ES2179996T3 - Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos. - Google Patents

Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos.

Info

Publication number
ES2179996T3
ES2179996T3 ES97121833T ES97121833T ES2179996T3 ES 2179996 T3 ES2179996 T3 ES 2179996T3 ES 97121833 T ES97121833 T ES 97121833T ES 97121833 T ES97121833 T ES 97121833T ES 2179996 T3 ES2179996 T3 ES 2179996T3
Authority
ES
Spain
Prior art keywords
hydrogen
ilmetilo
compounds
formula
iminometilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97121833T
Other languages
English (en)
Inventor
Peter Angehrn
Paul Hebeisen
Ingrid Heinze-Krauss
Malcolm Page
Valerie Runtz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Application granted granted Critical
Publication of ES2179996T3 publication Critical patent/ES2179996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE DERIVADOS DE CEFALOSPORINA QUE PRESENTAN LA FORMULA GENERAL (I), EN LA CUAL: X ES CH O N; R 1 ES HIDROGENO O CICLOPENTILO; R 2 ES UN GRUPO QUE PRESENTA LAS FORMULAS INDICADAS; R 3 ES HIDROGENO, UN ION DE UN METAL ALCALINO O UN GRUPO AMONIO TERCIARIO; R 4 ES HIDROGENO, UN GRUPO PROTECTOR DE AMINO, PIRROLIDIN 2 - ILMETILO, AZETIDIN - 3 - ILMETILO, IMINOMETILO, 1 CARBAMIMIDOILO; R SUP,5 ES HIDROGENO, DIALQUILCARBAMOILO, OE - HIDROXIALQUILO, OE - AMINOALQUILO, PIRIDINIO - 1 - ILMETILO, 1 - HIDROXI - 3 AMINOMETILPROPILO O (HIDROXI) - (PIRROLIDIN - 2 - IL)METILO; R6 ES HIDROGENO, TRIFLUOROMETILO O HIDROXI; Y R 7 ES ALQUILO, OE - HIDROXIALQUILO, CICLOALQUILO, 3 PIRROLIDINILO, 3 - AZETIDINILO, IMINOMETILO O 1 - CARBAMIMIDOILO; ASI COMO LOS ESTERES FACILMENTE HIDROLIZABLES DE LOS MISMOS, LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS Y LOS HIDRATOS DE LOS COMPUESTOS DE FORMULA I Y DE SUS ESTERES Y SALES; LA INVENCION TAMBIEN TRATA DE LA PREPARACION DE LOSCOMPUESTOS DE FORMULA I; DE SU USO COMO SUSTANCIAS FARMACEUTICAMENTE ACTIVAS; EN PARTICULAR PARA EL TRATAMIENTO Y LA PROFILAXIS DE ENFERMEDADES INFECCIOSAS, Y DE PREPARACIONES FARMACEUTICAS QUE CONTIENEN UN COMPUESTO DE FORMULA I PARA EL TRATAMIENTO Y LA PROFILAXIS DE ENFERMEDADES INFECCIOSAS.
ES97121833T 1996-12-19 1997-12-11 Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos. Expired - Lifetime ES2179996T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96120472 1996-12-19
EP97119528 1997-11-07

Publications (1)

Publication Number Publication Date
ES2179996T3 true ES2179996T3 (es) 2003-02-01

Family

ID=26142379

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97121833T Expired - Lifetime ES2179996T3 (es) 1996-12-19 1997-12-11 Cefalosporinas de vinil-pirrolidinona con sustituyentes basicos.

Country Status (20)

Country Link
US (1) US5981519A (es)
EP (1) EP0849269B9 (es)
JP (2) JP3264877B2 (es)
KR (3) KR100395985B1 (es)
CN (5) CN1104436C (es)
AT (1) ATE220402T1 (es)
AU (1) AU729653B2 (es)
CA (2) CA2628224C (es)
CY (1) CY2400B1 (es)
CZ (1) CZ405797A3 (es)
DE (1) DE69713865T2 (es)
DK (1) DK0849269T3 (es)
ES (1) ES2179996T3 (es)
HU (1) HUP9702474A3 (es)
IL (1) IL122604A0 (es)
MA (1) MA26457A1 (es)
NO (1) NO975901L (es)
NZ (1) NZ329363A (es)
PT (1) PT849269E (es)
TW (1) TW415949B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977381A (en) * 1998-01-12 1999-11-02 Hoffmann-La Roche Inc. Process for making 3-amino-pyrolidine derivatives
JP3872955B2 (ja) * 1998-06-15 2007-01-24 バジリア ファルマスーチカ アーゲー ３−（２−オキソ−〔１，３′〕ビピロリジニル−３−イリデンメチル）−セフェムの誘導体
US6232306B1 (en) * 1998-06-15 2001-05-15 Hoffmann-La Roche Inc. Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams
AU1654900A (en) * 1998-12-03 2000-06-19 F. Hoffmann-La Roche Ag Bi-pyrrolidinylvinl (carba) cephalosporins
ATE370146T1 (de) * 1999-07-05 2007-09-15 Basilea Pharmaceutica Ag Verfahren zur herstellung von cephalosporin- derivaten
WO2001004127A1 (en) * 1999-07-07 2001-01-18 F. Hoffmann-La Roche Ag Vinylpyrrolidinone derivatives with substituted thiazole ring
ATE341642T1 (de) 2000-04-19 2006-10-15 Basilea Pharmaceutica Ag Verfahren zur herstellung von d- asparaginderivaten
US6504025B2 (en) * 2000-05-24 2003-01-07 Basilea Pharmaceutica Ag Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives
KR100698814B1 (ko) * 2000-08-14 2007-03-23 바실리어 파마슈티카 아게 Ｎ-보호-3-피롤리딘-락탐 치환 포스포늄염의 제조 방법
ITMI20012363A1 (it) * 2001-11-09 2003-05-09 Antibioticos Spa Metodo per la sintesi di catene laterali di cefalosporine
PL1606293T3 (pl) * 2003-03-27 2010-01-29 Basilea Pharmaceutica Ag Cefalosporyna w postaci krystalicznej
EP2308562B1 (en) * 2003-12-25 2015-02-25 Ono Pharmaceutical Co., Ltd. Azetidine ring compounds and drugs comprising the same
US7569691B2 (en) * 2005-04-20 2009-08-04 Shin-Etsu Chemical Co., Ltd. Protected piperazino group-bearing organoxysilane compound and making method
CN101245077B (zh) * 2007-02-14 2010-06-02 山东轩竹医药科技有限公司 头孢菌素衍生物
CN101245079B (zh) * 2007-02-14 2010-07-07 山东轩竹医药科技有限公司 头孢抗生素衍生物
EA201070504A1 (ru) 2007-10-25 2010-12-30 Эйкеоджен, Инк. КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ
AR071318A1 (es) 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
CN101899059B (zh) * 2009-01-21 2012-02-15 山东轩竹医药科技有限公司 含有吡咯烷并环的头孢菌素衍生物
WO2010136423A1 (de) * 2009-05-25 2010-12-02 Sandoz Ag Verfahren zur herstellung von ceftobiprol medocaril
CN102030766B (zh) * 2009-09-30 2012-08-08 山东轩竹医药科技有限公司 含有二氢吡咯并杂环的头孢抗生素
CN103864851B (zh) * 2014-03-25 2016-08-17 华润赛科药业有限责任公司 作为前药的头孢吡普衍生物及其制备方法和用途
WO2024079094A1 (en) 2022-10-10 2024-04-18 Basilea Pharmaceutica International Ag, Allschwil Methods of treating staphylococcus aureus bacteremia infections

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94946A0 (en) * 1989-07-13 1991-06-10 Eisai Co Ltd 3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them
JPH08502513A (ja) * 1992-10-23 1996-03-19 藤沢薬品工業株式会社 セフェム化合物、およびそれらの医薬組成物
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
ES2185634T3 (es) * 1993-04-16 2003-05-01 Basilea Pharmaceutica Ag Derivados de cefalosporina.
EP0723965B1 (en) * 1993-09-29 2001-05-30 Meiji Seika Kaisha Ltd. Novel cephalosporin derivatives
TR199700859T1 (xx) 1995-02-27 1998-02-21 F. Hoffmann-La Roche Ag 3-Pirolidiliden-2-on-sefalosporin t�revleri.
JPH08319291A (ja) * 1995-05-25 1996-12-03 Meiji Seika Kaisha Ltd 新規セフェム誘導体
AT403161B (de) * 1995-07-19 1997-11-25 Biochemie Gmbh Verfahren zur herstellung von cephemverbindungen

Also Published As

Publication number Publication date
CN1347884A (zh) 2002-05-08
CN1325850A (zh) 2001-12-12
JP4043203B2 (ja) 2008-02-06
CN1183141C (zh) 2005-01-05
IL122604A0 (en) 1998-08-16
JPH10182657A (ja) 1998-07-07
CA2628224C (en) 2010-02-16
CN1104436C (zh) 2003-04-02
HUP9702474A2 (hu) 1998-11-30
CZ405797A3 (cs) 1998-07-15
HUP9702474A3 (en) 2001-04-28
PT849269E (pt) 2002-11-29
KR100395985B1 (ko) 2004-02-14
NZ329363A (en) 1999-01-28
DE69713865T2 (de) 2003-02-20
DK0849269T3 (da) 2002-10-28
NO975901D0 (no) 1997-12-16
CN1198833C (zh) 2005-04-27
CN1188112A (zh) 1998-07-22
CA2224438A1 (en) 1998-06-19
CN1347882A (zh) 2002-05-08
JP2002060390A (ja) 2002-02-26
EP0849269A1 (en) 1998-06-24
AU4846397A (en) 1998-06-25
AU729653B2 (en) 2001-02-08
NO975901L (no) 1998-06-22
CN1347883A (zh) 2002-05-08
CN1163496C (zh) 2004-08-25
HU9702474D0 (en) 1998-03-02
CY2400B1 (en) 2004-09-10
KR19980064240A (ko) 1998-10-07
EP0849269B9 (en) 2003-03-05
JP3264877B2 (ja) 2002-03-11
CA2224438C (en) 2009-02-24
MA26457A1 (fr) 2004-12-20
KR100310384B1 (ko) 2001-11-08
ATE220402T1 (de) 2002-07-15
DE69713865D1 (de) 2002-08-14
KR100331212B1 (ko) 2002-04-03
EP0849269B1 (en) 2002-07-10
US5981519A (en) 1999-11-09
CN1132833C (zh) 2003-12-31
TW415949B (en) 2000-12-21
CA2628224A1 (en) 1998-06-19

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