JPS55149212A - Gradually releasing preparation of methotrexate - Google Patents
Gradually releasing preparation of methotrexateInfo
- Publication number
- JPS55149212A JPS55149212A JP5695279A JP5695279A JPS55149212A JP S55149212 A JPS55149212 A JP S55149212A JP 5695279 A JP5695279 A JP 5695279A JP 5695279 A JP5695279 A JP 5695279A JP S55149212 A JPS55149212 A JP S55149212A
- Authority
- JP
- Japan
- Prior art keywords
- methotrexate
- polymer
- preparation
- gradually releasing
- releasing preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: Titled gradually releasing preparation made by dispersing methotrexate in a specific water-insoluble but hydrophilic polymer, thus being suitably applied in the cavity of uterus because of its appropriate flexibility and elasticity and used as a remedy for villioma with depressed side-effects.
CONSTITUTION: Methotrexate is dispersed in a water-insoluble and hydrophilic polymer of 20W70%, preferably 25W55% water content at 37°C to form a gradually releasing preparation of methotrexate. The polymer is, e.g., preferably a crosslinked homopolymer of acrylamide or N-vinylpyrrolidone or crosslinked polyvinyl alcohol. The polymer is made by mass polymerization. The effective components are prepd. by impregnation. The preparation is readily applied to the cavity of uterus by simple procedures and the irritation is reduced and it can stand the long-term staying. The elution rate of the effective components can be controlled by the water content. The concentration of methotrexate in the preparation is preferably 1W10% based on the carrier polymer.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5695279A JPS55149212A (en) | 1979-05-11 | 1979-05-11 | Gradually releasing preparation of methotrexate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5695279A JPS55149212A (en) | 1979-05-11 | 1979-05-11 | Gradually releasing preparation of methotrexate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS55149212A true JPS55149212A (en) | 1980-11-20 |
Family
ID=13041873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5695279A Pending JPS55149212A (en) | 1979-05-11 | 1979-05-11 | Gradually releasing preparation of methotrexate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55149212A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6067435A (en) * | 1983-08-15 | 1985-04-17 | アグリパット アクチエンゲゼルシヤフト | Bridged porous polymer for controlling drug release |
| EP0998919A3 (en) * | 1998-09-24 | 2000-08-02 | Basf Aktiengesellschaft | Solid dosage form with copolymeric binder |
-
1979
- 1979-05-11 JP JP5695279A patent/JPS55149212A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6067435A (en) * | 1983-08-15 | 1985-04-17 | アグリパット アクチエンゲゼルシヤフト | Bridged porous polymer for controlling drug release |
| EP0998919A3 (en) * | 1998-09-24 | 2000-08-02 | Basf Aktiengesellschaft | Solid dosage form with copolymeric binder |
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