AR060956A1 - Derivados de 1-[4-[benzoil(metil)amino]-3-(fenil)butil]azetidina para el trata-miento de desordenes gastrointestinales - Google Patents

Derivados de 1-[4-[benzoil(metil)amino]-3-(fenil)butil]azetidina para el trata-miento de desordenes gastrointestinales

Info

Publication number
AR060956A1
AR060956A1 ARP070102113A ARP070102113A AR060956A1 AR 060956 A1 AR060956 A1 AR 060956A1 AR P070102113 A ARP070102113 A AR P070102113A AR P070102113 A ARP070102113 A AR P070102113A AR 060956 A1 AR060956 A1 AR 060956A1
Authority
AR
Argentina
Prior art keywords
methyl
butil
benzoil
azetidine
phenyl
Prior art date
Application number
ARP070102113A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38723558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR060956(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR060956A1 publication Critical patent/AR060956A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente se refiere a compuestos de formula (1), a composiciones farmacéuticas que comprenden a dichos compuestos, y al uso de dichos compuestos en terapia. La presente además se refiere a procesos para la preparacion de compuestos de formula (1). Reivindicacion 1: Un compuesto de formula (1) donde R1 y R2 se selecciona cada uno en forma independiente de H, metilo, etilo, o R1 y R2 forman un anillo de 4, 5 o 6 miembros junto con el N de la amida, y dicho anillo contiene opcionalmente un átomo de O; X es Br o Cl; así como también sus sales farmacéutica y farmacologicamente aceptables, y los enantiomeros del compuesto de formula (1) y sus sales.
ARP070102113A 2006-05-18 2007-05-16 Derivados de 1-[4-[benzoil(metil)amino]-3-(fenil)butil]azetidina para el trata-miento de desordenes gastrointestinales AR060956A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80157706P 2006-05-18 2006-05-18

Publications (1)

Publication Number Publication Date
AR060956A1 true AR060956A1 (es) 2008-07-23

Family

ID=38723558

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102113A AR060956A1 (es) 2006-05-18 2007-05-16 Derivados de 1-[4-[benzoil(metil)amino]-3-(fenil)butil]azetidina para el trata-miento de desordenes gastrointestinales

Country Status (24)

Country Link
US (1) US8106208B2 (es)
EP (1) EP2024354B1 (es)
JP (1) JP5196381B2 (es)
KR (1) KR101429779B1 (es)
CN (1) CN101472910B (es)
AR (1) AR060956A1 (es)
AT (1) ATE525355T1 (es)
AU (1) AU2007253666B2 (es)
BR (1) BRPI0712405A2 (es)
CA (1) CA2652443C (es)
DK (1) DK2024354T3 (es)
ES (1) ES2373335T3 (es)
HK (1) HK1121758A1 (es)
IL (1) IL195197A (es)
MX (1) MX2008014686A (es)
MY (1) MY147474A (es)
NO (1) NO20084674L (es)
PL (1) PL2024354T3 (es)
PT (1) PT2024354E (es)
RU (1) RU2439067C2 (es)
TW (1) TW200813006A (es)
UY (1) UY30356A1 (es)
WO (1) WO2007136324A1 (es)
ZA (1) ZA200809909B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
CA2663280A1 (en) * 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Diaryl piperidine compounds as calcium channel blockers
EP2125711B1 (en) * 2007-03-08 2013-11-06 Albireo Ab 3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease
JP5780954B2 (ja) * 2008-05-08 2015-09-16 エヴォテック・アクチエンゲゼルシャフト ヒスタミンｈ３受容体アンタゴニストとしてのアゼチジン類及びシクロブタン類
CA2815350A1 (en) * 2010-10-22 2012-04-26 Janssen Pharmaceutica Nv Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
MX342140B (es) * 2011-09-30 2016-09-14 Janssen Pharmaceutica Nv Sal clorhidrato cristalina de (1-(4-fluorofenil)-1h-indol-5-il)-(3 -(4-(tiazol-2-carbonil)piperazin-1-il) azetidin-1-il)metanona y su uso en el tratamiento del dolor y transtornos metabolicos.
CN104529833B (zh) * 2014-12-10 2016-04-20 广东东阳光药业有限公司 取代的环丁烷羧酸类化合物及其用途
KR102476938B1 (ko) 2017-12-07 2022-12-13 기초과학연구원 핫전자 기반의 산화물-금속 하이브리드 역촉매

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310066D0 (en) 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
TW432061B (en) 1994-08-09 2001-05-01 Pfizer Res & Dev Lactams
GB9502644D0 (en) 1995-02-10 1995-03-29 Zeneca Ltd Heterocyclic derivatives
GB9600235D0 (en) 1996-01-05 1996-03-06 Pfizer Ltd Therapeutic agents
GB9601202D0 (en) 1996-01-22 1996-03-20 Pfizer Ltd Piperidones
GB9601697D0 (en) 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
GB9601680D0 (en) 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
GB9714129D0 (en) 1997-07-04 1997-09-10 Pfizer Ltd Azetidines
GB9812037D0 (en) 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
JP2002520316A (ja) * 1998-07-10 2002-07-09 アストラゼネカ・アクチエボラーグ ニューロキニン受容体アンタゴニストとしてのｎ−置換ナフタレンカルボキサミド
GB9922519D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9922521D0 (en) 1998-10-07 1999-11-24 Zeneca Ltd Compounds
GB9924141D0 (en) 1998-10-30 1999-12-15 Zeneca Ltd Treatment of gastric asthma
GB9826941D0 (en) 1998-12-09 1999-02-03 Zeneca Pharmaceuticals Compounds
SE0004827D0 (sv) 2000-12-22 2000-12-22 Astrazeneca Ab Therapeutic compounds
SE0103795D0 (sv) 2001-11-02 2001-11-02 Astrazeneca Ab Compounds and method for the treatment of överactive bladder
TW200508221A (en) 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
US20100069346A1 (en) * 2005-06-23 2010-03-18 Sara Holmqvist New Azetidine Derivatives as Neurokinin Receptor Antagonists for the Treatment of Gastrointestinal Diseases
EP1899318A4 (en) * 2005-06-23 2010-03-17 Astrazeneca Ab NEW AZETIDINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF STOMACH DARM DISEASES
AR057828A1 (es) * 2005-09-29 2007-12-19 Astrazeneca Ab Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
AR056087A1 (es) * 2005-09-29 2007-09-19 Astrazeneca Ab Derivados de azetidina como antagonistas de receptores de neuroquina nk

Also Published As

Publication number Publication date
ATE525355T1 (de) 2011-10-15
CN101472910B (zh) 2014-03-26
US8106208B2 (en) 2012-01-31
AU2007253666A1 (en) 2007-11-29
UY30356A1 (es) 2008-01-02
EP2024354A4 (en) 2009-11-11
DK2024354T3 (da) 2012-01-16
US20070270398A1 (en) 2007-11-22
TW200813006A (en) 2008-03-16
CA2652443C (en) 2014-01-14
BRPI0712405A2 (pt) 2012-10-16
RU2008149927A (ru) 2010-06-27
HK1121758A1 (en) 2009-04-30
NO20084674L (no) 2009-01-29
MY147474A (en) 2012-12-14
CA2652443A1 (en) 2007-11-29
AU2007253666B2 (en) 2012-03-15
JP2009537516A (ja) 2009-10-29
JP5196381B2 (ja) 2013-05-15
IL195197A0 (en) 2009-08-03
CN101472910A (zh) 2009-07-01
MX2008014686A (es) 2009-02-10
EP2024354B1 (en) 2011-09-21
IL195197A (en) 2013-10-31
KR101429779B1 (ko) 2014-08-19
RU2439067C2 (ru) 2012-01-10
PT2024354E (pt) 2011-12-19
WO2007136324A1 (en) 2007-11-29
ZA200809909B (en) 2009-08-26
EP2024354A1 (en) 2009-02-18
ES2373335T3 (es) 2012-02-02
PL2024354T3 (pl) 2012-02-29
KR20090018926A (ko) 2009-02-24

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