JPH06506944A - ニトログリセリン膏薬及びその製造方法 - Google Patents
ニトログリセリン膏薬及びその製造方法Info
- Publication number
- JPH06506944A JPH06506944A JP4510428A JP51042892A JPH06506944A JP H06506944 A JPH06506944 A JP H06506944A JP 4510428 A JP4510428 A JP 4510428A JP 51042892 A JP51042892 A JP 51042892A JP H06506944 A JPH06506944 A JP H06506944A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- nitroglycerin
- vinyl acetate
- acrylate
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (8)
- 1.支持体フィルム、アクリレートー酢酸ビニルコポリマーに基づく、ニトログ リセリン含有接着剤及び使用の前に除去され得る従来の保護フィルムを含んで成 る、ニトログリセリンの経皮投与のための皮膚膏薬であって、前記ニトログリセ リン含有接着剤が、1)有機溶媒における、モノマー混合物100重量%に基づ いて酢酸ビニル21〜40重量%、アクリル酸−C2−3−アルキルエステル5 5〜70重量%及びアクリル酸−C2−4−ヒドロキシルアクリルエステル3〜 10重量%を含む混合物のラジカル重合;2)有機溶媒における従来の架橋剤及 び膏薬の使に必要とされる量でのニトログリセリンの混合;及び 3)前記得られた混合物の加熱による架橋及び使用される溶媒又は溶媒混合物の 除去により製造されることを特徴とする皮膚膏薬。
- 2.前記アクリル酸−C2−4−ヒドロキシアルキルエステルがヒドロキシエチ ルアクリレートであることを特徴とする請求の範囲第1項記載の皮膚膏薬。
- 3.前記アクリル酸−C2−6−アルキルエステルが、2−ヒドロキシエチルア クリレートの他に、エチルアクリレートであることを特徴とする請求の範囲第1 又は2項記載の皮膚膏薬。
- 4.前記架橋剤がチタン酸エステル又はその混合物であることを特徴とする請求 の範囲第1〜3のいづれか1項記載の皮膚膏薬。
- 5.架橋のために、架橋剤を含み、そしてラジカル重合により得られるコポリマ ーの重量に基づいて、0.3〜3重量%のチタン酸エステル又はその混合物が使 用されることを特徴とする請求の範囲第4項記載の皮膚膏薬。
- 6.前記架橋剤がアセチルアセトナトチタン及び/又はポリブチルチタネートで あることを特徴とする請求の範囲第4又は5項記載の皮膚膏薬。
- 7.請求の範囲第1〜6のいづれか1項記載の膏薬の製造方法であって、膏薬の 使用のために必要とされる量でのニトログリセリン及び架橋剤を含み、そして有 機溶媒において、使用されるモノマー混合物の100重量%に基づいて、21〜 40重量%の酢酸ビニル、55〜70重量%のアクリル酸−C2−8−アルキル エステル及び3〜10重量%のアクリル酸−C2−4−ヒドロキシルアルキルエ ステルから成るモノマーの混合物のラジカル重合により製造されるアクリレート ー酢酸ビニルコポリマーの溶液が、膏薬の保護フィルムに、必要とされる層の厚 さで適用され、溶媒又は溶媒の混合物が加熱により除去され、それによって特定 のアクリレートー酢酸ビニルコポリマーが架橋され、その後、支持体フィルムが 適用され、そして膏薬が必要な大きさに切断され、そして/又は打抜きされるこ とを特徴とする方法。
- 8.前記特定のアクリレートー酢酸ビニルコポリマー、ニトログリセリン及び架 橋剤を、20〜40重量%のエタノール又はエタノールーメタノール混合物に一 緒に溶解し、その固形成分が、前記特定のアクリレートー酢酸ビニルコポリマー 、架橋剤及びニトログリセリンの混合物40〜60重量%から成ることを特徴と する請求の範囲第7項記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4118891.8 | 1991-06-10 | ||
DE4118891 | 1991-06-10 | ||
PCT/EP1992/001169 WO1992022292A1 (de) | 1991-06-10 | 1992-05-25 | Nitroglycerin-pflaster und verfahren zu seiner herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06506944A true JPH06506944A (ja) | 1994-08-04 |
JP2579729B2 JP2579729B2 (ja) | 1997-02-12 |
Family
ID=6433497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4510428A Expired - Lifetime JP2579729B2 (ja) | 1991-06-10 | 1992-05-25 | ニトログリセリン膏薬及びその製造方法 |
Country Status (18)
Country | Link |
---|---|
US (1) | US5498418A (ja) |
EP (2) | EP0588839B1 (ja) |
JP (1) | JP2579729B2 (ja) |
KR (1) | KR0165875B1 (ja) |
CN (1) | CN1053591C (ja) |
AT (1) | ATE126434T1 (ja) |
CA (1) | CA2109956C (ja) |
DE (1) | DE59203307D1 (ja) |
DK (1) | DK0588839T3 (ja) |
ES (1) | ES2077419T3 (ja) |
FI (1) | FI101854B (ja) |
GE (1) | GEP19991583B (ja) |
GR (1) | GR3017689T3 (ja) |
HU (1) | HU210334B (ja) |
IE (1) | IE67792B1 (ja) |
NO (2) | NO934518D0 (ja) |
UA (1) | UA29400C2 (ja) |
WO (1) | WO1992022292A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009510192A (ja) * | 2005-09-23 | 2009-03-12 | ナショナル スターチ アンド ケミカル インベストメント ホールディング コーポレイション | アクリルポリマー系接着剤 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
DE4406332C1 (de) * | 1994-02-28 | 1995-06-22 | Sanol Arznei Schwarz Gmbh | Pharmazeutische Verwendung von Nitroglycerin zur Verhinderung unerwünschter Wehentätigkeit bei Säugern in einer transdermalen Applikationsform |
US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
WO1998025591A1 (en) * | 1996-12-10 | 1998-06-18 | Rotta Research B.V. | Transdermal drug delivery system for the treatment of heart diseases |
EP0856311A1 (en) * | 1996-12-10 | 1998-08-05 | Rotta Research B.V. | Transdermal drug delivery system for the treatment of heart diseases |
CN1070367C (zh) * | 1997-08-07 | 2001-09-05 | 德阳华康药业有限公司 | 注射贴及其制备方法 |
DE19818955C2 (de) * | 1998-04-28 | 2000-06-29 | Lohmann Therapie Syst Lts | Zusammensetzung, enthaltend Polyacrylat, Polyterpen, Nitroglycerin und wahlweise Polyvinylacetat |
DE19830648A1 (de) * | 1998-07-09 | 2000-01-13 | Lohmann Therapie Syst Lts | Glyceroltrinitrathaltige Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE19831418C2 (de) * | 1998-07-14 | 2000-07-06 | Lohmann Therapie Syst Lts | Verfahren und Vorrichtung zum Herstellen flächenhafter Produkte aus Laminat, deren Übertragung auf eine Abdeckfolie und Endkonfektionierung |
TR200101790T2 (tr) | 1998-12-23 | 2001-10-22 | Idea Ag. | Yayılgan olmayan in vivo topik uygulamalar için geliştirilmiş formül |
EP1031347B1 (en) | 1999-01-27 | 2002-04-17 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
WO2001001962A1 (en) * | 1999-07-05 | 2001-01-11 | Idea Ag. | A method for the improvement of transport across adaptable semi-permeable barriers |
JP5021124B2 (ja) * | 2001-08-29 | 2012-09-05 | 日東電工株式会社 | 医療用粘着組成物、それを用いた医療用粘着テープおよび経皮吸収用テープ製剤 |
EP1293198B1 (en) * | 2001-09-14 | 2005-02-09 | Schwarz Pharma Ag | Device for transdermal administration for the treatment of urinary tract disorders |
EP1509210A1 (de) * | 2002-05-28 | 2005-03-02 | LABTEC GESELLSCHAFT FüR TECHNOLOGISCHE FORSCHUNG UND ENTWICKLUNG MBH | Pflaster, enthaltend fentanylum |
US7473432B2 (en) * | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
KR100563194B1 (ko) * | 2003-11-14 | 2006-03-21 | (주) 에프디엘 | 펜타닐을 유효성분으로 함유하는 경피투여제제 |
WO2006050926A2 (en) * | 2004-11-12 | 2006-05-18 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
US8153742B2 (en) * | 2005-09-23 | 2012-04-10 | Henkel Ag & Co. Kgaa | Acrylic polymer-based adhesives |
RU2700032C2 (ru) * | 2014-08-25 | 2019-09-12 | ХЕНКЕЛЬ АйПи ЭНД ХОЛДИНГ ГМБХ | Акриловые полимеры и их применение при трансдермальной доставке лекарственного средства |
CN105362254B (zh) * | 2015-12-09 | 2017-03-15 | 北京邦尼康达医药科技有限公司 | 一种硝酸甘油贴膜及其制备方法 |
DE202016007127U1 (de) | 2016-11-22 | 2016-12-19 | Ludwig Volker | Falzhilfe |
CN113125596B (zh) * | 2021-04-07 | 2023-01-13 | 马应龙药业集团股份有限公司 | 一种高效液相色谱法测定硝酸甘油软膏中有关物质的方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03220120A (ja) * | 1989-12-28 | 1991-09-27 | Nitto Denko Corp | アクリル系ゲル材およびアクリル系ゲル製剤 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
JPS5777617A (en) | 1980-10-20 | 1982-05-15 | Nichiban Co Ltd | Plaster for cardiac disease |
JPS5843368B2 (ja) * | 1980-10-30 | 1983-09-27 | 日東電工株式会社 | 消炎鎮痛貼付剤 |
JPS57116011A (en) | 1981-01-08 | 1982-07-19 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
JPS6059207B2 (ja) | 1981-03-13 | 1985-12-24 | 日東電工株式会社 | 複合製剤の製法 |
GB2105990B (en) | 1981-08-27 | 1985-06-19 | Nitto Electric Ind Co | Adhesive skin patches |
US4608249A (en) | 1982-11-02 | 1986-08-26 | Nitto Electric Industrial Co., Ltd. | Hydrophilic therapeutic material |
DE3315272C2 (de) | 1983-04-27 | 1986-03-27 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Pharmazeutisches Produkt und Verfahren zu seiner Herstellung |
ATE59302T1 (de) | 1984-07-24 | 1991-01-15 | Key Pharma | Klebende schicht zur transdermalen freigabe. |
US4751087A (en) | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
JPS62292877A (ja) * | 1986-06-13 | 1987-12-19 | Nippon Shokubai Kagaku Kogyo Co Ltd | 接着剤用組成物 |
DE3643987A1 (de) | 1986-12-22 | 1988-06-23 | Lohmann Therapie Syst Lts | Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung |
JPH0696529B2 (ja) | 1987-03-31 | 1994-11-30 | 積水化学工業株式会社 | ニトログリセリン貼付剤およびその製造方法 |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
JP2524190B2 (ja) * | 1988-05-11 | 1996-08-14 | 日東電工株式会社 | クロニジンを含有する粘着テ―プ製剤 |
EP0435199B2 (en) * | 1989-12-28 | 2000-01-19 | Nitto Denko Corporation | Acrylic gel material and acrylic gel preparation |
JP2882843B2 (ja) * | 1990-03-28 | 1999-04-12 | 日本化薬株式会社 | 門脈圧亢進症改善剤 |
JPH07116032B2 (ja) * | 1990-04-06 | 1995-12-13 | 積水化学工業株式会社 | ニトログリセリン貼付剤 |
-
1992
- 1992-05-25 WO PCT/EP1992/001169 patent/WO1992022292A1/de active IP Right Grant
- 1992-05-25 DE DE59203307T patent/DE59203307D1/de not_active Expired - Lifetime
- 1992-05-25 JP JP4510428A patent/JP2579729B2/ja not_active Expired - Lifetime
- 1992-05-25 ES ES92911100T patent/ES2077419T3/es not_active Expired - Lifetime
- 1992-05-25 UA UA93004272A patent/UA29400C2/uk unknown
- 1992-05-25 AT AT92911100T patent/ATE126434T1/de active
- 1992-05-25 US US08/142,316 patent/US5498418A/en not_active Expired - Lifetime
- 1992-05-25 CA CA002109956A patent/CA2109956C/en not_active Expired - Lifetime
- 1992-05-25 KR KR1019930703733A patent/KR0165875B1/ko not_active IP Right Cessation
- 1992-05-25 EP EP92911100A patent/EP0588839B1/de not_active Expired - Lifetime
- 1992-05-25 GE GEAP19922563A patent/GEP19991583B/en unknown
- 1992-05-25 EP EP92108798A patent/EP0518113A1/de active Pending
- 1992-05-25 HU HU9303532A patent/HU210334B/hu unknown
- 1992-05-25 DK DK92911100.3T patent/DK0588839T3/da active
- 1992-06-09 CN CN92105694A patent/CN1053591C/zh not_active Expired - Lifetime
- 1992-07-01 IE IE921863A patent/IE67792B1/en not_active IP Right Cessation
-
1993
- 1993-12-09 NO NO934518D patent/NO934518D0/no unknown
- 1993-12-09 FI FI935522A patent/FI101854B/fi not_active IP Right Cessation
- 1993-12-09 NO NO934518A patent/NO305384B1/no not_active IP Right Cessation
-
1995
- 1995-10-11 GR GR950402794T patent/GR3017689T3/el unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03220120A (ja) * | 1989-12-28 | 1991-09-27 | Nitto Denko Corp | アクリル系ゲル材およびアクリル系ゲル製剤 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009510192A (ja) * | 2005-09-23 | 2009-03-12 | ナショナル スターチ アンド ケミカル インベストメント ホールディング コーポレイション | アクリルポリマー系接着剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0518113A1 (de) | 1992-12-16 |
CA2109956A1 (en) | 1992-12-23 |
IE67792B1 (en) | 1996-04-17 |
EP0588839B1 (de) | 1995-08-16 |
DK0588839T3 (da) | 1995-12-27 |
JP2579729B2 (ja) | 1997-02-12 |
FI935522A0 (fi) | 1993-12-09 |
CN1072093A (zh) | 1993-05-19 |
NO305384B1 (no) | 1999-05-25 |
FI101854B1 (fi) | 1998-09-15 |
CA2109956C (en) | 1998-05-05 |
US5498418A (en) | 1996-03-12 |
EP0588839A1 (de) | 1994-03-30 |
GR3017689T3 (en) | 1996-01-31 |
FI101854B (fi) | 1998-09-15 |
ATE126434T1 (de) | 1995-09-15 |
IE921863A1 (en) | 1992-12-16 |
ES2077419T3 (es) | 1995-11-16 |
NO934518D0 (no) | 1993-12-09 |
CN1053591C (zh) | 2000-06-21 |
KR0165875B1 (ko) | 1999-01-15 |
HUT65979A (en) | 1994-08-29 |
DE59203307D1 (de) | 1995-09-21 |
FI935522A (fi) | 1993-12-09 |
NO934518L (no) | 1993-12-09 |
UA29400C2 (uk) | 2000-11-15 |
HU9303532D0 (en) | 1994-04-28 |
HU210334B (en) | 1995-03-28 |
GEP19991583B (en) | 1999-04-29 |
WO1992022292A1 (de) | 1992-12-23 |
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