FI916032A - Foerfarande foer framstaellning av terapeutiskt anvaendbara n-acyl-2,3-bensodiazepin-derivat. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara n-acyl-2,3-bensodiazepin-derivat. Download PDF

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Publication number
FI916032A
FI916032A FI916032A FI916032A FI916032A FI 916032 A FI916032 A FI 916032A FI 916032 A FI916032 A FI 916032A FI 916032 A FI916032 A FI 916032A FI 916032 A FI916032 A FI 916032A
Authority
FI
Finland
Prior art keywords
group
atoms
amino
acyl
double bond
Prior art date
Application number
FI916032A
Other languages
English (en)
Other versions
FI916032A0 (fi
FI102611B1 (fi
FI102611B (fi
Inventor
Ferenc Andrasi
Pal Berzsenyi
Peter Botka
Sandor Farkas
Nee Horvath Katali Goldschmidt
Tamas Hamori
Jeno Korosi
Imre Moravcsik
Istvan Tarnawa
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Publication of FI916032A0 publication Critical patent/FI916032A0/fi
Publication of FI916032A publication Critical patent/FI916032A/fi
Application granted granted Critical
Publication of FI102611B1 publication Critical patent/FI102611B1/fi
Publication of FI102611B publication Critical patent/FI102611B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
FI916032A 1990-12-21 1991-12-20 Menetelmä terapeuttisesti käyttökelpoisten 1-(4-asyyliaminofenyyli)-ja /tai-3-asyyli-7,8-metyleenidioksi-5H-2,3-bentsodiatsepiini-johdannaist en valmistamiseksi FI102611B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU839890 1990-12-21
HU398/90A HU219778B (hu) 1990-12-21 1990-12-21 Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US8060493 1993-06-21
US08/080,604 US5459137A (en) 1990-12-21 1993-06-21 N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (4)

Publication Number Publication Date
FI916032A0 FI916032A0 (fi) 1991-12-20
FI916032A true FI916032A (fi) 1992-06-22
FI102611B1 FI102611B1 (fi) 1999-01-15
FI102611B FI102611B (fi) 1999-01-15

Family

ID=26317922

Family Applications (1)

Application Number Title Priority Date Filing Date
FI916032A FI102611B (fi) 1990-12-21 1991-12-20 Menetelmä terapeuttisesti käyttökelpoisten 1-(4-asyyliaminofenyyli)-ja /tai-3-asyyli-7,8-metyleenidioksi-5H-2,3-bentsodiatsepiini-johdannaist en valmistamiseksi

Country Status (25)

Country Link
US (3) US5459137A (fi)
EP (1) EP0492485B1 (fi)
JP (1) JP2756742B2 (fi)
KR (1) KR0169134B1 (fi)
CN (2) CN1041420C (fi)
AT (1) ATE160350T1 (fi)
AU (1) AU641578B2 (fi)
BR (1) BR9105517A (fi)
CA (1) CA2057504C (fi)
CZ (1) CZ280769B6 (fi)
DE (1) DE69128236T2 (fi)
DK (1) DK0492485T3 (fi)
ES (1) ES2112848T3 (fi)
FI (1) FI102611B (fi)
GR (1) GR3026127T3 (fi)
HR (1) HRP920677B1 (fi)
HU (1) HU219778B (fi)
IE (1) IE914518A1 (fi)
IL (1) IL100449A (fi)
MX (1) MX9102734A (fi)
NO (1) NO300376B1 (fi)
NZ (1) NZ241110A (fi)
RU (1) RU2102387C1 (fi)
SI (1) SI9111966B (fi)
ZA (1) ZA9110064B (fi)

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US5521174A (en) * 1990-12-21 1996-05-28 Gyogyszerkutato Intezet Kv. N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
US5519019A (en) * 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) * 1994-08-01 1996-02-08 Schering Ag Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
DK1157992T3 (da) * 1994-08-31 2005-10-24 Lilly Co Eli Dihydro-2,3-benzodiazepinederivativer
US5665878A (en) 1994-08-31 1997-09-09 Eli Lilly And Company Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives
TR199501071A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
TR199501072A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevinin fiziksel bicimi.
TR199501070A2 (tr) 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevinin kristalli bicimi.
US5670640A (en) * 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HUP9701325A1 (hu) 1997-07-31 2000-08-28 Gyógyszerkutató Intézet Kft. Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) * 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
BR9812119A (pt) * 1997-08-12 2004-06-22 Egyt Gyogyszervegyeszeti Gyar Derivados de 1,3-dioxolo/4, 5-h//2,3/benzodiazepina, processo para a preparação dos mesmos e composição farmacêutica
JP2002519373A (ja) * 1998-07-02 2002-07-02 エーザイ株式会社 製薬組成物及びそれらの使用
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
DE50013066D1 (de) 1999-12-22 2006-08-03 Schott Ag Uv-reflektierendes interferenzschichtsystem
US6887867B2 (en) * 2000-06-16 2005-05-03 Transgenomic, Inc. 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
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US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
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DE2353187A1 (de) * 1973-05-02 1974-11-14 Kali Chemie Ag Neue benzodiazepinderivate
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények

Also Published As

Publication number Publication date
US5536832A (en) 1996-07-16
NO915060D0 (no) 1991-12-20
NZ241110A (en) 1994-04-27
AU8996391A (en) 1992-06-25
CN1041420C (zh) 1998-12-30
EP0492485B1 (en) 1997-11-19
ATE160350T1 (de) 1997-12-15
MX9102734A (es) 1992-06-01
JPH0570463A (ja) 1993-03-23
US5604223A (en) 1997-02-18
DE69128236D1 (de) 1998-01-02
IL100449A (en) 1995-12-31
BR9105517A (pt) 1992-09-01
KR0169134B1 (ko) 1999-01-15
HU219778B (hu) 2001-07-30
CN1191111A (zh) 1998-08-26
KR920012086A (ko) 1992-07-25
CN1062730A (zh) 1992-07-15
HU908398D0 (en) 1991-07-29
EP0492485A1 (en) 1992-07-01
US5459137A (en) 1995-10-17
NO915060L (no) 1992-06-22
SI9111966A (sl) 1998-04-30
DE69128236T2 (de) 1998-05-14
CA2057504A1 (en) 1992-06-22
CZ398591A3 (en) 1994-01-19
AU641578B2 (en) 1993-09-23
ZA9110064B (en) 1992-10-28
CN1135982C (zh) 2004-01-28
JP2756742B2 (ja) 1998-05-25
FI916032A0 (fi) 1991-12-20
DK0492485T3 (da) 1998-07-27
FI102611B1 (fi) 1999-01-15
NO300376B1 (no) 1997-05-20
ES2112848T3 (es) 1998-04-16
CZ280769B6 (cs) 1996-04-17
GR3026127T3 (en) 1998-05-29
FI102611B (fi) 1999-01-15
RU2102387C1 (ru) 1998-01-20
HUT59684A (en) 1992-06-29
IL100449A0 (en) 1992-09-06
HRP920677B1 (en) 2000-02-29
SI9111966B (en) 2001-04-30
CA2057504C (en) 2002-02-12
IE914518A1 (en) 1992-07-01
HRP920677A2 (en) 1994-08-31

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Owner name: GYOGYSZERKUTATO INTEZET K.V.

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