FI102611B1 - Menetelmä terapeuttisesti käyttökelpoisten 1-(4-asyyliaminofenyyli)-ja/tai-3-asyyli-7,8-metyleenidioksi-5H-2,3-bentsodiatsepiini-johdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 1-(4-asyyliaminofenyyli)-ja/tai-3-asyyli-7,8-metyleenidioksi-5H-2,3-bentsodiatsepiini-johdannaisten valmistamiseksiInfo
- Publication number
- FI102611B1 FI102611B1 FI916032A FI916032A FI102611B1 FI 102611 B1 FI102611 B1 FI 102611B1 FI 916032 A FI916032 A FI 916032A FI 916032 A FI916032 A FI 916032A FI 102611 B1 FI102611 B1 FI 102611B1
- Authority
- FI
- Finland
- Prior art keywords
- group
- atoms
- amino
- double bond
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU398/90A HU219778B (hu) | 1990-12-21 | 1990-12-21 | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
HU839890 | 1990-12-21 | ||
US8060493 | 1993-06-21 | ||
US08/080,604 US5459137A (en) | 1990-12-21 | 1993-06-21 | N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same |
Publications (4)
Publication Number | Publication Date |
---|---|
FI916032A0 FI916032A0 (fi) | 1991-12-20 |
FI916032A FI916032A (fi) | 1992-06-22 |
FI102611B FI102611B (fi) | 1999-01-15 |
FI102611B1 true FI102611B1 (fi) | 1999-01-15 |
Family
ID=26317922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI916032A FI102611B1 (fi) | 1990-12-21 | 1991-12-20 | Menetelmä terapeuttisesti käyttökelpoisten 1-(4-asyyliaminofenyyli)-ja/tai-3-asyyli-7,8-metyleenidioksi-5H-2,3-bentsodiatsepiini-johdannaisten valmistamiseksi |
Country Status (25)
Country | Link |
---|---|
US (3) | US5459137A (fi) |
EP (1) | EP0492485B1 (fi) |
JP (1) | JP2756742B2 (fi) |
KR (1) | KR0169134B1 (fi) |
CN (2) | CN1041420C (fi) |
AT (1) | ATE160350T1 (fi) |
AU (1) | AU641578B2 (fi) |
BR (1) | BR9105517A (fi) |
CA (1) | CA2057504C (fi) |
CZ (1) | CZ280769B6 (fi) |
DE (1) | DE69128236T2 (fi) |
DK (1) | DK0492485T3 (fi) |
ES (1) | ES2112848T3 (fi) |
FI (1) | FI102611B1 (fi) |
GR (1) | GR3026127T3 (fi) |
HR (1) | HRP920677B1 (fi) |
HU (1) | HU219778B (fi) |
IE (1) | IE914518A1 (fi) |
IL (1) | IL100449A (fi) |
MX (1) | MX9102734A (fi) |
NO (1) | NO300376B1 (fi) |
NZ (1) | NZ241110A (fi) |
RU (1) | RU2102387C1 (fi) |
SI (1) | SI9111966B (fi) |
ZA (1) | ZA9110064B (fi) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521174A (en) * | 1990-12-21 | 1996-05-28 | Gyogyszerkutato Intezet Kv. | N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith |
US5639751A (en) * | 1990-12-21 | 1997-06-17 | Cyogyszerkutato Intezet Kft | N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders |
US5519019A (en) * | 1990-12-21 | 1996-05-21 | Gyogyszerkutato Intezet | N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
DE4428835A1 (de) * | 1994-08-01 | 1996-02-08 | Schering Ag | Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel |
TR199501072A2 (tr) | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevinin fiziksel bicimi. |
US5665878A (en) * | 1994-08-31 | 1997-09-09 | Eli Lilly And Company | Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives |
TR199501071A2 (tr) * | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem. |
DK1157992T3 (da) * | 1994-08-31 | 2005-10-24 | Lilly Co Eli | Dihydro-2,3-benzodiazepinederivativer |
TR199501070A2 (tr) | 1994-08-31 | 1996-06-21 | Lilly Co Eli | Dihidro-2,3-benzodiazepin türevinin kristalli bicimi. |
US5670640A (en) * | 1996-02-02 | 1997-09-23 | Hoffmann-La Roche Inc. | Process for the manufacture of imidazodiazepine derivatives |
US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
ZA972746B (en) * | 1996-04-04 | 1998-10-09 | Egyt Gyogyszervegyeszeti Gyar | Novel 2,3-benzodiazepine derivatives |
HU9600871D0 (en) * | 1996-04-04 | 1996-05-28 | Gyogyszerkutato Intezet | New 2,3-benzodiazepine derivatives |
HUP9701325A1 (hu) | 1997-07-31 | 2000-08-28 | Gyógyszerkutató Intézet Kft. | Új 2,3-benzodiazepin-származékok |
UA67749C2 (uk) * | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
EP1015457B1 (en) * | 1997-08-12 | 2003-11-26 | Egis Gyogyszergyar Rt. | 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors |
JP2002519373A (ja) * | 1998-07-02 | 2002-07-02 | エーザイ株式会社 | 製薬組成物及びそれらの使用 |
HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
ES2266014T3 (es) | 1999-12-22 | 2007-03-01 | Schott Ag | Sistema de capas de interferencia reflectoras de uv. |
US6887867B2 (en) * | 2000-06-16 | 2005-05-03 | Transgenomic, Inc. | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors |
HU225100B1 (hu) * | 2000-12-21 | 2006-06-28 | Egyt Gyogyszervegyeszeti Gyar | 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk |
US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
US6638928B1 (en) | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
MXPA05005893A (es) * | 2002-12-03 | 2006-02-08 | Vela Pharmaceuticals Inc | Composicion farmaceutica de 1-(3-hidroxi -4-metoxifenil) -4-metil-5 -etil-7, 8-dimetoxi- 5h-2, 3-benzodiazepina y usos de la misma. |
EP1567161A4 (en) | 2002-12-03 | 2008-09-03 | Vela Acquisition Corp | PHARMACEUTICAL COMPOSITION OF 1- (3,4-DIMETHOXYPHENYL) -4-METHYL-5-ETHYL-7-METHOXY-8-HYDROXY-5H-2,3-BENZODIAZEPINE AND ITS USE |
US6864251B2 (en) | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
US6858605B2 (en) * | 2003-02-04 | 2005-02-22 | Ivax Drug Research Institute, Ltd. | Substituted 2,3-benzodiazepine derivatives |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
US20040224943A1 (en) * | 2003-02-19 | 2004-11-11 | Leventer Steven M. | Method of lowering body temperature with (R) - 2,3-benzodiazepines |
US20040162284A1 (en) * | 2003-02-19 | 2004-08-19 | Harris Herbert W. | Method of lowering body temperature with (S) tofisopam |
EP1625334B9 (en) | 2003-05-21 | 2012-07-25 | Alexza Pharmaceuticals, Inc. | Percussively ignited self-contained heating unit |
WO2005007106A2 (en) * | 2003-07-10 | 2005-01-27 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a non-nmda glutamate modulator for the treatment of central nervous system damage |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
WO2007077469A1 (en) * | 2005-12-30 | 2007-07-12 | Egis Gyógyszergyár | Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis |
US20080108603A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
US20080108622A1 (en) * | 2006-10-19 | 2008-05-08 | Eisenach James C | Combination therapy for the treatment of pain |
US20080216828A1 (en) | 2007-03-09 | 2008-09-11 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
TW200902024A (en) * | 2007-04-02 | 2009-01-16 | Teva Pharma | Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2353187A1 (de) * | 1973-05-02 | 1974-11-14 | Kali Chemie Ag | Neue benzodiazepinderivate |
HU191702B (en) * | 1984-06-27 | 1987-03-30 | Gyogyszerkutato Intezet | New process for preparing 1-aryl-5 h-2,3-benzodiazepines |
HU191698B (en) * | 1984-07-27 | 1987-03-30 | Gyogyszerkutato Intezet | Process for producing new 1-aryl-5h-2beta-benzodiazepines |
HU198494B (en) * | 1986-08-15 | 1989-10-30 | Gyogyszerkutato Intezet | Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same |
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
-
1990
- 1990-12-21 HU HU398/90A patent/HU219778B/hu unknown
-
1991
- 1991-12-12 CA CA002057504A patent/CA2057504C/en not_active Expired - Lifetime
- 1991-12-18 KR KR1019910023297A patent/KR0169134B1/ko not_active IP Right Cessation
- 1991-12-19 BR BR919105517A patent/BR9105517A/pt not_active Application Discontinuation
- 1991-12-19 RU SU5010635A patent/RU2102387C1/ru active
- 1991-12-20 NZ NZ241110A patent/NZ241110A/en not_active IP Right Cessation
- 1991-12-20 IE IE451891A patent/IE914518A1/en not_active IP Right Cessation
- 1991-12-20 ZA ZA9110064A patent/ZA9110064B/xx unknown
- 1991-12-20 CN CN91111088A patent/CN1041420C/zh not_active Expired - Fee Related
- 1991-12-20 IL IL10044991A patent/IL100449A/en not_active IP Right Cessation
- 1991-12-20 FI FI916032A patent/FI102611B1/fi not_active IP Right Cessation
- 1991-12-20 AU AU89963/91A patent/AU641578B2/en not_active Ceased
- 1991-12-20 MX MX9102734A patent/MX9102734A/es unknown
- 1991-12-20 CZ CS913985A patent/CZ280769B6/cs not_active IP Right Cessation
- 1991-12-20 SI SI9111966A patent/SI9111966B/sl unknown
- 1991-12-20 JP JP3354972A patent/JP2756742B2/ja not_active Expired - Fee Related
- 1991-12-20 NO NO915060A patent/NO300376B1/no not_active IP Right Cessation
- 1991-12-23 AT AT91121882T patent/ATE160350T1/de not_active IP Right Cessation
- 1991-12-23 DK DK91121882T patent/DK0492485T3/da active
- 1991-12-23 EP EP91121882A patent/EP0492485B1/en not_active Expired - Lifetime
- 1991-12-23 ES ES91121882T patent/ES2112848T3/es not_active Expired - Lifetime
- 1991-12-23 DE DE69128236T patent/DE69128236T2/de not_active Expired - Lifetime
-
1992
- 1992-09-30 HR HRP-1966/91A patent/HRP920677B1/xx not_active IP Right Cessation
-
1993
- 1993-06-21 US US08/080,604 patent/US5459137A/en not_active Expired - Lifetime
-
1995
- 1995-03-21 US US08/423,032 patent/US5604223A/en not_active Expired - Lifetime
- 1995-04-17 US US08/423,153 patent/US5536832A/en not_active Expired - Lifetime
-
1998
- 1998-01-10 CN CNB981039766A patent/CN1135982C/zh not_active Expired - Fee Related
- 1998-02-12 GR GR980400299T patent/GR3026127T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: GYOGYSZERKUTATO INTEZET K.V. |
|
MM | Patent lapsed |