HK1154852A1 - Use of indole derivatives as nurr-1 activators for treating parkinson s disease - Google Patents
Use of indole derivatives as nurr-1 activators for treating parkinson s diseaseInfo
- Publication number
- HK1154852A1 HK1154852A1 HK11109072.9A HK11109072A HK1154852A1 HK 1154852 A1 HK1154852 A1 HK 1154852A1 HK 11109072 A HK11109072 A HK 11109072A HK 1154852 A1 HK1154852 A1 HK 1154852A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nurr
- activators
- disease
- indole derivatives
- treating parkinson
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0854712A FR2933609B1 (fr) | 2008-07-10 | 2008-07-10 | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
PCT/FR2009/051372 WO2010004221A2 (fr) | 2008-07-10 | 2009-07-09 | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1154852A1 true HK1154852A1 (en) | 2012-05-04 |
Family
ID=40297845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11109072.9A HK1154852A1 (en) | 2008-07-10 | 2011-08-29 | Use of indole derivatives as nurr-1 activators for treating parkinson s disease |
Country Status (28)
Country | Link |
---|---|
US (1) | US8575210B2 (es) |
EP (1) | EP2300424B1 (es) |
JP (1) | JP5396650B2 (es) |
KR (1) | KR101606184B1 (es) |
CN (1) | CN102112441B (es) |
AR (1) | AR072718A1 (es) |
AT (1) | ATE541831T1 (es) |
AU (1) | AU2009269842B2 (es) |
BR (1) | BRPI0915627A8 (es) |
CA (1) | CA2730302C (es) |
CY (1) | CY1112638T1 (es) |
DK (1) | DK2300424T3 (es) |
EA (1) | EA018079B1 (es) |
ES (1) | ES2381180T3 (es) |
FR (1) | FR2933609B1 (es) |
HK (1) | HK1154852A1 (es) |
HR (1) | HRP20120231T1 (es) |
IL (1) | IL210386A (es) |
MX (1) | MX2011000353A (es) |
MY (1) | MY155959A (es) |
PL (1) | PL2300424T3 (es) |
PT (1) | PT2300424E (es) |
SA (1) | SA109300453B1 (es) |
SI (1) | SI2300424T1 (es) |
TW (1) | TWI414289B (es) |
UA (1) | UA102397C2 (es) |
WO (1) | WO2010004221A2 (es) |
ZA (1) | ZA201100041B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2955108B1 (fr) * | 2010-01-08 | 2012-03-16 | Fournier Lab Sa | Utilisation de derives de pyrrolopyridine comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
WO2013029338A1 (en) * | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
EP3701946A4 (en) | 2017-11-15 | 2021-08-25 | Korea Research Institute of Bioscience and Biotechnology | COMPOSITION FOR THE PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASES WITH A COMPOUND BASED ON DITERPEN |
KR102059160B1 (ko) | 2017-11-15 | 2019-12-24 | 한국생명공학연구원 | 다프난 또는 포볼 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
KR101964889B1 (ko) | 2017-11-17 | 2019-04-02 | 한국생명공학연구원 | 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
KR20240020098A (ko) | 2022-08-05 | 2024-02-14 | 엠테라파마 주식회사 | 다이터펜계 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 조성물 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004532194A (ja) * | 2001-03-14 | 2004-10-21 | エリ リリー アンド カンパニー | レチノイドxレセプターモジュレータ |
GB0119911D0 (en) * | 2001-08-15 | 2001-10-10 | Novartis Ag | Organic Compounds |
GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
EP1689389A4 (en) * | 2003-12-04 | 2009-06-17 | Nat Health Research Institutes | Indole compounds |
FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
FR2903105A1 (fr) | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
FR2903106B1 (fr) | 2006-07-03 | 2010-07-30 | Sanofi Aventis | Utilisations de 2-benzoyl-imidazopyridines en therapeutique |
FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
-
2008
- 2008-07-10 FR FR0854712A patent/FR2933609B1/fr not_active Expired - Fee Related
-
2009
- 2009-07-08 SA SA109300453A patent/SA109300453B1/ar unknown
- 2009-07-08 AR ARP090102577A patent/AR072718A1/es unknown
- 2009-07-09 UA UAA201100224A patent/UA102397C2/ru unknown
- 2009-07-09 SI SI200930209T patent/SI2300424T1/sl unknown
- 2009-07-09 DK DK09784501.0T patent/DK2300424T3/da active
- 2009-07-09 ES ES09784501T patent/ES2381180T3/es active Active
- 2009-07-09 MX MX2011000353A patent/MX2011000353A/es active IP Right Grant
- 2009-07-09 KR KR1020117000129A patent/KR101606184B1/ko not_active IP Right Cessation
- 2009-07-09 US US13/003,554 patent/US8575210B2/en not_active Expired - Fee Related
- 2009-07-09 EP EP09784501A patent/EP2300424B1/fr not_active Not-in-force
- 2009-07-09 PT PT09784501T patent/PT2300424E/pt unknown
- 2009-07-09 BR BRPI0915627A patent/BRPI0915627A8/pt not_active IP Right Cessation
- 2009-07-09 EA EA201170150A patent/EA018079B1/ru not_active IP Right Cessation
- 2009-07-09 PL PL09784501T patent/PL2300424T3/pl unknown
- 2009-07-09 CN CN2009801269277A patent/CN102112441B/zh not_active Expired - Fee Related
- 2009-07-09 CA CA2730302A patent/CA2730302C/fr not_active Expired - Fee Related
- 2009-07-09 AU AU2009269842A patent/AU2009269842B2/en not_active Ceased
- 2009-07-09 WO PCT/FR2009/051372 patent/WO2010004221A2/fr active Application Filing
- 2009-07-09 JP JP2011517215A patent/JP5396650B2/ja not_active Expired - Fee Related
- 2009-07-09 AT AT09784501T patent/ATE541831T1/de active
- 2009-07-09 MY MYPI2011000084A patent/MY155959A/en unknown
- 2009-07-10 TW TW098123503A patent/TWI414289B/zh not_active IP Right Cessation
-
2010
- 2010-12-30 IL IL210386A patent/IL210386A/en not_active IP Right Cessation
-
2011
- 2011-01-03 ZA ZA2011/00041A patent/ZA201100041B/en unknown
- 2011-08-29 HK HK11109072.9A patent/HK1154852A1/xx not_active IP Right Cessation
-
2012
- 2012-03-13 HR HR20120231T patent/HRP20120231T1/hr unknown
- 2012-03-14 CY CY20121100267T patent/CY1112638T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL241791A0 (en) | Historical use of 3,1-diphenylprop-2-en-1-one for the treatment of liver disorders | |
IL212464A0 (en) | Process for the preparation of protected l-alanine derivatives | |
IL234149A0 (en) | Use of olipristal acetate to treat uterine fibroids | |
HK1154852A1 (en) | Use of indole derivatives as nurr-1 activators for treating parkinson s disease | |
EP2331520A4 (en) | ROSAMINE DERIVATIVES AS AGENTS FOR CANCER TREATMENT | |
ZA201006827B (en) | Carboxamide-heteroaryl derivatives for the treatment of diabetes | |
PL2297115T3 (pl) | Pochodne di-alkoksychinazolin jako inhibitory receptora KDR | |
HK1201441A1 (en) | Process for the preparation of substituted pyrimidine derivatives | |
IL210290A0 (en) | Use of pyrimidylaminobenzamide derivatives for the treatment of fibrosis | |
IL205082A0 (en) | Process for the preparation of tetranorlabdane derivatives | |
HRP20130647T1 (en) | Novel composition for treatment of essential thrombocythemia | |
IL209417A0 (en) | 1-amino-alkylcyclohexane derivatives for the treatment of sleep disorders | |
IL209418A0 (en) | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumours | |
IL218526A0 (en) | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | |
IL213210A0 (en) | Arylcyclopropylacetamide derivatives useful as glucokinase activators | |
EP2250178A4 (en) | IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOL-BENZODIAZEPINE DERIVATIVES |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170709 |