AU2001222501A1 - Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade - Google Patents

Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

Info

Publication number
AU2001222501A1
AU2001222501A1 AU2001222501A AU2250101A AU2001222501A1 AU 2001222501 A1 AU2001222501 A1 AU 2001222501A1 AU 2001222501 A AU2001222501 A AU 2001222501A AU 2250101 A AU2250101 A AU 2250101A AU 2001222501 A1 AU2001222501 A1 AU 2001222501A1
Authority
AU
Australia
Prior art keywords
coagulation cascade
selective inhibition
polycyclic aryl
substituted polycyclic
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001222501A
Inventor
Ashton T. Hamme
Darin E. Jones
William L Neumann
Melvin L. Ruppel
Michael S. South
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/574,739 external-priority patent/US6750342B1/en
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of AU2001222501A1 publication Critical patent/AU2001222501A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001222501A 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade Abandoned AU2001222501A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/574,739 US6750342B1 (en) 1999-05-19 2000-05-18 Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US09574739 2000-05-18
PCT/US2000/031901 WO2001087851A1 (en) 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

Publications (1)

Publication Number Publication Date
AU2001222501A1 true AU2001222501A1 (en) 2001-11-26

Family

ID=24297415

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001222501A Abandoned AU2001222501A1 (en) 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade

Country Status (2)

Country Link
AU (1) AU2001222501A1 (en)
WO (1) WO2001087851A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04003163A (en) * 2001-10-03 2004-07-08 Pharmacia Corp 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade.
WO2003029224A1 (en) * 2001-10-03 2003-04-10 Pharmacia Corporation 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
US7094783B2 (en) 2002-06-26 2006-08-22 Bristol-Myers Squibb Company Bicyclic pyrimidinones as coagulation cascade inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
DE69314169T2 (en) * 1992-04-16 1998-01-15 Zeneca Ltd PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
MX9704439A (en) * 1994-12-13 1997-10-31 Corvas Int Inc Aromatic heterocyclic derivatives as enzyme inhibitors.
US5656645A (en) * 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US6011158A (en) * 1994-12-13 2000-01-04 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
KR100400639B1 (en) * 1995-04-27 2003-12-31 미쯔비시 웰 파마 가부시키가이샤 Heterocyclic amide compounds and their medicinal uses
KR20000068354A (en) * 1996-09-06 2000-11-25 다께다 가즈히꼬 Novel Acetamide Deriva-tives and Protease Inhibitors
CA2268381A1 (en) * 1996-10-11 1998-04-23 Cor Therapeutics, Inc. Selective factor xa inhibitors
EP0940400A4 (en) * 1996-10-25 2002-10-02 Mitsubishi Pharma Corp Novel heterocyclic amide compounds and medicinal uses thereof
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them
PT1049703E (en) * 1998-01-20 2003-06-30 Warner Lambert Co N-2- (5-BENZYLOXYCARBONYLAMINO-6-OXO-2- (4-FLUOROPHENYL) -1,6-DIHYDRO-1-PYRIMIDINYL) ACETOXYL-ASPARTIC ACID AS INHIBITOR OF THE INVENTION INTERLEUCINA-1BETA IN VIVO
WO2000032216A1 (en) * 1998-06-03 2000-06-08 Cortech Inc. Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
SK15852001A3 (en) * 1999-05-19 2003-06-03 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful as anticoagulants

Also Published As

Publication number Publication date
WO2001087851A1 (en) 2001-11-22

Similar Documents

Publication Publication Date Title
IL146244A0 (en) Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
AU2001265141A1 (en) Multifunctional periodic cellular solids and the method of making thereof
AU2862100A (en) Materials and methods for the purification of polyelectrolytes
AU2001238426A1 (en) Prepaints and methods of preparing paints from the prepaints
AU2001275870A1 (en) Methods and kits for the detection of arginine compounds
IL146245A0 (en) Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
AU2001243598A1 (en) Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
AU2002322041A1 (en) Multifunctional periodic cellular solids and the method of making the same
AU2001292137A1 (en) Quinazoline derivatives
AU2001288360A1 (en) Genomics-assisted rapid identification of targets
AU2002211370A1 (en) Inhibition of tgf-beta and uses thereof
AU2001219236A1 (en) Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
AU2002367752A1 (en) Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
AU2002214189A1 (en) Methods of identifying inhibitory compounds and uses thereof
AU2001222501A1 (en) Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
AU2001262111A1 (en) Aryl and heteroaryl sulfonates
AU2001217827A1 (en) Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
AU2002359792A1 (en) Methods and compositions for the inhibition of viral release
AU2088000A (en) Surveillance of structures
AU2001225523A1 (en) Novel arylpropionaldehyde derivatives and production and use of the same
AU2001286584A1 (en) Inhibition of protein-protein interaction
AU2002334854A1 (en) 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
AU2002220591A1 (en) Means for the identification of compounds capable of inhibiting karap-transduced signals
AU2002360614A1 (en) Methods of inhibiting fertility
AU2002362440A1 (en) 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade