ES2077419T3 - Emplasto con nitroglicerol y procedimiento para su produccion. - Google Patents
Emplasto con nitroglicerol y procedimiento para su produccion.Info
- Publication number
- ES2077419T3 ES2077419T3 ES92911100T ES92911100T ES2077419T3 ES 2077419 T3 ES2077419 T3 ES 2077419T3 ES 92911100 T ES92911100 T ES 92911100T ES 92911100 T ES92911100 T ES 92911100T ES 2077419 T3 ES2077419 T3 ES 2077419T3
- Authority
- ES
- Spain
- Prior art keywords
- plaster
- nitroglycerin
- weight
- acrylate
- costs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
LA INVENCION SE REFIERE A UN EMPLASTE PRINCIPAL PARA LA ADMINISTRACION TRANSDERMAL DE NITROGLICERINA, CONSISTIENDO JUNTO A UNA LAMINA SOPORTE Y UNA LAMINA DE PROTECCION RETIRABLE DE UNA MASA DE ADHESIVOS PARTICULARMENTE CONTENIENDO NITROGLICERINA A BASE DE UN COPOLIMERIZADO DE ACETATO DE VINILO-ACRILATO RETICULADO, CUYA MEZCLA DE MONOMEROS EMPLEADOS PARA LA POLIMERIZACION CONTIENE 21 A 40% EN PESO DE ACETATO DE VINILO, 55 A 70% EN PESO DE UN ESTER DE ACIDO ACRILICO C2-8-ALQUILO Y 3 A 10% EN PESO DE UN ESTER DE ACIDO ACRILICO SE RETICULA DESPUES DE LA MEZCLA DE UN RETICULADOR USUAL Y NITROGLICERINA ADICIONALMENTE A TRAVES DE CALENTAMIENTO Y ELIMINACION DE DISOLVENTES EXISTENTES. LA MASA DE ADHESIVO ESPECIAL CON ARREGLO A LA INVENCION NO TIENE SOLAMENTE UNA ELEVADA CAPACIDAD DE ABSORCION, SINO TAMBIEN UNA CAPACIDAD DE EMISION ELEVADA Y CONTROLABLE PARA NITROGLICERINA YA QUE LA CANTIDAD DE COLOCACION LIBRE POR DIA MANTIENE PEQUEÑA LA SUPERFICIE DE COLOCACION LIBRE DEL EMPLASTE Y LOS COSTES DELEMPLASTE SON PEQUEÑOS. SIMULTANEAMENTE SE SIMPLIFICA EL PROCESO DE PRODUCCION A TRAVES DE LA MASA DE ADHESIVO SENCILLA SE ECONOMIZA LA ADICION DE OTRA MATERIA PARA ELEVAR EL TRANSPORTE DE MATERIA TRANSEPIDERMAL Y MANTENER BAJOS LOS COSTES DEL EMPLASTE Y SE EVITAN LOS RIESGOS DE IRRITACIONES PRINCIPALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4118891 | 1991-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2077419T3 true ES2077419T3 (es) | 1995-11-16 |
Family
ID=6433497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92911100T Expired - Lifetime ES2077419T3 (es) | 1991-06-10 | 1992-05-25 | Emplasto con nitroglicerol y procedimiento para su produccion. |
Country Status (18)
Country | Link |
---|---|
US (1) | US5498418A (es) |
EP (2) | EP0518113A1 (es) |
JP (1) | JP2579729B2 (es) |
KR (1) | KR0165875B1 (es) |
CN (1) | CN1053591C (es) |
AT (1) | ATE126434T1 (es) |
CA (1) | CA2109956C (es) |
DE (1) | DE59203307D1 (es) |
DK (1) | DK0588839T3 (es) |
ES (1) | ES2077419T3 (es) |
FI (1) | FI101854B (es) |
GE (1) | GEP19991583B (es) |
GR (1) | GR3017689T3 (es) |
HU (1) | HU210334B (es) |
IE (1) | IE67792B1 (es) |
NO (2) | NO305384B1 (es) |
UA (1) | UA29400C2 (es) |
WO (1) | WO1992022292A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
DE4406332C1 (de) * | 1994-02-28 | 1995-06-22 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Verwendung von Nitroglycerin zur Verhinderung unerwünschter Wehentätigkeit bei Säugern in einer transdermalen Applikationsform |
US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
WO1998025591A1 (en) * | 1996-12-10 | 1998-06-18 | Rotta Research B.V. | Transdermal drug delivery system for the treatment of heart diseases |
ES2127711T1 (es) * | 1996-12-10 | 1999-05-01 | Rotta Res Bv | Sistema de administracion transdermal de farmacos para el tratamiento de enfermedades del corazon. |
CN1070367C (zh) * | 1997-08-07 | 2001-09-05 | 德阳华康药业有限公司 | 注射贴及其制备方法 |
DE19818955C2 (de) * | 1998-04-28 | 2000-06-29 | Lohmann Therapie Syst Lts | Zusammensetzung, enthaltend Polyacrylat, Polyterpen, Nitroglycerin und wahlweise Polyvinylacetat |
DE19830648A1 (de) * | 1998-07-09 | 2000-01-13 | Lohmann Therapie Syst Lts | Glyceroltrinitrathaltige Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE19831418C2 (de) * | 1998-07-14 | 2000-07-06 | Lohmann Therapie Syst Lts | Verfahren und Vorrichtung zum Herstellen flächenhafter Produkte aus Laminat, deren Übertragung auf eine Abdeckfolie und Endkonfektionierung |
DE69825495T2 (de) | 1998-12-23 | 2005-07-28 | Idea Ag | Verbesserte formulierung zur topischen, nichtinvasiven anwendung in vivo |
ES2173679T3 (es) | 1999-01-27 | 2002-10-16 | Idea Ag | Inmunizacion/transporte transnasal con vehiculos altamente adaptables. |
PT1031346E (pt) | 1999-01-27 | 2002-09-30 | Idea Ag | Vacinacao nao invasiva atraves da pele |
MXPA02000053A (es) * | 1999-07-05 | 2003-07-21 | Idea Ag | Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables. |
JP5021124B2 (ja) * | 2001-08-29 | 2012-09-05 | 日東電工株式会社 | 医療用粘着組成物、それを用いた医療用粘着テープおよび経皮吸収用テープ製剤 |
DK1293198T3 (da) * | 2001-09-14 | 2005-06-06 | Sanol Arznei Schwarz Gmbh | Anordning til transdermal indgivelse til behandling af urinkanallidelser |
CA2487123C (en) * | 2002-05-28 | 2011-10-18 | Labtec Gesellschaft Fuer Technologische Forschung Und Entwicklung Mbh | Patch containing fentanyl |
US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
KR100563194B1 (ko) * | 2003-11-14 | 2006-03-21 | (주) 에프디엘 | 펜타닐을 유효성분으로 함유하는 경피투여제제 |
WO2006050926A2 (en) * | 2004-11-12 | 2006-05-18 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
US20070072986A1 (en) * | 2005-09-23 | 2007-03-29 | Allison Luciano | Acrylic polymer-based adhesives |
EP1945685B1 (en) * | 2005-09-23 | 2018-11-07 | Henkel AG & Co. KGaA | Acrylic polymer-based adhesives |
CN106659591B (zh) * | 2014-08-25 | 2021-06-04 | 汉高知识产权控股有限责任公司 | 丙烯酸聚合物和它们在透皮药物递送中的用途 |
CN105362254B (zh) * | 2015-12-09 | 2017-03-15 | 北京邦尼康达医药科技有限公司 | 一种硝酸甘油贴膜及其制备方法 |
DE202016007127U1 (de) | 2016-11-22 | 2016-12-19 | Ludwig Volker | Falzhilfe |
CN113125596B (zh) * | 2021-04-07 | 2023-01-13 | 马应龙药业集团股份有限公司 | 一种高效液相色谱法测定硝酸甘油软膏中有关物质的方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
JPS5777617A (en) | 1980-10-20 | 1982-05-15 | Nichiban Co Ltd | Plaster for cardiac disease |
JPS5843368B2 (ja) | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
JPS57116011A (en) | 1981-01-08 | 1982-07-19 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
JPS6059207B2 (ja) | 1981-03-13 | 1985-12-24 | 日東電工株式会社 | 複合製剤の製法 |
GB2105990B (en) | 1981-08-27 | 1985-06-19 | Nitto Electric Ind Co | Adhesive skin patches |
US4608249A (en) | 1982-11-02 | 1986-08-26 | Nitto Electric Industrial Co., Ltd. | Hydrophilic therapeutic material |
DE3315272C2 (de) | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
EP0190262B1 (en) | 1984-07-24 | 1990-12-27 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
JPS62292877A (ja) * | 1986-06-13 | 1987-12-19 | Nippon Shokubai Kagaku Kogyo Co Ltd | 接着剤用組成物 |
DE3643987A1 (de) * | 1986-12-22 | 1988-06-23 | Lohmann Therapie Syst Lts | Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung |
JPH0696529B2 (ja) * | 1987-03-31 | 1994-11-30 | 積水化学工業株式会社 | ニトログリセリン貼付剤およびその製造方法 |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
JP2524190B2 (ja) * | 1988-05-11 | 1996-08-14 | 日東電工株式会社 | クロニジンを含有する粘着テ―プ製剤 |
DE69010317T3 (de) * | 1989-12-28 | 2000-10-12 | Nitto Denko Corp | Acrylgel und seine Herstellung. |
JP2700835B2 (ja) * | 1989-12-28 | 1998-01-21 | 日東電工株式会社 | アクリル系ゲル材およびアクリル系ゲル製剤 |
JP2882843B2 (ja) * | 1990-03-28 | 1999-04-12 | 日本化薬株式会社 | 門脈圧亢進症改善剤 |
JPH07116032B2 (ja) * | 1990-04-06 | 1995-12-13 | 積水化学工業株式会社 | ニトログリセリン貼付剤 |
-
1992
- 1992-05-25 UA UA93004272A patent/UA29400C2/uk unknown
- 1992-05-25 CA CA002109956A patent/CA2109956C/en not_active Expired - Lifetime
- 1992-05-25 GE GEAP19922563A patent/GEP19991583B/en unknown
- 1992-05-25 AT AT92911100T patent/ATE126434T1/de active
- 1992-05-25 EP EP92108798A patent/EP0518113A1/de active Pending
- 1992-05-25 WO PCT/EP1992/001169 patent/WO1992022292A1/de active IP Right Grant
- 1992-05-25 KR KR1019930703733A patent/KR0165875B1/ko not_active IP Right Cessation
- 1992-05-25 EP EP92911100A patent/EP0588839B1/de not_active Expired - Lifetime
- 1992-05-25 ES ES92911100T patent/ES2077419T3/es not_active Expired - Lifetime
- 1992-05-25 DE DE59203307T patent/DE59203307D1/de not_active Expired - Lifetime
- 1992-05-25 DK DK92911100.3T patent/DK0588839T3/da active
- 1992-05-25 HU HU9303532A patent/HU210334B/hu unknown
- 1992-05-25 US US08/142,316 patent/US5498418A/en not_active Expired - Lifetime
- 1992-05-25 JP JP4510428A patent/JP2579729B2/ja not_active Expired - Lifetime
- 1992-06-09 CN CN92105694A patent/CN1053591C/zh not_active Expired - Lifetime
- 1992-07-01 IE IE921863A patent/IE67792B1/en not_active IP Right Cessation
-
1993
- 1993-12-09 FI FI935522A patent/FI101854B/fi not_active IP Right Cessation
- 1993-12-09 NO NO934518A patent/NO305384B1/no not_active IP Right Cessation
- 1993-12-09 NO NO934518D patent/NO934518D0/no unknown
-
1995
- 1995-10-11 GR GR950402794T patent/GR3017689T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0588839B1 (de) | 1995-08-16 |
KR0165875B1 (ko) | 1999-01-15 |
DK0588839T3 (da) | 1995-12-27 |
FI935522A (fi) | 1993-12-09 |
JPH06506944A (ja) | 1994-08-04 |
WO1992022292A1 (de) | 1992-12-23 |
NO934518L (no) | 1993-12-09 |
UA29400C2 (uk) | 2000-11-15 |
IE921863A1 (en) | 1992-12-16 |
HU9303532D0 (en) | 1994-04-28 |
US5498418A (en) | 1996-03-12 |
JP2579729B2 (ja) | 1997-02-12 |
FI101854B1 (fi) | 1998-09-15 |
DE59203307D1 (de) | 1995-09-21 |
NO305384B1 (no) | 1999-05-25 |
GR3017689T3 (en) | 1996-01-31 |
EP0588839A1 (de) | 1994-03-30 |
EP0518113A1 (de) | 1992-12-16 |
CN1072093A (zh) | 1993-05-19 |
CA2109956A1 (en) | 1992-12-23 |
HU210334B (en) | 1995-03-28 |
ATE126434T1 (de) | 1995-09-15 |
FI101854B (fi) | 1998-09-15 |
IE67792B1 (en) | 1996-04-17 |
NO934518D0 (no) | 1993-12-09 |
CN1053591C (zh) | 2000-06-21 |
HUT65979A (en) | 1994-08-29 |
GEP19991583B (en) | 1999-04-29 |
CA2109956C (en) | 1998-05-05 |
FI935522A0 (fi) | 1993-12-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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