DE60112903D1 - Oxazolidinon-thioamide mit piperazinamid-substituenten - Google Patents

Oxazolidinon-thioamide mit piperazinamid-substituenten

Info

Publication number
DE60112903D1
DE60112903D1 DE60112903T DE60112903T DE60112903D1 DE 60112903 D1 DE60112903 D1 DE 60112903D1 DE 60112903 T DE60112903 T DE 60112903T DE 60112903 T DE60112903 T DE 60112903T DE 60112903 D1 DE60112903 D1 DE 60112903D1
Authority
DE
Germany
Prior art keywords
piperazinamide
thioamide
oxazolidinone
substituents
piperazinamide substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60112903T
Other languages
English (en)
Other versions
DE60112903T2 (de
Inventor
B Hester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60112903D1 publication Critical patent/DE60112903D1/de
Publication of DE60112903T2 publication Critical patent/DE60112903T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
DE60112903T 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid-substituenten Expired - Fee Related DE60112903T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18164000P 2000-02-10 2000-02-10
PCT/US2001/000682 WO2001058885A1 (en) 2000-02-10 2001-02-07 Oxazolidinone thioamides with piperazine amide substituents

Publications (2)

Publication Number Publication Date
DE60112903D1 true DE60112903D1 (de) 2005-09-29
DE60112903T2 DE60112903T2 (de) 2006-06-14

Family

ID=22665142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112903T Expired - Fee Related DE60112903T2 (de) 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid-substituenten

Country Status (17)

Country Link
US (1) US20010047004A1 (de)
EP (1) EP1263742B1 (de)
JP (1) JP2003522763A (de)
KR (1) KR20020072311A (de)
CN (1) CN1395569A (de)
AR (1) AR029226A1 (de)
AT (1) ATE302762T1 (de)
AU (1) AU2001234428A1 (de)
BR (1) BR0107645A (de)
CA (1) CA2395648A1 (de)
CO (1) CO5271737A1 (de)
DE (1) DE60112903T2 (de)
ES (1) ES2248284T3 (de)
MX (1) MXPA02007719A (de)
NZ (1) NZ520696A (de)
PE (1) PE20011089A1 (de)
WO (1) WO2001058885A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
CA2477379A1 (en) * 2002-02-28 2003-09-04 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
CA2478502A1 (en) * 2002-04-01 2003-10-09 Cadila Healthcare Limited Novel antiinfective compounds, process for their preparation and pharmaceutical compositions containing them
TW200403240A (en) 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
WO2004007489A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
EP1546140A2 (de) * 2002-07-11 2005-06-29 Wockhardt Limited Antimikrobielle oxazolidinone, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
US7217726B2 (en) * 2002-08-22 2007-05-15 Orchid Chemicals & Pharmaceuticals Limited Antibacterial agents
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
ES2271660T3 (es) * 2002-11-21 2007-04-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
CA2530140C (en) 2003-07-02 2010-11-09 Merck & Co., Inc. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
EP1654259A1 (de) * 2003-07-02 2006-05-10 Merck & Co., Inc. Mit einer cyclopropylgruppe substituierte oxazolidinonantibiotika und derivate davon
EP1723159B1 (de) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Makrozyklische verbindungen, deren herstellung und verwendung
JP2009506066A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
JP2009506063A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
WO2008073444A2 (en) * 2006-12-12 2008-06-19 The Johns Hopkins University Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria
WO2008148851A1 (en) 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CA2687754C (en) 2007-06-08 2015-12-08 Janssen Pharmaceutica N.V. Piperidine, piperazine derivatives for use as dgat inhibitors
AU2008258549B2 (en) 2007-06-08 2013-11-14 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
EP2170874A4 (de) * 2007-06-22 2011-08-31 Orchid Res Lab Ltd Neue verbindungen und deren verwendung
WO2009147170A2 (en) 2008-06-05 2009-12-10 Janssen Pharmaceutica Nv Drug combinations comprising a dgat inhibitor and a ppar-agonist
CN115466253A (zh) * 2021-06-16 2022-12-13 沈阳药科大学 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1169542A3 (ru) * 1981-09-08 1985-07-23 Эли Лилли Энд Компани (Фирма) Способ получени тиенопиридиний- или фуропиридиний-замещенных производных цефалоспорина
EP0984947B8 (de) * 1997-05-30 2005-06-15 Pharmacia & Upjohn Company LLC Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
WO1999012914A1 (fr) * 1997-09-11 1999-03-18 Hokuriku Seiyaku Co., Ltd. Derives de thiouree
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
WO2000073301A1 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Bicyclic oxazolidinones as antibacterial agent

Also Published As

Publication number Publication date
KR20020072311A (ko) 2002-09-14
CA2395648A1 (en) 2001-08-16
MXPA02007719A (es) 2002-10-11
AU2001234428A1 (en) 2001-08-20
PE20011089A1 (es) 2001-10-04
ES2248284T3 (es) 2006-03-16
DE60112903T2 (de) 2006-06-14
BR0107645A (pt) 2002-10-08
CN1395569A (zh) 2003-02-05
CO5271737A1 (es) 2003-04-30
NZ520696A (en) 2004-03-26
WO2001058885A1 (en) 2001-08-16
EP1263742B1 (de) 2005-08-24
ATE302762T1 (de) 2005-09-15
JP2003522763A (ja) 2003-07-29
AR029226A1 (es) 2003-06-18
US20010047004A1 (en) 2001-11-29
EP1263742A1 (de) 2002-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee