PT1049703E - Aldeido do acido n-¬2-(5-benziloxicarbonilamino-6-oxo-2-(4-fluorofenil)-1,6-di-hidro-1-pirimidinil)acetoxil|-l-aspartico como inibidor da enzima de conversao da interleucina-1beta in vivo - Google Patents
Aldeido do acido n-¬2-(5-benziloxicarbonilamino-6-oxo-2-(4-fluorofenil)-1,6-di-hidro-1-pirimidinil)acetoxil|-l-aspartico como inibidor da enzima de conversao da interleucina-1beta in vivoInfo
- Publication number
- PT1049703E PT1049703E PT98958672T PT98958672T PT1049703E PT 1049703 E PT1049703 E PT 1049703E PT 98958672 T PT98958672 T PT 98958672T PT 98958672 T PT98958672 T PT 98958672T PT 1049703 E PT1049703 E PT 1049703E
- Authority
- PT
- Portugal
- Prior art keywords
- inhibitor
- interleucina
- 1beta
- benzyloxycarbonylamino
- acetoxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7191898P | 1998-01-20 | 1998-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1049703E true PT1049703E (pt) | 2003-06-30 |
Family
ID=22104428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98958672T PT1049703E (pt) | 1998-01-20 | 1998-11-20 | Aldeido do acido n-¬2-(5-benziloxicarbonilamino-6-oxo-2-(4-fluorofenil)-1,6-di-hidro-1-pirimidinil)acetoxil|-l-aspartico como inibidor da enzima de conversao da interleucina-1beta in vivo |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1049703B1 (pt) |
JP (1) | JP2002509153A (pt) |
AT (1) | ATE232536T1 (pt) |
AU (1) | AU1466399A (pt) |
CA (1) | CA2309546A1 (pt) |
DE (1) | DE69811404T2 (pt) |
DK (1) | DK1049703T3 (pt) |
ES (1) | ES2193589T3 (pt) |
PT (1) | PT1049703E (pt) |
WO (1) | WO1999036426A1 (pt) |
ZA (1) | ZA99369B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
JP2004505013A (ja) | 2000-04-05 | 2004-02-19 | ファルマシア・コーポレーション | 凝固カスケードを選択的に阻害するのに有用な多環式アリール及びヘテロアリール置換4−ピリドン類 |
EP1268463B1 (en) | 2000-04-05 | 2005-02-16 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
JP2004501077A (ja) | 2000-04-17 | 2004-01-15 | ファルマシア・コーポレーション | 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換1,4−キノン |
AU2001222501A1 (en) * | 2000-05-18 | 2001-11-26 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US6943173B2 (en) | 2000-07-18 | 2005-09-13 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
MXPA03004458A (es) | 2000-11-20 | 2005-01-25 | Pharmacia Corp | Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion. |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
SG173211A1 (en) | 2001-06-26 | 2011-08-29 | Amgen Inc | Antibodies to opgl |
WO2003093242A2 (en) | 2001-10-03 | 2003-11-13 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
WO2003029216A1 (en) | 2001-10-03 | 2003-04-10 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
ES2449578T3 (es) | 2002-09-06 | 2014-03-20 | Amgen Inc. | Anticuerpo monoclonal anti-IL-1R1 humano terapéutico |
CN1950364B (zh) | 2004-03-12 | 2011-06-08 | 弗特克斯药品有限公司 | 制备天冬氨酸缩醛胱冬酶抑制剂的方法和中间体 |
EP1750689A1 (en) | 2004-05-15 | 2007-02-14 | Vertex Pharmaceuticals Incorporated | Treating seizures using ice inhibitors |
EP2295054A1 (en) | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
CN101268084A (zh) | 2005-07-28 | 2008-09-17 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂前体药物 |
JP5980790B2 (ja) | 2010-11-05 | 2016-08-31 | ブランダイス ユニバーシティBrandeis University | バイオマーカーとしての、ice切断されたアルファ−シヌクレイン |
US20210236599A1 (en) | 2018-08-13 | 2021-08-05 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
CN1118458C (zh) * | 1994-03-31 | 2003-08-20 | 弗特克斯药品有限公司 | 作为白细胞介素抑制剂的嘧啶基衍生物 |
-
1998
- 1998-11-20 DK DK98958672T patent/DK1049703T3/da active
- 1998-11-20 EP EP98958672A patent/EP1049703B1/en not_active Expired - Lifetime
- 1998-11-20 JP JP2000540142A patent/JP2002509153A/ja not_active Abandoned
- 1998-11-20 WO PCT/US1998/024848 patent/WO1999036426A1/en active IP Right Grant
- 1998-11-20 DE DE69811404T patent/DE69811404T2/de not_active Expired - Fee Related
- 1998-11-20 ES ES98958672T patent/ES2193589T3/es not_active Expired - Lifetime
- 1998-11-20 AT AT98958672T patent/ATE232536T1/de not_active IP Right Cessation
- 1998-11-20 CA CA002309546A patent/CA2309546A1/en not_active Abandoned
- 1998-11-20 PT PT98958672T patent/PT1049703E/pt unknown
- 1998-11-20 AU AU14663/99A patent/AU1466399A/en not_active Abandoned
-
1999
- 1999-01-19 ZA ZA9900369A patent/ZA99369B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE69811404T2 (de) | 2003-12-04 |
ZA99369B (en) | 1999-07-20 |
DK1049703T3 (da) | 2003-06-02 |
AU1466399A (en) | 1999-08-02 |
EP1049703A1 (en) | 2000-11-08 |
ES2193589T3 (es) | 2003-11-01 |
EP1049703B1 (en) | 2003-02-12 |
DE69811404D1 (de) | 2003-03-20 |
JP2002509153A (ja) | 2002-03-26 |
CA2309546A1 (en) | 1999-07-22 |
WO1999036426A1 (en) | 1999-07-22 |
ATE232536T1 (de) | 2003-02-15 |
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