ES2173679T3 - Inmunizacion/transporte transnasal con vehiculos altamente adaptables. - Google Patents

Inmunizacion/transporte transnasal con vehiculos altamente adaptables.

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Publication number
ES2173679T3
ES2173679T3 ES99101480T ES99101480T ES2173679T3 ES 2173679 T3 ES2173679 T3 ES 2173679T3 ES 99101480 T ES99101480 T ES 99101480T ES 99101480 T ES99101480 T ES 99101480T ES 2173679 T3 ES2173679 T3 ES 2173679T3
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Spain
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substance
droplet
forms
aggregates
substances
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ES99101480T
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Inventor
Juliane Stieber
Amia Chopra
Gregor Cevc
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Idea AG
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Idea AG
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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Abstract

Uso de un penetrante, suspendido o disperso en un solvente, en la forma de una gotita fluida minúscula rodeada por un recubrimiento tipo membrana de una o varias capas de al menos dos sustancias diferentes o dos formas diferentes de una sustancia con tendencia a agregarse, dichas sustancias o formas de una sustancia difieren en al menos un factor de 10 en solubilidad en un medio líquido preferiblemente acuoso, tal que el diámetro promedio de los homo-agregados de la sustancia o forma de la sustancia más soluble o el diámetro promedio de los hetero-agregados consisten en dichas ambas sustancias o formas de dicha sustancia es más pequeño que el diámetro de los homo-agregados de la sustancia menos soluble o formas de la sustancia y/o en donde el componente más soluble tiende a solubilizar la gotita penetrante y en donde el contenido de dichas cantidades de componente es hasta el 99 mol-% de la concentración requerida para solubilizar la gotita también corresponde hasta el 99 mol-% de la concentración saturante en una gotita no solubilizada, cualquiera es mayor, y/o en donde la energía de deformación elástica de la gotita envuelta por el recubrimiento de tipo membrana es al menos 5 veces menor, más preferiblemente es al menos 10 veces menor e idealmente es más de 10 veces inferior que los de los glóbulos rojos o de las bicapas de fosfolípidos con cadenas alifáticas fluidas como vehículo para la preparación de una composición farmacéutica, preferiblemente una vacuna, para administración transnasal.
ES99101480T 1999-01-27 1999-01-27 Inmunizacion/transporte transnasal con vehiculos altamente adaptables. Expired - Lifetime ES2173679T3 (es)

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DK1031347T3 (da) 2002-07-08
HUP0105400A2 (hu) 2002-05-29
KR20070094663A (ko) 2007-09-20
SI1031347T1 (en) 2002-10-31
EP1031347B1 (en) 2002-04-17
AU2293400A (en) 2000-08-18
CN101664388A (zh) 2010-03-10
CA2360643A1 (en) 2000-08-03
MXPA01007659A (es) 2003-06-24
AR052211A1 (es) 2007-03-07
KR20010101752A (ko) 2001-11-14
HU226119B1 (en) 2008-04-28
EP1143932A1 (en) 2001-10-17
WO2000044350A1 (en) 2000-08-03
BR0007780A (pt) 2002-02-05
JP2002535351A (ja) 2002-10-22
US7927622B1 (en) 2011-04-19
ATE216223T1 (de) 2002-05-15
HK1030364A1 (en) 2003-04-24
EP1031347A1 (en) 2000-08-30
AU772429B2 (en) 2004-04-29
PT1031347E (pt) 2002-09-30
DE69901284T2 (de) 2002-11-28
CN1344155A (zh) 2002-04-10
HUP0105400A3 (en) 2002-09-30

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