ES2064729T3 - Complejos de rutenio (iii) como agentes antineoplasticos. - Google Patents

Complejos de rutenio (iii) como agentes antineoplasticos.

Info

Publication number
ES2064729T3
ES2064729T3 ES90906961T ES90906961T ES2064729T3 ES 2064729 T3 ES2064729 T3 ES 2064729T3 ES 90906961 T ES90906961 T ES 90906961T ES 90906961 T ES90906961 T ES 90906961T ES 2064729 T3 ES2064729 T3 ES 2064729T3
Authority
ES
Spain
Prior art keywords
complexes
antineoplastic agents
ruthenium
iii
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90906961T
Other languages
English (en)
Inventor
Enzo Alessio
Giovanni Mestroni
Sabrina Pacor
Gianni Sava
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics SpA
Original Assignee
Boehringer Mannheim Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia SpA filed Critical Boehringer Mannheim Italia SpA
Application granted granted Critical
Publication of ES2064729T3 publication Critical patent/ES2064729T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS COMPLEJOS QUE TIENEN LA FORMULA (I), EN DONDE: R SUB 1 Y R SUB 2 SON GRUPOS DE ALQUILO, ALQUILARILO, ARILO O TETARILO, A ES CLORO, O UN GRUPO QUE TIENE LA FORMULA (A), (R1 Y R2 SON COMO SE HA DEFINIDO ARRIBA); B ES UN LIGANDO DE NITROGENO SELECCIONADO DEL AMONIACO, AMINAS PRIMARIAS, SECUNDARIAS O TERCIARIAS O NITROGENO QUE CONTIENE HETEROCICLOS, SON UTILES COMO AGENTES ANTINEOPLASTICOS
ES90906961T 1989-05-05 1990-05-02 Complejos de rutenio (iii) como agentes antineoplasticos. Expired - Lifetime ES2064729T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8920385A IT1230145B (it) 1989-05-05 1989-05-05 Complessi di rutenio (iii) come agenti antineoplastici.

Publications (1)

Publication Number Publication Date
ES2064729T3 true ES2064729T3 (es) 1995-02-01

Family

ID=11166245

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90906961T Expired - Lifetime ES2064729T3 (es) 1989-05-05 1990-05-02 Complejos de rutenio (iii) como agentes antineoplasticos.

Country Status (8)

Country Link
US (1) US5409893A (es)
EP (1) EP0471709B1 (es)
AT (1) ATE114663T1 (es)
AU (1) AU629341B2 (es)
DE (1) DE69014619T2 (es)
ES (1) ES2064729T3 (es)
IT (1) IT1230145B (es)
WO (1) WO1990013553A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317686D0 (en) * 1993-08-25 1993-10-13 Johnson Matthey Plc Pharmaceutical compositions
IT1284101B1 (it) * 1996-07-02 1998-05-08 Sigea Srl Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
GB0028025D0 (en) * 2000-11-17 2001-01-03 Univ York Compounds
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
WO2008154553A1 (en) * 2007-06-11 2008-12-18 Niiki Pharma Inc. Method of manufacturing a ruthenium complex
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
IL295075A (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
KR101824934B1 (ko) * 2009-12-11 2018-02-02 니키 파머 액퀴지션 코포레이션 2 췌장암의 치료 방법
JP6034288B2 (ja) * 2010-07-18 2016-11-30 ニーキ ファーマ インコーポレイテッド ルテニウム錯体を用いる併用療法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103665046A (zh) * 2012-08-31 2014-03-26 澳门科技大学 钌配合物及其制备方法和应用
CN104744518B (zh) * 2015-02-11 2018-08-07 中国中医科学院中药研究所 金属钌配合物及其制备方法和应用
CN115028665B (zh) * 2022-06-06 2023-12-26 山西大学 一种以手性甲硫氨酸和5-氯-8-羟基喹啉为配体的亚硝酰钌配合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557143A (en) * 1967-08-30 1971-01-19 Colgate Palmolive Co Bridged bicyclic ferrocene ethers and thioethers
US3576012A (en) * 1967-11-02 1971-04-20 Hercules Inc Nickel salts of iminoheterocyclicamides

Also Published As

Publication number Publication date
US5409893A (en) 1995-04-25
DE69014619D1 (de) 1995-01-12
AU5530290A (en) 1990-11-29
EP0471709B1 (en) 1994-11-30
EP0471709A1 (en) 1992-02-26
WO1990013553A1 (en) 1990-11-15
IT8920385A0 (it) 1989-05-05
AU629341B2 (en) 1992-10-01
ATE114663T1 (de) 1994-12-15
DE69014619T2 (de) 1995-05-18
IT1230145B (it) 1991-10-14

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