AR052211A1 - Uso de vehiculos altamente adaptables para transporte transnasal y la preparacion de vacunas - Google Patents

Uso de vehiculos altamente adaptables para transporte transnasal y la preparacion de vacunas

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Publication number
AR052211A1
AR052211A1 ARP000100373A ARP000100373A AR052211A1 AR 052211 A1 AR052211 A1 AR 052211A1 AR P000100373 A ARP000100373 A AR P000100373A AR P000100373 A ARP000100373 A AR P000100373A AR 052211 A1 AR052211 A1 AR 052211A1
Authority
AR
Argentina
Prior art keywords
substance
small
drop
substances
soluble
Prior art date
Application number
ARP000100373A
Other languages
English (en)
Inventor
Gregor Cevc
Amla Chopra
Juliane Stieber
Original Assignee
Idea Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idea Ag filed Critical Idea Ag
Publication of AR052211A1 publication Critical patent/AR052211A1/es

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Abstract

Uso de una penetrante suspendido o dispersado en un solvente en forma de una pequena gota de líquido rodeada por una cubierta en forma de membrana constituida por una o varias capas de al menos dos sustancias diferentes o dos formas diferentes de una sustancia con tendencia a la agregacion, definiendo dichas sustancias a formas de una sustancia en al menos un factor de 10 en la solubilidad en un medio líquido preferiblemente acuoso, de modo que el diámetro promedio de los homo-agregado de la sustancia más soluble o de la forma de la sustancia más soluble o el diámetro promedio de los hétero-agregado consistentes en ambas sustancias o formas de dichas sustancias es menor que el diámetro promedio de los homo-agregado de la sustancia o forma de sustancia menos soluble y/o en que el componente más soluble tiende a solubilizar la pequena gota penetrante y en que la concentracion de dicho componente es de hasta 99 mol % de la concentracion necesaria para solubilizar la pequena gota o corresponde a hasta 99 mol % de la concentracion de saturacion de la pequena gota no solubilizada, segun la que sea más alta, y/o en que la energía de deformacion elástica de la cubierta en forma de membrana que rodea la pequena gota es al menos 5 veces menor preferiblemente al menos 10 veces menor e idealmente más de 10 veces menor que la de los hematíes o de dicapas fosfolipídicas con cadenas alifáticas fluidas, actuando dichas pequenas gotas con soportes para la administracion transnasal de un compuesto farmacéuticamente activo, un antígeno, un alergénico, una mezcla de antígenos, y/o una mezcla de alergénicos.
ARP000100373A 1999-01-27 2000-01-27 Uso de vehiculos altamente adaptables para transporte transnasal y la preparacion de vacunas AR052211A1 (es)

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KR20030079784A (ko) 2002-04-04 2003-10-10 마츠시타 덴끼 산교 가부시키가이샤 냉동 사이클 장치와, 그것을 구비하는 공기 조화기,냉장고, 온수 공급기 및 극저온 냉동 장치
US7473432B2 (en) 2002-10-11 2009-01-06 Idea Ag NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
EP1551370B1 (en) 2002-10-11 2007-12-19 Idea Ag Aggregate with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
US7387788B1 (en) 2003-10-10 2008-06-17 Antares Pharma Ipl Ag Pharmaceutical compositions of nicotine and methods of use thereof
WO2005063213A1 (en) 2003-12-19 2005-07-14 Biodelivery Sciences International, Inc. Rigid liposomal cochleate and methods of use and manufacture
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
CA2584475A1 (en) 2004-11-12 2006-05-18 Idea Ag Extended surface aggregates in the treatment of skin conditions

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BR0007780A (pt) 2002-02-05
DK1031347T3 (da) 2002-07-08
JP2002535351A (ja) 2002-10-22
DE69901284T2 (de) 2002-11-28
HU226119B1 (en) 2008-04-28
AU2293400A (en) 2000-08-18
CN101664388A (zh) 2010-03-10
ES2173679T3 (es) 2002-10-16
EP1031347B1 (en) 2002-04-17
CN1344155A (zh) 2002-04-10
SI1031347T1 (en) 2002-10-31
KR20070094663A (ko) 2007-09-20
WO2000044350A1 (en) 2000-08-03
DE69901284D1 (de) 2002-05-23
MXPA01007659A (es) 2003-06-24
ATE216223T1 (de) 2002-05-15
AU772429B2 (en) 2004-04-29
CA2360643A1 (en) 2000-08-03
US7927622B1 (en) 2011-04-19
EP1143932A1 (en) 2001-10-17
HK1030364A1 (en) 2003-04-24
HUP0105400A3 (en) 2002-09-30
HUP0105400A2 (hu) 2002-05-29
EP1031347A1 (en) 2000-08-30
PT1031347E (pt) 2002-09-30
KR20010101752A (ko) 2001-11-14

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