DE69824966D1 - Aromatische c16-c20-substituierte tetrahydro-prostaglandine verwendbar wie fp agoniste - Google Patents

Aromatische c16-c20-substituierte tetrahydro-prostaglandine verwendbar wie fp agoniste

Info

Publication number
DE69824966D1
DE69824966D1 DE69824966T DE69824966T DE69824966D1 DE 69824966 D1 DE69824966 D1 DE 69824966D1 DE 69824966 T DE69824966 T DE 69824966T DE 69824966 T DE69824966 T DE 69824966T DE 69824966 D1 DE69824966 D1 DE 69824966D1
Authority
DE
Germany
Prior art keywords
agoniste
prostaglandine
aromatic
substituted tetrahydro
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824966T
Other languages
English (en)
Other versions
DE69824966T2 (de
Inventor
August Wos
Anthony Delong
S Amburgey
Biswanath De
George Dai
Yili Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Durham
Duke University
Original Assignee
University of Durham
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Durham, Duke University filed Critical University of Durham
Publication of DE69824966D1 publication Critical patent/DE69824966D1/de
Application granted granted Critical
Publication of DE69824966T2 publication Critical patent/DE69824966T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69824966T 1997-09-09 1998-09-04 Aromatische c16-c20-substituierte tetrahydro-prostaglandine verwendbar wie fp agoniste Expired - Lifetime DE69824966T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5821797P 1997-09-09 1997-09-09
US58217P 1997-09-09
PCT/US1998/018339 WO1999012895A1 (en) 1997-09-09 1998-09-04 Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists

Publications (2)

Publication Number Publication Date
DE69824966D1 true DE69824966D1 (de) 2004-08-12
DE69824966T2 DE69824966T2 (de) 2005-04-07

Family

ID=22015427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824966T Expired - Lifetime DE69824966T2 (de) 1997-09-09 1998-09-04 Aromatische c16-c20-substituierte tetrahydro-prostaglandine verwendbar wie fp agoniste

Country Status (24)

Country Link
US (1) US5977173A (de)
EP (1) EP1012136B1 (de)
JP (1) JP2001515882A (de)
KR (1) KR20010023839A (de)
CN (1) CN1269786A (de)
AR (1) AR013477A1 (de)
AT (1) ATE270660T1 (de)
AU (1) AU731153B2 (de)
BR (1) BR9811774A (de)
CA (1) CA2303764C (de)
CO (1) CO4970731A1 (de)
DE (1) DE69824966T2 (de)
ES (1) ES2223141T3 (de)
HU (1) HUP0100638A3 (de)
ID (1) ID23971A (de)
IL (1) IL134839A0 (de)
NO (1) NO20001141L (de)
NZ (1) NZ503735A (de)
PE (1) PE115499A1 (de)
PL (1) PL339212A1 (de)
SK (1) SK3372000A3 (de)
TR (1) TR200000671T2 (de)
WO (1) WO1999012895A1 (de)
ZA (1) ZA988230B (de)

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IL147771A0 (en) 1999-08-04 2002-08-14 Procter & Gamble Novel 2-decarboxy-2-phosphinico prostaglandin f analogs
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
KR100437873B1 (ko) * 2001-05-08 2004-06-26 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법 및 그의 입체특이적출발물질
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
EP1812017A2 (de) * 2004-10-21 2007-08-01 Duke University Ophthalmologische arzneimittel
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
WO2009058493A1 (en) * 2007-10-31 2009-05-07 Pamela Lipkin Prostaglandin analog compositions and methods to treat epithelial-related conditions
US20100074857A1 (en) * 2008-09-23 2010-03-25 Pamela Lipkin Compositions and methods to treat epithelial-related conditions
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
AU2009340420A1 (en) 2008-10-29 2010-08-26 Novaer Holdings, Inc. Amino acid salts of prostaglandins
EP2383263B1 (de) 2008-12-30 2014-04-16 Industry-academic Cooperation Foundation, Chosun University Neues thiazolidindionderivat und dessen verwendung
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
EP3828172A1 (de) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
WO2011057129A2 (en) 2009-11-09 2011-05-12 Allergan, Inc. Compositions and methods for stimulating hair growth
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
CN105263494A (zh) 2013-03-15 2016-01-20 爱瑞制药公司 联合治疗
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6907319B2 (ja) 2016-08-31 2021-07-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼科用組成物
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
WO2020056345A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

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US3776938A (en) * 1958-05-28 1973-12-04 S Bergstrom Dihydro-pge1
US4011262A (en) * 1972-07-13 1977-03-08 Pfizer Inc. 13,14-Dihydro-15-substituted-ω-pentanorprostaglandins of the two series
IL50310A (en) * 1972-11-08 1977-08-31 Pfizer Dimethyl ketophosphonates
US4024179A (en) * 1972-11-08 1977-05-17 Pfizer Inc. Substituted ω-pentanorprostaglandins
JPS5720305B2 (de) * 1973-02-28 1982-04-27
DE2365101A1 (de) * 1973-12-21 1975-07-10 Schering Ag Neue prostansaeurederivate und verfahren zu ihrer herstellung
DE2460990A1 (de) * 1974-12-21 1976-07-01 Hoechst Ag Neue prostaglandin-analoga und verfahren zu ihrer herstellung
GB1507211A (en) * 1975-02-14 1978-04-12 Ono Pharmaceutical Co Prostaglandin analogues
GB1506816A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
DE2517771A1 (de) * 1975-04-18 1976-10-28 Schering Ag Neue prostaglandin-acetylen-analoga und verfahren zu ihrer herstellung
US4051238A (en) * 1976-06-03 1977-09-27 The Upjohn Company Treatment of genital tract diseases of domestic animals with prostaglandins
DE2737808A1 (de) * 1976-08-27 1978-03-16 Pfizer 2-substituierte aryl-heterocyclische omega-pentanorprostaglandine
US4206151A (en) * 1978-12-21 1980-06-03 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl or cyclopropyl prostan-1-ols of the E, A and F series
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
US5166178B1 (en) * 1987-09-18 1998-07-21 R Tech Ueno Ltd Ocular hypotensive agents
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0569046B1 (de) * 1988-09-06 2002-11-13 Pharmacia Aktiebolag Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2039420C (en) * 1990-04-04 1996-12-10 Ryuji Ueno Treatment of cataract with 15-keto-prostaglandin compounds
US5302617A (en) * 1990-04-27 1994-04-12 Kabushikikaisha Ueno Seiyaku Oyo Kenkyuio Biochemical treatment with 15-dehydroxy-16-oxoprostaglandin compounds
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
US5409911A (en) * 1992-09-11 1995-04-25 Merck & Co., Inc. Prostaglandin analog for treating osteoporosis
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US5834498A (en) * 1992-09-21 1998-11-10 Allergan Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5332730A (en) * 1992-10-16 1994-07-26 Allergan, Inc. Azido derivatives of cyclopentane heptanoic or heptenoic acid
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US5545665A (en) * 1993-12-28 1996-08-13 Allergan Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
AU7672096A (en) * 1995-06-07 1998-06-03 Alcon Laboratories, Inc. Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5703108A (en) * 1996-02-28 1997-12-30 Pfizer Inc. Bone deposition by certain prostaglandin agonists
US5741810A (en) * 1996-02-29 1998-04-21 Allergan Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents
WO1997047595A1 (fr) * 1996-06-10 1997-12-18 R-Tech Ueno, Ltd. Antagoniste de l'endotheline
ATE221048T1 (de) * 1996-09-17 2002-08-15 Asahi Glass Co Ltd Fluorierte prostaglandinderivate und medikamente
AU5258698A (en) * 1996-11-12 1998-06-03 Alcon Laboratories, Inc. 15-ketal prostaglandins for the treatment of glaucoma or ocular hypertension
WO1998020880A2 (en) * 1996-11-12 1998-05-22 Alcon Laboratories, Inc. 11-halo prostaglandins for the treatment of glaucoma or ocular hypertension
CA2293325C (en) * 1997-05-09 2008-09-02 The Mount Sinai School Of Medicine Of The City University Of New York 8-iso-prostaglandins for glaucoma therapy

Also Published As

Publication number Publication date
EP1012136B1 (de) 2004-07-07
IL134839A0 (en) 2001-05-20
HUP0100638A3 (en) 2002-12-28
AU731153B2 (en) 2001-03-22
NO20001141D0 (no) 2000-03-06
BR9811774A (pt) 2000-08-29
NO20001141L (no) 2000-05-04
DE69824966T2 (de) 2005-04-07
SK3372000A3 (en) 2000-10-09
ES2223141T3 (es) 2005-02-16
WO1999012895A1 (en) 1999-03-18
AR013477A1 (es) 2000-12-27
PE115499A1 (es) 2000-02-03
EP1012136A1 (de) 2000-06-28
CA2303764A1 (en) 1999-03-18
US5977173A (en) 1999-11-02
CA2303764C (en) 2005-02-15
ATE270660T1 (de) 2004-07-15
AU9219398A (en) 1999-03-29
KR20010023839A (ko) 2001-03-26
TR200000671T2 (tr) 2000-07-21
PL339212A1 (en) 2000-12-04
NZ503735A (en) 2001-05-25
JP2001515882A (ja) 2001-09-25
HUP0100638A2 (hu) 2001-07-30
ZA988230B (en) 1999-03-09
ID23971A (id) 2000-06-14
CO4970731A1 (es) 2000-11-07
CN1269786A (zh) 2000-10-11

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Legal Events

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8328 Change in the person/name/address of the agent

Representative=s name: DERZEIT KEIN VERTRETER BESTELLT

8364 No opposition during term of opposition