EA201000277A1 - Соединения для лечения гепатита с - Google Patents

Соединения для лечения гепатита с

Info

Publication number
EA201000277A1
EA201000277A1 EA201000277A EA201000277A EA201000277A1 EA 201000277 A1 EA201000277 A1 EA 201000277A1 EA 201000277 A EA201000277 A EA 201000277A EA 201000277 A EA201000277 A EA 201000277A EA 201000277 A1 EA201000277 A1 EA 201000277A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
hepatitis
connections
compounds
hcv
Prior art date
Application number
EA201000277A
Other languages
English (en)
Other versions
EA015978B1 (ru
Inventor
Скотт У. Мартин
Карл П. Бергстрём
Роберт Дж. Джентлс
Кап-Сан Енг
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201000277A1 publication Critical patent/EA201000277A1/ru
Publication of EA015978B1 publication Critical patent/EA015978B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретение охватывает соединения формулы I, а также композиции и способы применения соединений. Соединения обладают активностью по отношению к вирусу гепатита С (HCV) и являются эффективными в лечении инфицированных HCV.
EA201000277A 2007-08-09 2008-08-01 Соединения для лечения гепатита с EA015978B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95481407P 2007-08-09 2007-08-09
US4994408P 2008-05-02 2008-05-02
US12/180,994 US7652004B2 (en) 2007-08-09 2008-07-28 Compounds for the treatment of hepatitis C
PCT/US2008/071881 WO2009029384A2 (en) 2007-08-09 2008-08-01 Compounds for the treatment of hepatitis c

Publications (2)

Publication Number Publication Date
EA201000277A1 true EA201000277A1 (ru) 2010-06-30
EA015978B1 EA015978B1 (ru) 2012-01-30

Family

ID=40261456

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000277A EA015978B1 (ru) 2007-08-09 2008-08-01 Соединения для лечения гепатита с

Country Status (18)

Country Link
US (1) US7652004B2 (ru)
EP (1) EP2183252B1 (ru)
JP (1) JP5465670B2 (ru)
KR (1) KR20100066492A (ru)
CN (1) CN101821267B (ru)
AR (1) AR067897A1 (ru)
AU (1) AU2008293845B2 (ru)
BR (1) BRPI0814931A2 (ru)
CA (1) CA2695781A1 (ru)
CL (1) CL2008002353A1 (ru)
CO (1) CO6251359A2 (ru)
EA (1) EA015978B1 (ru)
MX (1) MX2010001416A (ru)
NZ (1) NZ583149A (ru)
PE (1) PE20090618A1 (ru)
TW (1) TW200906418A (ru)
WO (1) WO2009029384A2 (ru)
ZA (1) ZA201000923B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005049622A1 (ja) * 2003-11-19 2007-06-07 日本たばこ産業株式会社 ５−５員縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての用途
US20070049593A1 (en) * 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
US8143243B2 (en) * 2007-08-09 2012-03-27 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
CN101918410B (zh) * 2007-11-20 2013-02-27 百时美施贵宝公司 与环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂
US8129367B2 (en) * 2007-11-21 2012-03-06 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
JP2011517673A (ja) 2008-03-27 2011-06-16 ブリストル−マイヤーズ スクイブ カンパニー 芳香族ヘテロ環縮合インドロベンザジアゼピンｈｃｖｎｓ５ｂ阻害剤
US8133884B2 (en) * 2008-05-06 2012-03-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
CN102388045A (zh) * 2009-02-11 2012-03-21 百时美施贵宝公司 用于治疗丙型肝炎的化合物
EP2655362A1 (en) 2010-12-22 2013-10-30 Abbvie Inc. Hepatitis c inhibitors and uses thereof
JP5915004B2 (ja) * 2011-06-22 2016-05-11 セントラル硝子株式会社 ピラゾール化合物の製造方法
CN103635461B (zh) * 2011-06-22 2016-01-20 中央硝子株式会社 吡唑化合物的制造方法
JP6306002B2 (ja) * 2012-07-18 2018-04-04 ブリストル−マイヤーズ・スクイブ・ホールディングス・アイルランドＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｈｏｌｄｉｎｇｓ Ｉｒｅｌａｎｄ （４ｂＳ，５ａＲ）−１２−シクロヘキシル−Ｎ−（Ｎ，Ｎ−ジメチルスルファモイル）−３−メトキシ−５ａ−（（１Ｒ，５Ｓ）−３−メチル−３，８−ジアザビシクロ［３．２．１］オクタン−８−カルボニル）−４ｂ，５，５ａ，６−テトラヒドロベンゾ［３，４］シクロプロパ［５，６］アゼピノ［１，２−Ａ］インドール−９−カルボキサミドを製造するための新規な方法および中間体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1719773T3 (da) 2004-02-24 2009-06-29 Japan Tobacco Inc Kondenserede heterotetracykliske forbindelser og anvendelse deraf som HCV-polymeraseinhibitor
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
BRPI0516972A (pt) 2004-10-26 2008-09-30 Angeletti P Ist Ricerche Bio composto, uso do mesmo, composição farmacêutica, método para inibir a polimerase do vìrus da hepatite c e/ou de tratar ou prevenir uma doença devido ao vìrus da hepatite c, e, processo para preparar um composto
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7473688B2 (en) * 2005-09-13 2009-01-06 Bristol-Myers Squibb Company Indolobenzazepine HCV NS5B inhibitors
US7456165B2 (en) * 2006-02-08 2008-11-25 Bristol-Myers Squibb Company HCV NS5B inhibitors
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521441B2 (en) * 2006-05-22 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
ES2343914T3 (es) * 2006-05-25 2010-08-12 Bristol-Myers Squibb Company Inhibidores de ns5b de hcv de indolobenzazepina condensada con ciclopropilo.
US7521442B2 (en) * 2006-05-25 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7452876B2 (en) * 2006-06-08 2008-11-18 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7541351B2 (en) * 2007-01-11 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7517872B2 (en) * 2007-02-22 2009-04-14 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7521444B2 (en) * 2007-03-14 2009-04-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7541353B2 (en) * 2007-03-14 2009-06-02 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7547690B2 (en) * 2007-03-14 2009-06-16 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US7538102B2 (en) * 2007-03-14 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US7538103B2 (en) * 2007-03-15 2009-05-26 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C

Also Published As

Publication number Publication date
CO6251359A2 (es) 2011-02-21
AU2008293845A1 (en) 2009-03-05
JP5465670B2 (ja) 2014-04-09
KR20100066492A (ko) 2010-06-17
BRPI0814931A2 (pt) 2015-02-03
WO2009029384A2 (en) 2009-03-05
EA015978B1 (ru) 2012-01-30
US7652004B2 (en) 2010-01-26
NZ583149A (en) 2011-07-29
CL2008002353A1 (es) 2008-10-24
EP2183252A2 (en) 2010-05-12
EP2183252B1 (en) 2015-01-14
MX2010001416A (es) 2010-03-01
AU2008293845B2 (en) 2013-02-14
US20090074715A1 (en) 2009-03-19
ZA201000923B (en) 2011-04-28
CN101821267A (zh) 2010-09-01
CN101821267B (zh) 2013-07-10
CA2695781A1 (en) 2009-03-05
TW200906418A (en) 2009-02-16
AR067897A1 (es) 2009-10-28
JP2010535787A (ja) 2010-11-25
WO2009029384A3 (en) 2009-05-28
PE20090618A1 (es) 2009-05-16

Similar Documents

Publication Publication Date Title
EA201000277A1 (ru) Соединения для лечения гепатита с
EA201001273A1 (ru) Ингибиторы вируса гепатита с
EA200901241A1 (ru) Соединения для лечения гепатита с
EA201390190A1 (ru) Ингибиторы вируса гепатита с
EA201001275A1 (ru) Конформационно-ограниченные бифенильные производные для применения в качестве ингибиторов вируса гепатита с
EA201270622A1 (ru) Ингибиторы вируса гепатита с
EA201171208A1 (ru) Ингибиторы вируса гепатита с
EA200900298A1 (ru) Ингибиторы вируса гепатита с
EA200802346A1 (ru) Циклопропилконденсированные индолобензазепиновые ингибиторы белка ns5b вируса гепатита с
EA201101082A1 (ru) Ингибиторы вируса гепатита с
EA201270656A1 (ru) Ингибиторы вируса гепатита с
CY1111423T1 (el) Αναστολεις ns5b hcv
ATE469155T1 (de) Cyclopropyl-fusionierte indolbenzazepin-hcv-ns5b- hemmer
EA201370017A1 (ru) Ингибиторы вируса гепатита с
EA201170401A8 (ru) Противовирусные соединения
ATE522532T1 (de) Verbindungen zur behandlung von hepatitis c
EA201390538A1 (ru) Противовирусные соединения
NO20090453L (no) Hepatitt C Virusinhibitorer
EA201391152A1 (ru) Ингибиторы вируса гепатита с
EA201001274A1 (ru) Имидазолилбифенильные имидазолы в качестве ингибиторов вируса гепатита с
DK2209789T3 (da) Cyclopropyl-kondenserede indolobenzazepin HCV NS5B-hæmmere
EA201000201A1 (ru) Азотсодержащие бициклические химические вещества для лечения вирусных инфекций
EA200900676A1 (ru) Ингибиторы вируса гепатита с
ATE494291T1 (de) Verbindungen zur behandlung von hepatitis c
ATE551343T1 (de) Tetracyclische verbindungen zur behandlung von hepatitis c

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU