereshumanos, perros, gatos y animales de ganado).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16870199P | 1999-12-03 | 1999-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR026711A1 true AR026711A1 (es) | 2003-02-26 |
Family
ID=22612589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000106402A AR026711A1 (es) | 1999-12-03 | 2000-12-04 | Derivados de heterociclo-alquilsulfonil-pirazol como agentes anti-inflamatorios /analgesicos |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6531492B1 (es) |
| EP (1) | EP1233959B1 (es) |
| JP (1) | JP2003517475A (es) |
| KR (1) | KR20020058074A (es) |
| CN (1) | CN1423646A (es) |
| AP (1) | AP2002002532A0 (es) |
| AR (1) | AR026711A1 (es) |
| AT (1) | ATE291019T1 (es) |
| AU (1) | AU783359B2 (es) |
| BG (1) | BG106694A (es) |
| BR (1) | BR0016031A (es) |
| CA (1) | CA2392931A1 (es) |
| CO (1) | CO5261496A1 (es) |
| DE (1) | DE60018792T2 (es) |
| DZ (1) | DZ3246A1 (es) |
| EA (1) | EA200200520A1 (es) |
| ES (1) | ES2238324T3 (es) |
| GT (1) | GT200000204A (es) |
| HK (1) | HK1052701A1 (es) |
| HU (1) | HUP0300157A3 (es) |
| IL (1) | IL149581A0 (es) |
| IS (1) | IS6376A (es) |
| MA (1) | MA26848A1 (es) |
| MX (1) | MXPA02005539A (es) |
| NO (1) | NO20022624L (es) |
| OA (1) | OA12100A (es) |
| PA (1) | PA8508201A1 (es) |
| PE (1) | PE20010962A1 (es) |
| PL (1) | PL356669A1 (es) |
| SK (1) | SK7412002A3 (es) |
| TN (1) | TNSN00235A1 (es) |
| WO (1) | WO2001040216A1 (es) |
| YU (1) | YU35102A (es) |
| ZA (1) | ZA200204285B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US20040248945A1 (en) * | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| CA2392931A1 (en) * | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
| WO2003018008A1 (fr) * | 2000-02-25 | 2003-03-06 | Shionogi & Co., Ltd. | Agent d'accélération de l'expression de apo ai |
| ES2241964T3 (es) | 2001-07-05 | 2005-11-01 | Pfizer Products Inc. | Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos. |
| DE10135027A1 (de) * | 2001-07-18 | 2003-02-06 | Solvay Pharm Gmbh | Verwendung Trifluoracetylalkyl-substituierter Phenyl-, Phenol- und Benzoylderivate in der Behandlung und/oder Prophylaxe von Obestias und deren Begleit- und/oder Folgeerkrankungen |
| GT200200183A (es) * | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| YU67702A (sh) * | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| DE60224299T2 (de) * | 2001-10-25 | 2008-12-11 | Novartis Ag | Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor |
| WO2003037351A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors |
| WO2003037330A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Sulfonyl-and sulfonylheteroaryl-pyrazoles with a hydrazinyl or nitrogen oxide substituent at the 5-position for use as cyclooxygenase inhibitors |
| WO2003037335A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 5-heteroatom-substituted pyrazoles |
| CA2464944A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | An efficient synthesis of 5-heteroatom-containing-pyrazoles |
| WO2003037352A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders |
| KR100686537B1 (ko) * | 2001-12-28 | 2007-02-27 | 씨제이 주식회사 | 사이클로옥시게나제-2 의 저해제로서 선택성이 뛰어난디아릴 1,2,4-트리아졸 유도체 |
| TW200403072A (en) * | 2002-01-23 | 2004-03-01 | Upjohn Co | Combination therapy for the treatment of bacterial infections |
| KR100470076B1 (ko) * | 2002-11-27 | 2005-02-05 | 씨제이 주식회사 | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 |
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| RU2379292C2 (ru) * | 2003-04-18 | 2010-01-20 | Мемори Фармасьютиклз Корпорейшн | Производные пиразола в качестве ингибиторов фосфодиэстеразы 4 |
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| CN109438365B (zh) * | 2018-12-06 | 2022-04-05 | 华南师范大学 | N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物 |
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| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| IL104311A (en) | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
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| US5401765A (en) | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
| US5434178A (en) | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
| ES2193609T3 (es) | 1993-11-30 | 2003-11-01 | Searle & Co | Pirazolil-bencenosulfonamidas sustituidas y su uso como inhibidores de la ciclooxigenasa ii. |
| US5475018A (en) | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| WO1996003392A1 (en) | 1994-07-27 | 1996-02-08 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| US5585504A (en) | 1994-09-16 | 1996-12-17 | Merck & Co., Inc. | Process of making cox-2 inhibitors having a lactone bridge |
| ES2191069T3 (es) | 1994-12-21 | 2003-09-01 | Merck Frosst Canada Inc | Diaril-2-(5h)-furanonas como inhibidores de cox-2. |
| US5691374A (en) | 1995-05-18 | 1997-11-25 | Merck Frosst Canada Inc. | Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors |
| WO1997011074A1 (fr) * | 1995-09-22 | 1997-03-27 | Fujisawa Pharmaceutical Co., Ltd. | Nouveaux procedes de production de derives de pyridoindole |
| US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| GB9520584D0 (en) | 1995-10-09 | 1995-12-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| WO1997016435A1 (en) | 1995-10-30 | 1997-05-09 | Merck Frosst Canada Inc. | 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors |
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2000
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- 2000-11-24 IL IL14958100A patent/IL149581A0/xx unknown
- 2000-11-24 WO PCT/IB2000/001748 patent/WO2001040216A1/en active IP Right Grant
- 2000-11-24 DZ DZ003246A patent/DZ3246A1/fr active
- 2000-11-24 EA EA200200520A patent/EA200200520A1/ru unknown
- 2000-11-24 HU HU0300157A patent/HUP0300157A3/hu unknown
- 2000-11-24 MX MXPA02005539A patent/MXPA02005539A/es unknown
- 2000-11-24 AT AT00974741T patent/ATE291019T1/de not_active IP Right Cessation
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- 2000-11-24 JP JP2001541900A patent/JP2003517475A/ja active Pending
- 2000-11-24 PL PL00356669A patent/PL356669A1/xx not_active Application Discontinuation
- 2000-11-24 BR BR0016031-8A patent/BR0016031A/pt not_active IP Right Cessation
- 2000-11-24 DE DE60018792T patent/DE60018792T2/de not_active Expired - Fee Related
- 2000-11-24 KR KR1020027007082A patent/KR20020058074A/ko not_active Application Discontinuation
- 2000-11-24 EP EP00974741A patent/EP1233959B1/en not_active Expired - Lifetime
- 2000-11-24 CN CN00818329A patent/CN1423646A/zh active Pending
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- 2000-11-28 US US09/724,446 patent/US6531492B1/en not_active Expired - Fee Related
- 2000-12-01 TN TNTNSN00235A patent/TNSN00235A1/fr unknown
- 2000-12-01 PE PE2000001289A patent/PE20010962A1/es not_active Application Discontinuation
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