PE20080937A1 - Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil)amino]metil]fenil]-2e-2-propenamida - Google Patents
Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil)amino]metil]fenil]-2e-2-propenamidaInfo
- Publication number
- PE20080937A1 PE20080937A1 PE2007000725A PE2007000725A PE20080937A1 PE 20080937 A1 PE20080937 A1 PE 20080937A1 PE 2007000725 A PE2007000725 A PE 2007000725A PE 2007000725 A PE2007000725 A PE 2007000725A PE 20080937 A1 PE20080937 A1 PE 20080937A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- salts
- propenamide
- indol
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A SALES Y FORMAS CRISTALINAS DEL COMPUESTO N-HIDROXI-3-[4-[[[2-(METIL-1H-INDOL-3-IL)ETIL)]AMINO]METIL]FENIL]-2E-2-PROPENAMIDA, EN DONDE DICHAS SALES SON SELECCIONADAS DE CLORHIDRATO, DL-LACTATO, L-LACTATO, D-LACTATO, MALEATO, MESILATO, TARTRATO, ACETATO, BENZOATO, CITRATO, FUMARATO, GENTISATO, MALATO, MALONATO, OXALATO, FOSFATO, PROPIONATO, SULFATO, SUCCINATO, SODIO, POTASIO, CALCIO Y ZINC. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE, SIENDO UTIL EN EL TRATAMIENTO Y PREVECION DE ENFERMEDADES MEDIADAS POR HISTONA-DESACETILASA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80452306P | 2006-06-12 | 2006-06-12 | |
US86999306P | 2006-12-14 | 2006-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080937A1 true PE20080937A1 (es) | 2008-08-29 |
Family
ID=38564366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000725A PE20080937A1 (es) | 2006-06-12 | 2007-06-08 | Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil)amino]metil]fenil]-2e-2-propenamida |
Country Status (38)
Country | Link |
---|---|
US (3) | US20090197936A1 (es) |
EP (1) | EP2032531B1 (es) |
JP (2) | JP2009540005A (es) |
KR (2) | KR20090026281A (es) |
AR (1) | AR061298A1 (es) |
AU (1) | AU2007257962B2 (es) |
BR (1) | BRPI0712771A2 (es) |
CA (1) | CA2654439C (es) |
CL (1) | CL2007001692A1 (es) |
CR (1) | CR10439A (es) |
DK (1) | DK2032531T3 (es) |
EA (1) | EA015212B1 (es) |
EC (1) | ECSP088979A (es) |
ES (1) | ES2570934T3 (es) |
GE (1) | GEP20105125B (es) |
GT (1) | GT200800279A (es) |
HK (1) | HK1126496A1 (es) |
HN (1) | HN2008001859A (es) |
HR (1) | HRP20160291T1 (es) |
HU (1) | HUE027126T2 (es) |
IL (1) | IL195087A (es) |
JO (1) | JO3138B1 (es) |
MA (1) | MA30563B1 (es) |
ME (1) | ME00531B (es) |
MX (1) | MX2008015901A (es) |
MY (1) | MY147345A (es) |
NO (1) | NO341871B1 (es) |
NZ (1) | NZ572547A (es) |
PE (1) | PE20080937A1 (es) |
PL (1) | PL2032531T3 (es) |
RS (1) | RS54640B1 (es) |
SI (1) | SI2032531T1 (es) |
SM (1) | SMP200900002B (es) |
SV (1) | SV2008003126A (es) |
TN (1) | TNSN08501A1 (es) |
TW (1) | TWI409254B (es) |
UY (1) | UY30403A1 (es) |
WO (1) | WO2007146715A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0712993A2 (pt) | 2006-06-12 | 2012-04-17 | Novartis Ag | polimorfos de n-hidróxi-3-[4[[[2-(2-metil-1h-indol-3-il) etil]amino]metil]fenil]-2e-2-propenamida |
MX2009007343A (es) * | 2007-01-10 | 2009-07-15 | Novartis Ag | Formulaciones de inhibidores de desacetilasa. |
US8003700B2 (en) * | 2008-04-07 | 2011-08-23 | Mutual Pharamaceutical Company, Inc. | Colchicine solid complex; methods of making; and methods of use thereof |
US8519002B2 (en) | 2008-04-07 | 2013-08-27 | Takeda Pharmaceuticals U.S.A., Inc. | Colchicine solid complex; methods of making; and methods of use thereof |
UY32297A (es) * | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
JP5263211B2 (ja) | 2010-03-30 | 2013-08-14 | ブラザー工業株式会社 | サーバ、プリンタ、及び、サーバのためのコンピュータプログラム |
EP2578570A1 (en) | 2011-10-07 | 2013-04-10 | Almirall, S.A. | Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis. |
EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
MA41544A (fr) | 2015-02-19 | 2017-12-26 | Novartis Ag | Dosages de panobinostat pour le traitement du myélome multiple |
WO2017221163A1 (en) * | 2016-06-21 | 2017-12-28 | Alembic Pharmaceuticals Limited | Novel salts and polymorphic forms of panobinostat |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
WO2005013958A1 (en) * | 2003-08-07 | 2005-02-17 | Novartis Ag | Histone deacetylase inhibitors as immunosuppressants |
US20050228300A1 (en) * | 2004-04-07 | 2005-10-13 | Triage Data Networks | Cuffless blood-pressure monitor and accompanying wireless mobile device |
JP2009540007A (ja) * | 2006-06-12 | 2009-11-19 | ノバルティス アクチエンゲゼルシャフト | N−ヒドロキシ−3−[4−[[[2−(2−メチル−1h−インドール−3−イル)エチル]アミノ]メチル]フェニル]−2e−2−プロペンアミドの塩の製造方法 |
BRPI0712993A2 (pt) * | 2006-06-12 | 2012-04-17 | Novartis Ag | polimorfos de n-hidróxi-3-[4[[[2-(2-metil-1h-indol-3-il) etil]amino]metil]fenil]-2e-2-propenamida |
-
2007
- 2007-06-07 ES ES07784348T patent/ES2570934T3/es active Active
- 2007-06-07 WO PCT/US2007/070558 patent/WO2007146715A1/en active Application Filing
- 2007-06-07 JP JP2009515572A patent/JP2009540005A/ja active Pending
- 2007-06-07 SI SI200731762A patent/SI2032531T1/sl unknown
- 2007-06-07 MX MX2008015901A patent/MX2008015901A/es not_active Application Discontinuation
- 2007-06-07 EP EP07784348.0A patent/EP2032531B1/en active Active
- 2007-06-07 KR KR1020087030228A patent/KR20090026281A/ko not_active Application Discontinuation
- 2007-06-07 AU AU2007257962A patent/AU2007257962B2/en not_active Ceased
- 2007-06-07 RS RS20160199A patent/RS54640B1/en unknown
- 2007-06-07 PL PL07784348T patent/PL2032531T3/pl unknown
- 2007-06-07 CA CA2654439A patent/CA2654439C/en active Active
- 2007-06-07 BR BRPI0712771-5A patent/BRPI0712771A2/pt not_active Application Discontinuation
- 2007-06-07 GE GEAP200711010A patent/GEP20105125B/en unknown
- 2007-06-07 SM SM200900002T patent/SMP200900002B/it unknown
- 2007-06-07 ME MEP-2008-879A patent/ME00531B/me unknown
- 2007-06-07 NZ NZ572547A patent/NZ572547A/en not_active IP Right Cessation
- 2007-06-07 DK DK07784348.0T patent/DK2032531T3/en active
- 2007-06-07 EA EA200802382A patent/EA015212B1/ru not_active IP Right Cessation
- 2007-06-07 HU HUE07784348A patent/HUE027126T2/en unknown
- 2007-06-07 KR KR1020157005106A patent/KR101629352B1/ko active Protection Beyond IP Right Term
- 2007-06-07 US US12/302,571 patent/US20090197936A1/en not_active Abandoned
- 2007-06-08 TW TW096120759A patent/TWI409254B/zh not_active IP Right Cessation
- 2007-06-08 PE PE2007000725A patent/PE20080937A1/es active IP Right Grant
- 2007-06-08 AR ARP070102500A patent/AR061298A1/es not_active Application Discontinuation
- 2007-06-11 CL CL200701692A patent/CL2007001692A1/es unknown
- 2007-06-11 UY UY30403A patent/UY30403A1/es not_active Application Discontinuation
- 2007-06-21 JO JOP/2007/0222A patent/JO3138B1/ar active
-
2008
- 2008-11-03 IL IL195087A patent/IL195087A/en unknown
- 2008-11-13 CR CR10439A patent/CR10439A/es unknown
- 2008-11-28 MY MYPI20084866A patent/MY147345A/en unknown
- 2008-12-02 TN TNP2008000501A patent/TNSN08501A1/en unknown
- 2008-12-10 GT GT200800279A patent/GT200800279A/es unknown
- 2008-12-11 HN HN2008001859A patent/HN2008001859A/es unknown
- 2008-12-12 MA MA31469A patent/MA30563B1/fr unknown
- 2008-12-12 SV SV2008003126A patent/SV2008003126A/es active IP Right Grant
- 2008-12-12 EC EC2008008979A patent/ECSP088979A/es unknown
-
2009
- 2009-01-09 NO NO20090128A patent/NO341871B1/no not_active IP Right Cessation
- 2009-06-17 HK HK09105414.8A patent/HK1126496A1/zh not_active IP Right Cessation
-
2010
- 2010-05-06 US US12/775,001 patent/US20100286409A1/en not_active Abandoned
-
2011
- 2011-01-14 US US13/006,485 patent/US20110112308A1/en not_active Abandoned
-
2013
- 2013-10-03 JP JP2013208363A patent/JP5771257B2/ja active Active
-
2016
- 2016-03-21 HR HRP20160291TT patent/HRP20160291T1/hr unknown
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Legal Events
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FG | Grant, registration |