ES2594867T3 - Unidad de calentamiento para usar en un dispositivo de administración de fármaco - Google Patents

Unidad de calentamiento para usar en un dispositivo de administración de fármaco Download PDF

Info

Publication number
ES2594867T3
ES2594867T3 ES08754883.0T ES08754883T ES2594867T3 ES 2594867 T3 ES2594867 T3 ES 2594867T3 ES 08754883 T ES08754883 T ES 08754883T ES 2594867 T3 ES2594867 T3 ES 2594867T3
Authority
ES
Spain
Prior art keywords
substrate
holes
drug
drug delivery
inches
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08754883.0T
Other languages
English (en)
Inventor
Martin J. Wensley
Marc Glazer
James Bresson
Ryan Timmons
Daniel J. Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alexza Pharmaceuticals Inc
Original Assignee
Alexza Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexza Pharmaceuticals Inc filed Critical Alexza Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2594867T3 publication Critical patent/ES2594867T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8268—Fuel storage cells

Abstract

Un dispositivo de administracion de farmaco en aerosol que comprende una unidad de suministro de farmaco (130) que comprende un sustrato (108), caracterizado por que el sustrato tiene una superficie que contiene una pluralidad de orificios pasantes (132) conformados, en el que el aire fluye a traves de dichos orificios, y en el que al menos una parte de la superficie esta revestida de una composicion de farmaco, en el que el sustrato tiene un espesor, y en el que los orificios son circulares y tienen un diametro de al menos un valor tan grande como el espesor del sustrato.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
5
15
25
35
45
55
65
Se puede usar un número de materiales diferentes para construir el sustrato. Normalmente, los sustratos son termoconductores e incluyen metales o aleaciones, tales como aluminio, hierro, cobre, acero inoxidable, oro, titanio y similares, aleaciones. Los orificios del sustrato pueden estar formados por cualquier método conocido en la técnica. En una variación, el sustrato termo-conductor es una lámina de papel metalizado de acero inoxidable que presenta orificios sometidos a ataque químico o perforados por toda la lámina. En algunas realizaciones, el acero inoxidable tiene ventajas con respecto a otros materiales tales como aluminio, debido a que presenta un bajo valor de conductividad térmica, sin un aumento apreciable en masa térmica. La baja conductividad térmica es útil, ya que el calor generado por el proceso necesita permanecer en el área intermedia de interés.
Una unidad de suministro de fármaco de la invención también puede comprender sustratos tratados, que se han descrito como que proporcionan una pureza mejorada del aerosol de la composición de fármaco generado a partir de las películas aplicadas sobre la misma. Los sustratos a modo de ejemplo de este tipo se describen en Bennett et al., Publicación de Estados Unidos n.º 2005/0034723. Los sustratos metálicos divulgados en la misma tienen una superficie exterior tratada. La superficie exterior tratada está normalmente tratada con ácido, tratada con calor, o es una superficie enriquecida con óxido metálico. Los enfoques de tratamiento divulgados en la misma son aplicables a diversos metales y aleaciones, incluyendo sin limitación, acero, acero inoxidables, aluminio, cromo, cobre, hierro, titanio y similares, siendo aluminio, cobre y acero, especialmente acero inoxidables, realizaciones particularmente preferidas. En una variación, el sustrato termo-conductor es una chapa de acero inoxidable tratada con SULFINERT®.
Alternativamente, el sustrato puede comprender un material cerámico o polímero. En una variación, el sustrato termo-conductor es una lámina de película de poliimida (película de poliimida de KAPTON®, DuPont, Wilmington, DE) que comprende una pluralidad de orificios. En tal caso, la unidad de suministro de fármaco puede además comprender un elemento de dispositivo de calentamiento dispuesto sobre o dentro del sustrato polimérico. Con el fin de rebajar la masa térmica, en algunas realizaciones preferidas, se puede usar una lámina fina de película de poliimida (de 5 x 104 pulgadas a 1 x 103 pulgadas (de 12,7 micras a 25,4 micras). En algunas realizaciones, se pueden formar trazas de dispositivo de calentamiento eléctricamente conductor sobre una superficie de la lámina de película de poliimida. Aunque las trazas del dispositivo de calentamiento normalmente comprenden cobre, también se contempla en la presente memoria que las trazas se pueden formar por medio de otros materiales conductores, tales como aluminio, níquel u oro.
Normalmente, el sustrato tiene un espesor de al menos 5 x 104 pulgadas (12,7 micras). Cuando el sustrato comprende un metal (por ejemplo acero inoxidable), el sustrato normalmente tiene un espesor dentro del intervalo de aproximadamente 5 x 104 pulgadas a aproximadamente 1 x 102 pulgadas (de 12,7 micras a 254 micras). Cuando el sustrato comprende un polímero (por ejemplo, una película de poliimida), el sustrato normalmente tiene un espesor dentro del intervalo de aproximadamente 5 x 104 pulgadas a aproximadamente 5 x 103 pulgadas (de 12,7 micras a 127 micras).
Al menos una parte de la superficie del sustrato comprende una pluralidad de orificios a través de los cuales puede pasar un flujo de gas. Normalmente, el sustrato comprende al menos 10, al menos 20, al menos 30, al menos 40, al menos 50, al menos 60, al menos 70, al menos 80, al menos 90, al menos 100, al menos 250, al menos 500 o más, orificios.
Normalmente, un gas (por ejemplo, aire) fluye a través de los orificios tras inhalación por parte de un sujeto que usa el dispositivo de administración de fármaco. El gas se puede extraer al interior de un dispositivo por medio de la acción de inhalación o, por el contrario, se puede proporcionar (por ejemplo, puede almacenarse dentro del dispositivo bajo presión hasta la inhalación).
Normalmente, los orificios tienen una forma regular, tal como un círculo, una elipse, un cuadrado, un rectángulo o un polígono regular. En una realización preferida, el sustrato comprende una pluralidad de orificios pequeños, circulares, espaciados regularmente, normalmente de tamaño igual o similar. No obstante, la invención no está limitada a ello y los orificios podrían ser de forma irregular, y/o tener tamaños y/o espaciado variables. La pluralidad de los orificios puede tener diferentes formas (por ejemplo, una combinación de orificios circulares y rectangulares).
Las dimensiones de los orificios normalmente permanecen uniformes ya que se extienden a través del sustrato, pero se encuentra dentro del alcance de la invención que los orificios puedan variar en cuanto a forma y dimensión ya que se extienden a través del sustrato. Por ejemplo, los orificios podrían tener forma ahusada, cónica, ya que los orificios tienen un diámetro sobre una superficie del sustrato más grande que sobre la otra.
En el caso de una unidad de suministro de fármaco que comprende un sustrato polimérico (por ejemplo, una película de poliimida) con trazas de dispositivo de calentamiento, los orificios están preferentemente ubicados entre las trazas del dispositivo de calentamiento, como se muestra en las Figuras 2A y 2B, que muestran sustratos de película de poliimida que tienen orificios de tamaño pequeño y grande, respectivamente. El sustrato 200 mostrado en la Figura 2A tiene orificios pequeños que miden 2,8 x 103 pulgadas por 5,25 x 103 pulgadas (71,1 micras por 133,3 micras). El dispositivo de calentamiento 20 mostrado en la Figura 2B tiene orificios grandes que miden 8,8 x 103 pulgadas por 9,8 x 102 pulgadas (223,5 pulgadas por 2489,2 micras). Las películas de poliimida tienen un espesor
7
imagen6
imagen7
imagen8
imagen9
5
15
25
35
45
55
65
rendimiento tras calentamiento de un 100 % de la película de fármaco y partículas de aerosol que tienen una pureza de fármaco de un 100 %, la relación entre dosis, espesor y área proporcionada anteriormente se correlaciona directamente con la dosis proporcionada al usuario. A medida que disminuye la pureza de partícula y/o el rendimiento en porcentaje, se pueden realizar ajustes en el área de sustrato, según sea necesario, para proporcionar la dosis deseada. De igual forma, como un experto en la técnica reconocerá, se pueden usar áreas de sustratos grandes diferentes del área calculada mínima para un espesor de película particular con el fin de proporcionar una dosis terapéuticamente eficaz del fármaco. Además, como puede apreciarse por parte del experto en la técnica, no es necesario revestir la película para completar el área superficial si dicho área superficial seleccionada supera el mínimo requerido para administrar la dosis terapéutica a partir de un espesor de película seleccionado.
Formación de Aerosoles de Condensación
También se divulga en la presente memoria un método para producir un aerosol de condensación que contiene fármaco que comprende proporcionar un sustrato que tiene un fármaco depositado sobre su superficie, en el que la superficie del sustrato tiene una pluralidad de orificios formados en la misma. El sustrato se calienta hasta una temperatura suficiente para vaporizar el fármaco al tiempo que proporciona simultáneamente un flujo de aire en dirección transversal al sustrato y a través del sustrato por medio de la pluralidad de orificios. Preferentemente, el fármaco se calienta hasta una temperatura y durante un tiempo que tiene como resultado un nivel aceptablemente bajo de descomposición. El fármaco vaporizado se mezcla de forma preferentemente rápida con el flujo de aire para enfriar y excluir la descomposición adicional del fármaco. A continuación, se permite que el fármaco vaporizado se condense para dar lugar a un aerosol que comprende partículas. Los términos "aire" y "gas" y la expresión "flujo de aire" se usan de forma intercambiable en la presente memoria, y se pretende que engloben aire ambiente así como también cualesquiera otros gases apropiados (es decir, fisiológicamente aceptables, no explosivos), incluyendo gases comprimidos. Por ejemplo, el dispositivo de la invención se puede unir a un tanque por separado de gas comprimido que insufla aire u otro gas apropiado a través de las perforaciones en el sustrato de manera concurrente con el calentamiento del sustrato.
Preferentemente, el fármaco en forma de aerosol tiene un nivel de pureza de al menos un 90 %; más preferentemente, al menos un 95 %; más preferentemente, al menos un 96 %; más preferentemente, al menos un 97 %. Según se usa en la presente memoria, el término "puro" se refiere a un fármaco en forma de aerosol que no contiene productos de degradación térmica, excipientes u otros contaminantes. Por ejemplo, un fármaco en forma de aerosol que sea al menos un 97 % puro contiene menos de un 3 % de productos de degradación térmica, excipientes u otros contaminantes. Tal y como se usa en la presente memoria, la expresión "producto de degradación térmica" significa cualquier subproducto que sea el resultado del calentamiento del fármaco.
El aerosol se caracteriza preferentemente por menos de un 10 % en peso de un producto de degradación térmica, más preferentemente, menos de un 5 %, más preferentemente, menos de un 1 %, más preferentemente, menos de un 0,5 %, más preferentemente, menos de un 0,1 %, más preferentemente, menos de un 0,03 % en peso de un producto de degradación térmica.
En determinadas realizaciones, por ejemplo, cuando el dispositivo de administración de fármaco está diseñado para un uso portátil con una fuente de energía de pila, puede resultar deseable un uso de energía eficiente: La minimización de la energía usada para liberar el fármaco del sustrato puede depender, al menos en parte, de la forma y dimensiones del sustrato, los materiales que forman el sustrato, y la colocación del sustrato dentro de las vías respiratorias. En determinadas realizaciones, el sustrato puede comprender un material eléctricamente resistivo tal como una papel metalizado. En determinadas realizaciones, el sustrato puede ser un papel metalizado de acero inoxidable y puede incluir una capa de uno o más materiales tales como una capa de oro para facilitar, por ejemplo, la formación de una conexión eléctrica y/o la modificación de las propiedades eléctricas tales como resistencia de una parte del papel metalizado. Las dimensiones apropiadas para un sustrato pueden depender al menos en parte, de la resistencia deseada, la cantidad de fármaco dispuesto sobre el sustrato, la cantidad de energía necesario para vaporizar el fármaco dispuesto sobre el sustrato y/o las consideraciones de estabilidad mecánica.
Dispositivos de Administración
Como se muestra en la Figura 1A, existe una unidad de suministro de fármaco 130 que tiene un sustrato termoconductor 108 que comprende una pluralidad de orificios 132 que se extienden a través del mismo. Un revestimiento de composición 134 es al menos una parte de la superficie superior 134.
La Figura 1B proporciona una vista en corte y perspectiva de otra realización de la unidad 140 de suministro de fármaco. La unidad de suministro de fármaco comprende un sustrato cilíndrico 142. Este sustrato puede formarse a partir de un material termo-conductor, por ejemplo. El sustrato 142 incluye una pluralidad de orificios 144 que se extienden a través del mismo. Se reviste una capa fina de un fármaco (no mostrada) sobre la superficie externa 142. Como se muestra en la parte de corte, existe un elemento de calentamiento 146 dispuesto en el sustrato 142. El sustrato 142 puede ser hueco con un elemento de calentamiento insertado en el interior del espacio hueco, o sólido con un elemento de calentamiento incorporado en el sustrato. El flujo de gas "inferior" al interior del espacio hueco
12
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27

Claims (1)

  1. imagen1
ES08754883.0T 2007-03-09 2008-03-10 Unidad de calentamiento para usar en un dispositivo de administración de fármaco Active ES2594867T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89411607P 2007-03-09 2007-03-09
US894116P 2007-03-09
PCT/US2008/056452 WO2008112661A2 (en) 2007-03-09 2008-03-10 Heating unit for use in a drug delivery device

Publications (1)

Publication Number Publication Date
ES2594867T3 true ES2594867T3 (es) 2016-12-23

Family

ID=39740406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08754883.0T Active ES2594867T3 (es) 2007-03-09 2008-03-10 Unidad de calentamiento para usar en un dispositivo de administración de fármaco

Country Status (4)

Country Link
US (4) US20080216828A1 (es)
EP (1) EP2121088B1 (es)
ES (1) ES2594867T3 (es)
WO (1) WO2008112661A2 (es)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7550133B2 (en) * 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625336B9 (en) 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Use of a layer of solid fuel, method for producing such a layer and associated heating unit
EP1656171B9 (en) * 2003-08-04 2010-10-20 Alexza Pharmaceuticals, Inc. Substrates for drug delivery device and methods of preparing
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US9675109B2 (en) 2005-07-19 2017-06-13 J. T. International Sa Method and system for vaporization of a substance
US11647783B2 (en) 2005-07-19 2023-05-16 Juul Labs, Inc. Devices for vaporization of a substance
US20160345631A1 (en) 2005-07-19 2016-12-01 James Monsees Portable devices for generating an inhalable vapor
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8991402B2 (en) 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
US7834295B2 (en) 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
US20100300433A1 (en) * 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
EP2316286A1 (en) * 2009-10-29 2011-05-04 Philip Morris Products S.A. An electrically heated smoking system with improved heater
US10857311B2 (en) * 2010-01-12 2020-12-08 Omega Life Science Ltd. Method and apparatus for producing fine concentrated aerosol
AT509046B1 (de) 2010-03-10 2011-06-15 Helmut Dr Buchberger Flächiger verdampfer
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
PL2672847T3 (pl) 2011-02-11 2015-10-30 Batmark Ltd Część składowa inhalatora
EA028767B1 (ru) * 2011-08-16 2017-12-29 Пакс Лэбс, Инк. Низкотемпературное электронное устройство испарения
RU2606326C2 (ru) 2011-09-06 2017-01-10 Бритиш Америкэн Тобэкко (Инвестментс) Лимитед Нагревание курительного материала
EP2753200B1 (en) 2011-09-06 2017-12-27 British American Tobacco (Investments) Limited Heating smokeable material
GB201207054D0 (en) 2011-09-06 2012-06-06 British American Tobacco Co Heating smokeable material
PT3811800T (pt) 2011-09-06 2023-04-28 Nicoventures Trading Ltd Aquecimento de material fumável
KR101953201B1 (ko) 2011-09-06 2019-02-28 브리티시 아메리칸 토바코 (인베스트먼츠) 리미티드 가열식 흡연가능 재료
AT511344B1 (de) 2011-10-21 2012-11-15 Helmut Dr Buchberger Inhalatorkomponente
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2504076A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
GB2504074A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic cigarette
US10517530B2 (en) 2012-08-28 2019-12-31 Juul Labs, Inc. Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
US10638792B2 (en) 2013-03-15 2020-05-05 Juul Labs, Inc. Securely attaching cartridges for vaporizer devices
GB2513639A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513637A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
CA3208137A1 (en) 2013-05-06 2014-11-13 Juul Labs, Inc. Nicotine salt formulations for aerosol devices and methods thereof
GB2514893B (en) 2013-06-04 2017-12-06 Nicoventures Holdings Ltd Container
CN105473012B (zh) 2013-06-14 2020-06-19 尤尔实验室有限公司 电子汽化设备中的具有单独的可汽化材料的多个加热元件
GB201311620D0 (en) 2013-06-28 2013-08-14 British American Tobacco Co Devices Comprising a Heat Source Material and Activation Chambers for the Same
ES2821907T3 (es) 2013-07-11 2021-04-28 Alexza Pharmaceuticals Inc Sal de nicotina con ácido metasalicílico
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
UA120912C2 (uk) 2013-10-29 2020-03-10 Брітіш Амерікан Тобакко (Інвестментс) Лімітед Пристрій для нагрівання курильного матеріалу
EP3076805A4 (en) 2013-12-05 2017-10-11 PAX Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
PT3504991T (pt) 2013-12-23 2021-03-01 Juul Labs Int Inc Sistemas de dispositivo e métodos de vaporização
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US9549573B2 (en) 2013-12-23 2017-01-24 Pax Labs, Inc. Vaporization device systems and methods
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US9220294B2 (en) 2014-02-11 2015-12-29 Timothy McCullough Methods and devices using cannabis vapors
US10821240B2 (en) * 2014-02-11 2020-11-03 Vapor Cartridge Technology Llc Methods and drug delivery devices using cannabis
US9380813B2 (en) * 2014-02-11 2016-07-05 Timothy McCullough Drug delivery system and method
GB201407426D0 (en) 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
US11478021B2 (en) 2014-05-16 2022-10-25 Juul Labs, Inc. Systems and methods for aerosolizing a vaporizable material
GB201411483D0 (en) 2014-06-27 2014-08-13 Batmark Ltd Vaporizer Assembly
GB201500582D0 (en) 2015-01-14 2015-02-25 British American Tobacco Co Apparatus for heating or cooling a material contained therein
GB2528673B (en) 2014-07-25 2020-07-01 Nicoventures Holdings Ltd Aerosol provision system
WO2016090303A1 (en) 2014-12-05 2016-06-09 Pax Labs, Inc. Calibrated dose control
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201423318D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Cartridge for use with apparatus for heating smokable material
GB201423312D0 (en) * 2014-12-29 2015-02-11 British American Tobacco Co Heating device for apparatus for heating smokable material and method of manufacture
GB201423317D0 (en) 2014-12-29 2015-02-11 British American Tobacco Co Apparatus for heating smokable material
MX2017011613A (es) 2015-03-11 2018-04-10 Alexza Pharmaceuticals Inc Utilización de materiales antiestáticos en los conductos de aire para el proceso de aerosol de condensación térmica.
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
GB201511359D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic vapour provision system
GB201511358D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
DE202017007467U1 (de) 2016-02-11 2021-12-08 Juul Labs, Inc. Befüllbare Verdampferkartusche
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
CN109068735A (zh) 2016-04-27 2018-12-21 尼科创业控股有限公司 电子气溶胶供应系统及其蒸发器
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
GB201612945D0 (en) 2016-07-26 2016-09-07 British American Tobacco Investments Ltd Method of generating aerosol
US11660403B2 (en) 2016-09-22 2023-05-30 Juul Labs, Inc. Leak-resistant vaporizer device
EP4272827A3 (en) 2016-12-09 2024-01-24 Alexza Pharmaceuticals, Inc. Method of treating epilepsy
JP7166327B2 (ja) * 2017-03-15 2022-11-07 シーエスピー テクノロジーズ，インコーポレイティド 吸入器並びに吸入器を使用する方法及び製造する方法
GB201705152D0 (en) * 2017-03-30 2017-05-17 British American Tobacco Investments Ltd An article for use with an apparatus for heating an aerosol generating agent
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
JP2021511893A (ja) * 2018-02-02 2021-05-13 アレクザ・ファーマシューティカルズ・インコーポレイテッドＡｌｅｘｚａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 電気式凝縮エアロゾル装置
CN108414609B (zh) * 2018-02-05 2023-09-22 吉林大学 一种中药蒸制过程中营养成分变化过程的在线质谱检测装置
EP3809893A1 (en) 2018-06-07 2021-04-28 Juul Labs, Inc. Cartridges for vaporizer devices
MX2022003189A (es) 2019-09-16 2022-06-08 Vapor Cartridge Tech Llc Sistema de administración de fármacos con sustratos apilables.
CN111672000A (zh) * 2020-06-09 2020-09-18 青岛市中医医院(青岛市海慈医院、青岛市康复医学研究所) 一种中医儿科用雾化吸入装置
JP1714441S (ja) 2020-10-30 2022-05-10 喫煙用エアロゾル発生器
USD990765S1 (en) 2020-10-30 2023-06-27 Nicoventures Trading Limited Aerosol generator
JP1715888S (ja) 2020-10-30 2022-05-25 喫煙用エアロゾル発生器
JP1714443S (ja) 2020-10-30 2022-05-10 喫煙用エアロゾル発生器
JP1714440S (ja) 2020-10-30 2022-05-10 喫煙用エアロゾル発生器
JP1714442S (ja) 2020-10-30 2022-05-10 喫煙用エアロゾル発生器
AU2022258576A1 (en) * 2021-04-14 2023-11-02 Research Triangle Institute Hot porous-solid metering systems and methods for generation of therapeutic aerosols by evaporation/condensation
USD989384S1 (en) 2021-04-30 2023-06-13 Nicoventures Trading Limited Aerosol generator

Family Cites Families (624)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1803334A (en) 1931-05-05 Ootthujp lehmann
US2243669A (en) 1941-05-27 Electrical vaporizer
US3080624A (en) 1963-03-12 weber iii
US1864980A (en) 1932-06-28 Vapobizeb
US1239634A (en) 1916-07-25 1917-09-11 Frank J Stuart Medical appliance.
US1535486A (en) 1922-08-28 1925-04-28 James W Lundy Electric-lamp bulb
US1514682A (en) 1923-05-03 1924-11-11 Wilson Harold Electric vaporizer
US2086140A (en) 1933-09-08 1937-07-06 Silten Ernst Automatic temperature regulated narcosis apparatus
US2084299A (en) 1934-12-15 1937-06-15 Arthur G Borden Medicament holder for nasal inhalers
US2230753A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
US2230754A (en) 1937-02-15 1941-02-04 Bilhuber Corp E Unsaturated ethylamine derivatives
GB502761A (en) 1938-01-29 1939-03-24 Christopher Engelbreth Improvements in and relating to hand inhalation apparatus
US2309846A (en) 1941-03-06 1943-02-02 Holm Einar Marius Inhaler
FR921852A (fr) 1945-12-06 1947-05-21 Diffuseur de produits volatils
US2469656A (en) 1946-04-19 1949-05-10 Peter H Lienert Vaporizer
US2714649A (en) 1952-11-25 1955-08-02 Lyle H Critzer Vaporizer
US2761055A (en) 1953-06-10 1956-08-28 Malcome Van Ike Lamp-heated vaporizer
US2741812A (en) 1954-02-15 1956-04-17 Tellier Andre Perfume dispenser
US2902484A (en) 1954-04-27 1959-09-01 Rhone Poulenc Sa Phenthiazine derivatives and processes for their preparation
US2887106A (en) 1956-09-27 1959-05-19 Robinson Joseph Combined vaporizer and cover for medicament jar
US2898649A (en) 1956-11-19 1959-08-11 Elaine T Cassidy Perfume diffuser
US3161478A (en) 1959-05-29 1964-12-15 Horst Corp Of America V D Heat resistant porous structure
US3371085A (en) 1959-12-10 1968-02-27 Hoffmann La Roche 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
US3043977A (en) 1960-03-30 1962-07-10 Puritron Corp Device and method for producing negative ions
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB903866A (en) 1961-05-09 1962-08-22 Dausse Lab Therapeutic preparations containing 7-substituted theophylline derivatives
NL135583C (es) 1961-10-10
US3299185A (en) 1962-09-27 1967-01-17 Ube Nitto Kasei Co Dyeable polyolefin fibers containing a binary copolymer of styrene and acrylonitrile
US3169095A (en) 1962-10-30 1965-02-09 Rexall Drug Chemical Self-propelling powder-dispensing compositions
NL289785A (es) 1962-11-29
GB1063512A (en) 1962-11-30 1967-03-30 Benger Lab Ltd Aerosols
US3282729A (en) 1963-02-27 1966-11-01 Union Carbide Corp Barrier coated thermoplastic olefin polymer substrates
US3200819A (en) 1963-04-17 1965-08-17 Herbert A Gilbert Smokeless non-tobacco cigarette
NL298071A (es) 1963-06-04
AT258912B (de) 1964-05-27 1967-12-27 Wander Ag Dr A Verfahren zur Herstellung neuer 11-basisch substituierter Dibenz [b,f] [1,4]oxazepine
IL26896A (en) 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US3909463A (en) 1968-11-29 1975-09-30 Allied Chem Grafted block copolymers of synthetic rubbers and polyolefins
US3987052A (en) 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US4008723A (en) 1970-03-23 1977-02-22 Imperial Chemical Industries Limited Smoking mixture
US3773955A (en) 1970-08-03 1973-11-20 Bristol Myers Co Analgetic compositions
US3831606A (en) 1971-02-19 1974-08-27 Alza Corp Auto inhaler
US3847650A (en) 1971-09-09 1974-11-12 Airco Inc Flashlamp with improved combustion foil and method of making same
US3749547A (en) 1971-09-09 1973-07-31 Airco Inc Flashlamp with improved combustible foil
US4166087A (en) 1971-11-22 1979-08-28 Cline-Buckner, Inc. Automatic intermittent vapor dispenser
US3701782A (en) 1972-02-10 1972-10-31 Upjohn Co 1-carbolower alkoxy - 6 - phenyl-4h-s-triazolo(1,4)benzodiazepine compounds
US3763347A (en) 1972-04-13 1973-10-02 Ncr Co Vaporous lamp
IE37524B1 (en) 1972-04-20 1977-08-17 Gallaher Ltd Synthetic smoking product
US3864326A (en) 1972-05-22 1975-02-04 Robert S Babington Spraying devices, in particular nebulizing devices
USRE30285E (en) 1972-05-22 1980-05-27 Spraying devices, in particular nebulizing devices
GB1366041A (en) 1972-07-21 1974-09-11 Kodama Bros Co Ltd Device for volatilizing insecticides and the like
US3949743A (en) 1973-03-19 1976-04-13 Schick Incorporated Medicated vapor production method and apparatus
US3930796A (en) 1973-09-13 1976-01-06 Universal Oil Products Company Catalytic fume control device
US3982095A (en) 1973-10-04 1976-09-21 Searle Cardio-Pulmonary Systems Inc. Respiratory humidifier
US3882323A (en) 1973-12-17 1975-05-06 Us Navy Method and apparatus for protecting sensitive information contained in thin-film microelectonic circuitry
US3971377A (en) 1974-06-10 1976-07-27 Alza Corporation Medicament dispensing process for inhalation therapy
US3894040A (en) 1974-09-16 1975-07-08 American Home Prod 2,5,6,7-Tetrahydro-3H-imidazo(1,2-D)(1,4)benzodiazepine-5,6-dicarboxylic acid esters
US4045156A (en) 1974-12-23 1977-08-30 Gte Sylvania Incorporated Photoflash lamp
US4020379A (en) 1975-10-02 1977-04-26 Eg&G, Inc. Bulb-shaped flashtube with metal envelope
US4104210A (en) 1975-12-17 1978-08-01 Monsanto Company Thermoplastic compositions of high unsaturation diene rubber and polyolefin resin
US4121583A (en) 1976-07-13 1978-10-24 Wen Yuan Chen Method and apparatus for alleviating asthma attacks
US4286604A (en) 1976-10-05 1981-09-01 Gallaher Limited Smoking materials
US4079742A (en) 1976-10-20 1978-03-21 Philip Morris Incorporated Process for the manufacture of synthetic smoking materials
US4160765A (en) 1976-11-17 1979-07-10 Smithkline Corporation Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4141369A (en) 1977-01-24 1979-02-27 Burruss Robert P Noncombustion system for the utilization of tobacco and other smoking materials
US4184099A (en) 1977-04-27 1980-01-15 International Flavors & Fragrances Inc. Composition for slow release of volatile ingredients at _high temperature; and article comprising same
DE2752384A1 (de) 1977-08-29 1979-03-15 Simes Pharmazeutisches praeparat auf der basis beklemmungsloesender mittel und hemmstoffe der beta-adrenergischen rezeptoren
CA1107584A (en) 1977-10-27 1981-08-25 William V. Youdelis Process for surface coating alloys to enhance corrosion resistance
US4189200A (en) 1977-11-14 1980-02-19 Amp Incorporated Sequentially actuated zero insertion force printed circuit board connector
SE7812207L (sv) 1977-12-01 1979-06-02 Welsh Nat School Med Apparat, forfarande och framstellda produkter for anvendning vid administration av antihistaminer
US4183912A (en) 1978-01-16 1980-01-15 American Home Products Corporation Inhalation therapy for relieving bronchial spasm using quaternary salts of promethazine
JPS54120065A (en) 1978-02-24 1979-09-18 Osaka Takeshi Stick for blind person
US4198200A (en) 1978-05-18 1980-04-15 Lord Corporation Damage-preventive coatings
US4284089A (en) 1978-10-02 1981-08-18 Ray Jon P Simulated smoking device
JPS5563397A (en) 1978-10-31 1980-05-13 Mitsubishi Electric Corp Manufacture of bolling heat transmission surface
US4276243A (en) 1978-12-08 1981-06-30 Western Electric Company, Inc. Vapor delivery control system and method
US4280629A (en) 1979-01-08 1981-07-28 Anchor Brush Company, Inc. Container for nail polish or the like
US4219031A (en) 1979-03-05 1980-08-26 Philip Morris Incorporated Smoking product having core of fibrillar carbonized matter
US4229931A (en) 1979-03-05 1980-10-28 Deere & Company Hydraulic height sensing system with cylinder by-pass
IL59407A (en) 1979-03-06 1983-12-30 Sanofi Sa Di-n-propylacetic acid diesters of glycerol,their preparation and pharmaceutical compositions containing them
US4654370A (en) 1979-03-12 1987-03-31 Abbott Laboratories Glyceryl valproates
US4251525A (en) 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4419650A (en) * 1979-08-23 1983-12-06 Georgina Chrystall Hirtle Liquid contact relay incorporating gas-containing finely reticular solid motor element for moving conductive liquid
WO1981000903A1 (en) 1979-09-29 1981-04-02 Matsushita Electric Ind Co Ltd Vapor generator
US4340072A (en) 1979-11-16 1982-07-20 Imperial Group Limited Smokeable device
ATE3774T1 (de) 1980-05-02 1983-06-15 Schering Corporation Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung.
US4391285A (en) 1980-05-09 1983-07-05 Philip Morris, Incorporated Smoking article
US4347855A (en) 1980-07-23 1982-09-07 Philip Morris Incorporated Method of making smoking articles
US4303083A (en) 1980-10-10 1981-12-01 Burruss Jr Robert P Device for evaporation and inhalation of volatile compounds and medications
US4376767A (en) 1981-01-02 1983-03-15 Merck & Co., Inc. Pyridylmethyl esters of selected bio-affecting carboxylic acids
US4346059A (en) 1981-03-03 1982-08-24 Donald Spector Aroma-generating lamp structure
DE3116951C2 (de) 1981-04-29 1984-12-20 Drägerwerk AG, 2400 Lübeck Vorrichtung zur Beimischung flüssiger Narkosemittel in das dem Patienten zuzuführende Atemgas
US4484577A (en) * 1981-07-23 1984-11-27 Key Pharmaceuticals, Inc. Drug delivery method and inhalation device therefor
JPS5876038A (ja) 1981-10-28 1983-05-09 高森　正之 殺虫剤や芳香剤の蒸発装置
US4935073A (en) 1981-11-27 1990-06-19 Sri International Process for applying coatings of zirconium and/or titantuim and a less noble metal to metal substrates and for converting the zirconium and/or titanium to an oxide, nitride, carbide, boride or silicide
US4617232A (en) 1982-04-15 1986-10-14 Kennecott Corporation Corrosion and wear resistant graphite material
GB2122903B (en) 1982-06-22 1986-11-05 Masayuki Takamori Vaporizers for vaporisable substances and support media for substances usable therewith
DE3224849A1 (de) 1982-07-02 1984-01-05 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Dampfinhaliergeraet
US4556539A (en) 1982-08-27 1985-12-03 Donald Spector Disc-playing aroma generator
US4508726A (en) 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
US4474191A (en) 1982-09-30 1984-10-02 Steiner Pierre G Tar-free smoking devices
GB2147216B (en) 1982-09-30 1987-03-04 Dainippon Jochugiku Kk Apparatus for heat-volatilizing medicinal agent
US5082668A (en) 1983-05-11 1992-01-21 Alza Corporation Controlled-release system with constant pushing source
US4753758A (en) 1983-05-19 1988-06-28 Intertech Resources Inc. Respiratory humidifier
DE3320441A1 (de) 1983-06-06 1984-12-06 Siemens AG, 1000 Berlin und 8000 München Mit fluessigkeitstroepfchen arbeitendes schreibgeraet mit an beiden enden starr mit einer duesenplatte verbundenen stabfoermigen piezoelektrischen wandlern
US4523589A (en) 1983-06-29 1985-06-18 Krauser Robert S Method and apparatus for treating ailments
US5038769A (en) 1983-06-29 1991-08-13 Krauser Robert S Method and apparatus for treating ailments
DE3326089A1 (de) 1983-07-20 1985-02-07 Gödecke AG, 1000 Berlin Zur inhalation bestimmte darreichungsform von calcium-antagonisten
DE133795T1 (de) 1983-08-01 1985-09-12 The Mclean Hospital Corp., Belmont, Mass. Gaba-ester und gaba-analoge ester.
US4588721A (en) 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
ATE44470T1 (de) 1983-11-08 1989-07-15 Bunnell Life Systems Inc Befeuchter, insbesondere fuer atmungshilfesysteme.
GB8405190D0 (en) 1984-02-28 1984-04-04 British Petroleum Co Plc Thermoplastic elastomer composition
US4627963A (en) 1984-02-29 1986-12-09 Lad Technology, Inc. Heat activated dispenser and method of dispensing a vapor therefrom
US4683231A (en) 1984-03-02 1987-07-28 Research Foundation For Mental Hygiene, Inc. Method of preventing withdrawal symptoms associated with the cessation or reduction of tobacco smoking
US4963367A (en) 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4647428A (en) 1984-06-04 1987-03-03 Gyulay Joseph M Air freshener method
US4755508A (en) 1984-06-26 1988-07-05 Merck & Co., Inc. Benzodiazepine analogs and use as antogonists of gastrin and cholecystokinin
US5020548A (en) 1985-08-26 1991-06-04 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US5042509A (en) 1984-09-14 1991-08-27 R. J. Reynolds Tobacco Company Method for making aerosol generating cartridge
US5067499A (en) 1984-09-14 1991-11-26 R. J. Reynolds Tobacco Company Smoking article
US4793365A (en) 1984-09-14 1988-12-27 R. J. Reynolds Tobacco Company Smoking article
US4854331A (en) 1984-09-14 1989-08-08 R. J. Reynolds Tobacco Company Smoking article
US4647433A (en) 1984-10-01 1987-03-03 Donald Spector Long-life aroma-generating capsule
CN1018607B (zh) 1984-12-21 1992-10-14 美国耳·杰·瑞诺兹烟草公司 吸烟制品
GB8501015D0 (en) 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
US4928714A (en) 1985-04-15 1990-05-29 R. J. Reynolds Tobacco Company Smoking article with embedded substrate
US5119834A (en) 1985-04-15 1992-06-09 R. J. Reynolds Tobacco Company Smoking article with improved substrate
WO1986006959A1 (en) 1985-05-22 1986-12-04 Liposome Technology, Inc. Liposome inhalation method and system
US4800903A (en) 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
US4722334A (en) 1985-07-16 1988-02-02 Transpirator Technologies, Inc. Method and apparatus for pulmonary and cardiovascular conditioning of racehorses and competition animals
US4989619A (en) * 1985-08-26 1991-02-05 R. J. Reynolds Tobacco Company Smoking article with improved fuel element
US5105831A (en) 1985-10-23 1992-04-21 R. J. Reynolds Tobacco Company Smoking article with conductive aerosol chamber
US4756318A (en) 1985-10-28 1988-07-12 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US5033483A (en) 1985-10-28 1991-07-23 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US5060666A (en) 1985-10-28 1991-10-29 R. J. Reynolds Tobacco Company Smoking article with tobacco jacket
US4793366A (en) * 1985-11-12 1988-12-27 Hill Ira D Nicotine dispensing device and methods of making the same
JPS62204756A (ja) 1986-03-04 1987-09-09 大研医工株式会社 薬剤揮散方法および装置
US4863720A (en) 1986-03-10 1989-09-05 Walter Burghart Pharmaceutical preparation and methods for its production
US4708151A (en) 1986-03-14 1987-11-24 R. J. Reynolds Tobacco Company Pipe with replaceable cartridge
US4765347A (en) 1986-05-09 1988-08-23 R. J. Reynolds Tobacco Company Aerosol flavor delivery system
US4771795A (en) 1986-05-15 1988-09-20 R. J. Reynolds Tobacco Company Smoking article with dual burn rate fuel element
US4917120A (en) 1986-05-21 1990-04-17 Advanced Tobacco Products, Inc. Nicotine impact modification
US4774971A (en) 1986-06-03 1988-10-04 Vieten Michael J Cigarette substitute
US4801411A (en) 1986-06-05 1989-01-31 Southwest Research Institute Method and apparatus for producing monosize ceramic particles
US4735217A (en) 1986-08-21 1988-04-05 The Procter & Gamble Company Dosing device to provide vaporized medicament to the lungs as a fine aerosol
US4858630A (en) 1986-12-08 1989-08-22 R. J. Reynolds Tobacco Company Smoking article with improved aerosol forming substrate
IE873108L (en) 1986-12-12 1988-06-12 Huels Chemische Werke Ag Impact modifying agent for use with smoking articles
US4734560A (en) 1987-01-20 1988-03-29 Medical Enterprises, Ltd. Vaporizing unit
US4819665A (en) 1987-01-23 1989-04-11 R. J. Reynolds Tobacco Company Aerosol delivery article
US4968885A (en) 1987-03-06 1990-11-06 Extrel Corporation Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors
US4924883A (en) 1987-03-06 1990-05-15 R. J. Reynolds Tobacco Company Smoking article
HU201685B (en) 1987-04-23 1990-12-28 Chinoin Gyogyszer Es Vegyeszet For producing pharmaceutical compositions for inhalation and compositions for scenting air containing volatile active component in cyclodextrine inclusion, and air-scenting composition
US4889850A (en) 1987-05-11 1989-12-26 Thornfeldt Carl R Treatment of colic and teething
US5017575A (en) 1987-06-09 1991-05-21 Golwyn Daniel H Treatment of immunologically based disorders, specifically Crohn's disease
GB8713645D0 (en) 1987-06-11 1987-07-15 Imp Tobacco Ltd Smoking device
US5019122A (en) 1987-08-21 1991-05-28 R. J. Reynolds Tobacco Company Smoking article with an enclosed heat conductive capsule containing an aerosol forming substance
US4935624A (en) 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
US5072726A (en) 1987-10-09 1991-12-17 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vaporizer for inhalation anesthetics during high-frequency jet ventilation and associated method
US4911157A (en) 1988-01-07 1990-03-27 Pegasus Research Corporation Self-regulating, heated nebulizer system
US4906417A (en) 1988-02-08 1990-03-06 Associated Mills Inc. Humidifier
US4853517A (en) 1988-03-28 1989-08-01 John G. Bowen Vaporizing unit
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5137034A (en) 1988-05-16 1992-08-11 R. J. Reynolds Tobacco Company Smoking article with improved means for delivering flavorants
US4881556A (en) 1988-06-06 1989-11-21 R. J. Reynolds Tobacco Company Low CO smoking article
US5264433A (en) 1988-07-07 1993-11-23 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
CH678151A5 (en) 1988-07-13 1991-08-15 Heinz Hermann Weick Self-medication nasal dispenser
US5345951A (en) 1988-07-22 1994-09-13 Philip Morris Incorporated Smoking article
US4852561A (en) 1988-07-27 1989-08-01 Sperry C R Inhalation device
US4947874A (en) * 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Smoking articles utilizing electrical energy
US4947875A (en) * 1988-09-08 1990-08-14 R. J. Reynolds Tobacco Company Flavor delivery articles utilizing electrical energy
US4922901A (en) * 1988-09-08 1990-05-08 R. J. Reynolds Tobacco Company Drug delivery articles utilizing electrical energy
EP0358114A3 (en) 1988-09-08 1990-11-14 R.J. Reynolds Tobacco Company Aerosol delivery articles utilizing electrical energy
US4950664A (en) 1988-09-16 1990-08-21 Rugby-Darby Group Companies, Inc. Nasal administration of benzodiazepine hypnotics
USRE36744E (en) 1988-09-16 2000-06-20 Ribogene, Inc. Nasal administration of benzodiazepine hypnotics
US4963289A (en) 1988-09-19 1990-10-16 The United States Of America As Represented By The United States Department Of Energy Method for producing monodisperse aerosols
US4917830A (en) 1988-09-19 1990-04-17 The United States Of America As Represented By The United States Department Of Energy Monodisperse aerosol generator
US5511726A (en) 1988-09-23 1996-04-30 Battelle Memorial Institute Nebulizer device
HU200105B (en) 1988-10-04 1990-04-28 Ferenc Inkovics Electrically actuated inhaler of uniform medicine feeding
US4984158A (en) 1988-10-14 1991-01-08 Hillsman Dean Metered dose inhaler biofeedback training and evaluation system
US4917119A (en) 1988-11-30 1990-04-17 R. J. Reynolds Tobacco Company Drug delivery article
US4906476A (en) 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US4959380A (en) 1988-12-19 1990-09-25 Wilson Jordan E Method of treating people to stop smoking and composition
US4881541A (en) 1988-12-21 1989-11-21 The Regents Of The University Of California Vaporizer for an anesthetic having a vapor pressure about one atmosphere
GB8900267D0 (en) 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US4892109A (en) 1989-03-08 1990-01-09 Brown & Williamson Tobacco Corporation Simulated smoking article
DE3908161A1 (de) 1989-03-13 1990-09-27 Bat Cigarettenfab Gmbh Rauchbarer artikel
GB8909891D0 (en) 1989-04-28 1989-06-14 Riker Laboratories Inc Device
JPH05501505A (ja) 1989-04-28 1993-03-25 ライカー　ラボラトリーズ，インコーポレイティド 乾燥粉末吸入装置
US5240922A (en) 1989-05-05 1993-08-31 Northern Sydney Area Health Service Fertility enhancement
US5496359A (en) 1989-07-25 1996-03-05 Smith & Nephew Richards, Inc. Zirconium oxide and zirconium nitride coated biocompatible leads
US4941483A (en) 1989-09-18 1990-07-17 R. J. Reynolds Tobacco Company Aerosol delivery article
US6048857A (en) 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6313176B1 (en) 1989-10-17 2001-11-06 Everett J. Ellinwood, Jr. Dosing method of administering deprenyl via intraoral administration or inhalation administration
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5093894A (en) 1989-12-01 1992-03-03 Philip Morris Incorporated Electrically-powered linear heating element
US5224498A (en) * 1989-12-01 1993-07-06 Philip Morris Incorporated Electrically-powered heating element
US5144962A (en) 1989-12-01 1992-09-08 Philip Morris Incorporated Flavor-delivery article
US5269327A (en) 1989-12-01 1993-12-14 Philip Morris Incorporated Electrical smoking article
US5060671A (en) 1989-12-01 1991-10-29 Philip Morris Incorporated Flavor generating article
US5408574A (en) 1989-12-01 1995-04-18 Philip Morris Incorporated Flat ceramic heater having discrete heating zones
CA2070823C (en) 1989-12-05 1999-01-12 William H. Ii Frey Neurologic agents for nasal administration to the brain
US5109180A (en) 1989-12-14 1992-04-28 Phillips Petroleum Company Apparatus providing a shatter-resistant electric lamp
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
GB9000042D0 (en) 1990-01-03 1990-03-07 Ralph John F Decorative wall covering applied to steel radiators
GB2239807A (en) 1990-01-09 1991-07-17 Boc Group Plc Anaesthetic vaporiser
US5376386A (en) 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
US5156170A (en) 1990-02-27 1992-10-20 R. J. Reynolds Tobacco Company Cigarette
US5099861A (en) 1990-02-27 1992-03-31 R. J. Reynolds Tobacco Company Aerosol delivery article
US5118494A (en) 1990-03-23 1992-06-02 Minnesota Mining And Manufacturing Company Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
US5366770A (en) 1990-04-17 1994-11-22 Xingwu Wang Aerosol-plasma deposition of films for electronic cells
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5192548A (en) 1990-04-30 1993-03-09 Riker Laboratoires, Inc. Device
IL98392A (en) 1990-06-07 1996-01-19 Wellcome Found History of indole, their preparation and the pharmaceutical preparations containing them
SE9002052D0 (sv) 1990-06-08 1990-06-08 Pharmacia Ab Smoking composition
US5167242A (en) 1990-06-08 1992-12-01 Kabi Pharmacia Aktiebolaq Nicotine-impermeable container and method of fabricating the same
US5455043A (en) 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5126123A (en) 1990-06-28 1992-06-30 Glaxo, Inc. Aerosol drug formulations
DE69110785T3 (de) 1990-08-02 2002-05-23 Boc Group Plc Narkosemittelverdampfer.
US5060667A (en) 1990-08-16 1991-10-29 Brown & Williamson Tobacco Corporation Smoking article
US5292499A (en) 1990-09-11 1994-03-08 University Of Wales College Of Cardiff Method of preparing medical aerosol formulations including drug dissolved in reverse micelles
US5166202A (en) 1990-09-19 1992-11-24 Trustees Of The University Of Pennsylvania Method for the treatment of panic disorder
US5175152A (en) 1990-09-28 1992-12-29 Singh Nikhilesh N Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form
NO904226D0 (no) 1990-09-28 1990-09-28 Forsvarets Forsknings Fukteanordning.
US5179966A (en) 1990-11-19 1993-01-19 Philip Morris Incorporated Flavor generating article
US5095921A (en) 1990-11-19 1992-03-17 Philip Morris Incorporated Flavor generating article
US5519019A (en) 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU219778B (hu) 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
FR2671487B1 (fr) 1991-01-14 1993-03-19 Oreal Utilisation d'un facteur de croissance dans une composition amincissante.
ATE179605T1 (de) 1991-02-09 1999-05-15 B S D Bio Science Dev Snc Di O Antireaktive antiasthmatische wirkung von acetylsalicylsäure durch inhalation
AU6130594A (en) 1991-03-05 1994-08-15 Miris Medical Corporation Method and device for correcting the drift offset of a pressure sensor of a flowmeter
US5404871A (en) 1991-03-05 1995-04-11 Aradigm Delivery of aerosol medications for inspiration
US5394866A (en) 1991-03-05 1995-03-07 Aradigm Corporation Automatic aerosol medication delivery system and methods
US5226411A (en) 1991-03-07 1993-07-13 Walter Levine Aerosol nebulizer heater
US5249586A (en) 1991-03-11 1993-10-05 Philip Morris Incorporated Electrical smoking
US5479948A (en) 1993-08-10 1996-01-02 Philip Morris Incorporated Electrical smoking article having continuous tobacco flavor web and flavor cassette therefor
US5505214A (en) 1991-03-11 1996-04-09 Philip Morris Incorporated Electrical smoking article and method for making same
US5186164A (en) 1991-03-15 1993-02-16 Puthalath Raghuprasad Mist inhaler
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5817656A (en) 1991-04-23 1998-10-06 Eli Lilly And Company Mental disorders
US5627178A (en) 1991-04-23 1997-05-06 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5605897A (en) 1991-04-23 1997-02-25 Eli Lilly And Company 2-methyl-thieno-benzodiazepine
US5164740A (en) 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
US5938117A (en) * 1991-04-24 1999-08-17 Aerogen, Inc. Methods and apparatus for dispensing liquids as an atomized spray
GB9109021D0 (en) 1991-04-26 1991-06-12 Boc Group Plc Dosing pump
GB9109442D0 (en) 1991-05-01 1991-06-26 Volex Group Plc Apparatus for emitting a chemical agent
US5160664A (en) 1991-05-31 1992-11-03 Msp Corporation High output monodisperse aerosol generator
US5261424A (en) 1991-05-31 1993-11-16 Philip Morris Incorporated Control device for flavor-generating article
US5149538A (en) 1991-06-14 1992-09-22 Warner-Lambert Company Misuse-resistive transdermal opioid dosage form
US5177071A (en) 1991-06-17 1993-01-05 Merck & Co., Inc. 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
US5285798A (en) 1991-06-28 1994-02-15 R. J. Reynolds Tobacco Company Tobacco smoking article with electrochemical heat source
CA2069687A1 (en) 1991-06-28 1992-12-29 Chandra Kumar Banerjee Tobacco smoking article with electrochemical heat source
US5457100A (en) 1991-12-02 1995-10-10 Daniel; David G. Method for treatment of recurrent paroxysmal neuropsychiatric
WO1993010910A1 (en) * 1991-12-04 1993-06-10 The Technology Partnership Limited Fluid droplet production apparatus and method
AU3152993A (en) 1991-12-16 1993-07-19 University Of Melbourne, The Improvements in the administration of aerosol compounds
US5363842A (en) 1991-12-20 1994-11-15 Circadian, Inc. Intelligent inhaler providing feedback to both patient and medical professional
GB9200047D0 (en) 1992-01-03 1992-02-26 Univ Alberta Nicotine-containing nasal spray
US5229120A (en) 1992-02-05 1993-07-20 Devincent James F Treatment for cocaine abuse
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
DK64592D0 (da) 1992-05-14 1992-05-14 Carlbiotech Ltd As Peptider til terapeutisk behandling
US5397652A (en) 1992-03-27 1995-03-14 The Louis Berkman Company Corrosion resistant, colored stainless steel and method of making same
US5318033A (en) 1992-04-17 1994-06-07 Hewlett-Packard Company Method and apparatus for increasing the frame rate and resolution of a phased array imaging system
US5554646A (en) * 1992-04-29 1996-09-10 Wisconsin Alumni Research Foundation Method for reducing body fat in animals
US5584701A (en) 1992-05-13 1996-12-17 University Of Florida Research Foundation, Incorporated Self regulating lung for simulated medical procedures
US5391081A (en) 1992-05-13 1995-02-21 University Of Florida Research Foundation, Incorporated Method and apparatus for simulating neuromuscular stimulation during medical surgery
US5525329A (en) 1992-05-21 1996-06-11 The Johns Hopkins University Inhibition of phosphodiesterase in olfactory mucosa
CA2115444C (en) 1992-06-12 2000-10-03 Yuji Makino Preparation for intratracheobronchial administration
US5622944A (en) 1992-06-12 1997-04-22 Affymax Technologies N.V. Testosterone prodrugs for improved drug delivery
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5284133A (en) 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
US5322075A (en) 1992-09-10 1994-06-21 Philip Morris Incorporated Heater for an electric flavor-generating article
US5613505A (en) 1992-09-11 1997-03-25 Philip Morris Incorporated Inductive heating systems for smoking articles
US5369723A (en) 1992-09-11 1994-11-29 Philip Morris Incorporated Tobacco flavor unit for electrical smoking article comprising fibrous mat
US5333106A (en) 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
AU5358694A (en) 1992-10-28 1994-05-24 Charles A. Rosen Method and devices for delivering drugs by inhalation
US5743250A (en) 1993-01-29 1998-04-28 Aradigm Corporation Insulin delivery enhanced by coached breathing
US5888477A (en) 1993-01-29 1999-03-30 Aradigm Corporation Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
US5507277A (en) * 1993-01-29 1996-04-16 Aradigm Corporation Lockout device for controlled release of drug from patient-activateddispenser
US6098620A (en) 1993-01-29 2000-08-08 Aradigm Corporation Device for aerosolizing narcotics
US5934272A (en) * 1993-01-29 1999-08-10 Aradigm Corporation Device and method of creating aerosolized mist of respiratory drug
US5915378A (en) * 1993-01-29 1999-06-29 Aradigm Corporation Creating an aerosolized formulation of insulin
US5694919A (en) * 1993-01-29 1997-12-09 Aradigm Corporation Lockout device for controlled release of drug from patient-activated dispenser
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US6024090A (en) 1993-01-29 2000-02-15 Aradigm Corporation Method of treating a diabetic patient by aerosolized administration of insulin lispro
US5558085A (en) * 1993-01-29 1996-09-24 Aradigm Corporation Intrapulmonary delivery of peptide drugs
US5724957A (en) 1993-01-29 1998-03-10 Aradigm Corporation Intrapulmonary delivery of narcotics
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5970973A (en) 1993-01-29 1999-10-26 Aradigm Corporation Method of delivering insulin lispro
US5372148A (en) 1993-02-24 1994-12-13 Philip Morris Incorporated Method and apparatus for controlling the supply of energy to a heating load in a smoking article
US5468936A (en) 1993-03-23 1995-11-21 Philip Morris Incorporated Heater having a multiple-layer ceramic substrate and method of fabrication
GB9310412D0 (en) 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5497763A (en) 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
CN1082365A (zh) 1993-05-25 1994-02-23 潘昆年 营养保健香烟
US6521187B1 (en) 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates
EP0705115A1 (de) 1993-06-03 1996-04-10 von Schrader, Barthold Inhalationseinrichtung
US5666977A (en) 1993-06-10 1997-09-16 Philip Morris Incorporated Electrical smoking article using liquid tobacco flavor medium delivery system
BR9406968A (pt) 1993-06-29 1996-08-06 Voges Innovation Pty Ltd Dispensador
US5388574A (en) 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
DE4328243C1 (de) 1993-08-19 1995-03-09 Sven Mielordt Rauch- oder Inhalationsvorrichtung
US5456247A (en) 1993-08-26 1995-10-10 Iowa State University Research Foundation, Inc. Method for delivering drugs soluble in a vaporization vehicle
US5462740A (en) 1993-09-17 1995-10-31 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
US5400969A (en) 1993-09-20 1995-03-28 Keene; Christopher M. Liquid vaporizer and diffuser
SE9303574D0 (sv) 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
JP2574120B2 (ja) 1993-11-10 1997-01-22 パラマウントベッド株式会社 褥瘡防止用低圧エアパッド
FI98270C (fi) 1993-11-29 1997-05-26 Instrumentarium Oy Menetelmä ja sovitelma anesteetin höyrystämisen yhteydessä
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
GB9401894D0 (en) 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
US5543434A (en) 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
US5522008A (en) 1994-03-16 1996-05-28 Bernard; Costello J. Device for heating and vaporizing a vaporizable module
US5451408A (en) 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
CA2189351C (en) 1994-05-13 2008-12-30 Stephen J. Farr Narcotic containing aerosol formulation
US5457101A (en) 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
MA23588A1 (fr) 1994-06-23 1995-12-31 Procter & Gamble Traitement du besoin en nicotine et/ou du syndrome de manque lie au tabagisme
AU2702795A (en) 1994-06-23 1996-01-19 Procter & Gamble Company, The Treatment of nicotine craving and/or smoking withdrawal symptoms with a solid or semi-solid composition containing nicotine and caffeine or xanthine, especially for nasal administration
MA23587A1 (fr) 1994-06-23 1995-12-31 Procter & Gamble Traitement du besoin en nicotine et/ou du syndrome de manque lie au tabagisme
CA2152684A1 (en) 1994-07-01 1996-01-02 Richard Anthony Henry Aerosol delivery of midazolam
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
US5456677A (en) 1994-08-22 1995-10-10 Spector; John E. Method for oral spray administration of caffeine
JPH10504825A (ja) 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
CN1039506C (zh) 1994-09-12 1998-08-12 宝山钢铁(集团)公司 室内空间静电防治和泄漏方法
WO1996009994A1 (en) 1994-09-26 1996-04-04 E.R. Squibb & Sons, Inc. Stainless steel alkali treatment
US5522385A (en) 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5537507A (en) 1994-09-28 1996-07-16 Advanced Ceramics Corporation Coated flash evaporator heater
WO1996010663A1 (en) 1994-09-30 1996-04-11 M & J Fibretech A/S A plant and a process for dry-producing a web-formed product
AU3745795A (en) 1994-10-14 1996-05-06 Glaxo Wellcome S.P.A. Use of CCK-B receptor antagonists for the treatment of sleepdisorders
EP0788387A4 (en) 1994-10-28 1998-07-08 Aradigm Corp DEVICE AND METHOD FOR PRODUCING AEROSOL MIST FOR BREATHABLE MEDICINE
US5767117A (en) 1994-11-18 1998-06-16 The General Hospital Corporation Method for treating vascular headaches
US5540959A (en) 1995-02-21 1996-07-30 Howard J. Greenwald Process for preparing a coated substrate
EP0810853B1 (en) 1995-02-24 2004-08-25 Elan Pharma International Limited Aerosols containing nanoparticle dispersions
US5747001A (en) 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
DE19507410C2 (de) 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Herstellung von Aerosolen
US5641938A (en) 1995-03-03 1997-06-24 Primex Technologies, Inc. Thermally stable gas generating composition
US5565148A (en) 1995-03-16 1996-10-15 Minnesota Mining And Manufacturing Company Device for selectively providing a multiplicity of aromas
JPH11502845A (ja) 1995-03-31 1999-03-09 アラディグム コーポレーション 造血剤の肺内輸送
US5586550A (en) 1995-08-31 1996-12-24 Fluid Propulsion Technologies, Inc. Apparatus and methods for the delivery of therapeutic liquids to the respiratory system
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
US5612053A (en) 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
CA2217950C (en) 1995-04-14 2001-12-25 Glaxo Wellcome Inc. Metered dose inhaler for albuterol
CA2218179A1 (en) 1995-04-14 1996-10-17 Glaxo Wellcome Inc. Metered dose inhaler for beclomethasone dipropionate
US6258341B1 (en) 1995-04-14 2001-07-10 Inhale Therapeutic Systems, Inc. Stable glassy state powder formulations
AP979A (en) 1995-04-14 2001-06-28 Glaxo Wellcome Inc Metered dose imhaler for salmeterol.
US5725756A (en) 1995-04-18 1998-03-10 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts with supercritical reaction media
US5690809A (en) 1995-04-18 1997-11-25 Center For Research, Inc. In situ mitigation of coke buildup in porous catalysts by pretreatment of hydrocarbon feed to reduce peroxides and oxygen impurities
US5776928A (en) 1995-04-21 1998-07-07 Eli Lilly And Company Method for treating dyskinesias with olanzapine
FR2733594B1 (fr) 1995-04-28 1997-06-06 France Etat Dispositif pour le prelevement de substances gazeuses, de liquides, d'aerosols ou meme de matieres pulverulents, en vue de leur analyse in situ
US5809997A (en) 1995-05-18 1998-09-22 Medtrac Technologies, Inc. Electronic medication chronolog device
WO2000066106A2 (en) 1999-04-30 2000-11-09 The Regents Of The University Of Michigan Use of benzodiazepines for treating autoimmune diseases induced by apoptosis
DE19519056A1 (de) 1995-05-24 1997-01-16 Klinge Co Chem Pharm Fab Verwendung von Antidepressiva zur Behandlung von Asthma und/oder Atemwegserkrankungen mittels inhalatorischer Applikation
US5874481A (en) 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
GB9512708D0 (en) 1995-06-22 1995-08-23 Reckitt & Colman Inc Improvements in or relating to organic compounds
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US6209538B1 (en) 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5591409A (en) 1995-08-15 1997-01-07 Watkins; Carl J. Providing aromas
SE9503141D0 (sv) 1995-09-12 1995-09-12 Siemens Elema Ab Narkosapparat
US5649554A (en) 1995-10-16 1997-07-22 Philip Morris Incorporated Electrical lighter with a rotatable tobacco supply
US6013050A (en) 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
AU7669496A (en) 1995-11-03 1997-05-22 University Of Kentucky Method for the intranasal administration of l-dopa prodrugs
US6017963A (en) 1995-11-14 2000-01-25 Euro-Celtique, S.A. Formulation for intranasal administration
US5564442A (en) 1995-11-22 1996-10-15 Angus Collingwood MacDonald Battery powered nicotine vaporizer
US6041777A (en) 1995-12-01 2000-03-28 Alliance Pharmaceutical Corp. Methods and apparatus for closed-circuit ventilation therapy
DE69632148T2 (de) 1995-12-14 2005-03-17 Taisho Pharmaceutical Co., Ltd. Aerosolzubereitung
SE9504580L (sv) 1995-12-21 1997-06-22 Siemens Elema Ab Förfarande vid förgasning av en narkosvätska och en förgasare
JP2000502346A (ja) 1995-12-21 2000-02-29 イーライ・リリー・アンド・カンパニー 皮膚炎の処置方法
WO1997027804A1 (en) 1996-02-05 1997-08-07 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
US5829436A (en) 1996-02-05 1998-11-03 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
GB9604329D0 (en) 1996-02-29 1996-05-01 Ici Plc Electrostatic spraying
EP0885038B1 (en) 1996-03-01 2011-06-15 The University Of Kansas Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents
US5833891A (en) 1996-10-09 1998-11-10 The University Of Kansas Methods for a particle precipitation and coating using near-critical and supercritical antisolvents
JPH11505547A (ja) 1996-03-13 1999-05-21 エール ユニバーシティ ナルトレキソン及び関連化合物を用いる禁煙処置
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
KR20000004966A (ko) 1996-03-25 2000-01-25 피터 지. 스트링거 편두통 치료 방법
US5944012A (en) 1996-03-25 1999-08-31 Pera; Ivo E. Method for dispensing antioxidant vitamins by inhalation background of the invention
AU2587297A (en) 1996-03-25 1997-10-17 Eli Lilly And Company Method for treating pain
GB9606677D0 (en) 1996-03-29 1996-06-05 Glaxo Wellcome Inc Process and device
US5875776A (en) 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
GB2312848B (en) 1996-04-26 1999-11-17 Bespak Plc Controlled flow inhalers
HUP9901575A3 (en) 1996-04-29 1999-11-29 Dura Pharmaceuticals Inc San D Methods of dry powder inhalation
US5743251A (en) 1996-05-15 1998-04-28 Philip Morris Incorporated Aerosol and a method and apparatus for generating an aerosol
US5855913A (en) 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5985309A (en) 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5929093A (en) 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
US6125853A (en) 1996-06-17 2000-10-03 Japan Tobacco, Inc. Flavor generation device
US6089857A (en) 1996-06-21 2000-07-18 Japan Tobacco, Inc. Heater for generating flavor and flavor generation appliance
GB9613015D0 (en) 1996-06-21 1996-08-28 Reckitt & Colman Inc Device
AU3400797A (en) 1996-06-27 1998-01-14 Merck & Co., Inc. A method for treating meniere's disease
BR9710289A (pt) 1996-07-11 1999-08-17 Farmarc Nederland Bv Composi-Æo farmac-utica contendo sal cido de adi-Æo de medicamento b sico
US6004516A (en) 1996-08-06 1999-12-21 Illinois Institute Of Technology Apparatus for generating odor upon electronic signal demand
US6325475B1 (en) 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
WO1998014180A1 (en) 1996-10-03 1998-04-09 Dmitri Kirpotin Hydrophilic microparticles and methods to prepare same
US5934289A (en) 1996-10-22 1999-08-10 Philip Morris Incorporated Electronic smoking system
US6290986B1 (en) 1996-10-24 2001-09-18 Pharmaceutical Applications Associates, Llc Method and composition for transdermal administration of pharmacologic agents
US6479074B2 (en) 1996-10-24 2002-11-12 Pharmaceutical Applications Associates Llc Methods and transdermal compositions for pain relief
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5906202A (en) 1996-11-21 1999-05-25 Aradigm Corporation Device and method for directing aerosolized mist to a specific area of the respiratory tract
US6694975B2 (en) * 1996-11-21 2004-02-24 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5878752A (en) * 1996-11-25 1999-03-09 Philip Morris Incorporated Method and apparatus for using, cleaning, and maintaining electrical heat sources and lighters useful in smoking systems and other apparatuses
US5744469A (en) 1996-11-26 1998-04-28 Eli Lilly And Company Method for treating dermatitis
CA2222830C (en) 1996-12-02 2004-03-30 Fisher & Paykel Limited Humidifier sleep apnea treatment apparatus
CA2275889C (en) 1996-12-30 2008-03-18 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
DE69732306T2 (de) 1997-01-16 2006-01-12 Massachusetts Institute Of Technology, Cambridge Zubereitung von partikelhaltigen arzneimitteln zur inhalation
WO1998034595A1 (de) 1997-02-05 1998-08-13 Jago Research Ag Medizinische aerosolformulierungen
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5829435A (en) 1997-02-24 1998-11-03 Aradigm Corporation Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles
US6051257A (en) 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same
US6192882B1 (en) 1997-02-24 2001-02-27 Aradigm Corporation Formulation and devices for monitoring the efficacy of the delivery of aerosols
US5837713A (en) 1997-02-26 1998-11-17 Mayo Foundation For Medical Education And Research Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids
US5769621A (en) 1997-05-23 1998-06-23 The Regents Of The University Of California Laser ablation based fuel ignition
US5907075A (en) 1997-06-11 1999-05-25 The University Of Kansas Solid acid supercritical alkylation reactions using carbon dioxide and/or other co-solvents
US5906811A (en) 1997-06-27 1999-05-25 Thione International, Inc. Intra-oral antioxidant preparations
US5928520A (en) 1997-07-16 1999-07-27 Abanaki Corporation Method and apparatus for extracting ground water contaiminants
KR100289448B1 (ko) 1997-07-23 2001-05-02 미즈노 마사루 향미발생장치
HUP9701284A3 (en) 1997-07-24 2005-11-28 Egyt Gyogyszervegyeszeti Gyar Use of 2,3-benzodiazepine derivatives for producing pharmaceutical compositions for treating and prophylacting illnesses and conditions connected with the endogene opioide system
US6090212A (en) 1997-08-15 2000-07-18 Micro C Technologies, Inc. Substrate platform for a semiconductor substrate during rapid high temperature processing and method of supporting a substrate
US5855564A (en) 1997-08-20 1999-01-05 Aradigm Corporation Aerosol extrusion mechanism
US6250301B1 (en) 1997-08-28 2001-06-26 Hortal Harm B.V. Vaporizer for inhalation and method for extraction of active ingredients from a crude natural product or other matrix
CN1176075A (zh) 1997-08-29 1998-03-18 宋国合 不燃烧口含无毒香烟制品及其制备方法
US6138683A (en) 1997-09-19 2000-10-31 Thione International, Inc. Smokeless tobacco products containing antioxidants
AU750567B2 (en) 1997-09-29 2002-07-25 Novartis Ag Stabilized preparations for use in nebulizers
US6390453B1 (en) 1997-10-22 2002-05-21 Microfab Technologies, Inc. Method and apparatus for delivery of fragrances and vapors to the nose
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
DE19881732D2 (de) 1997-11-12 2000-08-24 Bayer Ag 2-Phenyl-substituierte Imidazotriazinone als Phoshodiesterase Inhibitoren
CA2317428C (en) 1998-01-06 2008-08-05 Philip Morris Products Inc. Cigarette having reduced sidestream smoke
IL137162A0 (en) 1998-01-27 2001-07-24 American Cyanamid Co 2,3,4,5-tetrahydro -1h- [1,4]-benzodiazepine -3- hydroxamic acids as matrix metalloproteinase inhibitors
US5900249A (en) 1998-02-09 1999-05-04 Smith; David J. Multicomponent pain relief topical medication
US6044777A (en) 1998-02-09 2000-04-04 Walsh; Michael J. Composite metal safe and method of making
US6158431A (en) 1998-02-13 2000-12-12 Tsi Incorporated Portable systems and methods for delivery of therapeutic material to the pulmonary system
US5996589A (en) 1998-03-03 1999-12-07 Brown & Williamson Tobacco Corporation Aerosol-delivery smoking article
US6269810B1 (en) 1998-03-05 2001-08-07 Battelle Memorial Institute Pulmonary dosing system and method
US6544542B1 (en) 1998-03-05 2003-04-08 Nippon Shinyaku Co., Ltd. Fat emulsions for inhalational administration
US5980566A (en) 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
DE1073432T1 (de) 1998-04-14 2002-02-07 Gen Hospital Corp Verwendung von glycinrezeptoragonisten und glycinaufnahmeinhibitoren zur behandlung neuropsychiatrischer beschwerden
AU3764199A (en) 1998-04-29 1999-11-16 Genentech Inc. Spray dried formulations of igf-i
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
US6211171B1 (en) 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
EP1083951A4 (en) 1998-06-12 2004-07-07 Aradigm Corp METHOD FOR DISCHARGING POLYNUCLEOTIDS IN THE FORM OF AN AEROSOL IN THE RESPIRATION WAY
US6095153A (en) * 1998-06-19 2000-08-01 Kessler; Stephen B. Vaporization of volatile materials
TWI223598B (en) 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6241969B1 (en) 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
WO2000000215A1 (en) 1998-06-29 2000-01-06 Inhale Therapeutic Systems, Inc. Particulate delivery systems and methods of use
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
US6090403A (en) * 1998-08-17 2000-07-18 Lectec Corporation Inhalation therapy decongestant with foraminous carrier
AU1200100A (en) 1998-10-02 2000-04-26 Battelle Memorial Institute Inhalation chemotherapy for prevention and treatment of metastatic tumors in thelung
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6509005B1 (en) 1998-10-27 2003-01-21 Virginia Commonwealth University Δ9 Tetrahydrocannabinol (Δ9 THC) solution metered dose inhaler
US6255334B1 (en) 1998-10-30 2001-07-03 Pfizer Inc 5HT 1 receptor agonists and metoclopramide for the treatment of migraine
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
DE19854012C2 (de) 1998-11-12 2001-05-10 Reemtsma H F & Ph System zur Bereitstellung eines inhalierbaren Aerosols
DE19854007C2 (de) 1998-11-12 2001-05-17 Reemtsma H F & Ph System zur Bereitstellung eines inhalierbaren Aerosols
DE69935154T2 (de) 1998-11-12 2007-10-25 Inc. Transave Inhalationssystem
EP2266548B1 (de) 1998-11-13 2020-05-20 Jagotec AG Trockenpulver zur inhalation
US6070575A (en) 1998-11-16 2000-06-06 Aradigm Corporation Aerosol-forming porous membrane with certain pore structure
JP2002529212A (ja) 1998-11-16 2002-09-10 アラダイム コーポレーション 薬剤のエアロゾル化送達のための独特な孔構造を有する多孔性膜の製造法
US6113795A (en) 1998-11-17 2000-09-05 The University Of Kansas Process and apparatus for size selective separation of micro- and nano-particles
JP3506618B2 (ja) 1998-11-18 2004-03-15 ウシオ電機株式会社 黄色光放射用白熱電球
EP1137398B1 (en) 1998-12-11 2003-10-08 Pharmachemie B.V. Pharmaceutical preparation for inhalation of an opioid
BR9917082A (pt) 1998-12-24 2001-11-06 Du Pont Pharm Co Compostos inibidores da produção de proteìnas a"beta", método de tratamento de disfunções neurológicas associadas com a produção de "beta"-amilóide, composição farmacêutica e, método de inibição da atividade de y-secretase
AR022423A1 (es) 1999-01-27 2002-09-04 American Cyanamid Co Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
ES2173679T3 (es) 1999-01-27 2002-10-16 Idea Ag Inmunizacion/transporte transnasal con vehiculos altamente adaptables.
US6376550B1 (en) 1999-02-09 2002-04-23 Asta Medica Ag Pharmaceutical compositions containing tramadol for migraine
WO2000047203A1 (en) 1999-02-12 2000-08-17 Mqs, Inc. Formulation and system for intra-oral delivery of pharmaceutical agents
US6591839B2 (en) 1999-02-17 2003-07-15 Dieter Meyer Filter material for reducing harmful substances in tobacco smoke
US6053176A (en) 1999-02-23 2000-04-25 Philip Morris Incorporated Heater and method for efficiently generating an aerosol from an indexing substrate
US6444326B1 (en) 1999-03-05 2002-09-03 Restek Corporation Surface modification of solid supports through the thermal decomposition and functionalization of silanes
WO2000051491A1 (en) 1999-03-05 2000-09-08 Battelle Memorial Institute Method for safely and effectively administering a drug by inhalation
US6228445B1 (en) 1999-04-06 2001-05-08 Crucible Materials Corp. Austenitic stainless steel article having a passivated surface layer
JP2002543092A (ja) 1999-04-27 2002-12-17 イーライ・リリー・アンド・カンパニー 肺投与用インスリン結晶
US6503481B1 (en) 1999-05-03 2003-01-07 Battellepharma, Inc. Compositions for aerosolization and inhalation
US6428769B1 (en) 1999-05-04 2002-08-06 Aradigm Corporation Acute testosterone administration
US6309986B1 (en) 1999-05-07 2001-10-30 S. C. Johnson & Son, Inc. Mat for dispensing volatile materials
EP1180020B2 (en) 1999-05-27 2009-06-24 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6709739B1 (en) 1999-06-03 2004-03-23 Case Western Reserve University Closed cell metal composites
US6328033B1 (en) 1999-06-04 2001-12-11 Zohar Avrahami Powder inhaler
CA2374232C (en) 1999-06-11 2013-08-20 Aradigm Corporation Method for producing an aerosol
US6315985B1 (en) 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
US20020061281A1 (en) 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
EP1218048A4 (en) 1999-07-16 2009-08-26 Aradigm Corp SYSTEM FOR STOPPING SMOKING
JP2003507438A (ja) 1999-08-24 2003-02-25 セルゲイト， インコーポレイテッド オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強
CA2383794A1 (en) 1999-09-07 2001-03-15 Conjuchem Inc. Methods and compositions containing succinimide or maleimide derivatives of antineoplastic agents
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
JP2003509142A (ja) 1999-09-15 2003-03-11 アラダイム コーポレーション 減圧エアロゾル化孔構造
CN1377356A (zh) 1999-09-30 2002-10-30 纽罗杰有限公司 亚烷基二胺取代的杂环
YU26202A (sh) 1999-10-15 2004-12-31 F.Hoffmann-La Roche Ag. Derivati benzodiazepina
DE60044070D1 (de) 1999-10-29 2010-05-06 Novartis Ag Trockenpulverzusammensetzungen mit verbesserter Dispersität
AU1261501A (en) 1999-12-06 2001-06-18 Stanley L. Gore Compositions and methods for intranasal delivery of active agents to the brain
DE19959766A1 (de) 1999-12-11 2001-06-13 Bosch Gmbh Robert Glühstiftkerze
DE10001035A1 (de) 2000-01-13 2001-07-26 Bayer Ag Wirkstoffchip mit integriertem Heizelement
AU2001234005B2 (en) 2000-02-28 2006-01-19 Pharmakodex Limited Improvements in or relating to the delivery of oral drugs
WO2001069136A1 (en) 2000-03-10 2001-09-20 The Regents Of The University Of California Laser ignition
PT1265504E (pt) 2000-03-23 2009-09-04 Pmpi Llc Sistema eléctrico para fumar e método
US6632047B2 (en) 2000-04-14 2003-10-14 Board Of Regents, The University Of Texas System Heater element for use in an in situ thermal desorption soil remediation system
JP2001299916A (ja) 2000-04-18 2001-10-30 Kao Corp マスク型吸入器
US6551617B1 (en) 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
US20010039262A1 (en) 2000-04-26 2001-11-08 Balaji Venkataraman Methods and compositions for the treatment of cardiac indications
MY136453A (en) 2000-04-27 2008-10-31 Philip Morris Usa Inc "improved method and apparatus for generating an aerosol"
JP2004513071A (ja) 2000-05-23 2004-04-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク 肺の弾性繊維損傷に関連した呼吸器疾患の治療方法
AU2001225663A1 (en) 2000-06-15 2001-12-24 Respiratorius Ab A composition comprising a combination of receptor agonists and antagonists
GB0015981D0 (en) 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
FR2812545B1 (fr) 2000-08-03 2003-03-28 Air Liquide Sante Int Aerosol medicamenteux inhalable dans le traitement ou la prevention de la douceur
AU2001284158B2 (en) 2000-08-18 2004-03-25 Norton Healthcare, Ltd. Spray device
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US6514482B1 (en) 2000-09-19 2003-02-04 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
WO2002056932A2 (en) 2000-10-27 2002-07-25 Emlin Biosciences Thermal vaporizing device for drug delivery
US20030121906A1 (en) 2000-11-29 2003-07-03 Abbott Richard C. Resistive heaters and uses thereof
US6681998B2 (en) * 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6443152B1 (en) 2001-01-12 2002-09-03 Becton Dickinson And Company Medicament respiratory delivery device
US7594507B2 (en) 2001-01-16 2009-09-29 Hewlett-Packard Development Company, L.P. Thermal generation of droplets for aerosol
FI20010115A0 (fi) 2001-01-18 2001-01-18 Orion Corp Menetelmä nanopartikkelien valmistamiseksi
US6680668B2 (en) 2001-01-19 2004-01-20 Vishay Intertechnology, Inc. Fast heat rise resistor using resistive foil
JP2005511477A (ja) 2001-03-19 2005-04-28 プラエシス ファーマシューティカルズ インコーポレーテッド 持続放出のための医薬調合物
GB0108930D0 (en) 2001-04-10 2001-05-30 Boots Co Plc Therapeutic agents
US20030004142A1 (en) 2001-04-18 2003-01-02 Prior Christopher P. Use of NSAIDs for prevention and treatment of cellular abnormalities of the lung or bronchial pathway
US6554201B2 (en) 2001-05-02 2003-04-29 Aerogen, Inc. Insert molded aerosol generator and methods
US6550691B2 (en) * 2001-05-22 2003-04-22 Steve Pence Reagent dispenser head
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
WO2002094232A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antidepressants through an inhalation route
WO2002094242A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of rizatriptan or zolmitriptan through an inhalation route
US20080038363A1 (en) 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
DK1389096T3 (da) 2001-05-24 2009-06-22 Alexza Pharmaceuticals Inc Indgivelse af opiater gennem en inhalationsrute
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
CA2641760A1 (en) 2001-05-24 2002-11-28 Alexza Pharmaceuticals, Inc. Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
WO2002094244A2 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of benzodiazepines through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7078016B2 (en) 2001-11-21 2006-07-18 Alexza Pharmaceuticals, Inc. Delivery of caffeine through an inhalation route
US20030118512A1 (en) 2001-10-30 2003-06-26 Shen William W. Volatilization of a drug from an inclusion complex
US20030131843A1 (en) 2001-11-21 2003-07-17 Lu Amy T. Open-celled substrates for drug delivery
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20030138508A1 (en) 2001-12-18 2003-07-24 Novack Gary D. Method for administering an analgesic
PT1397145E (pt) 2001-06-19 2006-10-31 Norbert Muller Utilizacao de inibidores da cox-2 para o tratamento de esquizofrenia ou de disturbios de tiques
US6766220B2 (en) 2001-07-31 2004-07-20 Chrysalis Technologies Incorporated Method and apparatus for generating a volatilized liquid
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
WO2003024456A1 (en) 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating and preventing migraines
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6648950B2 (en) 2001-10-15 2003-11-18 Hewlett-Packard Development Company, L.P. Electro-thermal odor-releasing inks and methods for releasing odors from the same
US6779520B2 (en) 2001-10-30 2004-08-24 Iep Pharmaceutical Devices Inc. Breath actuated dry powder inhaler
GB0126150D0 (en) 2001-10-31 2002-01-02 Gw Pharma Ltd A device method and resistive element for vaporising a substance
WO2003041693A1 (en) 2001-11-09 2003-05-22 Alexza Molecular Delivery Corporation Delivery of diazepam through an inhalation route
US6684880B2 (en) 2001-12-04 2004-02-03 Hewlett-Packard Development Company, L.P. Applicator for dispensing bioactive compositions and methods for using the same
US20030106551A1 (en) 2001-12-06 2003-06-12 Sprinkel F. Murphy Resistive heater formed inside a fluid passage of a fluid vaporizing device
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
US6772756B2 (en) 2002-02-09 2004-08-10 Advanced Inhalation Revolutions Inc. Method and system for vaporization of a substance
US6961515B2 (en) 2002-02-15 2005-11-01 Dekko Technologies, Inc. PTC heater with flexible printed circuit board
US6728478B2 (en) 2002-02-21 2004-04-27 Dekko Heating Technologies, Inc. Heated chemical delivery system
WO2003087410A1 (en) * 2002-04-11 2003-10-23 Sequenom, Inc. Methods and devices for performing chemical reactions on a solid support
WO2003094900A1 (en) 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
US20060193788A1 (en) 2002-11-26 2006-08-31 Hale Ron L Acute treatment of headache with phenothiazine antipsychotics
ES2300589T3 (es) 2002-06-06 2008-06-16 S.C. JOHNSON & SON, INC. Volatilizacion de superficie localizada.
US7040314B2 (en) 2002-09-06 2006-05-09 Philip Morris Usa Inc. Aerosol generating devices and methods for generating aerosols suitable for forming propellant-free aerosols
US6772757B2 (en) 2002-10-25 2004-08-10 Chrysalis Technologies Incorporated Concentric controlled temperature profile fluid vaporizing device
JP2004149447A (ja) 2002-10-30 2004-05-27 Andrew Chii Wen Won ニコチン含有軟膏剤
JP2006514633A (ja) 2002-11-26 2006-05-11 アレックザ ファーマシューティカルズ， インコーポレイテッド 吸入によって送達される抗精神病薬を用いた頭痛の治療
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
JP2006514934A (ja) 2002-11-26 2006-05-18 アレックザ ファーマシューティカルズ， インコーポレイテッド 疼痛治療用薬剤製造のためのロキサピンまたはアモキサピンの使用
US7550133B2 (en) 2002-11-26 2009-06-23 Alexza Pharmaceuticals, Inc. Respiratory drug condensation aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
DK1578422T3 (da) 2002-12-20 2007-07-02 Niconovum Ab Fysisk og kemisk stabilt nikotin-indeholdende partikelholdigt materiale
US7360537B2 (en) 2003-04-16 2008-04-22 Trudell Medical International Antistatic medication delivery apparatus
EP1625336B9 (en) 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Use of a layer of solid fuel, method for producing such a layer and associated heating unit
EP1656171B9 (en) 2003-08-04 2010-10-20 Alexza Pharmaceuticals, Inc. Substrates for drug delivery device and methods of preparing
WO2005014090A1 (en) 2003-08-04 2005-02-17 Alexza Pharmaceuticals, Inc. Methods of determining film thicknesses for an aerosol delivery article
US7387788B1 (en) 2003-10-10 2008-06-17 Antares Pharma Ipl Ag Pharmaceutical compositions of nicotine and methods of use thereof
EP1703932A1 (en) 2003-12-15 2006-09-27 Alexza Molecular Delivery Corporation Treatment of breakthrough pain by drug aerosol inhalation
WO2005059804A2 (en) 2003-12-16 2005-06-30 Alexza Pharmaceuticals, Inc. Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real-time
US7402777B2 (en) 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US20060032496A1 (en) 2004-08-12 2006-02-16 Alexza Molecular Delivery Corporation Inhalation actuated percussive ignition system
US20100006092A1 (en) 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
EP2246086A3 (en) * 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
EP1809240A4 (en) 2004-10-12 2010-06-16 Alexza Pharmaceuticals Inc ADMINISTRATION OF A DRUG-FREE DRUG WITHOUT DANGER TO THE CARDIOVASCULAR SYSTEM
UA88792C2 (ru) 2004-11-10 2009-11-25 Таргасепт, Інк. Гидроксибензоатные соли метаникотиновых соединений
US7459469B2 (en) 2004-11-10 2008-12-02 Targacept, Inc. Hydroxybenzoate salts of metanicotine compounds
DE102005006374B3 (de) * 2005-02-11 2006-07-20 Pari GmbH Spezialisten für effektive Inhalation Aerosolerzeugungsvorrichtung und Inhalationstherapiegerät mit einer derartigen Vorrichtung
EP1853234A2 (en) 2005-02-15 2007-11-14 Elan Pharma International Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
ES2812250T3 (es) 2005-11-28 2021-03-16 Marinus Pharmaceuticals Inc Formulaciones de ganaxolona y procedimientos para la preparación y uso de las mismas
US7785482B2 (en) 2005-12-07 2010-08-31 General Electric Company Method of making an ignition device
WO2007079118A1 (en) 2005-12-29 2007-07-12 Molex Incorporated Heating element connector assembly with press-fit terminals
CN101437497A (zh) 2006-03-16 2009-05-20 尼科诺瓦姆股份公司 提供迅速释放尼古丁的口香糖组合物
EP2086314B1 (en) * 2006-09-22 2012-08-08 The Procter & Gamble Company Method of distributing a liquid active materials using an ultrasonic transducer
US8251060B2 (en) 2006-11-15 2012-08-28 Perfetti and Perfetti, LLC Device and method for delivering an aerosol drug
US20080299048A1 (en) 2006-12-22 2008-12-04 Alexza Pharmaceuticals, Inc. Mixed drug aerosol compositions
US7513781B2 (en) 2006-12-27 2009-04-07 Molex Incorporated Heating element connector assembly with insert molded strips
US20080210225A1 (en) 2007-03-01 2008-09-04 Rapha Institute For Health Disposable antistatic spacer
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
GB0714577D0 (en) 2007-07-26 2007-09-05 Sonitor Technologies As Mobile object communication and position determination
WO2008134668A2 (en) 2007-04-27 2008-11-06 Alexza Pharmaceuticals, Inc. Heat-labile prodrugs
DE102007041921A1 (de) 2007-09-04 2009-03-05 Siemens Ag Verfahren zur Herstellung und Kontaktierung von elektronischen Bauelementen mittels einer Substratplatte, insbesondere DCB-Keramik-Substratplatte
US20100276505A1 (en) * 2007-09-26 2010-11-04 Roger Earl Smith Drilling in stretched substrates
WO2009089550A1 (en) 2008-01-11 2009-07-16 Alexza Pharmaceuticals, Inc. Metal coordination complexes of volatile drugs
US8895546B2 (en) 2009-03-27 2014-11-25 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
ES2446306T3 (es) 2008-05-16 2014-03-07 Nono Inc. Uso de un inhibidor de psd-95 tratamiento para la epilepsia
US20100068155A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Reactant Formulations and Methods for Controlled Heating
US7834295B2 (en) 2008-09-16 2010-11-16 Alexza Pharmaceuticals, Inc. Printable igniters
US20100065052A1 (en) 2008-09-16 2010-03-18 Alexza Pharmaceuticals, Inc. Heating Units
US20100163020A1 (en) 2008-12-30 2010-07-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for administering an inhalable compound
US20100300433A1 (en) 2009-05-28 2010-12-02 Alexza Pharmaceuticals, Inc. Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol
US8425704B2 (en) 2009-08-04 2013-04-23 The United States Of America As Represented By The Secretary Of The Army Silicon-based explosive devices and methods of manufacture
US20100181387A1 (en) 2009-12-01 2010-07-22 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
MX339173B (es) * 2010-07-15 2016-05-12 Corinthian Ophthalmic Inc Dispositivo generador de gotas.
US20120048963A1 (en) 2010-08-26 2012-03-01 Alexza Pharmaceuticals, Inc. Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter
EA029180B1 (ru) 2010-12-02 2018-02-28 Юсб Фарма Гмбх Лекарственная форма лакозамида для приема один раз в сутки
EP2468116A1 (en) 2010-12-24 2012-06-27 Philip Morris Products S.A. An aerosol generating system having means for handling consumption of a liquid substrate
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US20130156823A1 (en) 2011-12-20 2013-06-20 MAP Pharmacauticals, Inc. Excipient-free Aerosol Formulation
US9277770B2 (en) 2013-03-14 2016-03-08 R. J. Reynolds Tobacco Company Atomizer for an aerosol delivery device formed from a continuously extending wire and related input, cartridge, and method
ES2821907T3 (es) 2013-07-11 2021-04-28 Alexza Pharmaceuticals Inc Sal de nicotina con ácido metasalicílico
US10194693B2 (en) 2013-09-20 2019-02-05 Fontem Holdings 1 B.V. Aerosol generating device
MX2017011613A (es) 2015-03-11 2018-04-10 Alexza Pharmaceuticals Inc Utilización de materiales antiestáticos en los conductos de aire para el proceso de aerosol de condensación térmica.
ES2886456T3 (es) 2016-04-29 2021-12-20 Univ Princeton Dispositivos para la vaporización controlada de fármacos
EP4272827A3 (en) 2016-12-09 2024-01-24 Alexza Pharmaceuticals, Inc. Method of treating epilepsy
JP2021511893A (ja) 2018-02-02 2021-05-13 アレクザ・ファーマシューティカルズ・インコーポレイテッドＡｌｅｘｚａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 電気式凝縮エアロゾル装置

Also Published As

Publication number Publication date
US20080216828A1 (en) 2008-09-11
US10625033B2 (en) 2020-04-21
US20170049974A1 (en) 2017-02-23
WO2008112661A2 (en) 2008-09-18
EP2121088A2 (en) 2009-11-25
EP2121088B1 (en) 2016-07-13
US11642473B2 (en) 2023-05-09
WO2008112661A3 (en) 2009-03-26
US20200246559A1 (en) 2020-08-06
US20230285691A1 (en) 2023-09-14

Similar Documents

Publication Publication Date Title
ES2594867T3 (es) Unidad de calentamiento para usar en un dispositivo de administración de fármaco
JP5947225B2 (ja) 面状の蒸発器
JP6864035B2 (ja) 気化器集成部品
ES2937697T3 (es) Cartucho para un sistema generador de aerosol
ES2871784T3 (es) Artículo generador de aerosol con difusor de calor
JP7009960B2 (ja) 発熱素子、気化装置、および吐出ヘッドによって吐出された流体を気化させる方法
US20210106775A1 (en) Electrical condensation aerosol device
US10821240B2 (en) Methods and drug delivery devices using cannabis
EP3132806B1 (en) Aerosol generator
US20090188626A1 (en) Plasma jet device
US20220338543A1 (en) Electronic atomization apparatus, and atomizer and heating body of electronic atomization apparatus
EP3473057B1 (en) Heater assembly for an aerosol-generating system
CA2939088A1 (en) Methods and drug delivery devices using cannabis
EP3826487B1 (en) Improved aerosol-generating system comprising individually activatable heating elements
KR20170067870A (ko) 하나 이상의 공동을 갖는 금속 기판 상에 배치된 탄소 나노튜브
WO2022161015A1 (zh) 具有保护罩的雾化芯
WO2007147906A1 (es) Placa calefactora y procedimiento de fabricación
EP4316280A1 (en) Dense arrangement heating mechanism and atomizing device thereof
WO2004071488A1 (en) Perfluorocarbon and hydrofluorocarbon formulations and methods of making and using same
KR20230151623A (ko) 에어로졸 발생 장치의 히팅 디바이스
CN114176254A (zh) 气溶胶生成系统及加热器
KR20240001984A (ko) 궐련형 전자담배 장치용 히터
KR20240002273A (ko) 궐련형 전자담배 장치