DE69713865D1 - Basisch substituierte Vinylpyrrolidin-Cephalosporine - Google Patents
Basisch substituierte Vinylpyrrolidin-CephalosporineInfo
- Publication number
- DE69713865D1 DE69713865D1 DE69713865T DE69713865T DE69713865D1 DE 69713865 D1 DE69713865 D1 DE 69713865D1 DE 69713865 T DE69713865 T DE 69713865T DE 69713865 T DE69713865 T DE 69713865T DE 69713865 D1 DE69713865 D1 DE 69713865D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen
- formula
- hydroxy
- ylmethyl
- omega
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 vinyl pyrrolidine cephalosporins Chemical class 0.000 title abstract 7
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 208000035473 Communicable disease Diseases 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229910001413 alkali metal ion Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96120472 | 1996-12-19 | ||
| EP97119528 | 1997-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69713865D1 true DE69713865D1 (de) | 2002-08-14 |
| DE69713865T2 DE69713865T2 (de) | 2003-02-20 |
Family
ID=26142379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69713865T Expired - Lifetime DE69713865T2 (de) | 1996-12-19 | 1997-12-11 | Basisch substituierte Vinylpyrrolidin-Cephalosporine |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5981519A (de) |
| EP (1) | EP0849269B9 (de) |
| JP (2) | JP3264877B2 (de) |
| KR (3) | KR100395985B1 (de) |
| CN (5) | CN1104436C (de) |
| AT (1) | ATE220402T1 (de) |
| AU (1) | AU729653B2 (de) |
| CA (2) | CA2224438C (de) |
| CY (1) | CY2400B1 (de) |
| CZ (1) | CZ405797A3 (de) |
| DE (1) | DE69713865T2 (de) |
| DK (1) | DK0849269T3 (de) |
| ES (1) | ES2179996T3 (de) |
| HU (1) | HUP9702474A3 (de) |
| IL (1) | IL122604A0 (de) |
| MA (1) | MA26457A1 (de) |
| NO (1) | NO975901L (de) |
| NZ (1) | NZ329363A (de) |
| PT (1) | PT849269E (de) |
| TW (1) | TW415949B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977381A (en) * | 1998-01-12 | 1999-11-02 | Hoffmann-La Roche Inc. | Process for making 3-amino-pyrolidine derivatives |
| BRPI9911178B8 (pt) * | 1998-06-15 | 2017-03-07 | Basilea Pharmaceutica Ag | derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos |
| US6232306B1 (en) * | 1998-06-15 | 2001-05-15 | Hoffmann-La Roche Inc. | Derivatives of 3-(2-oxo-[1,3′]bipyrrolidinyl-3-ylidenemethyl)-cephams |
| WO2000032605A1 (en) * | 1998-12-03 | 2000-06-08 | F. Hoffmann-La Roche Ag | Bi-pyrrolidinylvinl (carba) cephalosporins |
| ATE370146T1 (de) | 1999-07-05 | 2007-09-15 | Basilea Pharmaceutica Ag | Verfahren zur herstellung von cephalosporin- derivaten |
| AU6267100A (en) * | 1999-07-07 | 2001-01-30 | F. Hoffmann-La Roche Ag | Vinylpyrrolidinone derivatives with substituted thiazole ring |
| DE60123513T2 (de) | 2000-04-19 | 2007-05-10 | Basilea Pharmaceutica Ag | Verfahren zur Herstellung von D-Asparaginderivaten |
| US6504025B2 (en) * | 2000-05-24 | 2003-01-07 | Basilea Pharmaceutica Ag | Process for the preparation of vinyl-pyrrolidinone cephalosporin derivatives |
| JP3989832B2 (ja) * | 2000-08-14 | 2007-10-10 | バジリア ファルマスーチカ アーゲー | Ｎ−保護−３−ピロリジン−ラクタム置換ホスホニウム塩類の調製方法 |
| ITMI20012363A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Metodo per la sintesi di catene laterali di cefalosporine |
| ES2329244T3 (es) | 2003-03-27 | 2009-11-24 | Basilea Pharmaceutica Ag | Cefalosporina en forma cristalina. |
| US7511159B2 (en) * | 2003-12-25 | 2009-03-31 | Ono Pharmaceutical Co., Ltd. | Azetidine ring compounds and drugs comprising the same |
| US7569691B2 (en) * | 2005-04-20 | 2009-08-04 | Shin-Etsu Chemical Co., Ltd. | Protected piperazino group-bearing organoxysilane compound and making method |
| CN101245079B (zh) * | 2007-02-14 | 2010-07-07 | 山东轩竹医药科技有限公司 | 头孢抗生素衍生物 |
| CN101245077B (zh) * | 2007-02-14 | 2010-06-02 | 山东轩竹医药科技有限公司 | 头孢菌素衍生物 |
| EA201070504A1 (ru) | 2007-10-25 | 2010-12-30 | Эйкеоджен, Инк. | КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ |
| AR071318A1 (es) | 2008-04-15 | 2010-06-09 | Basilea Pharmaceutica Ag | Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso |
| WO2010030810A1 (en) * | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
| WO2010072672A1 (en) | 2008-12-24 | 2010-07-01 | Basilea Pharmaceutica Ag | New crystal polymorphs of ceftobiprole |
| CN101899059B (zh) * | 2009-01-21 | 2012-02-15 | 山东轩竹医药科技有限公司 | 含有吡咯烷并环的头孢菌素衍生物 |
| EP2435442B1 (de) * | 2009-05-25 | 2016-01-13 | Sandoz AG | Verfahren zur herstellung von ceftobiprol medocaril |
| CN102030766B (zh) * | 2009-09-30 | 2012-08-08 | 山东轩竹医药科技有限公司 | 含有二氢吡咯并杂环的头孢抗生素 |
| CN103864851B (zh) * | 2014-03-25 | 2016-08-17 | 华润赛科药业有限责任公司 | 作为前药的头孢吡普衍生物及其制备方法和用途 |
| WO2024079094A1 (en) | 2022-10-10 | 2024-04-18 | Basilea Pharmaceutica International Ag, Allschwil | Methods of treating staphylococcus aureus bacteremia infections |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94946A0 (en) * | 1989-07-13 | 1991-06-10 | Eisai Co Ltd | 3-substituted vinyl cephalosporin derivatives,their preparation and pharmaceutical compositions containing them |
| JPH08502513A (ja) * | 1992-10-23 | 1996-03-19 | 藤沢薬品工業株式会社 | セフェム化合物、およびそれらの医薬組成物 |
| US5523400A (en) * | 1993-04-16 | 1996-06-04 | Hoffmann-La Roche Inc. | Cephalosporin antibiotics |
| EP0620225B1 (de) * | 1993-04-16 | 2002-11-13 | Basilea Pharmaceutica AG | Cephalosporin-Derivate |
| DE69427365T2 (de) * | 1993-09-29 | 2002-02-28 | Meiji Seika Kaisha | Neue cephalosporinderivate |
| JPH08319291A (ja) * | 1995-05-25 | 1996-12-03 | Meiji Seika Kaisha Ltd | 新規セフェム誘導体 |
| AT403161B (de) * | 1995-07-19 | 1997-11-25 | Biochemie Gmbh | Verfahren zur herstellung von cephemverbindungen |
-
1997
- 1997-12-01 TW TW086118048A patent/TW415949B/zh not_active IP Right Cessation
- 1997-12-08 US US08/986,549 patent/US5981519A/en not_active Expired - Lifetime
- 1997-12-09 NZ NZ329363A patent/NZ329363A/xx unknown
- 1997-12-10 CA CA002224438A patent/CA2224438C/en not_active Expired - Lifetime
- 1997-12-10 CA CA2628224A patent/CA2628224C/en not_active Expired - Lifetime
- 1997-12-11 PT PT97121833T patent/PT849269E/pt unknown
- 1997-12-11 DE DE69713865T patent/DE69713865T2/de not_active Expired - Lifetime
- 1997-12-11 AT AT97121833T patent/ATE220402T1/de active
- 1997-12-11 EP EP97121833A patent/EP0849269B9/de not_active Expired - Lifetime
- 1997-12-11 ES ES97121833T patent/ES2179996T3/es not_active Expired - Lifetime
- 1997-12-11 DK DK97121833T patent/DK0849269T3/da active
- 1997-12-15 HU HU9702474A patent/HUP9702474A3/hu unknown
- 1997-12-15 IL IL12260497A patent/IL122604A0/xx unknown
- 1997-12-16 NO NO975901A patent/NO975901L/no not_active Application Discontinuation
- 1997-12-17 CZ CZ974057A patent/CZ405797A3/cs unknown
- 1997-12-17 KR KR1019970069917A patent/KR100395985B1/ko not_active IP Right Cessation
- 1997-12-18 CN CN97120875A patent/CN1104436C/zh not_active Expired - Lifetime
- 1997-12-18 MA MA24904A patent/MA26457A1/fr unknown
- 1997-12-18 CN CNB001337637A patent/CN1183141C/zh not_active Expired - Lifetime
- 1997-12-18 CN CNB001337629A patent/CN1163496C/zh not_active Expired - Lifetime
- 1997-12-18 AU AU48463/97A patent/AU729653B2/en not_active Expired
- 1997-12-19 JP JP35041397A patent/JP3264877B2/ja not_active Expired - Lifetime
-
2000
- 2000-11-03 CN CN00133761A patent/CN1132833C/zh not_active Expired - Lifetime
- 2000-11-03 CN CNB001337645A patent/CN1198833C/zh not_active Expired - Lifetime
-
2001
- 2001-03-29 KR KR1020010016369A patent/KR100310384B1/ko not_active IP Right Cessation
- 2001-03-29 KR KR1020010016370A patent/KR100331212B1/ko not_active IP Right Cessation
- 2001-05-28 JP JP2001158260A patent/JP4043203B2/ja not_active Expired - Fee Related
-
2003
- 2003-12-31 CY CY0300097A patent/CY2400B1/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |