EA200701849A1 - Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего - Google Patents

Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего

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Publication number
EA200701849A1
EA200701849A1 EA200701849A EA200701849A EA200701849A1 EA 200701849 A1 EA200701849 A1 EA 200701849A1 EA 200701849 A EA200701849 A EA 200701849A EA 200701849 A EA200701849 A EA 200701849A EA 200701849 A1 EA200701849 A1 EA 200701849A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
trunctional
mammalian
inhibition
basis
Prior art date
Application number
EA200701849A
Other languages
English (en)
Inventor
Джесс Д. Кайхер
Кристофер Дон Робертс
Original Assignee
Дженелабс Текнолоджис, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дженелабс Текнолоджис, Инк. filed Critical Дженелабс Текнолоджис, Инк.
Publication of EA200701849A1 publication Critical patent/EA200701849A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Данное изобретение направлено на новые соединения, которые используют при вирусных инфекциях у млекопитающих, опосредованных, по меньшей мере, частично вирусом из семейства вирусов Flaviviridae. В одном из своих аспектов, относящихся к композициям, настоящее изобретение направлено на соединения формулы (I).
EA200701849A 2005-02-28 2006-02-28 Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего EA200701849A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
PCT/US2006/007131 WO2006093986A1 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside prodrugs for treating viral infections

Publications (1)

Publication Number Publication Date
EA200701849A1 true EA200701849A1 (ru) 2008-02-28

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200701849A EA200701849A1 (ru) 2005-02-28 2006-02-28 Пролекарственные соединения трициклических нуклеозидов, фармацевтическая композиция на их основе и способ лечения и/или ингибирования вирусной инфекции у млекопитающего
EA200701850A EA200701850A1 (ru) 2005-02-28 2006-02-28 Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200701850A EA200701850A1 (ru) 2005-02-28 2006-02-28 Соединения трициклических нуклеозидов (варианты), фармацевтическая композиция на их основе и способ лечения или профилактики вирусных инфекций у млекопитающих

Country Status (18)

Country Link
US (4) US7524825B2 (ru)
EP (2) EP1853617A1 (ru)
JP (2) JP2008531704A (ru)
KR (2) KR20070106781A (ru)
CN (2) CN101128474A (ru)
AP (2) AP2007004128A0 (ru)
AR (1) AR058419A1 (ru)
AU (2) AU2006218704A1 (ru)
BR (2) BRPI0607769A2 (ru)
CA (2) CA2597685A1 (ru)
EA (2) EA200701849A1 (ru)
HR (2) HRP20070436A2 (ru)
IL (2) IL184954A0 (ru)
MX (2) MX2007010463A (ru)
NO (2) NO20074613L (ru)
TW (1) TW200640474A (ru)
WO (2) WO2006093986A1 (ru)
ZA (1) ZA200707410B (ru)

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RU2654482C2 (ru) * 2012-04-18 2018-05-21 Байокрист Фармасьютикалз, Инк. Композиции и способы ингибирования вирусной полимеразы

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2654482C2 (ru) * 2012-04-18 2018-05-21 Байокрист Фармасьютикалз, Инк. Композиции и способы ингибирования вирусной полимеразы

Also Published As

Publication number Publication date
CN101142226A (zh) 2008-03-12
WO2006093986A1 (en) 2006-09-08
CN101128474A (zh) 2008-02-20
AU2006218704A1 (en) 2006-09-08
AP2007004128A0 (en) 2007-08-31
BRPI0607770A2 (pt) 2009-06-13
EP1853617A1 (en) 2007-11-14
US20090253648A1 (en) 2009-10-08
NO20074613L (no) 2007-11-27
US20090208457A1 (en) 2009-08-20
JP2008531704A (ja) 2008-08-14
HRP20070435A9 (en) 2008-09-30
HRP20070436A2 (en) 2008-02-29
US7534771B2 (en) 2009-05-19
US7524825B2 (en) 2009-04-28
MX2007010460A (es) 2007-11-08
KR20070106781A (ko) 2007-11-05
MX2007010463A (es) 2007-11-08
EA200701850A1 (ru) 2008-02-28
CA2597683A1 (en) 2006-09-08
WO2006093987A1 (en) 2006-09-08
EP1853618A1 (en) 2007-11-14
TW200640474A (en) 2006-12-01
KR20070106767A (ko) 2007-11-05
US20060252715A1 (en) 2006-11-09
AR058419A1 (es) 2008-02-06
HRP20070435A2 (en) 2008-02-29
NO20074915L (no) 2007-11-20
ZA200707410B (en) 2008-10-29
JP2008531703A (ja) 2008-08-14
BRPI0607769A2 (pt) 2009-10-06
IL184954A0 (en) 2007-12-03
IL184955A0 (en) 2007-12-03
US20060194749A1 (en) 2006-08-31
AP2007004118A0 (en) 2007-08-31
CA2597685A1 (en) 2006-09-08
AU2006218705A1 (en) 2006-09-08

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