DE69102936D1 - Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung. - Google Patents

Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung.

Info

Publication number
DE69102936D1
DE69102936D1 DE69102936T DE69102936T DE69102936D1 DE 69102936 D1 DE69102936 D1 DE 69102936D1 DE 69102936 T DE69102936 T DE 69102936T DE 69102936 T DE69102936 T DE 69102936T DE 69102936 D1 DE69102936 D1 DE 69102936D1
Authority
DE
Germany
Prior art keywords
hydroxyphenylthio
bis
substituted
alkyl
alkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69102936T
Other languages
English (en)
Other versions
DE69102936T2 (de
Inventor
Simon J T Mao
Richard L Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69102936D1 publication Critical patent/DE69102936D1/de
Publication of DE69102936T2 publication Critical patent/DE69102936T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
DE69102936T 1990-05-09 1991-05-08 Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung. Expired - Fee Related DE69102936T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/521,293 US5061734A (en) 1990-05-09 1990-05-09 Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis

Publications (2)

Publication Number Publication Date
DE69102936D1 true DE69102936D1 (de) 1994-08-25
DE69102936T2 DE69102936T2 (de) 1994-12-15

Family

ID=24076166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69102936T Expired - Fee Related DE69102936T2 (de) 1990-05-09 1991-05-08 Bis(alkyl-substituierte-4-hydroxyphenylthio)alkan-Analoga als Inhibitoren der Kataraktentstehung.

Country Status (11)

Country Link
US (1) US5061734A (de)
EP (1) EP0456209B1 (de)
JP (1) JP3040005B2 (de)
KR (1) KR0168648B1 (de)
AT (1) ATE108652T1 (de)
AU (1) AU631738B2 (de)
DE (1) DE69102936T2 (de)
DK (1) DK0456209T3 (de)
ES (1) ES2060239T3 (de)
IE (1) IE64371B1 (de)
ZA (1) ZA913362B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
US5665770A (en) * 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5576278A (en) * 1995-06-07 1996-11-19 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use
US5686450A (en) * 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
WO1997026879A1 (en) * 1996-01-26 1997-07-31 The United States Of America, Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Hydroxylamine compositions for the prevention or retardation of cataracts
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
PL194329B1 (pl) * 1997-05-14 2007-05-31 Atherogenics Inc Zastosowanie monoestru probukolu kwasu bursztynowego lub jego farmaceutycznie dopuszczalnej soli dowytwarzania leku do leczenia choroby, której mediatorem jest VCAM-1
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EP1385501A2 (de) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol-monoesters und ihre verwendung zur erhöhung des hdl-plasmaspiegels und zur verbesserung der hdl-funktionalität
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
KR102591391B1 (ko) * 2021-03-03 2023-10-20 이수호 비산 방지 장치

Also Published As

Publication number Publication date
EP0456209A2 (de) 1991-11-13
AU631738B2 (en) 1992-12-03
KR0168648B1 (ko) 1999-01-15
EP0456209B1 (de) 1994-07-20
DE69102936T2 (de) 1994-12-15
AU7527791A (en) 1991-11-14
ZA913362B (en) 1992-03-25
IE911564A1 (en) 1991-11-20
ATE108652T1 (de) 1994-08-15
US5061734A (en) 1991-10-29
EP0456209A3 (en) 1992-06-24
DK0456209T3 (da) 1994-09-05
IE64371B1 (en) 1995-07-26
KR910019632A (ko) 1991-12-19
ES2060239T3 (es) 1994-11-16
JPH04226912A (ja) 1992-08-17
JP3040005B2 (ja) 2000-05-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee