CO5261496A1 - Derivados de heterociclo-alquilsulfonil-pirazol como agentes antiinflamatorios/analgesicos - Google Patents
Derivados de heterociclo-alquilsulfonil-pirazol como agentes antiinflamatorios/analgesicosInfo
- Publication number
- CO5261496A1 CO5261496A1 CO00092095A CO00092095A CO5261496A1 CO 5261496 A1 CO5261496 A1 CO 5261496A1 CO 00092095 A CO00092095 A CO 00092095A CO 00092095 A CO00092095 A CO 00092095A CO 5261496 A1 CO5261496 A1 CO 5261496A1
- Authority
- CO
- Colombia
- Prior art keywords
- aminocarbonyl
- aryl
- alkyl
- oxy
- alkoxy
- Prior art date
Links
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- -1 formamidyl Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Psychology (AREA)
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- Communicable Diseases (AREA)
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- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
Abstract
Un compuesto de fórmula<EMI FILE="00092095_1" ID="1" IMF=JPEG >Donde A es un hetrociclo selccionado del grupo constituido por<EMI FILE="00092095_2" ID="2" IMF=JPEG >m es 0, 1 ó 2;X es CR8 ó N;R2 es hidrógeno, halógeno, alquilo(C1-C6), alquenilo(C2-C6), alquinilo(C2-C6), alcoxi(C1-C6), alquil(C1-C6)-(C =0)-, formilo, formamidilo, ciano, nitro, HO-(C = O)-, alcoxi(C1-C6)-carbonilo, aminocarbonilo, N-alquil(C1-C6) -aminocarbonilo, N,N-[alquil(C1-C6)]2-aminocarbonilo, N-aril(C6-C10)-aminocarbonilo, N,N-[aril(C1-C6)]2-aminocarbonilo, N-alquil(C1-C6)-N-aril(C6-C10)-aminocarbonilo, arilo(C6-C10), aril(C6-C10)-oxi, heteroarilo(C2-C9), hetaroaril(C2-C9)-oxi, morfolino-carbonilo, alcoxi(C1-C6)-aminocarbonilo o alquil(C1-C6)-carbonilamino; donde dicho grupo R2, cuando es alquilo(C1-C6), puede estar opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente entre halógeno, hidroxi, alcoxi(C1-C6), ciano, nitro, HO-(C = O)-, alcoxi(C1-C6)-carbonilo, aminocarbonilo, N-alquil(C1-C6)-aminocarbonilo, N,N-[alquil(C1-C6)]2-aminocarbonilo, N-aril(C6-C10)-aminocarbonilo, N,N-[aril(C6-C10)]2-aminocarbonilo, N-alquil(C1-C6)-N-aril (C6-C10)-aminocarbonilo, arilo(C6-C10), aril(C6-C10)-oxi, heteroarilo(C2-C9), heteroaril(C2-C9)-oxi, morfolino-carbonilo, alcoxi(C1-C6)-aminocarbonilo o alquil(C1-C6)-carbonilamino; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16870199P | 1999-12-03 | 1999-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261496A1 true CO5261496A1 (es) | 2003-03-31 |
Family
ID=22612589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00092095A CO5261496A1 (es) | 1999-12-03 | 2000-12-04 | Derivados de heterociclo-alquilsulfonil-pirazol como agentes antiinflamatorios/analgesicos |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US6531492B1 (es) |
| EP (1) | EP1233959B1 (es) |
| JP (1) | JP2003517475A (es) |
| KR (1) | KR20020058074A (es) |
| CN (1) | CN1423646A (es) |
| AP (1) | AP2002002532A0 (es) |
| AR (1) | AR026711A1 (es) |
| AT (1) | ATE291019T1 (es) |
| AU (1) | AU783359B2 (es) |
| BG (1) | BG106694A (es) |
| BR (1) | BR0016031A (es) |
| CA (1) | CA2392931A1 (es) |
| CO (1) | CO5261496A1 (es) |
| DE (1) | DE60018792T2 (es) |
| DZ (1) | DZ3246A1 (es) |
| EA (1) | EA200200520A1 (es) |
| ES (1) | ES2238324T3 (es) |
| GT (1) | GT200000204A (es) |
| HK (1) | HK1052701A1 (es) |
| HU (1) | HUP0300157A3 (es) |
| IL (1) | IL149581A0 (es) |
| IS (1) | IS6376A (es) |
| MA (1) | MA26848A1 (es) |
| MX (1) | MXPA02005539A (es) |
| NO (1) | NO20022624L (es) |
| OA (1) | OA12100A (es) |
| PA (1) | PA8508201A1 (es) |
| PE (1) | PE20010962A1 (es) |
| PL (1) | PL356669A1 (es) |
| SK (1) | SK7412002A3 (es) |
| TN (1) | TNSN00235A1 (es) |
| WO (1) | WO2001040216A1 (es) |
| YU (1) | YU35102A (es) |
| ZA (1) | ZA200204285B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US20040248945A1 (en) * | 1999-04-23 | 2004-12-09 | Smithkline Beecham P.L.C. | Thiazolidinedione derivative and its use as antidiabetic |
| WO2001040216A1 (en) * | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
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| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
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