AU2001219236A1 - Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade - Google Patents
Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascadeInfo
- Publication number
- AU2001219236A1 AU2001219236A1 AU2001219236A AU1923601A AU2001219236A1 AU 2001219236 A1 AU2001219236 A1 AU 2001219236A1 AU 2001219236 A AU2001219236 A AU 2001219236A AU 1923601 A AU1923601 A AU 1923601A AU 2001219236 A1 AU2001219236 A1 AU 2001219236A1
- Authority
- AU
- Australia
- Prior art keywords
- useful
- coagulation cascade
- selective inhibition
- polycyclic aryl
- substituted polycyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/574,207 US6458952B1 (en) | 1999-05-19 | 2000-05-18 | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US09574207 | 2000-05-18 | ||
PCT/US2000/031885 WO2001087852A1 (en) | 2000-05-18 | 2000-11-20 | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001219236A1 true AU2001219236A1 (en) | 2001-11-26 |
Family
ID=24295129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001219236A Abandoned AU2001219236A1 (en) | 2000-05-18 | 2000-11-20 | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
Country Status (3)
Country | Link |
---|---|
US (2) | US6458952B1 (en) |
AU (1) | AU2001219236A1 (en) |
WO (1) | WO2001087852A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7015230B1 (en) * | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
PA8591801A1 (en) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | BENZAMID INHIBITORS OF THE P2X7 RECEIVER. |
KR20070115583A (en) * | 2004-06-29 | 2007-12-06 | 화이자 프로덕츠 인코포레이티드 | Method for preparing 5-[4-(2-hydroxy-ehtyl)-3,5-dioxo-4,5-dihydro-3h-[1,2,4]-triazin-2-yl]-benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
WO2008051902A2 (en) * | 2006-10-20 | 2008-05-02 | Cpd, Llc | Method of restoring the incretin effect |
UA112897C2 (en) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | BICYCLIC SUBSTITUTED URATILES AND THEIR APPLICATIONS FOR THE TREATMENT AND / OR PREVENTION OF DISEASES |
CN107405343A (en) | 2014-11-07 | 2017-11-28 | 明尼苏达大学董事会 | Salt and composition available for treatment disease |
CN116410143A (en) * | 2021-12-29 | 2023-07-11 | 杭州奥默医药股份有限公司 | Polysubstituted uracil derivative, preparation method and application thereof |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS5910541A (en) * | 1982-07-09 | 1984-01-20 | Takeda Chem Ind Ltd | Quinone compound |
JPS60255749A (en) * | 1984-05-31 | 1985-12-17 | Univ Nagoya | Quinone derivative |
US5304658A (en) * | 1984-08-01 | 1994-04-19 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
IL81264A (en) * | 1986-01-30 | 1990-11-05 | Takeda Chemical Industries Ltd | Quinone derivatives,their production and pharmaceutical compositions containing them |
US5008267A (en) * | 1988-10-29 | 1991-04-16 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same |
GB9216272D0 (en) | 1991-08-15 | 1992-09-09 | Ici Plc | Substituted heterocycles |
AU3959693A (en) | 1992-04-16 | 1993-11-18 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
US5618792A (en) | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
NZ298699A (en) | 1994-12-13 | 2001-03-30 | Corvas Int Inc | 3-amino-1,2-dihydropyrid-1-yl(and 5-amino-1,6-dihydro-6-oxo(and 5,6-dioxo)pyrimidin-1-yl)-acetyl-argininal derivatives, useful for the treatment of blood coagulation and thrombosis |
US5658930A (en) | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5656645A (en) | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US6011158A (en) | 1994-12-13 | 2000-01-04 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
EP0826671B1 (en) | 1995-04-27 | 2004-12-29 | Mitsubishi Pharma Corporation | Heterocyclic amide compounds and medicinal use of the same |
US5612378A (en) | 1995-06-06 | 1997-03-18 | 3-Dimensional Pharmaceuticals, Inc. | Bis-arylsulfonylaminobenzamide derivatives and the use thereof as factor Xa inhibitors |
US5741819A (en) * | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
JPH11508558A (en) | 1995-06-27 | 1999-07-27 | メルク エンド カンパニー インコーポレーテッド | Pyridinone thrombin inhibitor |
JP2000512616A (en) | 1996-02-22 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | Pyridinone thrombin inhibitor |
CZ340898A3 (en) | 1996-04-23 | 1999-02-17 | Merck And Co., Inc. | Compound, process of its preparation and pharmaceutical composition containing thereof |
US5668289A (en) | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
CA2263999A1 (en) | 1996-08-29 | 1998-03-05 | Merck & Co., Inc. | Integrin antagonists |
CA2263198A1 (en) | 1996-09-06 | 1998-03-12 | Nippon Kayaku Kabushiki Kaisha | Novel acetamide derivatives and protease inhibitors |
US5872138A (en) | 1996-09-13 | 1999-02-16 | Merck & Co., Inc. | Thrombin inhibitors |
CA2264037A1 (en) | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Thrombin inhibitors |
AU743735B2 (en) | 1996-10-11 | 2002-02-07 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
EP0932608A1 (en) | 1996-10-11 | 1999-08-04 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US5869487A (en) | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
EP0934064B1 (en) | 1996-10-24 | 2003-03-12 | Merck & Co., Inc. | Thrombin inhibitors |
CN1088706C (en) | 1996-10-25 | 2002-08-07 | 卫福有限公司 | Novel heterocyclic amide compounds and medicinal uses thereof |
CA2277929A1 (en) | 1997-01-22 | 1998-07-23 | Merck & Co., Inc. | Thrombin inhibitors |
US5792779A (en) | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
JP2001518932A (en) | 1997-03-24 | 2001-10-16 | メルク エンド カンパニー インコーポレーテッド | Thrombin inhibitors |
US5866573A (en) | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them |
RU2183642C2 (en) | 1997-05-02 | 2002-06-20 | Акцо Нобель Н.В. | Inhibitors of serine proteases |
JP2002512633A (en) | 1997-06-26 | 2002-04-23 | イーライ・リリー・アンド・カンパニー | Antithrombotic agent |
JP2002508771A (en) | 1997-06-26 | 2002-03-19 | イーライ・リリー・アンド・カンパニー | Antithrombotic agent |
JP2002506462A (en) | 1997-06-26 | 2002-02-26 | イーライ・リリー・アンド・カンパニー | Antithrombotic substance |
CA2301520A1 (en) | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
AU1605699A (en) | 1997-11-26 | 1999-06-15 | Corvas International, Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii) |
AU751412B2 (en) | 1997-11-26 | 2002-08-15 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors |
DK1049703T3 (en) | 1998-01-20 | 2003-06-02 | Abbott Gmbh & Co Kg | N- [2- (5-benzyloxycarbonylamino-6-oxo-2- (4-fluorophenyl) -1,6-dihydro-1-pyrimidinyl) acetoxyl] -L-aspartic acid aldehyde as an in vivo inhibitor of interleukin-1beta converting enzyme |
JP2002515434A (en) | 1998-05-19 | 2002-05-28 | メルク エンド カムパニー インコーポレーテッド | Pyrazinone thrombin inhibitors |
AU742178B2 (en) | 1998-05-26 | 2001-12-20 | Merck & Co., Inc. | Imidazopyridine thrombin inhibitors |
WO2000032216A1 (en) | 1998-06-03 | 2000-06-08 | Cortech Inc. | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors |
DE69942159D1 (en) | 1998-06-11 | 2010-04-29 | Ortho Mcneil Pharm Inc | Pyrazine protease inhibitors |
DE69912379T2 (en) * | 1998-08-14 | 2004-05-06 | Pfizer Inc. | Antithrombotic agents |
AU758237B2 (en) | 1998-09-28 | 2003-03-20 | Merck & Co., Inc. | Thrombin inhibitors |
EP1124822A4 (en) | 1998-10-30 | 2002-04-03 | Merck & Co Inc | Thrombin inhibitors |
EP1124823A1 (en) | 1998-10-30 | 2001-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
FR2786482B1 (en) | 1998-11-27 | 2002-08-09 | Synthelabo | NOVEL 2-PYRIDONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
WO2000039102A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
EP1178970A1 (en) | 1999-05-19 | 2002-02-13 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants |
AU771928B2 (en) | 1999-05-19 | 2004-04-08 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
BR0011273A (en) | 1999-05-19 | 2002-06-18 | Pharmacia Corp | Heteroaryl and polycyclic aryl uracils substituted as anticoagulant agents |
-
2000
- 2000-05-18 US US09/574,207 patent/US6458952B1/en not_active Expired - Fee Related
- 2000-11-20 WO PCT/US2000/031885 patent/WO2001087852A1/en active Search and Examination
- 2000-11-20 AU AU2001219236A patent/AU2001219236A1/en not_active Abandoned
-
2002
- 2002-08-08 US US10/215,292 patent/US20030023086A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20030023086A1 (en) | 2003-01-30 |
WO2001087852A1 (en) | 2001-11-22 |
US6458952B1 (en) | 2002-10-01 |
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