BR0108908A - Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos - Google Patents

Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos

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Publication number
BR0108908A
BR0108908A BR0108908-0A BR0108908A BR0108908A BR 0108908 A BR0108908 A BR 0108908A BR 0108908 A BR0108908 A BR 0108908A BR 0108908 A BR0108908 A BR 0108908A
Authority
BR
Brazil
Prior art keywords
analgesic agents
derivatives
pyrazole
inflammatory
ethers
Prior art date
Application number
BR0108908-0A
Other languages
English (en)
Inventor
Hengmiao Cheng
Jason Kenneth Dutra
Subas Man Sakya
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0108908A publication Critical patent/BR0108908A/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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Abstract

"DERIVADOS DE éTERES DE PIRAZOL COMO AGENTES ANTIINFLAMATóRIOS/ANALGéSICOS". A presente invenção refere-se com compostos da fórmula em que R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, A, X e Y são definidos como no relatório descritivo, com formulações farmacêuticas contendo estes compostos e com a sua utilização medicinal. Os compostos da invenção são úteis no tratamento ou alívio da inflamação e outros distúrbios associados com a inflamação, tais como artrite, câncer do cólon e doença de Alzheimer em mamíferos, preferencialmente em seres humanos, cães, gatos e animais vivos.
BR0108908-0A 2000-03-03 2001-02-22 Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos BR0108908A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18686900P 2000-03-03 2000-03-03
PCT/IB2001/000237 WO2001064669A1 (en) 2000-03-03 2001-02-22 Pyrazole ether derivatives as anti-inflammatory/analgesic agents

Publications (1)

Publication Number Publication Date
BR0108908A true BR0108908A (pt) 2002-12-24

Family

ID=22686598

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108908-0A BR0108908A (pt) 2000-03-03 2001-02-22 Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos

Country Status (16)

Country Link
US (3) US6878726B2 (pt)
EP (1) EP1259504A1 (pt)
JP (1) JP2003525288A (pt)
AR (1) AR027967A1 (pt)
AU (2) AU3217501A (pt)
BR (1) BR0108908A (pt)
CA (1) CA2401697A1 (pt)
CO (1) CO5271651A1 (pt)
GT (1) GT200100036A (pt)
HN (1) HN2001000037A (pt)
MX (1) MXPA02008627A (pt)
PA (1) PA8513101A1 (pt)
PE (1) PE20011164A1 (pt)
TN (1) TNSN01035A1 (pt)
WO (1) WO2001064669A1 (pt)
ZA (1) ZA200207015B (pt)

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SI2568988T1 (sl) 2010-05-11 2016-10-28 Janssen Pharmaceutica N.V. Farmacevtske formulacije, obsegajoče 1-(beta-D-glukopiranozil)-2-tienilmetilbenzenske derivate kot inhibitorje SGLT
RS55056B1 (sr) 2011-04-13 2016-12-30 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
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AU3217501A (en) 2001-09-12
JP2003525288A (ja) 2003-08-26
EP1259504A1 (en) 2002-11-27
CO5271651A1 (es) 2003-04-30
US6878726B2 (en) 2005-04-12
CA2401697A1 (en) 2001-09-07
PE20011164A1 (es) 2001-11-13
ZA200207015B (en) 2003-09-02
AU2001232175B2 (en) 2005-07-07
GT200100036A (es) 2001-12-18
US20050004135A1 (en) 2005-01-06
AR027967A1 (es) 2003-04-16
PA8513101A1 (es) 2003-06-30
US20040259879A1 (en) 2004-12-23
TNSN01035A1 (fr) 2005-11-10
US20020058681A1 (en) 2002-05-16

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