MX2012012092A - Sintesis novedosa para compuestos de tiazolidinadiona. - Google Patents
Sintesis novedosa para compuestos de tiazolidinadiona.Info
- Publication number
- MX2012012092A MX2012012092A MX2012012092A MX2012012092A MX2012012092A MX 2012012092 A MX2012012092 A MX 2012012092A MX 2012012092 A MX2012012092 A MX 2012012092A MX 2012012092 A MX2012012092 A MX 2012012092A MX 2012012092 A MX2012012092 A MX 2012012092A
- Authority
- MX
- Mexico
- Prior art keywords
- novel synthesis
- thiazolidinedione compounds
- compounds
- thiazolidinedione
- thiazolidinediones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/51—Acetal radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Abstract
La presente invención proporciona métodos novedosos para sintetizar compuestos sustitutos de PPAR?, por ejemplo tiazolidinadiona que son útiles para evitar y/o para tratar trastornos metabólicos tales como diabetes, obesidad, hipertensión y enfermedades inflamatorias.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32550210P | 2010-04-19 | 2010-04-19 | |
US32749810P | 2010-04-23 | 2010-04-23 | |
PCT/US2011/032822 WO2011133442A1 (en) | 2010-04-19 | 2011-04-18 | Novel synthesis for thiazolidinedione compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012012092A true MX2012012092A (es) | 2012-12-17 |
Family
ID=44148625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012092A MX2012012092A (es) | 2010-04-19 | 2011-04-18 | Sintesis novedosa para compuestos de tiazolidinadiona. |
Country Status (16)
Country | Link |
---|---|
US (1) | US8937182B2 (es) |
EP (1) | EP2560956B1 (es) |
JP (1) | JP2013525355A (es) |
KR (1) | KR101781665B1 (es) |
CN (1) | CN102947269B (es) |
AU (1) | AU2011242956B2 (es) |
CA (1) | CA2796437C (es) |
DK (1) | DK2560956T3 (es) |
ES (1) | ES2610623T3 (es) |
HK (1) | HK1178155A1 (es) |
HU (1) | HUE030263T2 (es) |
MX (1) | MX2012012092A (es) |
NZ (1) | NZ602883A (es) |
PL (1) | PL2560956T3 (es) |
RU (1) | RU2012148908A (es) |
WO (1) | WO2011133442A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011270701B2 (en) * | 2010-06-24 | 2015-05-14 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
MX349006B (es) * | 2010-08-10 | 2017-07-06 | Cirius Therapeutics Inc | Nueva sintesis para compuestos de tiazolidindiona. |
US8895748B2 (en) | 2010-08-10 | 2014-11-25 | Metabolic Solutions Development Company, Llc | Synthesis for thiazolidinedione compounds |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
WO2019154958A1 (en) | 2018-02-08 | 2019-08-15 | Enyo Pharma | Use of modulators of neet proteins for the treatment of infection |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
US5143930A (en) | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
DK0579733T3 (da) * | 1991-04-11 | 2001-10-15 | Upjohn Co | Thiazolidindionderivater, fremstilling og anvendelse deraf |
NO302471B1 (no) * | 1991-12-26 | 1998-03-09 | Sankyo Co | Tiazolidinforbindelser og farmasöytisk preparat |
JPH07188227A (ja) * | 1993-12-24 | 1995-07-25 | Japan Tobacco Inc | チアゾリジン誘導体及びオキサゾール誘導体 |
SE9702305D0 (sv) | 1997-06-17 | 1997-06-17 | Astra Ab | New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives |
AP869A (en) * | 1998-01-05 | 2000-09-04 | Pfizer | 2,3-Substituted indole compounds as anti-inflammatory and analgesic agents. |
US7407978B2 (en) | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
US6768008B2 (en) * | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
FR2817144B1 (fr) | 2000-11-29 | 2003-01-03 | Micro Mega Sa | Sequence d'instruments canalaires pour l'execution d'un protocole operatoire d'endodontie |
WO2003029251A1 (en) * | 2001-09-28 | 2003-04-10 | Biocon Limited | Novel process for the synthesis of thiazolidinedione derivatives |
FR2861069B1 (fr) | 2003-10-17 | 2005-12-09 | Galderma Res & Dev | NOUVEAUX LIGANDS ACTIVATEURS DES RECEPTEURS RARs, UTILISATION EN MEDECINE HUMAINE AINSI QU'EN COSMETIQUE |
PL2001468T3 (pl) | 2006-03-16 | 2013-03-29 | Metabolic Solutions Dev Co Llc | Analogi tiazolidynodionu |
PL2001469T3 (pl) * | 2006-03-16 | 2012-10-31 | Metabolic Solutions Dev Co Llc | Analogi tiazolidynodionu |
JP2009530293A (ja) | 2006-03-16 | 2009-08-27 | メタボリック ソリューションズ ディベロップメント カンパニー | チアゾリジンジオン類似体およびグルココルチコイドアゴニストの併用療法 |
US8367708B2 (en) * | 2006-12-01 | 2013-02-05 | Msd K.K. | Phenyl-isoxazol-3-ol derivative |
WO2008118327A1 (en) * | 2007-03-23 | 2008-10-02 | University Of Toledo | Conformationally restrained epothilone analogues as anti-leukemic agents |
AU2008301905B2 (en) | 2007-09-14 | 2013-06-27 | Cirius Therapeutics, Inc. | Thiazolidinedione analogues for the treatment of hypertension |
WO2009148195A1 (en) * | 2008-06-02 | 2009-12-10 | Daebong Ls, Ltd. | 5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same |
MX2012012094A (es) | 2010-04-19 | 2012-12-17 | Metabolic Solutions Dev Co Llc | Sintesis novedosa para compuestos de tiazolidinadiona. |
MX349006B (es) | 2010-08-10 | 2017-07-06 | Cirius Therapeutics Inc | Nueva sintesis para compuestos de tiazolidindiona. |
US8895748B2 (en) | 2010-08-10 | 2014-11-25 | Metabolic Solutions Development Company, Llc | Synthesis for thiazolidinedione compounds |
-
2011
- 2011-04-18 HU HUE11716155A patent/HUE030263T2/en unknown
- 2011-04-18 PL PL11716155T patent/PL2560956T3/pl unknown
- 2011-04-18 US US13/641,917 patent/US8937182B2/en active Active
- 2011-04-18 CN CN201180030253.8A patent/CN102947269B/zh not_active Expired - Fee Related
- 2011-04-18 MX MX2012012092A patent/MX2012012092A/es active IP Right Grant
- 2011-04-18 WO PCT/US2011/032822 patent/WO2011133442A1/en active Application Filing
- 2011-04-18 EP EP11716155.4A patent/EP2560956B1/en active Active
- 2011-04-18 KR KR1020127030070A patent/KR101781665B1/ko active IP Right Grant
- 2011-04-18 CA CA2796437A patent/CA2796437C/en active Active
- 2011-04-18 AU AU2011242956A patent/AU2011242956B2/en not_active Ceased
- 2011-04-18 DK DK11716155.4T patent/DK2560956T3/en active
- 2011-04-18 ES ES11716155.4T patent/ES2610623T3/es active Active
- 2011-04-18 NZ NZ602883A patent/NZ602883A/en not_active IP Right Cessation
- 2011-04-18 JP JP2013506202A patent/JP2013525355A/ja active Pending
- 2011-04-18 RU RU2012148908/04A patent/RU2012148908A/ru not_active Application Discontinuation
-
2013
- 2013-04-29 HK HK13105164.4A patent/HK1178155A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2013525355A (ja) | 2013-06-20 |
CA2796437A1 (en) | 2011-10-27 |
CN102947269A (zh) | 2013-02-27 |
AU2011242956B2 (en) | 2015-01-22 |
EP2560956B1 (en) | 2016-10-26 |
US8937182B2 (en) | 2015-01-20 |
KR20130051945A (ko) | 2013-05-21 |
NZ602883A (en) | 2014-09-26 |
WO2011133442A1 (en) | 2011-10-27 |
EP2560956A1 (en) | 2013-02-27 |
ES2610623T3 (es) | 2017-04-28 |
CA2796437C (en) | 2018-09-11 |
KR101781665B1 (ko) | 2017-09-25 |
RU2012148908A (ru) | 2014-05-27 |
AU2011242956A1 (en) | 2012-11-01 |
DK2560956T3 (en) | 2017-01-23 |
CN102947269B (zh) | 2015-11-25 |
HUE030263T2 (en) | 2017-04-28 |
HK1178155A1 (en) | 2013-09-06 |
PL2560956T3 (pl) | 2017-03-31 |
US20130204004A1 (en) | 2013-08-08 |
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Legal Events
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FG | Grant or registration |