BG97201A - Цис-2,3,3а,4,5,9в-хексахидро-1н-бензо(е)- индолови производни - Google Patents

Цис-2,3,3а,4,5,9в-хексахидро-1н-бензо(е)- индолови производни Download PDF

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Publication number
BG97201A
BG97201A BG097201A BG9720192A BG97201A BG 97201 A BG97201 A BG 97201A BG 097201 A BG097201 A BG 097201A BG 9720192 A BG9720192 A BG 9720192A BG 97201 A BG97201 A BG 97201A
Authority
BG
Bulgaria
Prior art keywords
cis
lower alkyl
hexahydro
benzo
indole derivatives
Prior art date
Application number
BG097201A
Other languages
English (en)
Other versions
BG61186B1 (bg
Inventor
Hans Bruderer
Thierry Godel
Rene Imhof
Roland Jakob-Roetne
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of BG97201A publication Critical patent/BG97201A/bg
Publication of BG61186B1 publication Critical patent/BG61186B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Цис-2,3,3а,4,5,9в-хексахидро-1н-бензо[е]индолови производни с обща формула i в която r1 означава остатък с формула-осо-nr4r5, r2 означава нисш алкил, нисш циклоалкил или нисш алкил, субституиран с: нисш циклоалкил, арил, ароил, ароиламино, амино или с пиперидин-1-ил, морфолин-4-ил, 1-оксаизоиндолин-2-ил, 1,3-диоксоизоиндолин-2-ил, 1,3-диоксо-октахидро-цис-изоиндолин-2-ил и 4,4-диметил-2,6-диоксопиперидин-1-ил, r3 е водород или нисш алкил, r4 е нисш алкил и r5 е водород или нисш алкил и съответните им транс-изомери или цис-трансизомерни смеси и техните фармацевтично приемливи присъединителни с киселини соли. 33 претенции
BG97201A 1991-12-20 1992-12-18 Цис-2,3,3а,4,5,9в-хексахидро-1н-бензо(е)- индолови производни BG61186B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH380691 1991-12-20
CH325492 1992-10-19

Publications (2)

Publication Number Publication Date
BG97201A true BG97201A (bg) 1993-12-24
BG61186B1 BG61186B1 (bg) 1997-02-28

Family

ID=25692569

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97201A BG61186B1 (bg) 1991-12-20 1992-12-18 Цис-2,3,3а,4,5,9в-хексахидро-1н-бензо(е)- индолови производни

Country Status (21)

Country Link
US (2) US5318966A (bg)
EP (1) EP0548664B1 (bg)
JP (1) JPH07119215B2 (bg)
CN (1) CN1037510C (bg)
AT (1) ATE123277T1 (bg)
AU (1) AU661076B2 (bg)
BG (1) BG61186B1 (bg)
CA (1) CA2084442A1 (bg)
CZ (1) CZ381092A3 (bg)
DE (1) DE59202406D1 (bg)
DK (1) DK0548664T3 (bg)
ES (1) ES2073847T3 (bg)
FI (1) FI925774A (bg)
GR (1) GR3017256T3 (bg)
HU (2) HU9203956D0 (bg)
IL (1) IL104080A (bg)
IS (1) IS3961A (bg)
MY (1) MY108026A (bg)
NO (1) NO179325C (bg)
NZ (1) NZ245463A (bg)
TW (1) TW239127B (bg)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486611A (en) * 1989-07-13 1996-01-23 The Upjohn Company Carboxamido-(1,2N)-carbocyclic-2-aminotetralin derivatives
WO1991000856A2 (en) * 1989-07-13 1991-01-24 The Upjohn Company (1,2n) and (3,2n)-carbocyclic-2-amino tetralin derivatives
ES2130135T3 (es) * 1990-01-11 1999-07-01 Upjohn Co Nuevos compuestos heterociclicos de 6,7,8,9-tetrahidro-3h-benz(e)indol con actividad terapeutica sobre el sistema nervioso central.
US5434170A (en) * 1993-12-23 1995-07-18 Andrulis Pharmaceuticals Corp. Method for treating neurocognitive disorders
WO1996003377A1 (en) * 1994-07-27 1996-02-08 Sankyo Company, Limited Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1277789A (en) * 1969-09-08 1972-06-14 Logeais Labor Jacques Improvements in or relating to new polycyclic pyrrole derivatives
JPS4930836B1 (bg) * 1971-07-22 1974-08-16
JPS4916862A (bg) * 1972-06-14 1974-02-14
SE8004002L (sv) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik Terapeutiskt anvendbara tetralinderivat
SE8302361D0 (sv) * 1983-04-27 1983-04-27 Astra Laekemedel Ab New tricyclic amines
JP2785879B2 (ja) * 1989-05-31 1998-08-13 ジ・アップジョン・カンパニー 治療学的に有用な２―アミノテトラリン誘導体
WO1991000856A2 (en) * 1989-07-13 1991-01-24 The Upjohn Company (1,2n) and (3,2n)-carbocyclic-2-amino tetralin derivatives

Also Published As

Publication number Publication date
CN1088576A (zh) 1994-06-29
DK0548664T3 (da) 1995-09-04
ES2073847T3 (es) 1995-08-16
NO179325C (no) 1996-09-18
JPH07119215B2 (ja) 1995-12-20
NZ245463A (en) 1995-05-26
CN1037510C (zh) 1998-02-25
CZ381092A3 (en) 1993-09-15
HUT68178A (en) 1995-05-29
AU661076B2 (en) 1995-07-13
FI925774A0 (fi) 1992-12-18
US5318967A (en) 1994-06-07
HU9203956D0 (en) 1993-03-29
EP0548664B1 (de) 1995-05-31
EP0548664A1 (de) 1993-06-30
AU3018692A (en) 1993-06-24
NO924829L (no) 1993-06-21
CA2084442A1 (en) 1993-06-21
IL104080A0 (en) 1993-05-13
DE59202406D1 (de) 1995-07-06
GR3017256T3 (en) 1995-11-30
IL104080A (en) 1997-04-15
ATE123277T1 (de) 1995-06-15
US5318966A (en) 1994-06-07
NO179325B (no) 1996-06-10
JPH06128228A (ja) 1994-05-10
NO924829D0 (no) 1992-12-14
MY108026A (en) 1996-07-30
BG61186B1 (bg) 1997-02-28
IS3961A (is) 1993-06-21
TW239127B (bg) 1995-01-21
FI925774A (fi) 1993-06-21

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