AR072718A1 - Uso de derivados de indol tales como los activadores de nurr-1 para el tratamiento de la enfermedad de parkinson - Google Patents

Uso de derivados de indol tales como los activadores de nurr-1 para el tratamiento de la enfermedad de parkinson

Info

Publication number
AR072718A1
AR072718A1 ARP090102577A ARP090102577A AR072718A1 AR 072718 A1 AR072718 A1 AR 072718A1 AR P090102577 A ARP090102577 A AR P090102577A AR P090102577 A ARP090102577 A AR P090102577A AR 072718 A1 AR072718 A1 AR 072718A1
Authority
AR
Argentina
Prior art keywords
parkinson
disease
treatment
nurr
activators
Prior art date
Application number
ARP090102577A
Other languages
English (en)
Inventor
Dongen Maria Johanna Petronella Van
Benaissa Boubia
Hartog Jacobus A J Den
Vliet Bernard J Van
Mireille Tallandier
Olivia Poupardin-Oliver
Original Assignee
Fournier Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Publication of AR072718A1 publication Critical patent/AR072718A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

La presente se refiere a un compuesto derivado de indol, en especial, a un compuesto terapéuticamente util, caracterizado porque se selecciona entre los compuestos de formula (1) en la cual: R1 representa un grupo halogeno o trifluorometilo, R2, representa un átomo de hidrogeno o un grupo alquilo C1-C4, R3 representa un grupo isopropilo (1-metiletilo) o un grupo terc-butilo (1,1-dimetiletilo) y n = 3 o 4 y sales farmacéuticamente aceptables de dichos compuestos de formula (1). Aplicacion Tratamiento de enfermedades neurodegenerativas y más particularmente, de la enfermedad de Parkinson. Composiciones farmacéuticas.
ARP090102577A 2008-07-10 2009-07-08 Uso de derivados de indol tales como los activadores de nurr-1 para el tratamiento de la enfermedad de parkinson AR072718A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0854712A FR2933609B1 (fr) 2008-07-10 2008-07-10 Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.

Publications (1)

Publication Number Publication Date
AR072718A1 true AR072718A1 (es) 2010-09-15

Family

ID=40297845

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102577A AR072718A1 (es) 2008-07-10 2009-07-08 Uso de derivados de indol tales como los activadores de nurr-1 para el tratamiento de la enfermedad de parkinson

Country Status (28)

Country Link
US (1) US8575210B2 (es)
EP (1) EP2300424B1 (es)
JP (1) JP5396650B2 (es)
KR (1) KR101606184B1 (es)
CN (1) CN102112441B (es)
AR (1) AR072718A1 (es)
AT (1) ATE541831T1 (es)
AU (1) AU2009269842B2 (es)
BR (1) BRPI0915627A8 (es)
CA (1) CA2730302C (es)
CY (1) CY1112638T1 (es)
DK (1) DK2300424T3 (es)
EA (1) EA018079B1 (es)
ES (1) ES2381180T3 (es)
FR (1) FR2933609B1 (es)
HK (1) HK1154852A1 (es)
HR (1) HRP20120231T1 (es)
IL (1) IL210386A (es)
MX (1) MX2011000353A (es)
MY (1) MY155959A (es)
PL (1) PL2300424T3 (es)
PT (1) PT2300424E (es)
SA (1) SA109300453B1 (es)
SI (1) SI2300424T1 (es)
TW (1) TWI414289B (es)
UA (1) UA102397C2 (es)
WO (1) WO2010004221A2 (es)
ZA (1) ZA201100041B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2955108B1 (fr) * 2010-01-08 2012-03-16 Fournier Lab Sa Utilisation de derives de pyrrolopyridine comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
EP2487159A1 (en) * 2011-02-11 2012-08-15 MSD Oss B.V. RorgammaT inhibitors
WO2013029338A1 (en) * 2011-09-01 2013-03-07 Glaxo Group Limited Novel compounds
KR101964889B1 (ko) 2017-11-17 2019-04-02 한국생명공학연구원 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물
KR102059160B1 (ko) 2017-11-15 2019-12-24 한국생명공학연구원 다프난 또는 포볼 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물
JP6959446B2 (ja) 2017-11-15 2021-11-02 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジーＫｏｒｅａ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｂｉｏｓｃｉｅｎｃｅ Ａｎｄ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ ジテルペン系化合物を含む神経変性疾患の予防又は治療用組成物
KR20240020098A (ko) 2022-08-05 2024-02-14 엠테라파마 주식회사 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03007779A (es) * 2001-03-14 2004-11-12 Lilly Co Eli Moduladores de los receptores de retinoides x.
GB0119911D0 (en) * 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
CN1886133B (zh) * 2003-12-04 2010-12-01 财团法人卫生研究院 吲哚化合物
FR2890071B1 (fr) * 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
FR2903106B1 (fr) 2006-07-03 2010-07-30 Sanofi Aventis Utilisations de 2-benzoyl-imidazopyridines en therapeutique
FR2903107B1 (fr) 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2903105A1 (fr) 2006-07-03 2008-01-04 Sanofi Aventis Sa Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
TWI414289B (zh) 2013-11-11
WO2010004221A3 (fr) 2010-05-06
SI2300424T1 (sl) 2012-04-30
MX2011000353A (es) 2011-02-22
AU2009269842B2 (en) 2013-08-22
FR2933609A1 (fr) 2010-01-15
TW201006468A (en) 2010-02-16
SA109300453B1 (ar) 2013-05-18
IL210386A0 (en) 2011-03-31
US8575210B2 (en) 2013-11-05
EP2300424B1 (fr) 2012-01-18
PT2300424E (pt) 2012-04-27
IL210386A (en) 2015-09-24
US20110178150A1 (en) 2011-07-21
JP5396650B2 (ja) 2014-01-22
HRP20120231T1 (hr) 2012-04-30
EP2300424A2 (fr) 2011-03-30
JP2011527326A (ja) 2011-10-27
FR2933609B1 (fr) 2010-08-27
BRPI0915627A8 (pt) 2017-05-16
EA201170150A1 (ru) 2011-06-30
EA018079B1 (ru) 2013-05-30
PL2300424T3 (pl) 2012-06-29
WO2010004221A2 (fr) 2010-01-14
DK2300424T3 (da) 2012-04-16
CA2730302C (fr) 2017-03-07
HK1154852A1 (en) 2012-05-04
CA2730302A1 (fr) 2010-01-14
CN102112441B (zh) 2013-07-10
ZA201100041B (en) 2012-03-28
AU2009269842A1 (en) 2010-01-14
KR101606184B1 (ko) 2016-03-24
ATE541831T1 (de) 2012-02-15
CN102112441A (zh) 2011-06-29
CY1112638T1 (el) 2016-02-10
MY155959A (en) 2015-12-31
ES2381180T3 (es) 2012-05-23
BRPI0915627A2 (pt) 2016-07-26
KR20110110759A (ko) 2011-10-07
UA102397C2 (ru) 2013-07-10

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