ES2060239T3 - Analogos de bis(alquil-sustituido-4-hidroxifeniltio)alcano como inhibidores de la formacion de cataratas. - Google Patents

Analogos de bis(alquil-sustituido-4-hidroxifeniltio)alcano como inhibidores de la formacion de cataratas.

Info

Publication number
ES2060239T3
ES2060239T3 ES91107480T ES91107480T ES2060239T3 ES 2060239 T3 ES2060239 T3 ES 2060239T3 ES 91107480 T ES91107480 T ES 91107480T ES 91107480 T ES91107480 T ES 91107480T ES 2060239 T3 ES2060239 T3 ES 2060239T3
Authority
ES
Spain
Prior art keywords
bis
substituted
alkyl
alkane
hydroxyphenyltio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91107480T
Other languages
English (en)
Inventor
Simon J T Mao
Richard L Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2060239T3 publication Critical patent/ES2060239T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

ESTA INVENCION TRATA DE UN METODO DE INHIBIR EL DESARROLLO DE UNA CATARATA EN UN PACIENTE QUE LO NECESITA, COMPRENDIENDO LA ADMINISTRACION A DICHO PACIENTE DE UNA CANTIDAD EFECTIVA DE UN INHIBIDOR DE LA CATARATA DE UN ANALOGO ALCANO BIS(ALQUILO-SUSTITUIDO-4-HIDROXIFENOLITIO).
ES91107480T 1990-05-09 1991-05-08 Analogos de bis(alquil-sustituido-4-hidroxifeniltio)alcano como inhibidores de la formacion de cataratas. Expired - Lifetime ES2060239T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/521,293 US5061734A (en) 1990-05-09 1990-05-09 Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis

Publications (1)

Publication Number Publication Date
ES2060239T3 true ES2060239T3 (es) 1994-11-16

Family

ID=24076166

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91107480T Expired - Lifetime ES2060239T3 (es) 1990-05-09 1991-05-08 Analogos de bis(alquil-sustituido-4-hidroxifeniltio)alcano como inhibidores de la formacion de cataratas.

Country Status (11)

Country Link
US (1) US5061734A (es)
EP (1) EP0456209B1 (es)
JP (1) JP3040005B2 (es)
KR (1) KR0168648B1 (es)
AT (1) ATE108652T1 (es)
AU (1) AU631738B2 (es)
DE (1) DE69102936T2 (es)
DK (1) DK0456209T3 (es)
ES (1) ES2060239T3 (es)
IE (1) IE64371B1 (es)
ZA (1) ZA913362B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
US5665770A (en) * 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5686450A (en) * 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
US5576278A (en) * 1995-06-07 1996-11-19 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use
US6001853A (en) * 1996-01-26 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Hydroxylamine compositions for the prevention or retardation of cataracts
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
CA2292388C (en) 1997-05-14 2004-07-20 Atherogenics, Inc. Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EP1385501A2 (en) * 2001-04-11 2004-02-04 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US8252840B2 (en) * 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes

Also Published As

Publication number Publication date
ZA913362B (en) 1992-03-25
IE911564A1 (en) 1991-11-20
AU631738B2 (en) 1992-12-03
EP0456209A3 (en) 1992-06-24
KR0168648B1 (ko) 1999-01-15
ATE108652T1 (de) 1994-08-15
DE69102936D1 (de) 1994-08-25
DE69102936T2 (de) 1994-12-15
US5061734A (en) 1991-10-29
JPH04226912A (ja) 1992-08-17
JP3040005B2 (ja) 2000-05-08
EP0456209A2 (en) 1991-11-13
KR910019632A (ko) 1991-12-19
IE64371B1 (en) 1995-07-26
EP0456209B1 (en) 1994-07-20
AU7527791A (en) 1991-11-14
DK0456209T3 (da) 1994-09-05

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