EA200200520A1 - Производные гетероциклоалкилсульфонилпиразола в качестве противовоспалительных/анальгетических агентов - Google Patents
Производные гетероциклоалкилсульфонилпиразола в качестве противовоспалительных/анальгетических агентовInfo
- Publication number
- EA200200520A1 EA200200520A1 EA200200520A EA200200520A EA200200520A1 EA 200200520 A1 EA200200520 A1 EA 200200520A1 EA 200200520 A EA200200520 A EA 200200520A EA 200200520 A EA200200520 A EA 200200520A EA 200200520 A1 EA200200520 A1 EA 200200520A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- heterocycloalkylsulfonylpyrazole
- analogical
- inflammatory
- derivatives
- agents
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 241000282326 Felis catus Species 0.000 abstract 1
- 241000282412 Homo Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I), где R, R, Rи А указаны в описании, к содержащим их фармацевтическим композициям и к их медицинскому применению. Соединения по изобретению могут использоваться для лечения или облегчения воспаления и других нарушений, связанных с воспалением, таких как остеоартрит, ревматоидный артрит, рак толстой кишки и болезнь Альцгеймера, у млекопитающих (предпочтительно человека, собак, кошек и домашнего скота).Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16870199P | 1999-12-03 | 1999-12-03 | |
| PCT/IB2000/001748 WO2001040216A1 (en) | 1999-12-03 | 2000-11-24 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200200520A1 true EA200200520A1 (ru) | 2002-10-31 |
Family
ID=22612589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200520A EA200200520A1 (ru) | 1999-12-03 | 2000-11-24 | Производные гетероциклоалкилсульфонилпиразола в качестве противовоспалительных/анальгетических агентов |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6531492B1 (ru) |
| EP (1) | EP1233959B1 (ru) |
| JP (1) | JP2003517475A (ru) |
| KR (1) | KR20020058074A (ru) |
| CN (1) | CN1423646A (ru) |
| AP (1) | AP2002002532A0 (ru) |
| AR (1) | AR026711A1 (ru) |
| AT (1) | ATE291019T1 (ru) |
| AU (1) | AU783359B2 (ru) |
| BG (1) | BG106694A (ru) |
| BR (1) | BR0016031A (ru) |
| CA (1) | CA2392931A1 (ru) |
| CO (1) | CO5261496A1 (ru) |
| DE (1) | DE60018792T2 (ru) |
| DZ (1) | DZ3246A1 (ru) |
| EA (1) | EA200200520A1 (ru) |
| ES (1) | ES2238324T3 (ru) |
| GT (1) | GT200000204A (ru) |
| HK (1) | HK1052701A1 (ru) |
| HU (1) | HUP0300157A3 (ru) |
| IL (1) | IL149581A0 (ru) |
| IS (1) | IS6376A (ru) |
| MA (1) | MA26848A1 (ru) |
| MX (1) | MXPA02005539A (ru) |
| NO (1) | NO20022624L (ru) |
| OA (1) | OA12100A (ru) |
| PA (1) | PA8508201A1 (ru) |
| PE (1) | PE20010962A1 (ru) |
| PL (1) | PL356669A1 (ru) |
| SK (1) | SK7412002A3 (ru) |
| TN (1) | TNSN00235A1 (ru) |
| WO (1) | WO2001040216A1 (ru) |
| YU (1) | YU35102A (ru) |
| ZA (1) | ZA200204285B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US20040248945A1 (en) * | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| WO2001040216A1 (en) * | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
| WO2003018008A1 (fr) * | 2000-02-25 | 2003-03-06 | Shionogi & Co., Ltd. | Agent d'accélération de l'expression de apo ai |
| EP1273582B1 (en) * | 2001-07-05 | 2005-06-29 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents |
| DE10135027A1 (de) * | 2001-07-18 | 2003-02-06 | Solvay Pharm Gmbh | Verwendung Trifluoracetylalkyl-substituierter Phenyl-, Phenol- und Benzoylderivate in der Behandlung und/oder Prophylaxe von Obestias und deren Begleit- und/oder Folgeerkrankungen |
| GT200200183A (es) * | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| YU67702A (sh) * | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| KR100954625B1 (ko) * | 2001-10-25 | 2010-04-27 | 노파르티스 아게 | 선택적 사이클로옥시게나제-2 억제제를 포함하는 조합물 |
| WO2003037351A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazoles and their use as cox-2 inhibitors |
| WO2003037352A1 (en) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders |
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| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
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