ES2064729T3 - Complejos de rutenio (iii) como agentes antineoplasticos. - Google Patents
Complejos de rutenio (iii) como agentes antineoplasticos.Info
- Publication number
- ES2064729T3 ES2064729T3 ES90906961T ES90906961T ES2064729T3 ES 2064729 T3 ES2064729 T3 ES 2064729T3 ES 90906961 T ES90906961 T ES 90906961T ES 90906961 T ES90906961 T ES 90906961T ES 2064729 T3 ES2064729 T3 ES 2064729T3
- Authority
- ES
- Spain
- Prior art keywords
- complexes
- antineoplastic agents
- ruthenium
- iii
- sub
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940034982 antineoplastic agent Drugs 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- BPEVHDGLPIIAGH-UHFFFAOYSA-N ruthenium(3+) Chemical class [Ru+3] BPEVHDGLPIIAGH-UHFFFAOYSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LOS COMPLEJOS QUE TIENEN LA FORMULA (I), EN DONDE: R SUB 1 Y R SUB 2 SON GRUPOS DE ALQUILO, ALQUILARILO, ARILO O TETARILO, A ES CLORO, O UN GRUPO QUE TIENE LA FORMULA (A), (R1 Y R2 SON COMO SE HA DEFINIDO ARRIBA); B ES UN LIGANDO DE NITROGENO SELECCIONADO DEL AMONIACO, AMINAS PRIMARIAS, SECUNDARIAS O TERCIARIAS O NITROGENO QUE CONTIENE HETEROCICLOS, SON UTILES COMO AGENTES ANTINEOPLASTICOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8920385A IT1230145B (it) | 1989-05-05 | 1989-05-05 | Complessi di rutenio (iii) come agenti antineoplastici. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064729T3 true ES2064729T3 (es) | 1995-02-01 |
Family
ID=11166245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90906961T Expired - Lifetime ES2064729T3 (es) | 1989-05-05 | 1990-05-02 | Complejos de rutenio (iii) como agentes antineoplasticos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5409893A (es) |
EP (1) | EP0471709B1 (es) |
AT (1) | ATE114663T1 (es) |
AU (1) | AU629341B2 (es) |
DE (1) | DE69014619T2 (es) |
ES (1) | ES2064729T3 (es) |
IT (1) | IT1230145B (es) |
WO (1) | WO1990013553A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9317686D0 (en) * | 1993-08-25 | 1993-10-13 | Johnson Matthey Plc | Pharmaceutical compositions |
IT1284101B1 (it) * | 1996-07-02 | 1998-05-08 | Sigea Srl | Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici |
WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
GB0028025D0 (en) * | 2000-11-17 | 2001-01-03 | Univ York | Compounds |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
PT2152084E (pt) * | 2007-06-11 | 2014-01-23 | Niiki Pharma Inc | Método de fabrico de um complexo de ruténio |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
ES2517367T3 (es) * | 2009-12-11 | 2014-11-03 | Niiki Pharma Inc. | Procedimiento de tratamiento de cáncer pancreático |
WO2012012305A2 (en) * | 2010-07-18 | 2012-01-26 | Niiki Pharma Inc. | Combination therapy using a ruthenium complex |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN103665046A (zh) * | 2012-08-31 | 2014-03-26 | 澳门科技大学 | 钌配合物及其制备方法和应用 |
CN104744518B (zh) * | 2015-02-11 | 2018-08-07 | 中国中医科学院中药研究所 | 金属钌配合物及其制备方法和应用 |
CN115028665B (zh) * | 2022-06-06 | 2023-12-26 | 山西大学 | 一种以手性甲硫氨酸和5-氯-8-羟基喹啉为配体的亚硝酰钌配合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3557143A (en) * | 1967-08-30 | 1971-01-19 | Colgate Palmolive Co | Bridged bicyclic ferrocene ethers and thioethers |
US3576012A (en) * | 1967-11-02 | 1971-04-20 | Hercules Inc | Nickel salts of iminoheterocyclicamides |
-
1989
- 1989-05-05 IT IT8920385A patent/IT1230145B/it active
-
1990
- 1990-05-02 WO PCT/EP1990/000699 patent/WO1990013553A1/en active IP Right Grant
- 1990-05-02 ES ES90906961T patent/ES2064729T3/es not_active Expired - Lifetime
- 1990-05-02 DE DE69014619T patent/DE69014619T2/de not_active Expired - Fee Related
- 1990-05-02 AT AT90906961T patent/ATE114663T1/de not_active IP Right Cessation
- 1990-05-02 AU AU55302/90A patent/AU629341B2/en not_active Ceased
- 1990-05-02 US US07/773,939 patent/US5409893A/en not_active Expired - Lifetime
- 1990-05-02 EP EP90906961A patent/EP0471709B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69014619D1 (de) | 1995-01-12 |
US5409893A (en) | 1995-04-25 |
AU5530290A (en) | 1990-11-29 |
IT8920385A0 (it) | 1989-05-05 |
AU629341B2 (en) | 1992-10-01 |
ATE114663T1 (de) | 1994-12-15 |
DE69014619T2 (de) | 1995-05-18 |
WO1990013553A1 (en) | 1990-11-15 |
EP0471709A1 (en) | 1992-02-26 |
EP0471709B1 (en) | 1994-11-30 |
IT1230145B (it) | 1991-10-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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