ES2193589T3 - Aldehido del acido n-(2-(5-benciloxicarbonil-amino-6-oxo-2-(4-fluorofenil)-1,6-dihidro-1-pirimidinil)acetoxil)-l-aspartico como un inhibidor (in vivo) del enzima de conversion de la interleucina-1beta. - Google Patents
Aldehido del acido n-(2-(5-benciloxicarbonil-amino-6-oxo-2-(4-fluorofenil)-1,6-dihidro-1-pirimidinil)acetoxil)-l-aspartico como un inhibidor (in vivo) del enzima de conversion de la interleucina-1beta.Info
- Publication number
- ES2193589T3 ES2193589T3 ES98958672T ES98958672T ES2193589T3 ES 2193589 T3 ES2193589 T3 ES 2193589T3 ES 98958672 T ES98958672 T ES 98958672T ES 98958672 T ES98958672 T ES 98958672T ES 2193589 T3 ES2193589 T3 ES 2193589T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitor
- interleucina
- benciloxicarbonil
- aspartico
- acetoxil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
El compuesto **(Fórmula)** y los estereoisómeros y sales, ésteres, amidas y pro-fármacos del mismo farmacéuticamente aceptables. El compuesto 1 muestra una actividad in vivo como inhibidor de ICE inesperadamente superior a la de los inhibidores de ICE de técnicas anteriores. De hecho, este es el primer inhibidor de ICE que muestra actividad in vivo en un modelo animal de ataque después de su administración periférica. Compuestos de técnicas anteriores tales como el compuesto 2 no presentan esta actividad.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7191898P | 1998-01-20 | 1998-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2193589T3 true ES2193589T3 (es) | 2003-11-01 |
Family
ID=22104428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98958672T Expired - Lifetime ES2193589T3 (es) | 1998-01-20 | 1998-11-20 | Aldehido del acido n-(2-(5-benciloxicarbonil-amino-6-oxo-2-(4-fluorofenil)-1,6-dihidro-1-pirimidinil)acetoxil)-l-aspartico como un inhibidor (in vivo) del enzima de conversion de la interleucina-1beta. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1049703B1 (es) |
JP (1) | JP2002509153A (es) |
AT (1) | ATE232536T1 (es) |
AU (1) | AU1466399A (es) |
CA (1) | CA2309546A1 (es) |
DE (1) | DE69811404T2 (es) |
DK (1) | DK1049703T3 (es) |
ES (1) | ES2193589T3 (es) |
PT (1) | PT1049703E (es) |
WO (1) | WO1999036426A1 (es) |
ZA (1) | ZA99369B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
WO2001077079A2 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
US20020022604A1 (en) | 2000-04-05 | 2002-02-21 | South Michael S. | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
CA2405684A1 (en) | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
WO2001087851A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
CA2416248A1 (en) * | 2000-07-18 | 2002-01-24 | Neurogen Corporation | 5-substituted 2-aryl-4-pyrimidinones |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
US6624180B2 (en) | 2000-11-20 | 2003-09-23 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
US7364736B2 (en) | 2001-06-26 | 2008-04-29 | Amgen Inc. | Antibodies to OPGL |
JP2005519866A (ja) | 2001-10-03 | 2005-07-07 | ファルマシア・コーポレーション | 凝固カスケードの選択阻害に有用な6員複素環式化合物 |
MXPA04003170A (es) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Compuestos policiclicos, sustituidos, provisto de 5 miembros, utiles para la inhibicion selectiva de la cascada de coagulacion. |
TWI289668B (en) | 2002-09-06 | 2007-11-11 | Amgen Inc | Therapeutic human anti-IL-1R1 monoclonal antibody |
WO2005117846A2 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
HUE024556T2 (hu) | 2004-03-12 | 2016-02-29 | Vertex Pharma | Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására |
US20060128696A1 (en) | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
WO2007015931A2 (en) | 2005-07-28 | 2007-02-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitor prodrugs |
JP6006908B2 (ja) | 2010-11-05 | 2016-10-12 | ブランダイス ユニバーシティBrandeis University | Ice阻害化合物およびその使用 |
EP3836954A1 (en) | 2018-08-13 | 2021-06-23 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
CN1118458C (zh) * | 1994-03-31 | 2003-08-20 | 弗特克斯药品有限公司 | 作为白细胞介素抑制剂的嘧啶基衍生物 |
-
1998
- 1998-11-20 ES ES98958672T patent/ES2193589T3/es not_active Expired - Lifetime
- 1998-11-20 CA CA002309546A patent/CA2309546A1/en not_active Abandoned
- 1998-11-20 JP JP2000540142A patent/JP2002509153A/ja not_active Abandoned
- 1998-11-20 WO PCT/US1998/024848 patent/WO1999036426A1/en active IP Right Grant
- 1998-11-20 DE DE69811404T patent/DE69811404T2/de not_active Expired - Fee Related
- 1998-11-20 PT PT98958672T patent/PT1049703E/pt unknown
- 1998-11-20 AU AU14663/99A patent/AU1466399A/en not_active Abandoned
- 1998-11-20 EP EP98958672A patent/EP1049703B1/en not_active Expired - Lifetime
- 1998-11-20 DK DK98958672T patent/DK1049703T3/da active
- 1998-11-20 AT AT98958672T patent/ATE232536T1/de not_active IP Right Cessation
-
1999
- 1999-01-19 ZA ZA9900369A patent/ZA99369B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU1466399A (en) | 1999-08-02 |
JP2002509153A (ja) | 2002-03-26 |
CA2309546A1 (en) | 1999-07-22 |
EP1049703A1 (en) | 2000-11-08 |
DE69811404D1 (de) | 2003-03-20 |
DE69811404T2 (de) | 2003-12-04 |
PT1049703E (pt) | 2003-06-30 |
ZA99369B (en) | 1999-07-20 |
ATE232536T1 (de) | 2003-02-15 |
EP1049703B1 (en) | 2003-02-12 |
WO1999036426A1 (en) | 1999-07-22 |
DK1049703T3 (da) | 2003-06-02 |
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