MX2007000007A - Inhibidores de polimerasa viral. - Google Patents
Inhibidores de polimerasa viral.Info
- Publication number
- MX2007000007A MX2007000007A MX2007000007A MX2007000007A MX2007000007A MX 2007000007 A MX2007000007 A MX 2007000007A MX 2007000007 A MX2007000007 A MX 2007000007A MX 2007000007 A MX2007000007 A MX 2007000007A MX 2007000007 A MX2007000007 A MX 2007000007A
- Authority
- MX
- Mexico
- Prior art keywords
- polymerase inhibitors
- viral polymerase
- compound
- particulary
- viralpolymerases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Un compuesto, representado por la formula (1) o un enantiomero, diastereoisomero o tautomero del mismo: (ver formula I) en donde A o B es nitrogeno y el otro B o A es O y los radicales R1, R2, R3, R5, R6, R7, R9 y R10 son como se definen en la presente, o una sal, ester o derivado del mismo, en calidad de inhibidores de la polimerasa viral. El compuesto se utiliza en calidad de inhibidor de ARN polimerasas dependientes de ARN, particularmente las polimerasas virales dentro de la familia Flaviviridae, mas particularmente a polimerasa del VRO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58867004P | 2004-07-16 | 2004-07-16 | |
PCT/CA2005/001103 WO2006007693A1 (en) | 2004-07-16 | 2005-07-15 | Viral polymerase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007000007A true MX2007000007A (es) | 2007-03-07 |
Family
ID=35784831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007000007A MX2007000007A (es) | 2004-07-16 | 2005-07-15 | Inhibidores de polimerasa viral. |
Country Status (19)
Country | Link |
---|---|
US (2) | US7241801B2 (es) |
EP (1) | EP1771442A4 (es) |
JP (1) | JP2008506638A (es) |
KR (1) | KR20070035092A (es) |
CN (1) | CN1984908A (es) |
AR (1) | AR050172A1 (es) |
AU (1) | AU2005263135A1 (es) |
BR (1) | BRPI0513431A (es) |
CA (1) | CA2573210A1 (es) |
EA (1) | EA200700038A1 (es) |
EC (1) | ECSP077171A (es) |
IL (1) | IL180665A0 (es) |
MX (1) | MX2007000007A (es) |
NO (1) | NO20070368L (es) |
PE (1) | PE20060569A1 (es) |
TW (1) | TW200617003A (es) |
UY (1) | UY29017A1 (es) |
WO (1) | WO2006007693A1 (es) |
ZA (1) | ZA200609578B (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
SI1718608T1 (sl) * | 2004-02-20 | 2013-11-29 | Boehringer Ingelheim International Gmbh | Inhibitorji virusne polimeraze |
US7348425B2 (en) | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
KR20070098914A (ko) * | 2005-01-14 | 2007-10-05 | 제네랩스 테크놀로지스, 인코포레이티드 | 바이러스 감염을 치료하기 위한 인돌 유도체 |
KR20070112165A (ko) * | 2005-02-11 | 2007-11-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 2,3-이치환된 인돌의 제조방법 |
EP1881828A4 (en) * | 2005-05-20 | 2009-06-03 | Valeant Res & Dev | TREATMENT OF HEPATITIS C (HCV) USING SUB-THERAPEUTIC DOSES OF RIBAVIRIN |
US8076365B2 (en) * | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007092000A1 (en) * | 2006-02-06 | 2007-08-16 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
GB0608928D0 (en) | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
FR2910813B1 (fr) | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | Nouvelle utilisation therapeutique pour le traitement des leucemies |
WO2009008906A2 (en) * | 2007-02-06 | 2009-01-15 | The Trustees Of The University Of Pennsylvania | Therapeutic compounds for blocking dna synthesis of pox viruses |
ES2381410T3 (es) | 2007-05-04 | 2012-05-28 | Vertex Pharmceuticals Incorporated | Terapia de combinación paa el tratamiento de infecciones por VHC |
JP2010533698A (ja) | 2007-07-17 | 2010-10-28 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | C型肝炎感染症の治療のための大環状インドール誘導体 |
US8242140B2 (en) | 2007-08-03 | 2012-08-14 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CA2693495A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
JP5529036B2 (ja) | 2007-12-05 | 2014-06-25 | エナンタ ファーマシューティカルズ インコーポレイテッド | フッ素化トリペプチドhcvセリンプロテアーゼ阻害剤 |
EP2234977A4 (en) | 2007-12-19 | 2011-04-13 | Boehringer Ingelheim Int | VIRAL POLYMERASE INHIBITORS |
JP2012514605A (ja) | 2009-01-07 | 2012-06-28 | サイネクシス,インコーポレーテッド | Hcvおよびhiv感染の治療への使用におけるシクロスポリン誘導体 |
WO2010114896A1 (en) | 2009-03-31 | 2010-10-07 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
US8936781B2 (en) | 2009-05-13 | 2015-01-20 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis C virus inhibitors |
NZ608720A (en) | 2010-09-21 | 2015-03-27 | Enanta Pharm Inc | Macrocyclic proline derived hcv serine protease inhibitors |
US9233921B2 (en) | 2013-03-08 | 2016-01-12 | The Trustees Of The University Of Pennsylvania | Potent poxvirus inhibitor |
CN107641121B (zh) * | 2016-07-20 | 2021-02-19 | 上海高驰资产管理有限公司 | 一种荧光探针及其制备方法和用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
MXPA03007760A (es) | 2001-03-08 | 2004-03-16 | Boehringer Ingelheim Ca Ltd | Analisis para identificar los inhibidores de la arn-polimerasa (ns5b) del hcv, dependiente del arn. |
US6841566B2 (en) | 2001-07-20 | 2005-01-11 | Boehringer Ingelheim, Ltd. | Viral polymerase inhibitors |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
-
2005
- 2005-07-14 UY UY29017A patent/UY29017A1/es not_active Application Discontinuation
- 2005-07-14 PE PE2005000809A patent/PE20060569A1/es not_active Application Discontinuation
- 2005-07-15 AR ARP050102935A patent/AR050172A1/es unknown
- 2005-07-15 TW TW094124015A patent/TW200617003A/zh unknown
- 2005-07-15 CA CA002573210A patent/CA2573210A1/en not_active Abandoned
- 2005-07-15 EP EP05768261A patent/EP1771442A4/en not_active Withdrawn
- 2005-07-15 KR KR1020077003911A patent/KR20070035092A/ko not_active Application Discontinuation
- 2005-07-15 JP JP2007520631A patent/JP2008506638A/ja active Pending
- 2005-07-15 AU AU2005263135A patent/AU2005263135A1/en not_active Abandoned
- 2005-07-15 US US11/182,987 patent/US7241801B2/en active Active
- 2005-07-15 WO PCT/CA2005/001103 patent/WO2006007693A1/en active Application Filing
- 2005-07-15 CN CNA2005800237228A patent/CN1984908A/zh active Pending
- 2005-07-15 EA EA200700038A patent/EA200700038A1/ru unknown
- 2005-07-15 BR BRPI0513431-5A patent/BRPI0513431A/pt not_active IP Right Cessation
- 2005-07-15 MX MX2007000007A patent/MX2007000007A/es active IP Right Grant
-
2006
- 2006-11-17 ZA ZA200609578A patent/ZA200609578B/xx unknown
-
2007
- 2007-01-11 IL IL180665A patent/IL180665A0/en unknown
- 2007-01-16 EC EC2007007171A patent/ECSP077171A/es unknown
- 2007-01-19 NO NO20070368A patent/NO20070368L/no not_active Application Discontinuation
- 2007-05-25 US US11/753,678 patent/US20070249629A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
UY29017A1 (es) | 2006-02-24 |
CA2573210A1 (en) | 2006-01-26 |
US20070249629A1 (en) | 2007-10-25 |
BRPI0513431A (pt) | 2008-05-06 |
US20060052418A1 (en) | 2006-03-09 |
US7241801B2 (en) | 2007-07-10 |
JP2008506638A (ja) | 2008-03-06 |
AR050172A1 (es) | 2006-10-04 |
ECSP077171A (es) | 2007-02-28 |
KR20070035092A (ko) | 2007-03-29 |
TW200617003A (en) | 2006-06-01 |
AU2005263135A1 (en) | 2006-01-26 |
NO20070368L (no) | 2007-01-30 |
EP1771442A4 (en) | 2009-12-30 |
EP1771442A1 (en) | 2007-04-11 |
PE20060569A1 (es) | 2006-06-22 |
EA200700038A1 (ru) | 2007-08-31 |
ZA200609578B (en) | 2008-08-27 |
WO2006007693A1 (en) | 2006-01-26 |
CN1984908A (zh) | 2007-06-20 |
IL180665A0 (en) | 2007-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2007000007A (es) | Inhibidores de polimerasa viral. | |
UA86962C2 (en) | Viral polymerase inhibitors | |
MXPA05007754A (es) | Inhibidores de polimerasa viral. | |
DE602004017126D1 (de) | Acylsulfonamid-verbindungen als inhibitoren der rna-abhängigen rna-polymerase | |
UA91255C2 (uk) | Антивірусні нуклеозиди | |
MEP58308A (en) | Hepatitis c inhibitor compounds | |
IL198741A0 (en) | Hepatitis c virus inhibitor compounds, compositions containing the same and uses thereof | |
MY146923A (en) | Novel piperazine compound, and use thereof as hcv polymerase inhibitor | |
DE60319820D1 (de) | Pyrazoloä1,5-aüpyrimidin-verbindungen als antivirale agentien | |
DE602005014804D1 (de) | Substituierte 5-carboxyamidpyrazoles und ä1,2,4ütriazole als viruzide | |
MX2009006864A (es) | Inhibidores novedosos de c jun-n-terminal cinasas. | |
MY142972A (en) | Macrocyclic inhibitors of hepatitis c virus | |
ATE542826T1 (de) | Inhibitoren des hepatitis-c-virus | |
TW200621761A (en) | Heterocyclic antiviral compounds | |
HRP20050082A2 (en) | 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors | |
MX2011012541A (es) | Compuestos heterociclicos antivirales. | |
TNSN07439A1 (en) | Derivatives of,4,5 - diarylpyrrole, preparation method thereof and use of same in therapeutics | |
MX2007005177A (es) | 5-oxo pirazoles y [1,2,4]triazoles sustituidos como agentes antivirales. | |
CY1114456T1 (el) | Αναστολεις ιικης πολυμερασης | |
TH86773B (th) | ตัวยับยั้ง hcv ns3 โปรตีเอส | |
UY28168A1 (es) | Inhibidores de las polimerasas virales |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |