EA200802382A1 - Соли n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида - Google Patents

Соли n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида

Info

Publication number
EA200802382A1
EA200802382A1 EA200802382A EA200802382A EA200802382A1 EA 200802382 A1 EA200802382 A1 EA 200802382A1 EA 200802382 A EA200802382 A EA 200802382A EA 200802382 A EA200802382 A EA 200802382A EA 200802382 A1 EA200802382 A1 EA 200802382A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
EA200802382A
Other languages
English (en)
Other versions
EA015212B1 (ru
Inventor
Мурат Ацемоглы
Джоджиндер С. Байва
Пьотр Карпински
Димитрис Папоутсакис
Джоел Слейд
Франк Штовассер
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38564366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200802382(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200802382A1 publication Critical patent/EA200802382A1/ru
Publication of EA015212B1 publication Critical patent/EA015212B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В заявке получены и охарактеризованы соли N-гидрокси-3-[4-[[[2-(2-метил-1Н-индол-3- ил)этил]амино]метил]фенил]-2Е-2-пропенамида.
EA200802382A 2006-06-12 2007-06-07 Соли n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида EA015212B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80452306P 2006-06-12 2006-06-12
US86999306P 2006-12-14 2006-12-14
PCT/US2007/070558 WO2007146715A1 (en) 2006-06-12 2007-06-07 Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Publications (2)

Publication Number Publication Date
EA200802382A1 true EA200802382A1 (ru) 2009-06-30
EA015212B1 EA015212B1 (ru) 2011-06-30

Family

ID=38564366

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802382A EA015212B1 (ru) 2006-06-12 2007-06-07 Соли n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида

Country Status (38)

Country Link
US (3) US20090197936A1 (ru)
EP (1) EP2032531B1 (ru)
JP (2) JP2009540005A (ru)
KR (2) KR20090026281A (ru)
AR (1) AR061298A1 (ru)
AU (1) AU2007257962B2 (ru)
BR (1) BRPI0712771A2 (ru)
CA (1) CA2654439C (ru)
CL (1) CL2007001692A1 (ru)
CR (1) CR10439A (ru)
DK (1) DK2032531T3 (ru)
EA (1) EA015212B1 (ru)
EC (1) ECSP088979A (ru)
ES (1) ES2570934T3 (ru)
GE (1) GEP20105125B (ru)
GT (1) GT200800279A (ru)
HK (1) HK1126496A1 (ru)
HN (1) HN2008001859A (ru)
HR (1) HRP20160291T1 (ru)
HU (1) HUE027126T2 (ru)
IL (1) IL195087A (ru)
JO (1) JO3138B1 (ru)
MA (1) MA30563B1 (ru)
ME (1) ME00531B (ru)
MX (1) MX2008015901A (ru)
MY (1) MY147345A (ru)
NO (1) NO341871B1 (ru)
NZ (1) NZ572547A (ru)
PE (1) PE20080937A1 (ru)
PL (1) PL2032531T3 (ru)
RS (1) RS54640B1 (ru)
SI (1) SI2032531T1 (ru)
SM (1) SMP200900002B (ru)
SV (1) SV2008003126A (ru)
TN (1) TNSN08501A1 (ru)
TW (1) TWI409254B (ru)
UY (1) UY30403A1 (ru)
WO (1) WO2007146715A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009540006A (ja) 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの多形
AU2008204928B2 (en) * 2007-01-10 2011-03-31 Novartis Ag Formulations of deacetylase inhibitors
US8519002B2 (en) 2008-04-07 2013-08-27 Takeda Pharmaceuticals U.S.A., Inc. Colchicine solid complex; methods of making; and methods of use thereof
US8003700B2 (en) * 2008-04-07 2011-08-23 Mutual Pharamaceutical Company, Inc. Colchicine solid complex; methods of making; and methods of use thereof
UY32297A (es) * 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
JP5263211B2 (ja) 2010-03-30 2013-08-14 ブラザー工業株式会社 サーバ、プリンタ、及び、サーバのためのコンピュータプログラム
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
MA41544A (fr) 2015-02-19 2017-12-26 Novartis Ag Dosages de panobinostat pour le traitement du myélome multiple
WO2017221163A1 (en) * 2016-06-21 2017-12-28 Alembic Pharmaceuticals Limited Novel salts and polymorphic forms of panobinostat

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
WO2005013958A1 (en) * 2003-08-07 2005-02-17 Novartis Ag Histone deacetylase inhibitors as immunosuppressants
US20050228300A1 (en) * 2004-04-07 2005-10-13 Triage Data Networks Cuffless blood-pressure monitor and accompanying wireless mobile device
CA2654230C (en) * 2006-06-12 2012-09-11 Novartis Ag Process for making a lactate salt of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
JP2009540006A (ja) * 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの多形

Also Published As

Publication number Publication date
PE20080937A1 (es) 2008-08-29
AU2007257962A1 (en) 2007-12-21
CA2654439C (en) 2014-08-05
SMP200900002B (it) 2010-01-19
GT200800279A (es) 2010-06-16
KR20090026281A (ko) 2009-03-12
US20100286409A1 (en) 2010-11-11
EA015212B1 (ru) 2011-06-30
SMAP200900002A (it) 2009-01-14
KR20150029765A (ko) 2015-03-18
PL2032531T3 (pl) 2016-07-29
TNSN08501A1 (en) 2010-04-14
AU2007257962B2 (en) 2011-06-23
IL195087A0 (en) 2009-08-03
CA2654439A1 (en) 2007-12-21
BRPI0712771A2 (pt) 2012-09-25
ES2570934T3 (es) 2016-05-23
MX2008015901A (es) 2009-01-12
ME00531B (me) 2011-10-10
MY147345A (en) 2012-11-30
EP2032531A1 (en) 2009-03-11
JO3138B1 (ar) 2017-09-20
JP2009540005A (ja) 2009-11-19
JP5771257B2 (ja) 2015-08-26
CL2007001692A1 (es) 2008-05-09
RS54640B1 (en) 2016-08-31
NO341871B1 (no) 2018-02-12
HRP20160291T1 (hr) 2016-04-22
UY30403A1 (es) 2008-01-31
KR101629352B1 (ko) 2016-06-13
IL195087A (en) 2012-10-31
AR061298A1 (es) 2008-08-20
ECSP088979A (es) 2009-01-30
US20090197936A1 (en) 2009-08-06
HN2008001859A (es) 2011-07-19
JP2013256542A (ja) 2013-12-26
SV2008003126A (es) 2011-07-05
NO20090128L (no) 2009-03-11
US20110112308A1 (en) 2011-05-12
SI2032531T1 (sl) 2016-05-31
CR10439A (es) 2009-01-15
NZ572547A (en) 2011-06-30
HUE027126T2 (en) 2016-08-29
EP2032531B1 (en) 2016-02-10
TW200815343A (en) 2008-04-01
HK1126496A1 (zh) 2009-09-04
TWI409254B (zh) 2013-09-21
MA30563B1 (fr) 2009-07-01
DK2032531T3 (en) 2016-04-11
GEP20105125B (en) 2010-11-25
WO2007146715A1 (en) 2007-12-21

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