ES2073502T3 - Derivados de isoquinolina y sus sales como inhibidores de la proteasa. - Google Patents
Derivados de isoquinolina y sus sales como inhibidores de la proteasa.Info
- Publication number
- ES2073502T3 ES2073502T3 ES90125396T ES90125396T ES2073502T3 ES 2073502 T3 ES2073502 T3 ES 2073502T3 ES 90125396 T ES90125396 T ES 90125396T ES 90125396 T ES90125396 T ES 90125396T ES 2073502 T3 ES2073502 T3 ES 2073502T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- group
- salts
- hydrogen atom
- protease inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 3
- -1 AMINO Chemical group 0.000 abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION PROPORCIONA NUEVOS COMPUESTOS Y SUS SALES, Y TIENE LA ESTRUCTURA DONDE R SUB 1 ES UN GRUPO DE GUIANIDINOBENZOILOXI Y, R SUB 2 ES UN ATOMO DE HIDROGENO, HIDROXI, CIANO-COR SUB 3 (ES UN AMINO O UN GRUPO DE ALQUILO BAJO) O UN GRUPO -COOR SUB 4 [DONDE R SUB 4 ES UN ATOMO DE HIDROGENO, ALQUILO BAJO, FENIL, BENCIL O UN GRUPO -CH SUB 2 CONR SUB 5 R SUB 6 (DONDE R SUB 5 Y R SUB 6 SON LOS MISMOS O DISTINTOS Y SELECCIONADOS DE UN ATOMO DE HIDROGENO Y GRUPOS DE ALQUILO BAJOS)] O UN GRUPO -COOR SUB 4 [ DONDE R SUB 4 ES UN (C SUB 1, C SUB 3 O C SUB 4) ALQUILO, FENILO, BENCILO O GRUPO -CH SUB 2 CONR SUB 5 R SUB 6 (DONDE R SUB 5 Y R SUB 6 SON LOS MISMOS 0 DIFERENTES Y SELECCIONADOS DE UN ATOMO DE HIDROGENO Y GRUPOS DE ALQUILO BAJOS)]. LOS COMPONENETES, DONDE R SUB 1 ES UN GRUPO GUANIDINOBENZOILOXI Y SON INHIBIDORES PROTEASICOS UTILES COMO AGENTES ANTITRIPSINOS.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34273789A JP2886586B2 (ja) | 1989-12-28 | 1989-12-28 | 新規グアニジノ安息香酸誘導体及びその酸付加塩 |
JP2150484A JP2654848B2 (ja) | 1990-06-08 | 1990-06-08 | 新規イソキノリン誘導体またはその酸付加塩 |
JP15048390A JP2654847B2 (ja) | 1990-06-08 | 1990-06-08 | 新規イソキノリン誘導体 |
JP28026290A JP2930399B2 (ja) | 1990-10-18 | 1990-10-18 | 新規イソキノリン誘導体またはその酸付加塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2073502T3 true ES2073502T3 (es) | 1995-08-16 |
Family
ID=27473025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90125396T Expired - Lifetime ES2073502T3 (es) | 1989-12-28 | 1990-12-24 | Derivados de isoquinolina y sus sales como inhibidores de la proteasa. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0435235B1 (es) |
AT (1) | ATE119523T1 (es) |
CA (1) | CA2033374A1 (es) |
DE (1) | DE69017627T2 (es) |
DK (1) | DK0435235T3 (es) |
ES (1) | ES2073502T3 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448269B1 (en) | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US6066673A (en) * | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE757496A (fr) * | 1969-10-14 | 1971-03-16 | Ono Pharmaceutical Co | Nouveaux esters phenyles de l'acide guanidinocaproique et leur production |
GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
-
1990
- 1990-12-24 ES ES90125396T patent/ES2073502T3/es not_active Expired - Lifetime
- 1990-12-24 AT AT90125396T patent/ATE119523T1/de not_active IP Right Cessation
- 1990-12-24 DE DE69017627T patent/DE69017627T2/de not_active Expired - Lifetime
- 1990-12-24 EP EP90125396A patent/EP0435235B1/en not_active Expired - Lifetime
- 1990-12-24 DK DK90125396.3T patent/DK0435235T3/da active
- 1990-12-28 CA CA002033374A patent/CA2033374A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0435235A1 (en) | 1991-07-03 |
CA2033374A1 (en) | 1991-06-29 |
DE69017627D1 (de) | 1995-04-13 |
EP0435235B1 (en) | 1995-03-08 |
DE69017627T2 (de) | 1995-10-26 |
ATE119523T1 (de) | 1995-03-15 |
DK0435235T3 (da) | 1995-05-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2051693T3 (es) | Procedimiento para preparar compuestos biciclos de sulfonamida. | |
NO971538L (no) | Purin- og guaninforbindelser som inhibitorer for PNP | |
AR002012A1 (es) | Un compuesto, una composicion farmaceutica que lo comprende, su uso, metodo de tratamiento terapeutico, metodo para la preparacion del compuesto. | |
AR008111A1 (es) | Compuesto de tiazol, inhibidor de proteina quinasa c que lo comprende y procedimiento para preparar dicho compuesto. | |
MX9806246A (es) | PIPERIDINAS NOVEDOSAS DERIVADAS DE 1-/(PIPERAZIN-1-IL)ARIL-(OXI/AMINO)CARBONIL(4-ARIL-PIPERIDIN A COMO ANTAGONISTAS SELECTIVOS DEL RECEPTOR 5-HT-1D- beta-. | |
ES2009785B3 (es) | Procedimiento para preparar derivados de tioxantona. | |
ES2097142T3 (es) | Derivados de indol, su preparacion y medicamento que los contiene destinado para la prevencion y para el tratamiento de la nefritis. | |
AR246289A1 (es) | Composicion inhibidora de polimerizacion. | |
ES551989A0 (es) | Procedimiento para preparar un derivado de cefalosporina. | |
DE69102936D1 (de) | Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung. | |
ES2073502T3 (es) | Derivados de isoquinolina y sus sales como inhibidores de la proteasa. | |
AR027335A1 (es) | Compuestos de piperidina-4-sulfonamida, proceso de preparacion de los mismos, y composiciones farmaceuticas que los contienen | |
ES2064729T3 (es) | Complejos de rutenio (iii) como agentes antineoplasticos. | |
ES2108595B1 (es) | Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion. | |
ES2125161B1 (es) | Nuevos derivados de 2-(3h)-oxazolona. | |
ES2032752T3 (es) | Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina. | |
ES2146275T3 (es) | Derivados de camptotecina, preparaciones de los mismos y agentes antitumorales. | |
IT8619566A0 (it) | Pistola mitragliatrice perfezionata per cartucce di diverso tipo. | |
BG92842A (bg) | Метод за получаване на бета-карбонил-карбоксиамиди на 1,3-тиазолидини | |
DK571786A (da) | Cephalosporinderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske midler med indhold heraf | |
ES2059374T3 (es) | Substancia 4181-2 y sus derivados. | |
SE9001269L (sv) | 2-substituerade n,n'-ditrimetoxbensoylpiperaziner, en framstaellningsmetod foer dessa samt terapeutiska kompositioner som innehaaller dem | |
ES2172294T3 (es) | Nuevos derivados del 1-indanol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
NO972943L (no) | 4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende dem og deres anvendelse | |
ATE56964T1 (de) | 5-chlor-1,3,4-thiadiazol-2-yloxy-acetamide. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 435235 Country of ref document: ES |