DK0492485T3 - N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling - Google Patents

N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling

Info

Publication number
DK0492485T3
DK0492485T3 DK91121882T DK91121882T DK0492485T3 DK 0492485 T3 DK0492485 T3 DK 0492485T3 DK 91121882 T DK91121882 T DK 91121882T DK 91121882 T DK91121882 T DK 91121882T DK 0492485 T3 DK0492485 T3 DK 0492485T3
Authority
DK
Denmark
Prior art keywords
group
atoms
amino
double bond
general formula
Prior art date
Application number
DK91121882T
Other languages
English (en)
Inventor
Imre Moravcsik
Ferenc Dr Andrasi
Pal Dr Berzsenyi
Peter Botka
Sandor Dr Farkas
Tamas Dr Hamori
Jeno Dr Korosi
Istvan Dr Tarnawa
Katalin Dr Goldschmidt
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Application granted granted Critical
Publication of DK0492485T3 publication Critical patent/DK0492485T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DK91121882T 1990-12-21 1991-12-23 N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling DK0492485T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU398/90A HU219778B (hu) 1990-12-21 1990-12-21 Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US08/080,604 US5459137A (en) 1990-12-21 1993-06-21 N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (1)

Publication Number Publication Date
DK0492485T3 true DK0492485T3 (da) 1998-07-27

Family

ID=26317922

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91121882T DK0492485T3 (da) 1990-12-21 1991-12-23 N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling

Country Status (25)

Country Link
US (3) US5459137A (da)
EP (1) EP0492485B1 (da)
JP (1) JP2756742B2 (da)
KR (1) KR0169134B1 (da)
CN (2) CN1041420C (da)
AT (1) ATE160350T1 (da)
AU (1) AU641578B2 (da)
BR (1) BR9105517A (da)
CA (1) CA2057504C (da)
CZ (1) CZ280769B6 (da)
DE (1) DE69128236T2 (da)
DK (1) DK0492485T3 (da)
ES (1) ES2112848T3 (da)
FI (1) FI102611B1 (da)
GR (1) GR3026127T3 (da)
HR (1) HRP920677B1 (da)
HU (1) HU219778B (da)
IE (1) IE914518A1 (da)
IL (1) IL100449A (da)
MX (1) MX9102734A (da)
NO (1) NO300376B1 (da)
NZ (1) NZ241110A (da)
RU (1) RU2102387C1 (da)
SI (1) SI9111966B (da)
ZA (1) ZA9110064B (da)

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US5519019A (en) * 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
HU219777B (hu) * 1993-07-02 2001-07-30 Gyógyszerkutató Intézet Kft. Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) * 1994-08-01 1996-02-08 Schering Ag Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
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TR199501070A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevinin kristalli bicimi.
DE69534407T2 (de) * 1994-08-31 2006-03-16 Eli Lilly And Co., Indianapolis Dihydro-2,3-Benzodiazepinderivate
US6329364B1 (en) * 1994-08-31 2001-12-11 Eli Lilly And Company Crystalline form of dihydro-2,3-benzodiazepine derivative
TR199501072A2 (tr) * 1994-08-31 1996-06-21 Lilly Co Eli Dihidro-2,3-benzodiazepin türevinin fiziksel bicimi.
US5670640A (en) * 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) * 1996-04-04 1996-05-28 Gyogyszerkutato Intezet New 2,3-benzodiazepine derivatives
HUP9701325A1 (hu) 1997-07-31 2000-08-28 Gyógyszerkutató Intézet Kft. Új 2,3-benzodiazepin-származékok
RU2208014C2 (ru) * 1997-08-12 2003-07-10 Эгиш Дьёдьсердьяр Рт. ПРОИЗВОДНЫЕ 1,3-ДИОКСОЛ/4,5-h//2,3/БЕНЗОДИАЗЕПИНА, ЯВЛЯЮЩИЕСЯ ИНГИБИТОРАМИ AMPA/КАИНАТНОГО РЕЦЕПТОРА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБ ЛЕЧЕНИЯ
UA67749C2 (uk) 1997-08-12 2004-07-15 Егіш Дьйодьсердьяр Рт. Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
JP2002519373A (ja) * 1998-07-02 2002-07-02 エーザイ株式会社 製薬組成物及びそれらの使用
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
EP1248959B1 (de) 1999-12-22 2006-06-21 Schott Ag Uv-reflektierendes interferenzschichtsystem
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
AU2003293405A1 (en) 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7022700B2 (en) 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US20040152694A1 (en) * 2003-02-04 2004-08-05 Istvan Kurucz Methods and compositions for treating inflammatory disorders of the airways
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20050079166A1 (en) 2003-05-21 2005-04-14 Alexza Molecular Delivery Corporation Self-contained heating unit and drug-supply unit employing same
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DE2353187A1 (de) * 1973-05-02 1974-11-14 Kali Chemie Ag Neue benzodiazepinderivate
HU191702B (en) * 1984-06-27 1987-03-30 Gyogyszerkutato Intezet New process for preparing 1-aryl-5 h-2,3-benzodiazepines
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények

Also Published As

Publication number Publication date
EP0492485B1 (en) 1997-11-19
JP2756742B2 (ja) 1998-05-25
ATE160350T1 (de) 1997-12-15
CN1062730A (zh) 1992-07-15
US5536832A (en) 1996-07-16
FI102611B (fi) 1999-01-15
CN1135982C (zh) 2004-01-28
IL100449A0 (en) 1992-09-06
CN1041420C (zh) 1998-12-30
HU908398D0 (en) 1991-07-29
FI916032A (fi) 1992-06-22
DE69128236D1 (de) 1998-01-02
EP0492485A1 (en) 1992-07-01
CN1191111A (zh) 1998-08-26
CA2057504C (en) 2002-02-12
CZ398591A3 (en) 1994-01-19
US5459137A (en) 1995-10-17
GR3026127T3 (en) 1998-05-29
FI916032A0 (fi) 1991-12-20
MX9102734A (es) 1992-06-01
AU641578B2 (en) 1993-09-23
US5604223A (en) 1997-02-18
HU219778B (hu) 2001-07-30
HUT59684A (en) 1992-06-29
ZA9110064B (en) 1992-10-28
KR920012086A (ko) 1992-07-25
IE914518A1 (en) 1992-07-01
HRP920677A2 (en) 1994-08-31
JPH0570463A (ja) 1993-03-23
NO915060L (no) 1992-06-22
CZ280769B6 (cs) 1996-04-17
ES2112848T3 (es) 1998-04-16
CA2057504A1 (en) 1992-06-22
DE69128236T2 (de) 1998-05-14
SI9111966A (sl) 1998-04-30
FI102611B1 (fi) 1999-01-15
NO300376B1 (no) 1997-05-20
SI9111966B (en) 2001-04-30
NZ241110A (en) 1994-04-27
IL100449A (en) 1995-12-31
AU8996391A (en) 1992-06-25
HRP920677B1 (en) 2000-02-29
KR0169134B1 (ko) 1999-01-15
NO915060D0 (no) 1991-12-20
RU2102387C1 (ru) 1998-01-20
BR9105517A (pt) 1992-09-01

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