ATE108652T1 - Bis(alkyl-substituierte-4-hydroxyphenylthio)alk n-analoga als inhibitoren der kataraktentstehung. - Google Patents

Bis(alkyl-substituierte-4-hydroxyphenylthio)alk n-analoga als inhibitoren der kataraktentstehung.

Info

Publication number
ATE108652T1
ATE108652T1 AT91107480T AT91107480T ATE108652T1 AT E108652 T1 ATE108652 T1 AT E108652T1 AT 91107480 T AT91107480 T AT 91107480T AT 91107480 T AT91107480 T AT 91107480T AT E108652 T1 ATE108652 T1 AT E108652T1
Authority
AT
Austria
Prior art keywords
hydroxyphenylthio
bis
substituted
alkyl
alk
Prior art date
Application number
AT91107480T
Other languages
English (en)
Inventor
Simon J T Mao
Richard L Jackson
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE108652T1 publication Critical patent/ATE108652T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
AT91107480T 1990-05-09 1991-05-08 Bis(alkyl-substituierte-4-hydroxyphenylthio)alk n-analoga als inhibitoren der kataraktentstehung. ATE108652T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/521,293 US5061734A (en) 1990-05-09 1990-05-09 Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis

Publications (1)

Publication Number Publication Date
ATE108652T1 true ATE108652T1 (de) 1994-08-15

Family

ID=24076166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91107480T ATE108652T1 (de) 1990-05-09 1991-05-08 Bis(alkyl-substituierte-4-hydroxyphenylthio)alk n-analoga als inhibitoren der kataraktentstehung.

Country Status (11)

Country Link
US (1) US5061734A (de)
EP (1) EP0456209B1 (de)
JP (1) JP3040005B2 (de)
KR (1) KR0168648B1 (de)
AT (1) ATE108652T1 (de)
AU (1) AU631738B2 (de)
DE (1) DE69102936T2 (de)
DK (1) DK0456209T3 (de)
ES (1) ES2060239T3 (de)
IE (1) IE64371B1 (de)
ZA (1) ZA913362B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
US5665770A (en) * 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5576278A (en) * 1995-06-07 1996-11-19 Alcon Laboratories, Inc. Stable liquid enzyme compositions and methods of use
US5686450A (en) * 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
US6001853A (en) * 1996-01-26 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Hydroxylamine compositions for the prevention or retardation of cataracts
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
KR100953990B1 (ko) 1997-05-14 2010-04-21 아테로제닉스, 인코포레이티드 Ｖｃａｍ-1의 발현을 억제하기 위한 화합물 및 억제방법
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2444429A1 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
BRPI0809423A2 (pt) * 2007-03-26 2014-09-09 Salutria Pharmaceuticals Llc Usos e composições de derivados de probucol para o tratamento de diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
KR102591391B1 (ko) * 2021-03-03 2023-10-20 이수호 비산 방지 장치

Also Published As

Publication number Publication date
DE69102936D1 (de) 1994-08-25
US5061734A (en) 1991-10-29
AU631738B2 (en) 1992-12-03
KR0168648B1 (ko) 1999-01-15
JP3040005B2 (ja) 2000-05-08
AU7527791A (en) 1991-11-14
DE69102936T2 (de) 1994-12-15
EP0456209A3 (en) 1992-06-24
KR910019632A (ko) 1991-12-19
IE64371B1 (en) 1995-07-26
EP0456209B1 (de) 1994-07-20
ZA913362B (en) 1992-03-25
DK0456209T3 (da) 1994-09-05
IE911564A1 (en) 1991-11-20
EP0456209A2 (de) 1991-11-13
JPH04226912A (ja) 1992-08-17
ES2060239T3 (es) 1994-11-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee