AR103264A1 - Derivados de 3,5-aminopirazol como inhibidores de quinasa rc - Google Patents

Derivados de 3,5-aminopirazol como inhibidores de quinasa rc

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Publication number
AR103264A1
AR103264A1 ARP150104275A ARP150104275A AR103264A1 AR 103264 A1 AR103264 A1 AR 103264A1 AR P150104275 A ARP150104275 A AR P150104275A AR P150104275 A ARP150104275 A AR P150104275A AR 103264 A1 AR103264 A1 AR 103264A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocyclyl
heteroaryl
cycloalkyl
aryl
Prior art date
Application number
ARP150104275A
Other languages
English (en)
Original Assignee
Axikin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Axikin Pharmaceuticals Inc filed Critical Axikin Pharmaceuticals Inc
Publication of AR103264A1 publication Critical patent/AR103264A1/es

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se proporcionan en la presente 3,5-diaminopirazoles, que son útiles para modular la actividad de la quinasa regulada en EPOC, y composiciones farmacéuticas de los mismos. También se proporcionan en la presente uso para tratar, prevenir o mejorar uno o más síntomas de un trastorno, enfermedad o afección mediado por la quinasa RC. Reivindicación 1: Un compuesto de fórmula (1), o un estereoisómero, enantiómero, mezcla de enantiómeros, mezcla de diastereómeros, o variante isotópica de los mismos; o una sal aceptable para uso farmacéutico, solvato, hidrato, o profármaco del mismo; donde: R¹ es arilo C₆₋₁₄, heteroarilo, o heterociclilo; R² y R³ son cada uno independientemente alquilo C₁₋₆ o cicloalquilo C₃₋₁₀; donde cada alquilo, cicloalquilo, arilo, heteroarilo o heterociclilo está opcionalmente sustituido con uno o más sustituyentes Q, donde cada Q se selecciona independientemente de halo, alquilo C₁₋₆, heteroarilo, y heterociclilo, cada uno de los cuales está además opcionalmente sustituido con uno o más alquilo C₁₋₆; con la condición de que el compuesto no sea 3-((3-clorofenil)amino)-5-((4-hidroxi-3,5-dimetil-bencilo)amino)-1H-pirazol-4-carboxamida.
ARP150104275A 2014-12-23 2015-12-22 Derivados de 3,5-aminopirazol como inhibidores de quinasa rc AR103264A1 (es)

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